{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:37:15Z","timestamp":1791668235927,"version":"4.3.4"},"reference-count":63,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007457","name":"JPB Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000882","name":"Brain Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000882","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001671","name":"Hereditary Disease Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001671","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.neuron.2020.01.004","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T10:36:40Z","timestamp":1580380600000},"page":"76-89.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Genome-wide In\u00a0Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity"],"prefix":"10.1016","volume":"106","author":[{"given":"Mary H.","family":"Wertz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mollie R.","family":"Mitchem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Sebastian","family":"Pineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea J.","family":"Hachigian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeseung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Powers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Kulicke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurrein K.","family":"Madan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medina","family":"Colic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Therrien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Vernon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria F.","family":"Beja-Glasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudra","family":"Hegde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manolis","family":"Kellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Traver","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Doench","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Heiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2020.01.004_bib1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2020.01.004_bib2","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1523\/JNEUROSCI.3920-03.2004","article-title":"Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor","volume":"24","author":"Baquet","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.01.004_bib3","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.1128\/jvi.71.9.6641-6649.1997","article-title":"Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector","volume":"71","author":"Bl\u00f6mer","year":"1997","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.neuron.2020.01.004_bib4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.neuron.2020.01.004_bib5","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1073\/pnas.1818629116","article-title":"Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder","volume":"116","author":"Chen","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2020.01.004_bib6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13073-019-0665-3","article-title":"Identifying chemogenetic interactions from CRISPR knockout screens with drugZ","volume":"11","author":"Colic","year":"2019","journal-title":"Genome Med"},{"key":"10.1016\/j.neuron.2020.01.004_bib7","doi-asserted-by":"crossref","first-page":"aaf1420","DOI":"10.1126\/science.aaf1420","article-title":"A global genetic interaction network maps a wiring diagram of cellular function","volume":"353","author":"Costanzo","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neuron.2020.01.004_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2020.01.004_bib9","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nbt.3437","article-title":"Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9","volume":"34","author":"Doench","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neuron.2020.01.004_bib10","doi-asserted-by":"crossref","first-page":"e7275","DOI":"10.1371\/journal.pone.0007275","article-title":"RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation","volume":"4","author":"Doumanis","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2020.01.004_bib11","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0028-3908(82)90082-X","article-title":"Spontaneous and drug-induced rotation following localized 6-hydroxydopamine and kainic acid-induced lesions of the neostriatum","volume":"21","author":"Dunnett","year":"1982","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuron.2020.01.004_bib12","doi-asserted-by":"crossref","first-page":"a007476","DOI":"10.1101\/cshperspect.a007476","article-title":"Huntington\u2019s disease","volume":"3","author":"Finkbeiner","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuron.2020.01.004_bib13","doi-asserted-by":"crossref","first-page":"e1003921","DOI":"10.1371\/journal.pgen.1003921","article-title":"Neuron-specific feeding RNAi in C. elegans and its use in a screen for essential genes required for GABA neuron function","volume":"9","author":"Firnhaber","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neuron.2020.01.004_bib14","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.cell.2015.07.003","article-title":"Identification of genetic factors that modify clinical onset of Huntington\u2019s disease","volume":"162","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2020.01.004_bib15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2019.06.036","article-title":"CAG repeat not polyglutamine length determines timing of Huntington\u2019s disease onset","volume":"178","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2020.01.004_bib16","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1016\/j.celrep.2017.11.018","article-title":"Control of Huntington\u2019s disease-associated phenotypes by the striatum-enriched transcription factor Foxp2","volume":"21","author":"Hachigian","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2020.01.004_bib17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nbt.4091","article-title":"Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors","volume":"36","author":"Haghverdi","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neuron.2020.01.004_bib18","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1534\/g3.117.041277","article-title":"Evaluation and design of genome-wide CRISPR\/SpCas9 knockout screens","volume":"7","author":"Hart","year":"2017","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.neuron.2020.01.004_bib19","doi-asserted-by":"crossref","first-page":"e50717","DOI":"10.1371\/journal.pone.0050717","article-title":"Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington\u2019s disease","volume":"7","author":"Heikkinen","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2020.01.004_bib20","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.cell.2008.10.028","article-title":"A translational profiling approach for the molecular characterization of CNS cell types","volume":"135","author":"Heiman","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2020.01.004_bib21","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","article-title":"Regional and cellular gene expression changes in human Huntington\u2019s disease brain","volume":"15","author":"Hodges","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2020.01.004_bib22","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1073\/pnas.98.4.1811","article-title":"The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington\u2019s disease pathogenesis","volume":"98","author":"Holbert","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2020.01.004_bib23","first-page":"1485","article-title":"Huntington\u2019s disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels","volume":"8","author":"Horvath","year":"2016","journal-title":"Aging (Albany N.Y.)"},{"key":"10.1016\/j.neuron.2020.01.004_bib24","doi-asserted-by":"crossref","first-page":"e23228","DOI":"10.1371\/journal.pone.0023228","article-title":"Quantitative expression profile of distinct functional regions in the adult mouse brain","volume":"6","author":"Kasukawa","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2020.01.004_bib25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0896-6273(01)00273-2","article-title":"Nucleoside diphosphate kinase, a source of GTP, is required for dynamin-dependent synaptic vesicle recycling","volume":"30","author":"Krishnan","year":"2001","journal-title":"Neuron"},{"issue":"W1","key":"10.1016\/j.neuron.2020.01.004_bib26","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuron.2020.01.004_bib27","doi-asserted-by":"crossref","first-page":"223.e1","DOI":"10.1016\/j.neurobiolaging.2018.10.019","article-title":"A comprehensive screening of copy number variability in dementia with Lewy bodies","volume":"75","author":"Kun-Rodrigues","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2020.01.004_bib28","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1093\/bioinformatics\/btq466","article-title":"ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments","volume":"26","author":"Lachmann","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2020.01.004_bib29","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nn.4256","article-title":"Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice","volume":"19","author":"Langfelder","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2020.01.004_bib30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2164-13-91","article-title":"Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons","volume":"13","author":"Lejeune","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1016\/j.neuron.2020.01.004_bib31","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1074\/jbc.272.5.2607","article-title":"A 16-kDa protein functions as a new regulatory protein for Hsc70 molecular chaperone and is identified as a member of the Nm23\/nucleoside diphosphate kinase family","volume":"272","author":"Leung","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2020.01.004_bib32","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/hmg\/9.9.1259","article-title":"Decreased expression of striatal signaling genes in a mouse model of Huntington\u2019s disease","volume":"9","author":"Luthi-Carter","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2020.01.004_bib33","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. The Huntington\u2019s Disease Collaborative Research Group","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2020.01.004_bib34","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1093\/hmg\/ddu343","article-title":"Deficiency of Ube3a in Huntington\u2019s disease mice brain increases aggregate load and accelerates disease pathology","volume":"23","author":"Maheshwari","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2020.01.004_bib35","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2020.01.004_bib36","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.ejca.2010.02.042","article-title":"The Nm23-H1 metastasis suppressor as a translational target","volume":"46","author":"Marshall","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.neuron.2020.01.004_bib37","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer\u2019s disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2020.01.004_bib38","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nrn1886","article-title":"Ageing and neuronal vulnerability","volume":"7","author":"Mattson","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2020.01.004_bib39","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1093\/hmg\/10.19.2109","article-title":"Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery","volume":"10","author":"Mazarakis","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2020.01.004_bib40","doi-asserted-by":"crossref","first-page":"e49838","DOI":"10.1371\/journal.pone.0049838","article-title":"Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington\u2019s disease: zQ175","volume":"7","author":"Menalled","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2020.01.004_bib41","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.cell.2006.01.040","article-title":"A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen","volume":"124","author":"Moffat","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2020.01.004_bib42","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1038\/s41467-018-03933-2","article-title":"A geometric approach to characterize the functional identity of single cells","volume":"9","author":"Mohammadi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2020.01.004_bib43","article-title":"Multi-resolution single-cell state characterization via joint archetypal\/network analysis","author":"Mohammadi","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.neuron.2020.01.004_bib45","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S1474-4422(17)30161-8","article-title":"Identification of genetic variants associated with Huntington\u2019s disease progression: a genome-wide association study","volume":"16","author":"Moss","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuron.2020.01.004_bib46","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.tibtech.2018.03.004","article-title":"Strategies for in\u00a0vivo genome editing in nondividing cells","volume":"36","author":"Nami","year":"2018","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.neuron.2020.01.004_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(02)00231-8","article-title":"Mutation analysis and association studies of the ubiquitin carboxy-terminal hydrolase L1 gene in Huntington\u2019s disease","volume":"328","author":"Naz\u00e9","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2020.01.004_bib48","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1073\/pnas.1221292110","article-title":"Extensive changes in DNA methylation are associated with expression of mutant huntingtin","volume":"110","author":"Ng","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2020.01.004_bib49","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1007\/s12035-016-0010-4","article-title":"Genome-wide analysis of RAR\u03b2 transcriptional targets in mouse striatum links retinoic acid signaling with Huntington\u2019s disease and other neurodegenerative disorders","volume":"54","author":"Niewiadomska-Cimicka","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuron.2020.01.004_bib50","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2014.09.014","article-title":"CRISPR-Cas9 knockin mice for genome editing and cancer modeling","volume":"159","author":"Platt","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2020.01.004_bib51","doi-asserted-by":"crossref","first-page":"14467","DOI":"10.1523\/JNEUROSCI.1278-15.2015","article-title":"Retinoic acid receptor \u03b2 controls development of striatonigral projection neurons through FGF-dependent and Meis1-dependent mechanisms","volume":"35","author":"Rataj-Baniowska","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.01.004_bib52","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nmeth924","article-title":"Genome-scale loss-of-function screening with a lentiviral RNAi library","volume":"3","author":"Root","year":"2006","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2020.01.004_bib53","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/342177a0","article-title":"Reduced Nm23\/Awd protein in tumour metastasis and aberrant Drosophila development","volume":"342","author":"Rosengard","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2020.01.004_bib54","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2020.01.004_bib56","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1001\/jama.2010.574","article-title":"Genome-wide analysis of genetic loci associated with Alzheimer disease","volume":"303","author":"Seshadri","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.neuron.2020.01.004_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/gtc.12183","article-title":"Experimental design for stable genetic manipulation in mammalian cell lines: lentivirus and alternatives","volume":"20","author":"Shearer","year":"2015","journal-title":"Genes Cells"},{"key":"10.1016\/j.neuron.2020.01.004_bib58","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1073\/pnas.1417231112","article-title":"Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington\u2019s disease","volume":"112","author":"Shema","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2020.01.004_bib59","doi-asserted-by":"crossref","first-page":"eaaf6295","DOI":"10.1126\/scitranslmed.aaf6295","article-title":"Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP\/PS1 mice","volume":"9","author":"Shi","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuron.2020.01.004_bib60","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuron.2020.01.004_bib61","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12929-015-0137-z","article-title":"Linear correlation between average fluorescence intensity of green fluorescent protein and the multiplicity of infection of recombinant adenovirus","volume":"22","author":"Tsai","year":"2015","journal-title":"J.\u00a0Biomed. Sci."},{"key":"10.1016\/j.neuron.2020.01.004_bib62","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1126\/science.287.5454.864","article-title":"Synaptic assembly of the brain in the absence of neurotransmitter secretion","volume":"287","author":"Verhage","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neuron.2020.01.004_bib63","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington\u2019s disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neuron.2020.01.004_bib64","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.cell.2014.09.002","article-title":"A Drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases","volume":"159","author":"Yamamoto","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2020.01.004_bib65","doi-asserted-by":"crossref","first-page":"e93891","DOI":"10.1371\/journal.pone.0093891","article-title":"Large-scale RNA interference screening in mammalian cells identifies novel regulators of mutant huntingtin aggregation","volume":"9","author":"Yamanaka","year":"2014","journal-title":"PLoS ONE"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627320300040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627320300040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:24:56Z","timestamp":1760253896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627320300040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0896627320300040"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2020.01.004","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide In\u00a0Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2020.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}