{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:38:06Z","timestamp":1791639486757,"version":"4.3.4"},"reference-count":72,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"vor","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["DP2 MH100011"],"award-info":[{"award-number":["DP2 MH100011"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH\/Office of the Director","doi-asserted-by":"publisher","award":["R35 NS097306"],"award-info":[{"award-number":["R35 NS097306"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.neuron.2019.03.042","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T10:39:31Z","timestamp":1556188771000},"page":"944-959.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":178,"title":["Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion"],"prefix":"10.1016","volume":"102","author":[{"given":"Karuna S.","family":"Meda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tosha","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao M.","family":"Braz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc L.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helia","family":"Seifikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan I.","family":"Basbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikaas S.","family":"Sohal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2019.03.042_bib1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0306-4522(91)90333-J","article-title":"Thalamocortical responses of mouse somatosensory (barrel) cortex in\u00a0vitro","volume":"41","author":"Agmon","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2019.03.042_bib2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0304-3940(01)02122-X","article-title":"Prefrontal cortical hyperactivity in patients with sympathetically mediated chronic pain","volume":"311","author":"Apkarian","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2019.03.042_bib3","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1097\/j.pain.0000000000001040","article-title":"Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain","volume":"158","author":"Bannister","year":"2017","journal-title":"Pain."},{"key":"10.1016\/j.neuron.2019.03.042_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2019.03.042_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0306-4522(91)90151-D","article-title":"Restricted cortical termination fields of the midline and intralaminar thalamic nuclei in the rat","volume":"42","author":"Berendse","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2019.03.042_bib6","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/(SICI)1096-9861(19990322)405:4<421::AID-CNE1>3.0.CO;2-2","article-title":"Differential projections to the intralaminar and gustatory thalamus from the parabrachial area: a PHA-L study in the rat","volume":"405","author":"Bester","year":"1999","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2019.03.042_bib7","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1523\/JNEUROSCI.3667-13.2014","article-title":"Nerve injury-induced neuropathic pain causes disinhibition of the anterior cingulate cortex","volume":"34","author":"Blom","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib8","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nn.4568","article-title":"Thalamic projections sustain prefrontal activity during working memory maintenance","volume":"20","author":"Bolkan","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib9","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.pain.2007.08.013","article-title":"Prevalence of chronic pain with neuropathic characteristics in the general population","volume":"136","author":"Bouhassira","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2019.03.042_bib10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejpain.2005.06.009","article-title":"Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment","volume":"10","author":"Breivik","year":"2006","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.neuron.2019.03.042_bib11","doi-asserted-by":"crossref","first-page":"7668","DOI":"10.1073\/pnas.96.14.7668","article-title":"Forebrain mechanisms of nociception and pain: analysis through imaging","volume":"96","author":"Casey","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2019.03.042_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1744-8069-6-42","article-title":"Roles of the anterior cingulate cortex and medial thalamus in short-term and long-term aversive information processing","volume":"6","author":"Chai","year":"2010","journal-title":"Mol. Pain"},{"key":"10.1016\/j.neuron.2019.03.042_bib13","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1523\/JNEUROSCI.11-03-00852.1991","article-title":"Distributions of spinothalamic, spinohypothalamic, and spinotelencephalic fibers revealed by anterograde transport of PHA-L in rats","volume":"11","author":"Cliffer","year":"1991","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib14","doi-asserted-by":"crossref","first-page":"17002","DOI":"10.1038\/nrdp.2017.2","article-title":"Neuropathic pain","volume":"3","author":"Colloca","year":"2017","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.neuron.2019.03.042_bib15","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.1523\/JNEUROSCI.4565-14.2015","article-title":"The mediodorsal thalamus drives feedforward inhibition in the anterior cingulate cortex via parvalbumin interneurons","volume":"35","author":"Delevich","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib16","doi-asserted-by":"crossref","first-page":"16922","DOI":"10.1523\/JNEUROSCI.3644-10.2010","article-title":"Projection-specific neuromodulation of medial prefrontal cortex neurons","volume":"30","author":"Dembrow","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neures.2007.06.1473","article-title":"Inhibition of glutamatergic transmission by morphine in the basolateral amygdaloid nucleus reduces pain-induced aversion","volume":"59","author":"Deyama","year":"2007","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuron.2019.03.042_bib18","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1152\/jn.1978.41.6.1592","article-title":"Nociceptive responses of neurons in medial thalamus and their relationship to spinothalamic pathways","volume":"41","author":"Dong","year":"1978","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2019.03.042_bib19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0006-8993(84)90361-5","article-title":"A reinvestigation of the analgesic effects induced by stimulation of the periaqueductal gray matter in the rat. II. Differential characteristics of the analgesia induced by ventral and dorsal PAG stimulation","volume":"306","author":"Fardin","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2019.03.042_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1037\/0033-2909.112.2.205","article-title":"Sensory and affective components of pain: separation and synthesis","volume":"112","author":"Fernandez","year":"1992","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.neuron.2019.03.042_bib21","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1523\/JNEUROSCI.23-09-03930.2003","article-title":"Gating of hippocampal-evoked activity in prefrontal cortical neurons by inputs from the mediodorsal thalamus and ventral tegmental area","volume":"23","author":"Floresco","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3171\/jns.1962.19.2.0089","article-title":"Pain \u201crelief\u201d by cingulotomy","volume":"19","author":"Folt","year":"1963","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.neuron.2019.03.042_bib23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.pain.2004.04.030","article-title":"Contributions of the anterior cingulate cortex and amygdala to pain- and fear-conditioned place avoidance in rats","volume":"110","author":"Gao","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2019.03.042_bib24","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1523\/JNEUROSCI.5835-11.2012","article-title":"Synaptic activity unmasks dopamine D2 receptor modulation of a specific class of layer V pyramidal neurons in prefrontal cortex","volume":"32","author":"Gee","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/cne.901840107","article-title":"Differential origins of spinothalamic tract projections to medial and lateral thalamus in the rat","volume":"184","author":"Giesler","year":"1979","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2019.03.042_bib26","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nature22324","article-title":"Maintenance of persistent activity in a frontal thalamocortical loop","volume":"545","author":"Guo","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2019.03.042_bib27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0006-8993(93)91669-J","article-title":"Lesions of the amygdala block conditional hypoalgesia on the tail flick test","volume":"612","author":"Helmstetter","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2019.03.042_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00429-007-0150-4","article-title":"Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat","volume":"212","author":"Hoover","year":"2007","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neuron.2019.03.042_bib29","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1097\/00001756-199708180-00013","article-title":"Electrophysiological study of the connection between medial thalamus and anterior cingulate cortex in the rat","volume":"8","author":"Hsu","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuron.2019.03.042_bib30","first-page":"81","article-title":"Evoked responses of the anterior cingulate cortex to stimulation of the medial thalamus","volume":"43","author":"Hsu","year":"2000","journal-title":"Chin. J. Physiol."},{"key":"10.1016\/j.neuron.2019.03.042_bib31","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/neurosurgery\/21.CN_suppl_1.334","article-title":"Stereotactic anterior cingulate lesions for persistent pain: a report on 68 cases","volume":"21","author":"Hurt","year":"1974","journal-title":"Clin. Neurosurg."},{"key":"10.1016\/j.neuron.2019.03.042_bib32","doi-asserted-by":"crossref","first-page":"8077","DOI":"10.1073\/pnas.141218998","article-title":"The affective component of pain in rodents: direct evidence for a contribution of the anterior cingulate cortex","volume":"98","author":"Johansen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2019.03.042_bib33","doi-asserted-by":"crossref","first-page":"e659","DOI":"10.1097\/PR9.0000000000000659","article-title":"Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls","volume":"3","author":"Juarez-Salinas","year":"2018","journal-title":"Pain Rep."},{"key":"10.1016\/j.neuron.2019.03.042_bib34","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/nn.2407","article-title":"Unmasking the tonic-aversive state in neuropathic pain","volume":"12","author":"King","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/cne.901710204","article-title":"The cortical projections of the mediodorsal nucleus and adjacent thalamic nuclei in the rat","volume":"171","author":"Krettek","year":"1977","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2019.03.042_bib36","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0006-8993(93)91683-J","article-title":"Direct synaptic connections between thalamocortical axon terminals from the mediodorsal thalamic nucleus (MD) and corticothalamic neurons to MD in the prefrontal cortex","volume":"612","author":"Kuroda","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2019.03.042_bib37","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0301-0082(97)00070-1","article-title":"An ultrastructural study of the neural circuit between the prefrontal cortex and the mediodorsal nucleus of the thalamus","volume":"54","author":"Kuroda","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuron.2019.03.042_bib38","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.expneurol.2004.04.003","article-title":"Differential effect of anterior cingulate cortex lesion on mechanical hypersensitivity and escape\/avoidance behavior in an animal model of neuropathic pain","volume":"188","author":"LaGraize","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2019.03.042_bib39","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.neuro.23.1.155","article-title":"Emotion circuits in the brain","volume":"23","author":"LeDoux","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib40","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.brainres.2004.02.038","article-title":"Effect of mediodorsal thalamic nucleus lesion on contextual fear conditioning in rats","volume":"1008","author":"Li","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2019.03.042_bib41","doi-asserted-by":"crossref","first-page":"e70921","DOI":"10.1371\/journal.pone.0070921","article-title":"Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2019.03.042_bib42","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1523\/JNEUROSCI.13-06-02689.1993","article-title":"Patterns of increased brain activity indicative of pain in a rat model of peripheral mononeuropathy","volume":"13","author":"Mao","year":"1993","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nn.2233","article-title":"Representation of negative motivational value in the primate lateral habenula","volume":"12","author":"Matsumoto","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(91)90247-L","article-title":"Organization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat","volume":"44","author":"McDonald","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2019.03.042_bib45","series-title":"The Skin Senses","first-page":"423","article-title":"Sensory, motivational, and central determinants of pain: a new conceptual model","author":"Melzack","year":"1968"},{"issue":"Suppl 1","key":"10.1016\/j.neuron.2019.03.042_bib46","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1016\/j.neuroimage.2007.03.054","article-title":"Brain imaging of neuropathic pain","volume":"37","author":"Moisset","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuron.2019.03.042_bib47","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/cne.902720205","article-title":"Organization of cortical and subcortical projections to anterior cingulate cortex in the cat","volume":"272","author":"Musil","year":"1988","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2019.03.042_bib48","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1213\/ANE.0b013e31826e1007","article-title":"Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm and changes in dorsal root ganglia Activated Transcription Factor 3: The effects of gabapentin, ketorolac and etanercept","volume":"116","author":"Park","year":"2013","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.neuron.2019.03.042_bib49","doi-asserted-by":"crossref","first-page":"e18383","DOI":"10.7554\/eLife.18383","article-title":"Asymmetric effects of activating and inactivating cortical interneurons","volume":"5","author":"Phillips","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2019.03.042_bib50","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1111\/j.1460-9568.1994.tb00621.x","article-title":"Anatomical and electrophysiological evidence for an excitatory amino acid pathway from the thalamic mediodorsal nucleus to the prefrontal cortex in the rat","volume":"6","author":"Pirot","year":"1994","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib51","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1126\/science.288.5472.1769","article-title":"Psychological and neural mechanisms of the affective dimension of pain","volume":"288","author":"Price","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neuron.2019.03.042_bib52","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.pain.2011.03.002","article-title":"Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy","volume":"152","author":"Qu","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2019.03.042_bib53","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.277.5328.968","article-title":"Pain affect encoded in human anterior cingulate but not somatosensory cortex","volume":"277","author":"Rainville","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neuron.2019.03.042_bib54","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3171\/jns.1991.74.3.0415","article-title":"Spontaneous neuronal hyperactivity in the medial and intralaminar thalamic nuclei of patients with deafferentation pain","volume":"74","author":"Rinaldi","year":"1991","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.neuron.2019.03.042_bib55","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0361-9230(83)90029-1","article-title":"Convergence of basolateral amygdaloid and mediodorsal thalamic projections in different areas of the frontal cortex in the rat","volume":"10","author":"Sarter","year":"1983","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuron.2019.03.042_bib56","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nature22073","article-title":"Thalamic amplification of cortical connectivity sustains attentional control","volume":"545","author":"Schmitt","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2019.03.042_bib57","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1152\/jn.1992.68.5.1720","article-title":"Nociceptive neurons in area 24 of rabbit cingulate cortex","volume":"68","author":"Sikes","year":"1992","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2019.03.042_bib58","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/nn.3145","article-title":"Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance","volume":"15","author":"Stamatakis","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib59","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1098\/rstb.2002.1156","article-title":"Thalamocortical control of feed-forward inhibition in awake somatosensory \u2018barrel\u2019 cortex","volume":"357","author":"Swadlow","year":"2002","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.neuron.2019.03.042_bib60","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/cercor\/13.1.25","article-title":"Fast-spike interneurons and feedforward inhibition in awake sensory neocortex","volume":"13","author":"Swadlow","year":"2003","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neuron.2019.03.042_bib61","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1046\/j.1460-9568.2003.02952.x","article-title":"Differential contributions of the basolateral and central nuclei of the amygdala in the negative affective component of chemical somatic and visceral pains in rats","volume":"18","author":"Tanimoto","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib62","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.neuron.2007.07.012","article-title":"The cerebral signature for pain perception and its modulation","volume":"55","author":"Tracey","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.03.042_bib63","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3959(98)00184-5","article-title":"The cortical representation of pain","volume":"79","author":"Treede","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2019.03.042_bib64","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.pain.2010.12.003","article-title":"Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity","volume":"152","author":"Urban","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2019.03.042_bib65","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/cne.902420203","article-title":"Prosencephalic afferents to the mediodorsal thalamic nucleus","volume":"242","author":"Velayos","year":"1985","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2019.03.042_bib67","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/(SICI)1096-9861(19980105)390:1<133::AID-CNE11>3.0.CO;2-Y","article-title":"Organization of diencephalic projections from the medullary sbunucleus reticularis dorsalis: a retrograde and anterograde tracer study in the rat","volume":"390","author":"Villanueva","year":"1998","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2019.03.042_bib68","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrn1704","article-title":"Pain and emotion interactions in subregions of the cingulate gyrus","volume":"6","author":"Vogt","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib69","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neulet.2007.04.064","article-title":"Does the medial thalamus play a role in the negative affective component of visceral pain in rats?","volume":"420","author":"Wang","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2019.03.042_bib70","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1523\/JNEUROSCI.2639-12.2013","article-title":"Pathological activity in mediodorsal thalamus of rats with spinal cord injury pain","volume":"33","author":"Whitt","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.03.042_bib71","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-8993(96)00561-6","article-title":"Morphological and electrophysiological properties of ACCx nociceptive neurons in rats","volume":"735","author":"Yamamura","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2019.03.042_bib72","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1152\/jn.00623.2006","article-title":"Intracortical circuits in rat anterior cingulate cortex are activated by nociceptive inputs mediated by medial thalamus","volume":"96","author":"Yang","year":"2006","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2019.03.042_bib73","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3171\/jns.1987.66.3.0364","article-title":"Pain relief by electrical stimulation of the periaqueductal and periventricular gray matter. Evidence for a non-opioid mechanism","volume":"66","author":"Young","year":"1987","journal-title":"J.\u00a0Neurosurg."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627319303319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627319303319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:17:28Z","timestamp":1760253448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627319303319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0896627319303319"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2019.03.042","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2019.03.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}