{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:47:51Z","timestamp":1790531271655,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":384,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-14-CE13-0004-01"],"award-info":[{"award-number":["ANR-14-CE13-0004-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-LABX-65"],"award-info":[{"award-number":["ANR-10-LABX-65"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-11-IDEX-0004-02"],"award-info":[{"award-number":["ANR-11-IDEX-0004-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.neuron.2018.12.024","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T11:33:05Z","timestamp":1547724785000},"page":"625-634.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["Synergistic Activity of Floor-Plate- and Ventricular-Zone-Derived Netrin-1 in Spinal Cord Commissural Axon Guidance"],"prefix":"10.1016","volume":"101","author":[{"given":"Juan Antonio","family":"Moreno-Bravo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Roig Puiggros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mehlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Ch\u00e9dotal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2018.12.024_bib1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.celrep.2014.10.037","article-title":"A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous system","volume":"9","author":"Belle","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2018.12.024_bib2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2017.03.008","article-title":"Tridimensional visualization and analysis of early human development","volume":"169","author":"Belle","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.12.024_bib3","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.celrep.2015.07.028","article-title":"Complete loss of netrin-1 results in embryonic lethality and severe axon guidance defects without increased neural cell death","volume":"12","author":"Bin","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2018.12.024_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0092-8674(03)00199-5","article-title":"The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance","volume":"113","author":"Charron","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.12.024_bib5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.conb.2010.07.008","article-title":"Further tales of the midline","volume":"21","author":"Ch\u00e9dotal","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuron.2018.12.024_bib6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.tins.2014.08.009","article-title":"Development and plasticity of commissural circuits: from locomotion to brain repair","volume":"37","author":"Ch\u00e9dotal","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2018.12.024_bib7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fncir.2015.00036","article-title":"Sensory and spinal inhibitory dorsal midline crossing is independent of Robo3","volume":"9","author":"Comer","year":"2015","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.neuron.2018.12.024_bib8","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature22331","article-title":"Floor-plate-derived netrin-1 is dispensable for commissural axon guidance","volume":"545","author":"Dominici","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.12.024_bib9","doi-asserted-by":"crossref","DOI":"10.1242\/dev.150375","article-title":"Non-cell autonomous control of precerebellar neuron migration by Slit and Robo proteins","volume":"145","author":"Dominici","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.neuron.2018.12.024_bib10","article-title":"Commissural axon navigation in the spinal cord: a repertoire of repulsive forces is in command","author":"Ducuing","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.neuron.2018.12.024_bib11","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/386796a0","article-title":"Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene","volume":"386","author":"Fazeli","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.12.024_bib12","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.celrep.2015.06.047","article-title":"A floor-plate extracellular protein-protein interaction screen identifies Draxin as a secreted netrin-1 antagonist","volume":"12","author":"Gao","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2018.12.024_bib13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.ne.19.030196.002013","article-title":"Mechanisms and molecules that control growth cone guidance","volume":"19","author":"Goodman","year":"1996","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2018.12.024_bib14","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cell.2004.07.024","article-title":"Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities","volume":"118","author":"Harfe","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.12.024_bib15","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1126\/science.1165187","article-title":"Draxin, a repulsive guidance protein for spinal cord and forebrain commissures","volume":"323","author":"Islam","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.12.024_bib16","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0092-8674(94)90421-9","article-title":"Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord","volume":"78","author":"Kennedy","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.12.024_bib17","doi-asserted-by":"crossref","first-page":"8866","DOI":"10.1523\/JNEUROSCI.5191-05.2006","article-title":"Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord","volume":"26","author":"Kennedy","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.12.024_bib18","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.neuron.2018.02.010","article-title":"Structural basis for Draxin-modulated axon guidance and fasciculation by netrin-1 through DCC","volume":"97","author":"Liu","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.12.024_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0896-6273(04)00179-5","article-title":"Conserved roles for Slit and Robo proteins in midline commissural axon guidance","volume":"42","author":"Long","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.12.024_bib20","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/cne.10068","article-title":"Spatiotemporal expression patterns of slit and robo genes in the rat brain","volume":"442","author":"Marillat","year":"2002","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2018.12.024_bib21","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ydbio.2005.09.049","article-title":"Adjacent pioneer commissural interneuron growth cones switch from contact avoidance to axon fasciculation after midline crossing","volume":"288","author":"Moon","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.neuron.2018.12.024_bib22","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1126\/science.1173851","article-title":"Traction on immobilized netrin-1 is sufficient to reorient axons","volume":"325","author":"Moore","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.12.024_bib23","doi-asserted-by":"crossref","DOI":"10.1242\/dev.159400","article-title":"Commissural neurons transgress the CNS\/PNS boundary in absence of ventricular zone-derived netrin-1","volume":"145","author":"Moreno-Bravo","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.neuron.2018.12.024_bib24","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature05246","article-title":"Boc is a receptor for sonic hedgehog in the guidance of commissural axons","volume":"444","author":"Okada","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.12.024_bib25","first-page":"119","article-title":"La r\u00e9tine des vert\u00e9br\u00e9s","volume":"1","author":"Ram\u00f3n y Cajal","year":"1892","journal-title":"Cellule"},{"key":"10.1016\/j.neuron.2018.12.024_bib26","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.neuron.2011.04.014","article-title":"VEGF mediates commissural axon chemoattraction through its receptor Flk1","volume":"70","author":"Ruiz de Almodovar","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.12.024_bib27","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0092-8674(94)90420-0","article-title":"The netrins define a family of axon outgrowth-promoting\u00a0proteins homologous to C. elegans UNC-6","volume":"78","author":"Serafini","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.12.024_bib28","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0092-8674(00)81795-X","article-title":"Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system","volume":"87","author":"Serafini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.12.024_bib29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s004270000073","article-title":"An amphioxus netrin gene is expressed in midline structures during embryonic and larval development","volume":"210","author":"Shimeld","year":"2000","journal-title":"Dev. Genes Evol."},{"key":"10.1016\/j.neuron.2018.12.024_bib30","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/336775a0","article-title":"Chemotropic guidance of developing axons in the mammalian central nervous system","volume":"336","author":"Tessier-Lavigne","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.12.024_bib31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/12703","article-title":"Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety","volume":"23","author":"Tronche","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2018.12.024_bib32","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.neuron.2017.03.007","article-title":"Netrin1 produced by neural progenitors, not floor plate cells, is required for axon guidance in the spinal cord","volume":"94","author":"Varadarajan","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.12.024_bib33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<123::AID-GENE7>3.0.CO;2-O","article-title":"Expression pattern of a Krox-20\/Cre knock-in allele in the developing hindbrain, bones, and peripheral nervous system","volume":"26","author":"Voiculescu","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.neuron.2018.12.024_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2018.12.025","article-title":"Long-range guidance of spinal commissural axons by Netrin1 and Sonic Hedgehog from midline floor plate cells","author":"Wu","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.12.024_bib34","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1126\/science.1255149","article-title":"Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism","volume":"344","author":"Xu","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.12.024_bib35","doi-asserted-by":"crossref","first-page":"11992","DOI":"10.1038\/s41598-017-12269-8","article-title":"Netrin-1 derived from the ventricular zone, but not the floor plate, directs hindbrain commissural axons to the ventral midline","volume":"7","author":"Yamauchi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2018.12.024_bib36","first-page":"3686","article-title":"Phenotypic analysis of mice completely lacking netrin 1","volume":"142","author":"Yung","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.neuron.2018.12.024_bib37","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.celrep.2018.01.068","article-title":"Netrin-1 confines rhombic lip-derived neurons to the CNS","volume":"22","author":"Yung","year":"2018","journal-title":"Cell Rep."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318311243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318311243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:15:48Z","timestamp":1760253348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627318311243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0896627318311243"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2018.12.024","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic Activity of Floor-Plate- and Ventricular-Zone-Derived Netrin-1 in Spinal Cord Commissural Axon Guidance","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2018.12.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}