{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:01:38Z","timestamp":1790564498951,"version":"4.1.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":383,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR 2419"],"award-info":[{"award-number":["FOR 2419"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KN556\/11-1"],"award-info":[{"award-number":["KN556\/11-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK1459"],"award-info":[{"award-number":["GRK1459"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KN556\/14592"],"award-info":[{"award-number":["KN556\/14592"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB877"],"award-info":[{"award-number":["SFB877"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK1459"],"award-info":[{"award-number":["GRK1459"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Landesforschungsf\u00f6rderung Hamburg"},{"name":"Ritz-Stiftung"},{"name":"Forschungsf\u00f6rderung Medizinische Fakult\u00e4t Hamburg"},{"name":"Creutzfeldt-Jakob Disease Foundation"},{"name":"Werner-Otto-Stiftung"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.neuron.2018.08.010","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T11:01:04Z","timestamp":1535626864000},"page":"1155-1169.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression"],"prefix":"10.1016","volume":"99","author":[{"given":"Frank F.","family":"Heisler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Pechmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Wieser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann C.","family":"Altmeppen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonhard","family":"Veenendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Muhia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Schweizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Glatzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Krasemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kneussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2018.08.010_bib1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature20414","article-title":"Defects in trafficking bridge Parkinson\u2019s disease pathology and genetics","volume":"539","author":"Abeliovich","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.08.010_bib2","doi-asserted-by":"crossref","first-page":"4964","DOI":"10.1093\/emboj\/17.17.4964","article-title":"Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1","volume":"17","author":"Adams","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2018.08.010_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tcb.2015.08.007","article-title":"Cell biology of prions and prionoids: a status report","volume":"26","author":"Aguzzi","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib4","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1111\/febs.12196","article-title":"Roles of endoproteolytic \u03b1-cleavage and shedding of the prion protein in neurodegeneration","volume":"280","author":"Altmeppen","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.neuron.2018.08.010_bib5","doi-asserted-by":"crossref","first-page":"e04260","DOI":"10.7554\/eLife.04260","article-title":"The sheddase ADAM10 is a potent modulator of prion disease","volume":"4","author":"Altmeppen","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2018.08.010_bib6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tins.2011.10.002","article-title":"Prion protein at the crossroads of physiology and disease","volume":"35","author":"Biasini","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2018.08.010_bib7","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1083\/jcb.110.3.743","article-title":"Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells","volume":"110","author":"Borchelt","year":"1990","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib8","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.1469-445X.2000.02091.x","article-title":"Neuroinvasion of prions: insights from mouse models","volume":"85","author":"Brandner","year":"2000","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.neuron.2018.08.010_bib9","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/356577a0","article-title":"Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein","volume":"356","author":"B\u00fceler","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.08.010_bib10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.tcb.2004.12.002","article-title":"The highways and byways of prion protein trafficking","volume":"15","author":"Campana","year":"2005","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib11","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201711083","article-title":"Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons","author":"Cheng","year":"2018","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib12","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1038\/emm.2014.117","article-title":"Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies","volume":"47","author":"Ciechanover","year":"2015","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.neuron.2018.08.010_bib13","doi-asserted-by":"crossref","first-page":"a006833","DOI":"10.1101\/cshperspect.a006833","article-title":"Prions","volume":"3","author":"Colby","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib14","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1096\/fj.11-202077","article-title":"Prion-infected cells regulate the release of exosomes with distinct ultrastructural features","volume":"26","author":"Coleman","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.neuron.2018.08.010_bib15","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1038\/emboj.2008.133","article-title":"Huntingtin phosphorylation acts as a molecular switch for anterograde\/retrograde transport in neurons","volume":"27","author":"Colin","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2018.08.010_bib16","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.neuro.24.1.519","article-title":"Prion diseases of humans and animals: their causes and molecular basis","volume":"24","author":"Collinge","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2018.08.010_bib17","doi-asserted-by":"crossref","first-page":"560421","DOI":"10.1155\/2013\/560421","article-title":"Early delivery of misfolded PrP from ER to lysosomes by autophagy","volume":"2013","author":"Cortes","year":"2013","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib18","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.str.2014.11.016","article-title":"The LisH motif of muskelin is crucial for oligomerization and governs intracellular localization","volume":"23","author":"Delto","year":"2015","journal-title":"Structure"},{"key":"10.1016\/j.neuron.2018.08.010_bib19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.arr.2016.05.001","article-title":"Impact of lysosome status on extracellular vesicle content and release","volume":"32","author":"Eitan","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neuron.2018.08.010_bib20","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.cell.2011.01.021","article-title":"Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles","volume":"144","author":"Encalada","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.08.010_bib21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.nbd.2009.07.015","article-title":"Influence of ADAM10 on prion protein processing and scrapie infectiosity in\u00a0vivo","volume":"36","author":"Endres","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuron.2018.08.010_bib22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/jnc.13514","article-title":"Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity","volume":"137","author":"Falker","year":"2016","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuron.2018.08.010_bib23","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1073\/pnas.0308413101","article-title":"Cells release prions in association with exosomes","volume":"101","author":"Fevrier","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.08.010_bib24","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/j.1460-2075.1996.tb00467.x","article-title":"Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie","volume":"15","author":"Fischer","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2018.08.010_bib25","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1083\/jcb.201302078","article-title":"JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors","volume":"202","author":"Fu","year":"2013","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib26","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.tcb.2014.05.002","article-title":"Integrated regulation of motor-driven organelle transport by scaffolding proteins","volume":"24","author":"Fu","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib27","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1099\/vir.0.80811-0","article-title":"No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis","volume":"86","author":"Glatzel","year":"2005","journal-title":"J.\u00a0Gen. Virol."},{"issue":"Pt A","key":"10.1016\/j.neuron.2018.08.010_bib28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mcn.2014.12.009","article-title":"Prion degradation pathways: potential for therapeutic intervention","volume":"66","author":"Goold","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2018.08.010_bib29","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/j.celrep.2018.04.112","article-title":"Neurobeachin and the kinesin KIF21B are critical for endocytic recycling of NMDA receptors and regulate social behavior","volume":"23","author":"Gromova","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.neuron.2018.08.010_bib30","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1093\/hmg\/ddt237","article-title":"Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in\u00a0vivo","volume":"22","author":"Gunawardena","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2018.08.010_bib31","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1074\/jbc.M115.684258","article-title":"Stimulating the release of exosomes increases the intercellular transfer of prions","volume":"291","author":"Guo","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.08.010_bib32","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ceb.2004.06.002","article-title":"Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction","volume":"16","author":"Guzik","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neuron.2011.03.008","article-title":"Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons","volume":"70","author":"Heisler","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.08.010_bib34","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1073\/pnas.1304301111","article-title":"GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites","volume":"111","author":"Heisler","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.08.010_bib35","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.neuron.2010.09.039","article-title":"Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease","volume":"68","author":"Hirokawa","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.08.010_bib36","doi-asserted-by":"crossref","first-page":"26589","DOI":"10.1074\/jbc.R116.757955","article-title":"Exosomes in the pathology of neurodegenerative diseases","volume":"291","author":"Howitt","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.08.010_bib37","doi-asserted-by":"crossref","first-page":"e51305","DOI":"10.1371\/journal.pone.0051305","article-title":"Amyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development","volume":"7","author":"Kaiser","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2018.08.010_bib38","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrn3445","article-title":"Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics","volume":"14","author":"Kneussel","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2018.08.010_bib39","doi-asserted-by":"crossref","first-page":"P1738","DOI":"10.1016\/j.cell.2014.06.002","article-title":"SnapShot: receptor dynamics at plastic synapses","volume":"157","author":"Kneussel","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.08.010_bib40","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1172\/JCI80339","article-title":"Serine 421 regulates mutant huntingtin toxicity and clearance in mice","volume":"126","author":"Kratter","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2018.08.010_bib41","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nature19312","article-title":"The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6","volume":"536","author":"K\u00fcffer","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.08.010_bib42","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/path.1711660404","article-title":"Lysosomes as key organelles in the pathogenesis of prion encephalopathies","volume":"166","author":"Laszlo","year":"1992","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.neuron.2018.08.010_bib43","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nature07761","article-title":"Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers","volume":"457","author":"Laur\u00e9n","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.08.010_bib44","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13024-018-0248-6","article-title":"Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein","volume":"13","author":"Linsenmeier","year":"2018","journal-title":"Mol. Neurodegener"},{"key":"10.1016\/j.neuron.2018.08.010_bib45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ceb.2015.04.013","article-title":"Extracellular vesicles shuffling intercellular messages: for good or for bad","volume":"35","author":"Lo Cicero","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib46","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1097\/01.wnr.0000134931.81690.34","article-title":"Cathepsin B and L are involved in degradation of prions in GT1-1 neuronal cells","volume":"15","author":"Luhr","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuron.2018.08.010_bib47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.conb.2014.03.015","article-title":"Axon and dendritic trafficking","volume":"27","author":"Maeder","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuron.2018.08.010_bib48","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1242\/jcs.114801","article-title":"4-hydroxytamoxifen leads to PrPSc clearance by conveying both PrPC and PrPSc to lysosomes independently of autophagy","volume":"126","author":"Marzo","year":"2013","journal-title":"J.\u00a0Cell Sci."},{"issue":"Pt B","key":"10.1016\/j.neuron.2018.08.010_bib49","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.brainres.2016.04.009","article-title":"The stress of prion disease","volume":"1648","author":"Mays","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2018.08.010_bib50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jad.2016.09.049","article-title":"A genome wide association study suggests the association of muskelin with early onset bipolar disorder: Implications for a GABAergic epileptogenic neurogenesis model","volume":"208","author":"Nassan","year":"2017","journal-title":"J.\u00a0Affect. Disord."},{"key":"10.1016\/j.neuron.2018.08.010_bib51","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1348-0421.2008.00046.x","article-title":"Synthetic fibril peptide promotes clearance of scrapie prion protein by lysosomal degradation","volume":"52","author":"Okemoto-Nakamura","year":"2008","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.neuron.2018.08.010_bib52","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/S0960-9822(01)00475-4","article-title":"Cdc42, dynein, and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilization","volume":"11","author":"Palazzo","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib53","doi-asserted-by":"crossref","first-page":"e3872","DOI":"10.1371\/journal.pone.0003872","article-title":"The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes","volume":"3","author":"Polymenidou","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2018.08.010_bib54","doi-asserted-by":"crossref","first-page":"12915","DOI":"10.1523\/JNEUROSCI.5910-12.2013","article-title":"Postnatal disruption of the disintegrin\/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions","volume":"33","author":"Prox","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.08.010_bib55","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4161\/pri.27892","article-title":"The GPI-anchoring of PrP: implications in sorting and pathogenesis","volume":"8","author":"Puig","year":"2014","journal-title":"Prion"},{"key":"10.1016\/j.neuron.2018.08.010_bib56","doi-asserted-by":"crossref","first-page":"15482","DOI":"10.1523\/JNEUROSCI.3258-14.2014","article-title":"Emerging roles of extracellular vesicles in the nervous system","volume":"34","author":"Rajendran","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.08.010_bib57","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/128_2011_160","article-title":"Neuroprotective and neurotoxic signaling by the prion protein","volume":"305","author":"Resenberger","year":"2011","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.neuron.2018.08.010_bib58","doi-asserted-by":"crossref","first-page":"29247","DOI":"10.1074\/jbc.M114.589564","article-title":"First demonstration of transmissible spongiform encephalopathy-associated prion protein (PrPTSE) in extracellular vesicles from plasma of mice infected with mouse-adapted variant Creutzfeldt-Jakob disease by in\u00a0vitro amplification","volume":"289","author":"Sa\u00e1","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.08.010_bib59","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature09768","article-title":"Prion propagation and toxicity in\u00a0vivo occur in two distinct mechanistic phases","volume":"470","author":"Sandberg","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.08.010_bib60","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.neuron.2016.01.026","article-title":"Prions and protein assemblies that convey biological information in health and disease","volume":"89","author":"Sanders","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.08.010_bib61","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1348-0421.2010.00272.x","article-title":"The effects of lysosomal and proteasomal inhibitors on abnormal forms of prion protein degradation in murine macrophages","volume":"54","author":"Sassa","year":"2010","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.neuron.2018.08.010_bib62","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","article-title":"The biology of huntingtin","volume":"89","author":"Saudou","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.08.010_bib63","doi-asserted-by":"crossref","first-page":"8640","DOI":"10.1128\/JVI.00378-14","article-title":"Axonal and transynaptic spread of prions","volume":"88","author":"Shearin","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.neuron.2018.08.010_bib64","doi-asserted-by":"crossref","first-page":"21658","DOI":"10.1038\/srep21658","article-title":"Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells","volume":"6","author":"Shim","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2018.08.010_bib65","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1038\/nprot.2007.365","article-title":"Cryosectioning and immunolabeling","volume":"2","author":"Slot","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuron.2018.08.010_bib66","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1093\/emboj\/cdg344","article-title":"The mechanism of internalization of\u00a0glycosylphosphatidylinositol-anchored prion protein","volume":"22","author":"Sunyach","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2018.08.010_bib67","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2202-8-28","article-title":"Neuronal expression of muskelin in the rodent central nervous system","volume":"8","author":"Tagnaouti","year":"2007","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neuron.2018.08.010_bib68","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1083\/jcb.200801133","article-title":"Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation","volume":"182","author":"Valiyaveettil","year":"2008","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib69","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejcb.2008.08.001","article-title":"Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy","volume":"88","author":"Veith","year":"2009","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib70","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.bbrc.2005.10.146","article-title":"KDEL-tagged anti-prion intrabodies impair PrP lysosomal degradation and inhibit scrapie infectivity","volume":"338","author":"Vetrugno","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuron.2018.08.010_bib71","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.1371\/journal.pbio.0030233","article-title":"Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomes","volume":"3","author":"Vonderheit","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neuron.2018.08.010_bib72","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.cell.2011.09.036","article-title":"Arc\/Arg3.1 regulates an endosomal pathway essential for activity-dependent \u03b2-amyloid generation","volume":"147","author":"Wu","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.08.010_bib73","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1093\/emboj\/20.19.5383","article-title":"Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein","volume":"20","author":"Yedidia","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2018.08.010_bib74","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1242\/jcs.165472","article-title":"The multivesicular body is the major internal site of prion conversion","volume":"128","author":"Yim","year":"2015","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.neuron.2018.08.010_bib75","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.bbamem.2015.12.018","article-title":"Glycosylphosphatidylinositol-anchored proteins: membrane organization and transport","volume":"1858","author":"Zurzolo","year":"2016","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318306834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318306834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T21:12:06Z","timestamp":1568841126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627318306834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":75,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0896627318306834"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2018.08.010","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2018.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}