{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:30:43Z","timestamp":1790937043712,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS083845"],"award-info":[{"award-number":["NS083845"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS 099328"],"award-info":[{"award-number":["NS 099328"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS103123"],"award-info":[{"award-number":["NS103123"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001157","name":"Harvard NeuroDiscovery Center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001157","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.neuron.2018.09.014","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T10:39:48Z","timestamp":1539167988000},"page":"75-90.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":142,"title":["Abrogating Native \u03b1-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson\u2019s Disease"],"prefix":"10.1016","volume":"100","author":[{"given":"Silke","family":"Nuber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Rajsombath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Minakaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian P.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ericsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Caldarone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Dettmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J.","family":"Selkoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2018.09.014_bib1","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1056\/NEJMoa033277","article-title":"Mutations in the glucocerebrosidase gene and Parkinson\u2019s disease in Ashkenazi Jews","volume":"351","author":"Aharon-Peretz","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuron.2018.09.014_bib2","doi-asserted-by":"crossref","first-page":"29739","DOI":"10.1074\/jbc.M600933200","article-title":"Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease","volume":"281","author":"Anderson","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.09.014_bib3","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/mds.25421","article-title":"Alpha-synuclein\u00a0p.H50Q, a novel pathogenic mutation for Parkinson\u2019s disease","volume":"28","author":"Appel-Cresswell","year":"2013","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neuron.2018.09.014_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature10324","article-title":"\u03b1-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation","volume":"477","author":"Bartels","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.09.014_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fnins.2015.00037","article-title":"Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods","volume":"9","author":"Barth","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuron.2018.09.014_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0006-291X(65)90743-6","article-title":"Metabolism of glucocerebrosides. Ii. Evidence of an enzymatic deficiency in Gaucher\u2019s disease","volume":"18","author":"Brady","year":"1965","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuron.2018.09.014_bib7","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1126\/science.aam9080","article-title":"Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson\u2019s disease","volume":"357","author":"Burbulla","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.09.014_bib8","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1126\/science.1195227","article-title":"Alpha-synuclein promotes SNARE-complex assembly in\u00a0vivo and in\u00a0vitro","volume":"329","author":"Burr\u00e9","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.09.014_bib9","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.1038\/nature12125","article-title":"Properties of native brain alpha-synuclein","volume":"498","author":"Burr\u00e9","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.09.014_bib10","doi-asserted-by":"crossref","first-page":"E4274","DOI":"10.1073\/pnas.1416598111","article-title":"\u03b1-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation","volume":"111","author":"Burr\u00e9","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.09.014_bib11","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nmeth.2450","article-title":"Improved tools for the Brainbow toolbox","volume":"10","author":"Cai","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2018.09.014_bib12","doi-asserted-by":"crossref","first-page":"16025","DOI":"10.1038\/npjparkd.2016.25","article-title":"Parkinson\u2019s disease as a system-level disorder","volume":"2","author":"Caligiore","year":"2016","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.neuron.2018.09.014_bib13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.expneurol.2012.11.007","article-title":"Expression of human E46K-mutated \u03b1-synuclein in BAC-transgenic rats replicates early-stage Parkinson\u2019s disease features and enhances vulnerability to mitochondrial impairment","volume":"240","author":"Cannon","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2018.09.014_bib14","doi-asserted-by":"crossref","first-page":"10451","DOI":"10.1073\/pnas.181356498","article-title":"Induction of stereotypy in dopamine-deficient mice requires striatal D1 receptor activation","volume":"98","author":"Chartoff","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.09.014_bib15","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/ana.21995","article-title":"Clinical progression in Parkinson disease and the neurobiology of axons","volume":"67","author":"Cheng","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuron.2018.09.014_bib16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.semcdb.2015.10.031","article-title":"Calcium signaling in membrane repair","volume":"45","author":"Cheng","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.neuron.2018.09.014_bib17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.febslet.2004.09.038","article-title":"Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein","volume":"576","author":"Choi","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuron.2018.09.014_bib18","first-page":"2802","article-title":"Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy","volume":"260","author":"Coelho","year":"2013","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.neuron.2018.09.014_bib19","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1074\/jbc.273.16.9443","article-title":"Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes","volume":"273","author":"Davidson","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.09.014_bib20","doi-asserted-by":"crossref","first-page":"6371","DOI":"10.1074\/jbc.M112.403311","article-title":"In\u00a0vivo cross-linking reveals principally oligomeric forms of \u03b1-synuclein and \u03b2-synuclein in neurons and non-neural cells","volume":"288","author":"Dettmer","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.09.014_bib21","doi-asserted-by":"crossref","first-page":"7314","DOI":"10.1038\/ncomms8314","article-title":"Parkinson-causing \u03b1-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation","volume":"6","author":"Dettmer","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2018.09.014_bib22","doi-asserted-by":"crossref","first-page":"9596","DOI":"10.1073\/pnas.1505953112","article-title":"KTKEGV repeat motifs are key mediators of normal \u03b1-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity","volume":"112","author":"Dettmer","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.09.014_bib23","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1093\/hmg\/ddx227","article-title":"Loss of native \u03b1-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells","volume":"26","author":"Dettmer","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2018.09.014_bib24","doi-asserted-by":"crossref","first-page":"35104","DOI":"10.1074\/jbc.M111.247965","article-title":"E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment","volume":"286","author":"Emmer","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.09.014_bib25","doi-asserted-by":"crossref","first-page":"15345","DOI":"10.1074\/jbc.M111.318949","article-title":"\u03b1-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli\u00a0exists predominantly as disordered monomer","volume":"287","author":"Fauvet","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.09.014_bib26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00005072-199603000-00001","article-title":"Neuropathology of Parkinson\u2019s disease","volume":"55","author":"Forno","year":"1996","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neuron.2018.09.014_bib27","first-page":"266","article-title":"Diversity of pathological features other than Lewy bodies in familial Parkinson\u2019s disease due to SNCA mutations","volume":"2","author":"Fujishiro","year":"2013","journal-title":"Am. J. Neurodegener. Dis."},{"key":"10.1016\/j.neuron.2018.09.014_bib28","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1126\/science.aan6160","article-title":"Structural basis of membrane disruption and cellular toxicity by \u03b1-synuclein oligomers","volume":"358","author":"Fusco","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.09.014_bib29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.yfrne.2014.02.002","article-title":"Sex differences in Parkinson\u2019s disease","volume":"35","author":"Gillies","year":"2014","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neuron.2018.09.014_bib30","doi-asserted-by":"crossref","first-page":"e3394","DOI":"10.1371\/journal.pone.0003394","article-title":"Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region","volume":"3","author":"Herrera","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2018.09.014_bib31","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nsmb.2075","article-title":"Mechanism and function of synaptotagmin-mediated membrane apposition","volume":"18","author":"Hui","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.neuron.2018.09.014_bib32","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/mds.26797","article-title":"Endolysosomal dysfunction in Parkinson\u2019s disease: Recent developments and future challenges","volume":"31","author":"Kett","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neuron.2018.09.014_bib33","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1073\/pnas.1700465115","article-title":"GBA1 deficiency negatively affects physiological \u03b1-synuclein tetramers and related multimers","volume":"115","author":"Kim","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.09.014_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng0298-106","article-title":"Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson\u2019s disease","volume":"18","author":"Kr\u00fcger","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2018.09.014_bib35","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/jnen\/62.12.1241","article-title":"Morphogenesis of Lewy bodies: Dissimilar incorporation of alpha-synuclein, ubiquitin, and p62","volume":"62","author":"Kuusisto","year":"2003","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neuron.2018.09.014_bib36","doi-asserted-by":"crossref","first-page":"e23939","DOI":"10.1371\/journal.pone.0023939","article-title":"Improved immunodetection of endogenous \u03b1-synuclein","volume":"6","author":"Lee","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2018.09.014_bib37","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/ana.23894","article-title":"G51D \u03b1-synuclein mutation causes a novel parkinsonian-pyramidal syndrome","volume":"73","author":"Lesage","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuron.2018.09.014_bib38","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1073\/pnas.0406976102","article-title":"Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson\u2019s disease-linked mutations","volume":"102","author":"Li","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.09.014_bib39","doi-asserted-by":"crossref","first-page":"22670","DOI":"10.1074\/jbc.M501508200","article-title":"A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: Implications for pathogenesis of Parkinson disease","volume":"280","author":"Liu","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.09.014_bib40","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nn.4529","article-title":"\u03b1-Synuclein promotes dilation of the exocytotic fusion pore","volume":"20","author":"Logan","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.09.014_bib41","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.parkreldis.2004.01.001","article-title":"A critical review of the\u00a0development and importance of proteinaceous aggregates in animal models of Parkinson\u2019s disease: New insights into Lewy body formation","volume":"10","author":"Meredith","year":"2004","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.neuron.2018.09.014_bib42","doi-asserted-by":"crossref","first-page":"7818","DOI":"10.1021\/bi047846q","article-title":"Cleavage of alpha-synuclein by calpain: Potential role in degradation of fibrillized and nitrated species of alpha-synuclein","volume":"44","author":"Mishizen-Eberz","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuron.2018.09.014_bib43","doi-asserted-by":"crossref","first-page":"e81314","DOI":"10.1371\/journal.pone.0081314","article-title":"A new method for quantitative immunoblotting of endogenous \u03b1-synuclein","volume":"8","author":"Newman","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2018.09.014_bib44","doi-asserted-by":"crossref","first-page":"9958","DOI":"10.1073\/pnas.1610993113","article-title":"Caspase-1 clipping causes complications for \u03b1-synuclein","volume":"113","author":"Nuber","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.09.014_bib45","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1523\/JNEUROSCI.3040-07.2008","article-title":"Neurodegeneration and motor dysfunction in a conditional model of Parkinson\u2019s disease","volume":"28","author":"Nuber","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.09.014_bib46","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/brain\/aws358","article-title":"A progressive dopaminergic phenotype associated with neurotoxic conversion of \u03b1-synuclein\u00a0in BAC-transgenic rats","volume":"136","author":"Nuber","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2018.09.014_bib47","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00401-014-1255-5","article-title":"Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD","volume":"127","author":"Nuber","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2018.09.014_bib48","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.expneurol.2007.11.019","article-title":"Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies","volume":"210","author":"Obi","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2018.09.014_bib49","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/brain\/awn349","article-title":"Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies","volume":"132","author":"Paleologou","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2018.09.014_bib50","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.neuron.2018.09.014_bib71","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1212\/WNL.0b013e31828727ba","article-title":"A novel a-synuclein missense mutation in Parkinson disease","volume":"80","author":"Proukakis","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2018.09.014_bib52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/exnr.2002.7882","article-title":"Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice","volume":"175","author":"Richfield","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2018.09.014_bib53","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.neuroscience.2009.03.002","article-title":"Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice","volume":"160","author":"Schell","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2018.09.014_bib54","first-page":"447","article-title":"Increased tyrosine hydroxylase expression accompanied\u00a0by glial changes within the non-lesioned hemisphere in the 6-hydroxydopamine model of Parkinson\u2019s disease","volume":"32","author":"Schlachetzki","year":"2014","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.neuron.2018.09.014_bib55","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0896-6273(03)00024-2","article-title":"The formation of highly soluble oligomers of alpha-synuclein\u00a0is regulated by fatty acids and enhanced in Parkinson\u2019s disease","volume":"37","author":"Sharon","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.09.014_bib56","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/syn.20381","article-title":"Alterations in dendritic morphology of the prefrontal cortical and striatum neurons in the unilateral 6-OHDA-rat model of Parkinson\u2019s disease","volume":"61","author":"Solis","year":"2007","journal-title":"Synapse"},{"key":"10.1016\/j.neuron.2018.09.014_bib57","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrn.2016.178","article-title":"Selective neuronal vulnerability in Parkinson disease","volume":"18","author":"Surmeier","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2018.09.014_bib58","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1523\/JNEUROSCI.4965-05.2006","article-title":"Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): Implications for Lewy body disorders","volume":"26","author":"Tofaris","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.09.014_bib59","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1091\/mbc.e14-02-0741","article-title":"Formation of \u03b1-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes","volume":"25","author":"Volpicelli-Daley","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neuron.2018.09.014_bib60","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1002\/jnr.21310","article-title":"Accumulation of phosphorylated alpha-synuclein in dopaminergic neurons of transgenic mice that express human alpha-synuclein","volume":"85","author":"Wakamatsu","year":"2007","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.neuron.2018.09.014_bib61","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.expneurol.2012.11.020","article-title":"Changes in properties of serine 129 phosphorylated \u03b1-synuclein with progression of Lewy-type histopathology in human brains","volume":"240","author":"Walker","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2018.09.014_bib62","doi-asserted-by":"crossref","first-page":"17797","DOI":"10.1073\/pnas.1113260108","article-title":"A soluble \u03b1-synuclein construct forms a dynamic tetramer","volume":"108","author":"Wang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.09.014_bib63","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1016\/j.cub.2014.08.027","article-title":"\u03b1-synuclein multimers cluster synaptic vesicles and attenuate recycling","volume":"24","author":"Wang","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2018.09.014_bib64","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00703325","article-title":"Dense core vesicles around the Lewy body in incidental Parkinson\u2019s disease: An electron microscopic study","volume":"39","author":"Watanabe","year":"1977","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2018.09.014_bib65","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1074\/jbc.M112.418871","article-title":"Monomeric synucleins generate membrane curvature","volume":"288","author":"Westphal","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.09.014_bib66","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1073\/pnas.1100976108","article-title":"In\u00a0vivo demonstration that alpha-synuclein oligomers are toxic","volume":"108","author":"Winner","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.09.014_bib67","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1021\/cn3002027","article-title":"Structures of the E46K mutant-type \u03b1-synuclein protein and impact of E46K mutation on the structures of the wild-type \u03b1-synuclein protein","volume":"4","author":"Wise-Scira","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neuron.2018.09.014_bib68","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.nbd.2015.04.007","article-title":"Effects of impaired membrane interactions on \u03b1-synuclein aggregation and neurotoxicity","volume":"79","author":"Ysselstein","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuron.2018.09.014_bib69","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1091\/mbc.e11-02-0159","article-title":"Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells","volume":"22","author":"Zhang","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neuron.2018.09.014_bib70","doi-asserted-by":"crossref","first-page":"12695","DOI":"10.1021\/jf5045102","article-title":"Expression, purification, and characterization of almond (Prunus dulcis) allergen Pru du 4","volume":"62","author":"Zhang","year":"2014","journal-title":"J.\u00a0Agric. Food Chem."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318307876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318307876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:14:13Z","timestamp":1760253253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627318307876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0896627318307876"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2018.09.014","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abrogating Native \u03b1-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson\u2019s Disease","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2018.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}