{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:39:06Z","timestamp":1790836746932,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":389,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.neuron.2020.08.013","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T10:35:19Z","timestamp":1599561319000},"page":"691-706.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":160,"title":["Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus"],"prefix":"10.1016","volume":"108","author":[{"given":"Hankyul","family":"Kwak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuhyun","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangwoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyeong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Im","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Moo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go Eun","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Eun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmin Mason","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunpil","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiesi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Hun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsung","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taehwang","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Woo","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Duk","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Eun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeick","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunbeom","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Chul","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3555-0980","authenticated-orcid":false,"given":"C. Justin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunji","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2020.08.013_bib1","doi-asserted-by":"crossref","first-page":"e0203761","DOI":"10.1371\/journal.pone.0203761","article-title":"Activity changes in neuron-astrocyte networks in culture under the effect of norepinephrine","volume":"13","author":"Bar El","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2020.08.013_bib2","doi-asserted-by":"crossref","first-page":"11513","DOI":"10.1523\/JNEUROSCI.2679-05.2005","article-title":"Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics","volume":"25","author":"Belelli","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib3","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1523\/JNEUROSCI.4366-15.2016","article-title":"Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers","volume":"36","author":"Berglund","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuron.2011.12.012","article-title":"Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease","volume":"73","author":"Brickley","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2020.08.013_bib5","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1152\/jn.00426.2001","article-title":"Properties of primary sensory (lemniscal) synapses in the ventrobasal thalamus and the relay of high-frequency sensory inputs","volume":"87","author":"Castro-Alamancos","year":"2002","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2020.08.013_bib6","doi-asserted-by":"crossref","first-page":"e12727","DOI":"10.7554\/eLife.12727","article-title":"Sensitive red protein calcium indicators for imaging neural activity","volume":"5","author":"Dana","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2020.08.013_bib7","doi-asserted-by":"crossref","first-page":"6778","DOI":"10.1523\/JNEUROSCI.23-17-06778.2003","article-title":"The relay of high-frequency sensory signals in the Whisker-to-barreloid pathway","volume":"23","author":"Desch\u00eanes","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ceca.2013.09.001","article-title":"\u03b11-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice","volume":"54","author":"Ding","year":"2013","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neuron.2020.08.013_bib9","series-title":"The Physiology of Synapses","author":"Eccles","year":"1964"},{"key":"10.1016\/j.neuron.2020.08.013_bib10","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1002\/anie.201207403","article-title":"Quantitative interpretation of diffusion-ordered NMR spectra: can we rationalize small molecule diffusion coefficients?","volume":"52","author":"Evans","year":"2013","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.neuron.2020.08.013_bib11","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1021\/acs.analchem.7b05032","article-title":"Improving the Interpretation of Small Molecule Diffusion Coefficients","volume":"90","author":"Evans","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.neuron.2020.08.013_bib12","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.neuron.2019.02.037","article-title":"A Genetically Encoded Fluorescent Sensor for Rapid and Specific In\u00a0Vivo Detection of Norepinephrine","volume":"102","author":"Feng","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2020.08.013_bib13","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/BF00236407","article-title":"Lemniscal and extralemniscal thalamic lesions and tactile discrimination in the rat","volume":"15","author":"Finger","year":"1972","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neuron.2020.08.013_bib14","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0006-8993(73)90724-5","article-title":"The concentration of GABA within inhibitory nerve terminals","volume":"62","author":"Fonnum","year":"1973","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2020.08.013_bib15","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1137\/0717021","article-title":"Monotone Piecewise Cubic Interpolation","volume":"17","author":"Fritsch","year":"1980","journal-title":"SIAM J. Numer. Anal."},{"key":"10.1016\/j.neuron.2020.08.013_bib16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fphys.2019.00023","article-title":"Bestrophin-3 Expression in a Subpopulation of Astrocytes in the Neonatal Brain After Hypoxic-Ischemic Injury","volume":"10","author":"Golubinskaya","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neuron.2020.08.013_bib17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5607\/en.2019.28.2.183","article-title":"Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain","volume":"28","author":"Han","year":"2019","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.neuron.2020.08.013_bib18","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.cub.2019.11.079","article-title":"Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson\u2019s Disease","volume":"30","author":"Heo","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2020.08.013_bib19","doi-asserted-by":"crossref","first-page":"14850","DOI":"10.1523\/JNEUROSCI.1174-13.2013","article-title":"Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus","volume":"33","author":"Herd","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib20","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1523\/JNEUROSCI.5298-05.2006","article-title":"Noradrenergic activation amplifies bottom-up and top-down signal-to-noise ratios in sensory thalamus","volume":"26","author":"Hirata","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0014-5793(92)80752-3","article-title":"Regulation of gastric mucosal diamine oxidase activity by gastrin","volume":"307","author":"Hougaard","year":"1992","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuron.2020.08.013_bib22","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/j.1460-9568.2011.07645.x","article-title":"Non-neuronal, slow GABA signalling in the ventrobasal thalamus targets \u03b4-subunit-containing GABA(A) receptors","volume":"33","author":"Jim\u00e9nez-Gonz\u00e1lez","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib23","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nm.3639","article-title":"GABA from reactive astrocytes impairs memory in mouse models of Alzheimer\u2019s disease","volume":"20","author":"Jo","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2020.08.013_bib24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.5607\/en.2016.25.3.120","article-title":"Neuronal Expression and Cell-Type-Specific Gene-Silencing of Best1 in Thalamic Reticular Nucleus Neurons Using pSico-Red System","volume":"25","author":"Jung","year":"2016","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.neuron.2020.08.013_bib25","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1152\/jn.1997.77.5.2661","article-title":"Physiology and pharmacology of corticothalamic stimulation-evoked responses in rat somatosensory thalamic neurons in\u00a0vitro","volume":"77","author":"Kao","year":"1997","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2020.08.013_bib26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-neuro-070918-050443","article-title":"The Emerging Nature of Astrocyte Diversity","volume":"42","author":"Khakh","year":"2019","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib27","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1126\/science.aac4690","article-title":"Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons","volume":"350","author":"Kim","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.neuron.2020.08.013_bib28","doi-asserted-by":"crossref","first-page":"350","DOI":"10.5607\/en.2017.26.6.350","article-title":"AAV-Mediated Astrocyte-Specific Gene Expression under Human ALDH1L1 Promoter in Mouse Thalamus","volume":"26","author":"Koh","year":"2017","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.neuron.2020.08.013_bib29","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/nbt.3350","article-title":"Optogenetic control of endogenous Ca(2+) channels in\u00a0vivo","volume":"33","author":"Kyung","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neuron.2020.08.013_bib30","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1126\/science.1184334","article-title":"Channel-mediated tonic GABA release from glia","volume":"330","author":"Lee","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.neuron.2020.08.013_bib31","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1152\/jn.1998.80.5.2521","article-title":"Synchronization of golgi and granule cell firing in a detailed network model of the cerebellar granule cell layer","volume":"80","author":"Maex","year":"1998","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2020.08.013_bib32","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1085\/jgp.200509473","article-title":"The light peak of the electroretinogram is dependent on voltage-gated calcium channels and antagonized by bestrophin (best-1)","volume":"127","author":"Marmorstein","year":"2006","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.neuron.2020.08.013_bib33","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/0959-4388(94)90056-6","article-title":"Sensory gating mechanisms of the thalamus","volume":"4","author":"McCormick","year":"1994","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuron.2020.08.013_bib34","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.neuron.2014.05.001","article-title":"Discriminative and affective touch: sensing and feeling","volume":"82","author":"McGlone","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2020.08.013_bib35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbi.2014.12.008","article-title":"N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes","volume":"234","author":"Morgan","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.neuron.2020.08.013_bib36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1756-6606-6-54","article-title":"High glutamate permeability and distal localization of Best1 channel in CA1 hippocampal astrocyte","volume":"6","author":"Park","year":"2013","journal-title":"Mol. Brain"},{"key":"10.1016\/j.neuron.2020.08.013_bib37","doi-asserted-by":"crossref","first-page":"eaav0316","DOI":"10.1126\/sciadv.aav0316","article-title":"Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer\u2019s disease","volume":"5","author":"Park","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neuron.2020.08.013_bib38","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0736-5748(94)90086-8","article-title":"Gene expression in astrocytes is affected by subculture","volume":"12","author":"Passaquin","year":"1994","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresrev.2004.04.008","article-title":"The thalamic reticular nucleus: structure, function and concept","volume":"46","author":"Pinault","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.neuron.2020.08.013_bib40","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41593-018-0283-1","article-title":"Locus coeruleus activation enhances thalamic feature selectivity via norepinephrine regulation of intrathalamic circuit dynamics","volume":"22","author":"Rodenkirch","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib41","doi-asserted-by":"crossref","first-page":"R1051","DOI":"10.1016\/j.cub.2015.09.039","article-title":"Organization of the locus coeruleus-norepinephrine system","volume":"25","author":"Schwarz","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2020.08.013_bib42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1042\/bj1440029","article-title":"Putrescine catabolism in mammalian brain","volume":"144","author":"Seiler","year":"1974","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuron.2020.08.013_bib43","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1523\/JNEUROSCI.5255-05.2006","article-title":"GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression","volume":"26","author":"Serrano","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib44","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0166-2236(00)01714-8","article-title":"Tonic and burst firing: dual modes of thalamocortical relay","volume":"24","author":"Sherman","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib45","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.neuron.2016.11.030","article-title":"New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In\u00a0Vivo","volume":"92","author":"Srinivasan","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2020.08.013_bib46","doi-asserted-by":"crossref","first-page":"RC223","DOI":"10.1523\/JNEUROSCI.22-10-j0003.2002","article-title":"Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons","volume":"22","author":"Stell","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib47","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.celrep.2015.09.029","article-title":"Whisking-Related Changes in Neuronal Firing and Membrane Potential Dynamics in the Somatosensory Thalamus of Awake Mice","volume":"13","author":"Urbain","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2020.08.013_bib48","series-title":"Astrocytes in (Patho)Physiology of the Nervous System","first-page":"49","article-title":"Neurotransmitter Receptors in Astrocytes","author":"Verkhratsky","year":"2008"},{"key":"10.1016\/j.neuron.2020.08.013_bib49","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.00042.2016","article-title":"Physiology of Astroglia","volume":"98","author":"Verkhratsky","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuron.2020.08.013_bib50","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00424-019-02310-2","article-title":"Astroglial atrophy in Alzheimer\u2019s disease","volume":"471","author":"Verkhratsky","year":"2019","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.neuron.2020.08.013_bib51","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3109\/10799893.2010.509728","article-title":"Theme and variations on kinetics of GPCR activation\/deactivation","volume":"30","author":"Vilardaga","year":"2010","journal-title":"J.\u00a0Recept. Signal Transduct. Res."},{"key":"10.1016\/j.neuron.2020.08.013_bib52","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrn3725","article-title":"Astrocyte Ca2+ signalling: an unexpected complexity","volume":"15","author":"Volterra","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib53","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1523\/JNEUROSCI.2403-17.2018","article-title":"Primary Tactile Thalamus Spiking Reflects Cognitive Signals","volume":"38","author":"Waiblinger","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib54","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/nn.2670","article-title":"Thalamic synchrony and the adaptive gating of information flow to cortex","volume":"13","author":"Wang","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2020.08.013_bib55","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neulet.2018.01.012","article-title":"The signaling role for chloride in the bidirectional communication between neurons and astrocytes","volume":"689","author":"Wilson","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2020.08.013_bib56","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cell.2012.09.005","article-title":"TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation","volume":"151","author":"Woo","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2020.08.013_bib57","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1073\/pnas.1721187115","article-title":"Control of motor coordination by astrocytic tonic GABA release through modulation of excitation\/inhibition balance in cerebellum","volume":"115","author":"Woo","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2020.08.013_bib58","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bbr.2012.09.044","article-title":"Novel, whisker-dependent texture discrimination task for mice","volume":"237","author":"Wu","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuron.2020.08.013_bib59","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1038\/ncomms5159","article-title":"Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer\u2019s [corrected] disease model","volume":"5","author":"Wu","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2020.08.013_bib60","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1529\/biophysj.106.085431","article-title":"Kinetic properties of GABA rho1 homomeric receptors expressed in HEK293 cells","volume":"91","author":"Yang","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuron.2020.08.013_bib61","doi-asserted-by":"crossref","first-page":"211","DOI":"10.5607\/en.2015.24.3.211","article-title":"Disinhibitory Action of Astrocytic GABA at the Perforant Path to Dentate Gyrus Granule Neuron Synapse Reverses to Inhibitory in Alzheimer\u2019s Disease Model","volume":"24","author":"Yarishkin","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.neuron.2020.08.013_bib62","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1113\/jphysiol.2014.278754","article-title":"Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition","volume":"592","author":"Yoon","year":"2014","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2020.08.013_bib63","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.neuron.2018.08.015","article-title":"Reducing Astrocyte Calcium Signaling In\u00a0Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior","volume":"99","author":"Yu","year":"2018","journal-title":"Neuron"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627320306449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627320306449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:29:41Z","timestamp":1760254181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627320306449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0896627320306449"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2020.08.013","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738636069.793583463","asserted-by":"object"}]},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2020.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}