{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:38:22Z","timestamp":1790685502564,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH111773"],"award-info":[{"award-number":["MH111773"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG058160"],"award-info":[{"award-number":["AG058160"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH106939"],"award-info":[{"award-number":["MH106939"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001391","name":"Whitehall Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["14SDG20440029"],"award-info":[{"award-number":["14SDG20440029"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.neuron.2018.07.010","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T11:19:24Z","timestamp":1532603964000},"page":"493-510.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":108,"title":["Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways"],"prefix":"10.1016","volume":"99","author":[{"given":"Chia-Yu","family":"Yeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Asrican","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Jhoan","family":"Quintanilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Cass\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Gebara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hechen","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Toni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2018.07.010_bib1","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.1073\/pnas.0800946105","article-title":"NMDA receptors inhibit synapse unsilencing during brain development","volume":"105","author":"Adesnik","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.07.010_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/(SICI)1096-9861(19960304)366:2<270::AID-CNE7>3.0.CO;2-2","article-title":"Axon arbors and synaptic connections of hippocampal mossy cells in the rat in\u00a0vivo","volume":"366","author":"Buckmaster","year":"1996","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2018.07.010_bib3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1126\/science.aan4074","article-title":"Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory","volume":"359","author":"Bui","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.07.010_bib4","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1523\/JNEUROSCI.3620-13.2014","article-title":"Hilar mossy cells provide the first glutamatergic synapses to adult-born dentate granule cells","volume":"34","author":"Chancey","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.07.010_bib5","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.neuron.2016.12.019","article-title":"In\u00a0vivo imaging of dentate gyrus mossy cells in behaving mice","volume":"93","author":"Danielson","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.07.010_bib6","doi-asserted-by":"crossref","first-page":"E1152","DOI":"10.1073\/pnas.1218991110","article-title":"Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb","volume":"110","author":"Deshpande","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.07.010_bib7","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1002\/hipo.22044","article-title":"Characterization of dopamine D1 and D2 receptor-expressing neurons in the mouse hippocampus","volume":"22","author":"Gangarossa","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuron.2018.07.010_bib8","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/stem.2266","article-title":"Heterogeneity of radial glia-like cells in the adult hippocampus","volume":"34","author":"Gebara","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.neuron.2018.07.010_bib9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.neuron.2016.12.026","article-title":"Spatial representations of granule cells and mossy cells of the dentate gyrus","volume":"93","author":"GoodSmith","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.07.010_bib10","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1126\/science.aar7732","article-title":"Revising concepts about adult stem cells","volume":"359","author":"G\u00f6tz","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.07.010_bib11","doi-asserted-by":"crossref","first-page":"e13761","DOI":"10.1371\/journal.pone.0013761","article-title":"Channelrhodopsin-2 localised to the axon initial segment","volume":"5","author":"Grubb","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2018.07.010_bib12","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.celrep.2015.12.061","article-title":"An NMDA receptor-dependent mechanism underlies inhibitory synapse development","volume":"14","author":"Gu","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2018.07.010_bib13","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1093\/cercor\/bhv127","article-title":"Differential recruitment of dentate gyrus interneuron types by commissural versus perforant pathways","volume":"26","author":"Hsu","year":"2016","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neuron.2018.07.010_bib14","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/mp.2017.7","article-title":"Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior","volume":"23","author":"Hutchison","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2018.07.010_bib15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nprot.2010.169","article-title":"In\u00a0vivo two-photon imaging of sensory-evoked dendritic calcium signals in cortical neurons","volume":"6","author":"Jia","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuron.2018.07.010_bib16","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.neuron.2012.10.036","article-title":"Hilar mossy cell degeneration causes transient dentate granule cell hyperexcitability and impaired pattern separation","volume":"76","author":"Jinde","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.07.010_bib17","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.cell.2006.10.041","article-title":"Postnatal deletion of Numb\/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche","volume":"127","author":"Kuo","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.07.010_bib18","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neuron.2009.02.027","article-title":"Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach","volume":"62","author":"Lu","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.07.010_bib19","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.neuron.2013.02.030","article-title":"The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function","volume":"78","author":"Lu","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.07.010_bib20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/cne.10964","article-title":"Neural stem and progenitor cells in nestin-GFP transgenic mice","volume":"469","author":"Mignone","year":"2004","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2018.07.010_bib21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/bies.201200136","article-title":"A circuit-based gatekeeper for adult neural stem cell proliferation: parvalbumin-expressing interneurons of the dentate gyrus control the activation and proliferation of quiescent adult neural stem cells","volume":"35","author":"Moss","year":"2013","journal-title":"BioEssays"},{"key":"10.1016\/j.neuron.2018.07.010_bib22","doi-asserted-by":"crossref","first-page":"E2536","DOI":"10.1073\/pnas.1514652113","article-title":"Fine processes of Nestin-GFP-positive radial glia-like stem cells in the adult dentate gyrus ensheathe local synapses and vasculature","volume":"113","author":"Moss","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.07.010_bib23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature21376","article-title":"Prefrontal cortex output circuits guide reward seeking through divergent cue encoding","volume":"543","author":"Otis","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.07.010_bib24","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1126\/science.aao5056","article-title":"Live imaging of neurogenesis in the adult mouse hippocampus","volume":"359","author":"Pilz","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.07.010_bib25","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/hipo.22408","article-title":"drd2-cre:ribotag mouse line unravels the possible diversity of dopamine d2 receptor-expressing cells of the dorsal mouse hippocampus","volume":"25","author":"Puighermanal","year":"2015","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuron.2018.07.010_bib26","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/glia.22505","article-title":"Polarized distribution of AMPA, but not GABAA, receptors in radial glia-like cells of the adult dentate gyrus","volume":"61","author":"Renzel","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.neuron.2018.07.010_bib27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/BF01181525","article-title":"Five types of basket cell in the hippocampal dentate gyrus: a combined Golgi and electron microscopic study","volume":"12","author":"Ribak","year":"1983","journal-title":"J.\u00a0Neurocytol."},{"key":"10.1016\/j.neuron.2018.07.010_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fninf.2018.00014","article-title":"NeuroMatic: an integrated open-source software toolkit for acquisition, analysis and simulation of electrophysiological data","volume":"12","author":"Rothman","year":"2018","journal-title":"Front. Neuroinform."},{"key":"10.1016\/j.neuron.2018.07.010_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1152\/jn.1995.74.1.179","article-title":"Electrophysiological evidence that dentate hilar mossy cells are excitatory and innervate both granule cells and interneurons","volume":"74","author":"Scharfman","year":"1995","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2018.07.010_bib30","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nrn.2016.87","article-title":"The enigmatic mossy cell of the dentate gyrus","volume":"17","author":"Scharfman","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2018.07.010_bib31","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3389\/fncir.2012.00106","article-title":"Hilar mossy cells of the dentate gyrus: a historical perspective","volume":"6","author":"Scharfman","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.neuron.2018.07.010_bib32","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuron.2016.12.011","article-title":"Physiological properties and behavioral correlates of hippocampal granule cells and mossy cells","volume":"93","author":"Senzai","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.07.010_bib33","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.stem.2015.07.013","article-title":"Single-cell RNA-seq with waterfall reveals molecular cascades underlying adult neurogenesis","volume":"17","author":"Shin","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neuron.2018.07.010_bib34","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.stem.2015.04.003","article-title":"Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis","volume":"16","author":"Sierra","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neuron.2018.07.010_bib35","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nature11306","article-title":"Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision","volume":"489","author":"Song","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.07.010_bib36","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1038\/nn.3572","article-title":"Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus","volume":"16","author":"Song","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.07.010_bib37","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1101\/cshperspect.a018937","article-title":"Neuronal circuitry mechanisms regulating adult mammalian neurogenesis","volume":"8","author":"Song","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuron.2018.07.010_bib38","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-neuro-071013-014048","article-title":"Chemogenetic tools to interrogate brain functions","volume":"37","author":"Sternson","year":"2014","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2018.07.010_bib39","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1098\/rstb.2012.0038","article-title":"Serotonin receptor expression along the dorsal-ventral axis of mouse hippocampus","volume":"367","author":"Tanaka","year":"2012","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.neuron.2018.07.010_bib40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-4939-1096-0_14","article-title":"Acute brain slice methods for adult and aging animals: application of targeted patch clamp analysis and optogenetics","volume":"1183","author":"Ting","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.neuron.2018.07.010_bib41","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/ncomms2101","article-title":"Monosynaptic inputs to new neurons in the dentate gyrus","volume":"3","author":"Vivar","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2018.07.010_bib42","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2013.04.017","article-title":"Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males","volume":"153","author":"Yang","year":"2013","journal-title":"Cell"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318305841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318305841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:12:59Z","timestamp":1760253179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627318305841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0896627318305841"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2018.07.010","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2018.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}