{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:54:23Z","timestamp":1793246063401,"version":"4.5.0"},"reference-count":114,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.neuron.2019.05.029","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T10:38:46Z","timestamp":1560422326000},"page":"489-505.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":123,"title":["A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory"],"prefix":"10.1016","volume":"103","author":[{"given":"Ayesha","family":"Sengupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2019.05.029_bib1","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1460-9568.2006.04603.x","article-title":"Enhancement of conditioned fear extinction by infusion of the GABA(A) agonist muscimol into the rat prefrontal cortex and amygdala","volume":"23","author":"Akirav","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0306-4522(03)00518-9","article-title":"Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in\u00a0vivo","volume":"122","author":"Allers","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2019.05.029_bib3","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1523\/JNEUROSCI.5196-09.2010","article-title":"VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety","volume":"30","author":"Amilhon","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib4","first-page":"342","article-title":"5HT 2A receptor blockade in dorsomedial striatum reduces repetitive behaviors in BTBR mice. Genes","volume":"16","author":"Amodeo","year":"2017","journal-title":"Brain Behav"},{"key":"10.1016\/j.neuron.2019.05.029_bib5","doi-asserted-by":"crossref","first-page":"9680","DOI":"10.1523\/JNEUROSCI.2600-05.2005","article-title":"Lesions of the basal amygdala block expression of conditioned fear but not extinction","volume":"25","author":"Anglada-Figueroa","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib6","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.1101678","article-title":"Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice","volume":"306","author":"Ansorge","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.neuron.2019.05.029_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1460-9568.2011.07936.x","article-title":"Projections and interconnections of genetically defined serotonin neurons in mice","volume":"35","author":"Bang","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib8","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.biopsych.2015.06.025","article-title":"Stress Enables Reinforcement-Elicited Serotonergic Consolidation of Fear Memory","volume":"79","author":"Baratta","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2019.05.029_bib9","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.biopsych.2013.09.003","article-title":"Variation in serotonin transporter expression modulates fear-evoked hemodynamic responses and theta-frequency neuronal oscillations in the amygdala","volume":"75","author":"Barkus","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2019.05.029_bib10","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","article-title":"A review of central 5-HT receptors and their function","volume":"38","author":"Barnes","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuron.2019.05.029_bib11","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.neuron.2015.08.024","article-title":"Hippocampal Theta Input to the Amygdala Shapes Feedforward Inhibition to Gate Heterosynaptic Plasticity","volume":"87","author":"Bazelot","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.05.029_bib12","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/s41593-018-0167-4","article-title":"The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism","volume":"21","author":"Beas","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib13","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00429-016-1278-x","article-title":"Mapping the connectivity of serotonin transporter immunoreactive axons to excitatory and inhibitory neurochemical synapses in the mouse limbic brain","volume":"222","author":"Belmer","year":"2017","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neuron.2019.05.029_bib14","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1073\/pnas.1523341113","article-title":"Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity","volume":"113","author":"Berndt","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2019.05.029_bib15","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1038\/npp.2015.157","article-title":"Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala","volume":"40","author":"Bocchio","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuron.2019.05.029_bib16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fncir.2016.00024","article-title":"Serotonin, Amygdala and Fear: Assembling the Puzzle","volume":"10","author":"Bocchio","year":"2016","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.neuron.2019.05.029_bib17","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.neuron.2017.03.022","article-title":"Synaptic Plasticity, Engrams, and Network Oscillations in Amygdala Circuits for Storage and Retrieval of Emotional Memories","volume":"94","author":"Bocchio","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.05.029_bib18","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1046\/j.1471-4159.2001.00194.x","article-title":"Acute and chronic effects of citalopram on postsynaptic 5-hydroxytryptamine(1A) receptor-mediated feedback: a microdialysis study in the amygdala","volume":"76","author":"Bosker","year":"2001","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuron.2019.05.029_bib19","doi-asserted-by":"crossref","first-page":"e1500251","DOI":"10.1126\/sciadv.1500251","article-title":"Prefrontal inputs to the amygdala instruct fear extinction memory formation","volume":"1","author":"Bukalo","year":"2015","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neuron.2019.05.029_bib20","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.biopsych.2004.02.029","article-title":"The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine","volume":"55","author":"Burghardt","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2019.05.029_bib21","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.neuropharm.2011.04.008","article-title":"Raphe serotonin neurons are not homogenous:\u00a0electrophysiological, morphological and neurochemical evidence","volume":"61","author":"Calizo","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuron.2019.05.029_bib22","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1176\/appi.ajp.2010.09101452","article-title":"Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits","volume":"167","author":"Caspi","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuron.2019.05.029_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0306-4522(03)00076-9","article-title":"Serotonin type II receptor activation facilitates synaptic plasticity via N-methyl-D-aspartate-mediated mechanism in the rat basolateral amygdala","volume":"119","author":"Chen","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2019.05.029_bib24","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1046\/j.1460-9568.1998.00229.x","article-title":"Serotonin depresses excitatory synaptic transmission and depolarization-evoked Ca2+ influx in rat basolateral amygdala via 5-HT1A receptors","volume":"10","author":"Cheng","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib25","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.biopsych.2009.09.011","article-title":"5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress","volume":"67","author":"Christianson","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2019.05.029_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.06346","article-title":"Serotonergic neurons signal reward and punishment on multiple timescales","volume":"4","author":"Cohen","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2019.05.029_bib27","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bbr.2006.12.003","article-title":"Anxiogenic-like effects of mCPP microinfusions into the amygdala (but not dorsal or ventral hippocampus) in mice exposed to elevated plus-maze","volume":"178","author":"Corn\u00e9lio","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuron.2019.05.029_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.20975","article-title":"Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons","volume":"6","author":"Correia","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2019.05.029_bib29","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1038\/nn.4651","article-title":"Cellular and oscillatory substrates of fear extinction learning","volume":"20","author":"Davis","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib30","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1002\/wdev.301","article-title":"Serotonin neuron development: shaping molecular and structural identities","volume":"7","author":"Deneris","year":"2018","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.neuron.2019.05.029_bib31","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1007\/s00429-015-1142-4","article-title":"Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain","volume":"221","author":"Fernandez","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neuron.2019.05.029_bib32","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1002\/cne.22407","article-title":"Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain","volume":"518","author":"Fu","year":"2010","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2019.05.029_bib33","doi-asserted-by":"crossref","first-page":"e87709","DOI":"10.1371\/journal.pone.0087709","article-title":"Distribution of VGLUT3 in highly collateralized axons from the rat dorsal raphe nucleus as revealed by single-neuron reconstructions","volume":"9","author":"Gagnon","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2019.05.029_bib34","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/0269881110389095","article-title":"Cannabidiol injected into the bed nucleus of the stria terminalis reduces the expression of contextual fear conditioning via 5-HT 1A receptors","volume":"26","author":"Gomes","year":"2012","journal-title":"J.\u00a0Psychopharmacol"},{"key":"10.1016\/j.neuron.2019.05.029_bib35","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0091-3057(95)02135-3","article-title":"Role of 5-HT in stress, anxiety, and depression","volume":"54","author":"Graeff","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuron.2019.05.029_bib36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0006-8993(99)01208-1","article-title":"Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor","volume":"826","author":"Grahn","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2019.05.029_bib37","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41380-017-0003-3","article-title":"Identification of a novel gene regulating amygdala-mediated fear extinction","volume":"24","author":"Gunduz-Cinar","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2019.05.029_bib38","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neuropharm.2017.09.013","article-title":"Serotonin gating of cortical and thalamic glutamate inputs onto principal neurons of the basolateral amygdala","volume":"126","author":"Guo","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuron.2019.05.029_bib39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1460-9568.2006.05276.x","article-title":"Neurochemical identification of stereotypic burst-firing neurons in the rat dorsal raphe nucleus using juxtacellular labelling methods","volume":"25","author":"Haj\u00f3s","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib40","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00213-010-2089-z","article-title":"Functional topography of midbrain and pontine serotonergic systems: implications for synaptic regulation of serotonergic circuits","volume":"213","author":"Hale","year":"2011","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neuron.2019.05.029_bib41","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1152\/jn.00656.2014","article-title":"Distinct ensembles of medial prefrontal cortex neurons are activated by threatening stimuli that elicit excitation vs. inhibition of movement","volume":"114","author":"Halladay","year":"2015","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2019.05.029_bib42","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/nn.3869","article-title":"Encoding of fear learning and memory in distributed neuronal circuits","volume":"17","author":"Herry","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib43","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nature07166","article-title":"Switching on and off fear by distinct neuronal circuits","volume":"454","author":"Herry","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2019.05.029_bib44","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.neubiorev.2008.03.006","article-title":"Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease","volume":"32","author":"Holmes","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuron.2019.05.029_bib45","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1038\/sj.npp.1300266","article-title":"Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior","volume":"28","author":"Holmes","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuron.2019.05.029_bib46","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.biopsych.2010.09.024","article-title":"Looking on the bright side of serotonin transporter gene variation","volume":"69","author":"Homberg","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2019.05.029_bib47","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ejphar.2004.06.061","article-title":"Selective serotonin reuptake inhibitor reduces conditioned fear through its effect in the amygdala","volume":"497","author":"Inoue","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuron.2019.05.029_bib48","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejphar.2012.09.028","article-title":"Effects of serotonergic terminal lesion in the amygdala on conditioned fear and innate fear in rats","volume":"696","author":"Izumi","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuron.2019.05.029_bib49","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/npp.2008.71","article-title":"Stress impairs 5-HT2A receptor-mediated serotonergic facilitation of GABA release in juvenile rat basolateral amygdala","volume":"34","author":"Jiang","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuron.2019.05.029_bib50","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nn.2594","article-title":"Neural substrates for expectation-modulated fear learning in the amygdala and periaqueductal gray","volume":"13","author":"Johansen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib51","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0896-6273(94)90283-6","article-title":"Synaptic glutamate release by postnatal rat serotonergic neurons in microculture","volume":"12","author":"Johnson","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.05.029_bib52","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.pbb.2015.09.021","article-title":"Pharmacological depletion of serotonin in the basolateral amygdala complex reduces anxiety and disrupts fear conditioning","volume":"138","author":"Johnson","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuron.2019.05.029_bib53","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nn.4251","article-title":"4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior","volume":"19","author":"Karalis","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib54","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1073\/pnas.0508360103","article-title":"Serotonergic neuron diversity: identification of raphe neurons with discharges time-locked to the hippocampal theta rhythm","volume":"103","author":"Kocsis","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2019.05.029_bib55","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1073\/pnas.1400335111","article-title":"Coming to terms with fear","volume":"111","author":"LeDoux","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2019.05.029_bib56","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ejphar.2005.12.008","article-title":"5-HT1A receptor agonist affects fear conditioning through stimulations of the postsynaptic 5-HT1A receptors in the hippocampus and amygdala","volume":"532","author":"Li","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuron.2019.05.029_bib57","doi-asserted-by":"crossref","first-page":"10503","DOI":"10.1038\/ncomms10503","article-title":"Serotonin neurons in the dorsal raphe nucleus encode reward signals","volume":"7","author":"Li","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2019.05.029_bib58","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1046\/j.1460-9568.1999.00561.x","article-title":"Pre- or post-training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5-HT1A receptors","volume":"11","author":"Liang","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib59","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nn.3582","article-title":"Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety","volume":"17","author":"Likhtik","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib60","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.euroneuro.2010.08.005","article-title":"Opposing alterations in anxiety and species-typical behaviours in serotonin transporter overexpressor and knockout mice","volume":"21","author":"Line","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuron.2019.05.029_bib61","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1111\/ejn.12744","article-title":"Reduced sensitivity to both positive and negative reinforcement in mice over-expressing the 5-hydroxytryptamine transporter","volume":"40","author":"Line","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib62","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.neuron.2014.02.010","article-title":"Dorsal raphe neurons signal reward through 5-HT and glutamate","volume":"81","author":"Liu","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.05.029_bib63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0376-8716(02)00330-7","article-title":"Inhaled drugs of abuse enhance serotonin-3 receptor function","volume":"70","author":"Lopreato","year":"2003","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuron.2019.05.029_bib64","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0304-3940(91)90499-J","article-title":"Serotonergic projections from the nucleus raphe dorsalis to the amygdala in the rat","volume":"134","author":"Ma","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2019.05.029_bib65","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbr.2006.10.031","article-title":"5-HT2- and D1-mechanisms of the basolateral nucleus of the amygdala enhance conditioned fear and impair unconditioned fear","volume":"177","author":"Macedo","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuron.2019.05.029_bib66","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/ph3010019","article-title":"The Timing of Antidepressant Effects: A\u00a0Comparison of Diverse Pharmacological and Somatic Treatments","volume":"3","author":"Machado-Vieira","year":"2010","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.neuron.2019.05.029_bib67","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature19318","article-title":"Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala","volume":"537","author":"Marcinkiewcz","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2019.05.029_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.20552","article-title":"Activity patterns of serotonin neurons underlying cognitive flexibility","volume":"6","author":"Matias","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2019.05.029_bib69","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00213-010-1987-4","article-title":"Juvenile stress attenuates the dorsal hippocampal postsynaptic 5-HT1A receptor function in adult rats","volume":"214","author":"Matsuzaki","year":"2011","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neuron.2019.05.029_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.18247","article-title":"Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior","volume":"6","author":"McCall","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2019.05.029_bib71","doi-asserted-by":"crossref","first-page":"9024","DOI":"10.1523\/JNEUROSCI.4465-13.2014","article-title":"Aversive prediction error signals in the amygdala","volume":"34","author":"McHugh","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib72","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.psych.121208.131631","article-title":"Fear extinction as a model for translational neuroscience: ten years of progress","volume":"63","author":"Milad","year":"2012","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.neuron.2019.05.029_bib73","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/cne.21486","article-title":"Serotonin-immunoreactive axon terminals innervate pyramidal cells and interneurons in the rat basolateral amygdala","volume":"505","author":"Muller","year":"2007","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2019.05.029_bib74","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1267\/ahc.12.20","article-title":"Immunofluorescent studies on the localization of tyrosine hydroxylase and dopamine-\u03b2-hydroxylase in the mes-, di-, and telencephalon of the rat using unperfused fresh frozen sections","volume":"12","author":"Nagatsu","year":"1979","journal-title":"Acta Histochem. Cytochem."},{"key":"10.1016\/j.neuron.2019.05.029_bib75","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nature14366","article-title":"A circuit mechanism for differentiating positive and negative associations","volume":"520","author":"Namburi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2019.05.029_bib76","doi-asserted-by":"crossref","first-page":"e22600","DOI":"10.1371\/journal.pone.0022600","article-title":"Social defeat: impact on fear extinction and amygdala-prefrontal cortical theta synchrony in 5-HTT deficient mice","volume":"6","author":"Narayanan","year":"2011","journal-title":"PLoS ONE"},{"issue":"Suppl","key":"10.1016\/j.neuron.2019.05.029_bib77","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/nn943","article-title":"Treatment of mood disorders","volume":"5","author":"Nemeroff","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib78","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1503\/jpn.110116","article-title":"Behavioural therapy based on distraction alleviates impaired fear extinction in male serotonin transporter knockout rats","volume":"37","author":"Nonkes","year":"2012","journal-title":"J.\u00a0Psychiatry Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib79","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.celrep.2014.06.042","article-title":"Organization of monosynaptic inputs to the serotonin and dopamine neuromodulatory systems","volume":"8","author":"Ogawa","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2019.05.029_bib80","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1152\/jn.1998.79.1.217","article-title":"Ionic mechanisms of intrinsic oscillations in neurons of the basolateral amygdaloid complex","volume":"79","author":"Pape","year":"1998","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2019.05.029_bib81","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/physrev.00037.2009","article-title":"Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear","volume":"90","author":"Pape","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuron.2019.05.029_bib82","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nn.3296","article-title":"Implications of memory modulation for post-traumatic stress and fear disorders","volume":"16","author":"Parsons","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib83","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.neuron.2014.07.002","article-title":"A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei","volume":"83","author":"Pollak Dorocic","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.05.029_bib84","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1152\/jn.1999.82.1.69","article-title":"Serotonergic modulation of neurotransmission in the rat basolateral amygdala","volume":"82","author":"Rainnie","year":"1999","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2019.05.029_bib85","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4103\/0019-5545.33264","article-title":"The limbic system","volume":"49","author":"Rajmohan","year":"2007","journal-title":"Indian J. Psychiatry"},{"key":"10.1016\/j.neuron.2019.05.029_bib86","doi-asserted-by":"crossref","first-page":"12379","DOI":"10.1523\/JNEUROSCI.1020-13.2014","article-title":"Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function","volume":"34","author":"Rebello","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib87","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cell.2018.07.043","article-title":"Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems","volume":"175","author":"Ren","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2019.05.029_bib88","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.neuron.2016.04.037","article-title":"Ventral Pallidum Neurons Encode Incentive Value and Promote Cue-Elicited Instrumental Actions","volume":"90","author":"Richard","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.05.029_bib89","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.neuroscience.2011.09.024","article-title":"Sleep-waking discharge profiles of dorsal raphe nucleus neurons in mice","volume":"197","author":"Sakai","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2019.05.029_bib90","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0306-4522(01)00103-8","article-title":"Differentiation of presumed serotonergic dorsal raphe neurons in relation to behavior and wake-sleep states","volume":"104","author":"Sakai","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2019.05.029_bib91","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2019.05.029_bib92","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature14600","article-title":"Viral-genetic tracing of the input-output organization of a central noradrenaline circuit","volume":"524","author":"Schwarz","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2019.05.029_bib93","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.neuroscience.2010.09.058","article-title":"Phasic responses in dorsal raphe serotonin neurons to noxious stimuli","volume":"171","author":"Schweimer","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2019.05.029_bib94","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1126\/science.1085818","article-title":"Amygdalar and Hippocampal Theta Rhythm Synchronization During Fear Memory Retrieval","volume":"301","author":"Seidenbecher","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neuron.2019.05.029_bib95","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1523\/JNEUROSCI.2238-16.2016","article-title":"Control of Amygdala Circuits by 5-HT Neurons via 5-HT and Glutamate Cotransmission","volume":"37","author":"Sengupta","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib96","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.neuron.2013.11.006","article-title":"Long-range connectivity defines behavioral specificity of amygdala neurons","volume":"81","author":"Senn","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.05.029_bib97","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1126\/science.aau8722","article-title":"Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode","volume":"363","author":"Seo","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.neuron.2019.05.029_bib98","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/npp.2010.184","article-title":"Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear","volume":"36","author":"Sierra-Mercado","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuron.2019.05.029_bib99","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1038\/sj.npp.1300552","article-title":"Effects of serotonin\u00a0transporter promoter polymorphisms on serotonin function","volume":"29","author":"Smith","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuron.2019.05.029_bib100","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuroscience.2011.01.042","article-title":"Investigation of a central nucleus of the amygdala\/dorsal raphe nucleus serotonergic circuit implicated in fear-potentiated startle","volume":"179","author":"Spannuth","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2019.05.029_bib101","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0306-4522(81)90146-9","article-title":"Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals","volume":"6","author":"Steinbusch","year":"1981","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2019.05.029_bib102","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbr.2003.12.020","article-title":"Inescapable shock activates serotonergic neurons in all raphe nuclei of rat","volume":"153","author":"Takase","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuron.2019.05.029_bib103","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.celrep.2015.10.061","article-title":"Activity of Raph\u00e9 Serotonergic Neurons Controls Emotional Behaviors","volume":"13","author":"Teissier","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2019.05.029_bib104","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.neuron.2018.04.030","article-title":"Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation","volume":"98","author":"Teixeira","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.05.029_bib105","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrn3945","article-title":"Neuronal circuits for fear and anxiety","volume":"16","author":"Tovote","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2019.05.029_bib106","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1126\/science.1178307","article-title":"Fast Synaptic Subcortical Control of Hippocampal Circuits","volume":"326","author":"Varga","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuron.2019.05.029_bib107","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.biopsych.2005.10.010","article-title":"Pharmacotherapy of depressed children and adolescents: current issues and potential directions","volume":"59","author":"Vasa","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2019.05.029_bib108","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jchemneu.2011.05.008","article-title":"Functional organization of the dorsal raphe efferent system with special consideration of nitrergic cell groups","volume":"41","author":"Vasudeva","year":"2011","journal-title":"J.\u00a0Chem. Neuroanat."},{"key":"10.1016\/j.neuron.2019.05.029_bib109","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.celrep.2019.01.014","article-title":"Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons","volume":"26","author":"Wang","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2019.05.029_bib110","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.neuron.2014.06.024","article-title":"Presynaptic partners of dorsal raphe serotonergic and GABAergic neurons","volume":"83","author":"Weissbourd","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2019.05.029_bib111","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1126\/science.1123432","article-title":"Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice","volume":"313","author":"Weisstaub","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.neuron.2019.05.029_bib112","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuroscience.2012.06.008","article-title":"A serotonergic discrimination favoring synaptic inputs that accompany robust spike firing in lateral amygdala neurons","volume":"220","author":"Yamamoto","year":"2012","journal-title":"Neuroscience"},{"issue":"2, Suppl","key":"10.1016\/j.neuron.2019.05.029_bib113","doi-asserted-by":"crossref","first-page":"52S","DOI":"10.1016\/S0893-133X(99)00047-0","article-title":"Altered emotional states in knockout mice lacking 5-HT1A or 5-HT1B receptors","volume":"21","author":"Zhuang","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuron.2019.05.029_bib114","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2016.11.045","article-title":"AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors","volume":"93","author":"Zingg","year":"2017","journal-title":"Neuron"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627319304829?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627319304829?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:21:38Z","timestamp":1760253698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627319304829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":114,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0896627319304829"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2019.05.029","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2019.05.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}