{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:44:20Z","timestamp":1790779460242,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":380,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01NS097428"],"award-info":[{"award-number":["R01NS097428"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Estate of Lilly Fulop"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.neuron.2018.11.032","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T11:56:22Z","timestamp":1544529382000},"page":"224-231.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Axoglial Adhesion by Cadm4 Regulates CNS Myelination"],"prefix":"10.1016","volume":"101","author":[{"given":"Nimrod","family":"Elazar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anya","family":"Vainshtein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neev","family":"Golan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharath","family":"Vijayaragavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Schaeren-Wiemers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Eshed-Eisenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3325-0597","authenticated-orcid":false,"given":"Elior","family":"Peles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2018.11.032_bib1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuroscience.2013.08.062","article-title":"On the resemblance of synapse formation and CNS myelination","volume":"276","author":"Almeida","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2018.11.032_bib2","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.cub.2018.02.068","article-title":"Myelination of neuronal cell bodies when myelin supply exceeds axonal demand","volume":"28","author":"Almeida","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2018.11.032_bib3","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1016\/j.cub.2015.07.056","article-title":"CNS myelin sheath lengths are an intrinsic property of oligodendrocytes","volume":"25","author":"Bechler","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2018.11.032_bib4","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1523\/JNEUROSCI.4317-05.2006","article-title":"Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology","volume":"26","author":"Brockschnieder","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.11.032_bib5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.devcel.2013.05.013","article-title":"Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in\u00a0vivo","volume":"25","author":"Czopka","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuron.2018.11.032_bib6","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.mcn.2005.12.001","article-title":"Unraveling the differential expression of the two isoforms of myelin-associated glycoprotein in a mouse expressing GFP-tagged S-MAG specifically regulated and targeted into the different myelin compartments","volume":"31","author":"Erb","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2018.11.032_bib7","doi-asserted-by":"crossref","first-page":"34864","DOI":"10.1074\/jbc.M110.120865","article-title":"N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion","volume":"285","author":"Fogel","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.11.032_bib8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnmol.2017.00024","article-title":"Redundant postsynaptic functions of SynCAMs 1-3 during synapse formation","volume":"10","author":"Fowler","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neuron.2018.11.032_bib9","doi-asserted-by":"crossref","first-page":"10250","DOI":"10.1073\/pnas.0912103107","article-title":"Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brain","volume":"107","author":"Galuska","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.11.032_bib10","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/glia.20688","article-title":"Identification of Tmem10\/Opalin as an oligodendrocyte enriched gene using expression profiling combined with genetic cell ablation","volume":"56","author":"Golan","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.neuron.2018.11.032_bib11","doi-asserted-by":"crossref","first-page":"10950","DOI":"10.1523\/JNEUROSCI.0571-13.2013","article-title":"Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy","volume":"33","author":"Golan","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.11.032_bib12","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nn.3992","article-title":"Neuronal activity biases axon selection for myelination in\u00a0vivo","volume":"18","author":"Hines","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.11.032_bib13","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nmeth.2105","article-title":"A culture system to study oligodendrocyte myelination processes using engineered nanofibers","volume":"9","author":"Lee","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2018.11.032_bib14","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.aaf6463","article-title":"Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system","volume":"352","author":"Marques","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.11.032_bib15","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1083\/jcb.200705132","article-title":"Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination","volume":"178","author":"Maurel","year":"2007","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2018.11.032_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.conb.2017.06.005","article-title":"Architecting the myelin landscape","volume":"47","author":"Osso","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuron.2018.11.032_bib17","doi-asserted-by":"crossref","first-page":"12815","DOI":"10.1523\/JNEUROSCI.2665-08.2008","article-title":"Disruption of Nectin-like 1 cell adhesion molecule leads to delayed axonal myelination in the CNS","volume":"28","author":"Park","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.11.032_bib29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1471-2202-8-90","article-title":"The adhesion molecule Necl-3\/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion","volume":"8","author":"Pellissier","year":"2007","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neuron.2018.11.032_bib18","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.neuron.2016.07.021","article-title":"Somatodendritic expression of JAM2 inhibits oligodendrocyte myelination","volume":"91","author":"Redmond","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.11.032_bib19","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1038\/nn.4160","article-title":"Cell type- and brain region-resolved mouse brain proteome","volume":"18","author":"Sharma","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.11.032_bib20","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/glia.23116","article-title":"The logistics of myelin biogenesis in the central nervous system","volume":"65","author":"Snaidero","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.neuron.2018.11.032_bib21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cell.2013.11.044","article-title":"Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue","volume":"156","author":"Snaidero","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.11.032_bib22","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nn1915","article-title":"A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination","volume":"10","author":"Spiegel","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.11.032_bib23","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrm2457","article-title":"Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation","volume":"9","author":"Takai","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neuron.2018.11.032_bib24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neulet.2008.08.023","article-title":"Neuronal RA175\/SynCAM1 isoforms are processed by tumor necrosis factor-alpha-converting\u00a0enzyme (TACE)\/ADAM17-like proteases","volume":"444","author":"Tanabe","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2018.11.032_bib25","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.neuron.2008.09.011","article-title":"Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system","volume":"60","author":"Watkins","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.11.032_bib26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/dvdy.24238","article-title":"CNS myelination requires cytoplasmic dynein function","volume":"244","author":"Yang","year":"2015","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.neuron.2018.11.032_bib27","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.11.032_bib28","doi-asserted-by":"crossref","first-page":"e64264","DOI":"10.1371\/journal.pone.0064264","article-title":"Necl-4\/SynCAM-4 is expressed in myelinating oligodendrocytes but not required for axonal myelination","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS ONE"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318310419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318310419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:15:59Z","timestamp":1760253359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627318310419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0896627318310419"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2018.11.032","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Axoglial Adhesion by Cadm4 Regulates CNS Myelination","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2018.11.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}