{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:40:50Z","timestamp":1790102450726,"version":"4.0.1"},"reference-count":78,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":373,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY024334"],"award-info":[{"award-number":["R01EY024334"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R24EY023937"],"award-info":[{"award-number":["R24EY023937"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY003176"],"award-info":[{"award-number":["P30EY003176"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Thome Foundation"},{"DOI":"10.13039\/100001116","name":"Foundation for Fighting Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001116","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.neuron.2019.02.015","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T10:31:24Z","timestamp":1552386684000},"page":"574-586.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Retinoic Acid Induces Hyperactivity, and Blocking Its Receptor Unmasks Light Responses and Augments Vision in Retinal Degeneration"],"prefix":"10.1016","volume":"102","author":[{"given":"Michael","family":"Telias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bristol","family":"Denlinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Helft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billie","family":"Beckwith-Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2019.02.015_bib1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1091\/mbc.e05-06-0519","article-title":"Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells","volume":"17","author":"Aggarwal","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neuron.2019.02.015_bib2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00441-015-2337-y","article-title":"Changes in morphology of retinal ganglion cells with eccentricity in retinal degeneration","volume":"364","author":"Anderson","year":"2016","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.neuron.2019.02.015_bib3","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1194\/jlr.R100015-JLR200","article-title":"Gene expression regulation by retinoic acid","volume":"43","author":"Balmer","year":"2002","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.neuron.2019.02.015_bib4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3389\/fncel.2015.00330","article-title":"Blockade of pathological retinal ganglion cell hyperactivity improves optogenetically evoked light responses in rd1 mice","volume":"9","author":"Barrett","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2019.02.015_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-94-017-9050-5_1","article-title":"History of retinoic acid receptors","volume":"70","author":"Benbrook","year":"2014","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.neuron.2019.02.015_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuron.2006.02.026","article-title":"Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration","volume":"50","author":"Bi","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.02.015_bib7","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1523\/JNEUROSCI.5800-10.2011","article-title":"An intrinsic neural oscillator in the degenerating mouse retina","volume":"31","author":"Borowska","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.02.015_bib8","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1523\/JNEUROSCI.2235-12.2013","article-title":"P2X7 receptor channels allow direct permeation of nanometer-sized dyes","volume":"33","author":"Browne","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.02.015_bib9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1126\/science.1190897","article-title":"Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa","volume":"329","author":"Busskamp","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.neuron.2019.02.015_bib10","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/mt.2014.181","article-title":"The expression pattern of systemically injected AAV9 in the developing mouse retina is determined by age","volume":"23","author":"Byrne","year":"2015","journal-title":"Mol. Ther."},{"key":"10.1016\/j.neuron.2019.02.015_bib11","first-page":"1771","article-title":"Glycosidic enzymes enhance retinal transduction following intravitreal delivery of AAV2","volume":"17","author":"Cehajic-Kapetanovic","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.neuron.2019.02.015_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuropharm.2012.12.004","article-title":"Synaptic retinoic acid signaling and homeostatic synaptic plasticity","volume":"78","author":"Chen","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuron.2019.02.015_bib13","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1152\/jn.00437.2014","article-title":"Intrinsic bursting of AII amacrine cells underlies oscillations in the rd1 mouse retina","volume":"112","author":"Choi","year":"2014","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2019.02.015_bib14","doi-asserted-by":"crossref","first-page":"11707","DOI":"10.1073\/pnas.0603806103","article-title":"Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells","volume":"103","author":"Chute","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2019.02.015_bib15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0014-4835(02)00305-6","article-title":"Evidence that ganglion cells react to retinal detachment","volume":"76","author":"Coblentz","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.neuron.2019.02.015_bib16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1242\/dev.116.2.357","article-title":"Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in\u00a0vivo","volume":"116","author":"Conlon","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.neuron.2019.02.015_bib17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/ceo.12812","article-title":"Performance of real-world functional vision tasks by blind subjects improves after implantation with the Argus\u00ae II retinal prosthesis system","volume":"45","author":"Dagnelie","year":"2017","journal-title":"Clin. Experiment. Ophthalmol."},{"key":"10.1016\/j.neuron.2019.02.015_bib18","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1073\/pnas.90.7.2989","article-title":"Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants","volume":"90","author":"Damm","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2019.02.015_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/343177a0","article-title":"Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene","volume":"343","author":"de Th\u00e9","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2019.02.015_bib20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0006-8993(96)01352-2","article-title":"Brain energy metabolism in early blind subjects: neural activity in the visual cortex","volume":"750","author":"De Volder","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2019.02.015_bib21","first-page":"291","article-title":"Electrical stimulation of anterior visual pathways in retinitis pigmentosa","volume":"42","author":"Delbeke","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuron.2019.02.015_bib22","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.cell.2008.09.002","article-title":"Retinoic acid synthesis and signaling during early organogenesis","volume":"134","author":"Duester","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2019.02.015_bib23","first-page":"334","article-title":"Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin","volume":"23","author":"Eleftheriou","year":"2017","journal-title":"Mol. Vis."},{"key":"10.1016\/j.neuron.2019.02.015_bib24","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1023\/A:1007071406746","article-title":"Localization of retinoid binding proteins, retinoid receptors, and retinaldehyde dehydrogenase in the chick eye","volume":"28","author":"Fischer","year":"1999","journal-title":"J.\u00a0Neurocytol."},{"key":"10.1016\/j.neuron.2019.02.015_bib25","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1124\/pr.58.4.4","article-title":"International Union of Pharmacology. LX. Retinoic acid receptors","volume":"58","author":"Germain","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuron.2019.02.015_bib26","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.chembiol.2009.03.008","article-title":"Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists","volume":"16","author":"Germain","year":"2009","journal-title":"Chem. Biol."},{"key":"10.1016\/j.neuron.2019.02.015_bib27","first-page":"1546","article-title":"Characterization of rhodopsin mis-sorting and constitutive activation in a transgenic rat model of retinitis pigmentosa","volume":"41","author":"Green","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuron.2019.02.015_bib28","doi-asserted-by":"crossref","first-page":"e0122008","DOI":"10.1371\/journal.pone.0122008","article-title":"Identification of active retinaldehyde dehydrogenase isoforms in the postnatal human eye","volume":"10","author":"Harper","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2019.02.015_bib29","doi-asserted-by":"crossref","first-page":"D258","DOI":"10.1093\/nar\/gkh036","article-title":"The Gene Ontology (GO) database and informatics resource","volume":"32","author":"Harris","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuron.2019.02.015_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1083\/jcb.200604150","article-title":"BMP action in skeletogenesis involves attenuation of retinoid signaling","volume":"174","author":"Hoffman","year":"2006","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2019.02.015_bib31","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.ophtha.2011.09.028","article-title":"Interim results from the international trial of Second Sight\u2019s visual prosthesis","volume":"119","author":"Humayun","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.neuron.2019.02.015_bib32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/ng0297-216","article-title":"Retinopathy induced in mice by targeted disruption of the rhodopsin gene","volume":"15","author":"Humphries","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2019.02.015_bib33","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1523\/JNEUROSCI.2812-04.2004","article-title":"ATP-induced non-neuronal cell permeabilization in the rat inner retina","volume":"24","author":"Innocenti","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.02.015_bib34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.exer.2015.05.013","article-title":"Aberrant activity in retinal degeneration impairs central visual processing and relies on Cx36-containing gap junctions","volume":"150","author":"Ivanova","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.neuron.2019.02.015_bib35","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1076\/ceyr.19.4.338.5307","article-title":"Retinoic acid receptors and retinoid X receptors in the mature retina: subtype determination and cellular distribution","volume":"19","author":"Janssen","year":"1999","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.neuron.2019.02.015_bib36","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.exer.2016.03.018","article-title":"Retinal remodeling in human retinitis pigmentosa","volume":"150","author":"Jones","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.neuron.2019.02.015_bib37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2045-3701-2-11","article-title":"Retinoic acid synthesis and functions in early embryonic development","volume":"2","author":"Kam","year":"2012","journal-title":"Cell Biosci."},{"key":"10.1016\/j.neuron.2019.02.015_bib38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1096\/fj.11-192914","article-title":"Retinoid receptors trigger neuritogenesis in retinal degenerations","volume":"26","author":"Lin","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.neuron.2019.02.015_bib39","doi-asserted-by":"crossref","first-page":"16015","DOI":"10.1073\/pnas.0804801105","article-title":"Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity","volume":"105","author":"Maghsoodi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2019.02.015_bib40","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1385\/MN:28:2:139","article-title":"Retinal remodeling in inherited photoreceptor degenerations","volume":"28","author":"Marc","year":"2003","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuron.2019.02.015_bib41","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S1350-9462(03)00039-9","article-title":"Neural remodeling in retinal degeneration","volume":"22","author":"Marc","year":"2003","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.neuron.2019.02.015_bib42","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.1523\/JNEUROSCI.1533-08.2008","article-title":"Functional stability of retinal ganglion cells after degeneration-induced changes in synaptic input","volume":"28","author":"Margolis","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.02.015_bib43","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1046-2023(02)00232-3","article-title":"Gene delivery to the eye using adeno-associated viral vectors","volume":"28","author":"Martin","year":"2002","journal-title":"Methods"},{"key":"10.1016\/j.neuron.2019.02.015_bib44","doi-asserted-by":"crossref","first-page":"14282","DOI":"10.1523\/JNEUROSCI.4968-08.2008","article-title":"Retinal ganglion cells survive and maintain normal dendritic morphology in a mouse model of inherited photoreceptor degeneration","volume":"28","author":"Mazzoni","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.02.015_bib45","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1242\/dev.115.2.371","article-title":"Asymmetrical retinoic acid synthesis in the dorsoventral axis of the retina","volume":"115","author":"McCaffery","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.neuron.2019.02.015_bib46","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/neu.20237","article-title":"Retinoic acid signaling and function in the adult hippocampus","volume":"66","author":"McCaffery","year":"2006","journal-title":"J.\u00a0Neurobiol."},{"key":"10.1016\/j.neuron.2019.02.015_bib47","first-page":"795","article-title":"Preservation of ganglion cell layer neurons in age-related macular degeneration","volume":"42","author":"Medeiros","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuron.2019.02.015_bib48","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/1073858404263520","article-title":"Retinoic acid signaling in the nervous system of adult vertebrates","volume":"10","author":"Mey","year":"2004","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neuron.2019.02.015_bib49","doi-asserted-by":"crossref","first-page":"7601","DOI":"10.1073\/pnas.1100223108","article-title":"Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibition","volume":"108","author":"Middleton","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2019.02.015_bib50","first-page":"175","article-title":"Histopathology of the human retina in retinitis pigmentosa","volume":"17","author":"Milam","year":"1998","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.neuron.2019.02.015_bib51","first-page":"1312","article-title":"Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes","volume":"42","author":"Mori","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuron.2019.02.015_bib52","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1021\/cn200037p","article-title":"Tuning photochromic ion channel blockers","volume":"2","author":"Mourot","year":"2011","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neuron.2019.02.015_bib53","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nmeth.1897","article-title":"Rapid optical control of nociception with an ion-channel photoswitch","volume":"9","author":"Mourot","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2019.02.015_bib54","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1167\/iovs.12-9477","article-title":"Autosomal recessive retinitis pigmentosa due to ABCA4 mutations: clinical, pathologic, and molecular characterization","volume":"53","author":"Mullins","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuron.2019.02.015_bib55","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuron.2003.08.006","article-title":"A\u00a0requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification","volume":"40","author":"Novitch","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.02.015_bib56","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/cne.23487","article-title":"The effect of photoreceptor degeneration on ganglion cell morphology","volume":"522","author":"O\u2019Brien","year":"2014","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2019.02.015_bib57","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.exer.2010.08.013","article-title":"Retinol dehydrogenases (RDHs) in the visual cycle","volume":"91","author":"Parker","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.neuron.2019.02.015_bib58","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1002\/cne.22322","article-title":"Progression of neuronal and synaptic remodeling in the rd10 mouse model of retinitis pigmentosa","volume":"518","author":"Phillips","year":"2010","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2019.02.015_bib59","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neuron.2012.05.022","article-title":"Photochemical restoration of visual responses in blind mice","volume":"75","author":"Polosukhina","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.02.015_bib60","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.exer.2015.05.008","article-title":"Electrophysiological assessment of retinal ganglion cell function","volume":"141","author":"Porciatti","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.neuron.2019.02.015_bib61","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/0006-2952(88)90030-5","article-title":"Inhibition of mouse cytosolic\u00a0aldehyde dehydrogenase by 4-(diethylamino)benzaldehyde","volume":"37","author":"Russo","year":"1988","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuron.2019.02.015_bib62","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2019.02.015_bib63","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2019.02.015_bib64","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1152\/jn.01061.2010","article-title":"Changes in physiological properties of rat ganglion cells during retinal degeneration","volume":"105","author":"Sekirnjak","year":"2011","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2019.02.015_bib65","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1152\/jn.00144.2007","article-title":"Emergence of sustained spontaneous hyperactivity and temporary preservation of OFF responses in ganglion cells of the retinal degeneration (rd1) mouse","volume":"99","author":"Stasheff","year":"2008","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2019.02.015_bib66","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1152\/jn.00704.2010","article-title":"Developmental time course distinguishes changes in spontaneous and light-evoked retinal ganglion cell activity in rd1 and rd10 mice","volume":"105","author":"Stasheff","year":"2011","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2019.02.015_bib67","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1586\/17434440.2014.862494","article-title":"The functional performance of the Argus II retinal prosthesis","volume":"11","author":"Stronks","year":"2014","journal-title":"Expert Rev. Med. Devices"},{"key":"10.1016\/j.neuron.2019.02.015_bib68","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.neuron.2014.01.003","article-title":"Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells","volume":"81","author":"Tochitsky","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.02.015_bib69","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neuron.2016.08.038","article-title":"How Azobenzene Photoswitches Restore Visual Responses to the Blind Retina","volume":"92","author":"Tochitsky","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.02.015_bib70","doi-asserted-by":"crossref","first-page":"10748","DOI":"10.1021\/acs.chemrev.7b00723","article-title":"Restoring Vision to the Blind with Chemical Photoswitches","volume":"118","author":"Tochitsky","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.neuron.2019.02.015_bib71","doi-asserted-by":"crossref","first-page":"13972","DOI":"10.1523\/JNEUROSCI.2399-13.2013","article-title":"Block of gap junctions eliminates aberrant activity and restores light responses during retinal degeneration","volume":"33","author":"Toychiev","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.02.015_bib72","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.molmed.2018.06.006","article-title":"Seeing the Light after 25 Years of Retinal Gene Therapy","volume":"24","author":"Trapani","year":"2018","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neuron.2019.02.015_bib73","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1113\/jphysiol.2011.225060","article-title":"Intrinsic oscillatory activity arising within the electrically coupled AII amacrine-ON cone bipolar cell network is driven by voltage-gated Na+ channels","volume":"590","author":"Trenholm","year":"2012","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2019.02.015_bib74","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0166-2236(98)01341-1","article-title":"Homeostatic plasticity in neuronal networks: the more things change, the more they stay the same","volume":"22","author":"Turrigiano","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2019.02.015_bib75","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0022-3565(25)11103-8","article-title":"Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in\u00a0vivo","volume":"261","author":"Van Wauwe","year":"1992","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuron.2019.02.015_bib76","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0026-895X(24)13265-8","article-title":"Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2\/3 receptors","volume":"53","author":"Virginio","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuron.2019.02.015_bib77","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/7225","article-title":"Pore dilation of neuronal P2X receptor channels","volume":"2","author":"Virginio","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2019.02.015_bib78","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fnsys.2012.00008","article-title":"Network deficiency exacerbates impairment in a mouse model of retinal degeneration","volume":"6","author":"Yee","year":"2012","journal-title":"Front. Syst. Neurosci."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627319301242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627319301242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:18:23Z","timestamp":1760253503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627319301242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":78,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0896627319301242"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2019.02.015","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735314082.793565420","asserted-by":"object"}]},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinoic Acid Induces Hyperactivity, and Blocking Its Receptor Unmasks Light Responses and Augments Vision in Retinal Degeneration","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2019.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}