{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:25:46Z","timestamp":1792797946955,"version":"4.5.0"},"reference-count":83,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":389,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005270","name":"McKnight Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000875","name":"Pew Charitable Trusts","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001068","name":"Dana Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001341","name":"Richard and Susan Smith Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005310","name":"Klarman Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005310","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.neuron.2020.08.024","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T12:49:41Z","timestamp":1600692581000},"page":"623-639.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":118,"title":["Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface"],"prefix":"10.1016","volume":"108","author":[{"given":"Frederick B.","family":"Shipley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Dani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Deister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua P.","family":"Head","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Sadegh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryann M.","family":"Fame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan L.","family":"Shannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa I.","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kishkovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn J.","family":"Goldey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangmin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Kirchhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Wyart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher I.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Andermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria K.","family":"Lehtinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2020.08.024_bib1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/01616412.1980.11739563","article-title":"Ultrastructural observations suggesting apocrine secretion in the choroid plexus: a comparative study","volume":"1","author":"Agnew","year":"1980","journal-title":"Neurol. Res."},{"key":"10.1016\/j.neuron.2020.08.024_bib2","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1113\/JP271143","article-title":"Calcium signalling in salivary gland physiology and dysfunction","volume":"594","author":"Ambudkar","year":"2016","journal-title":"J.\u00a0Physiol."},{"issue":"11 Pt B","key":"10.1016\/j.neuron.2020.08.024_bib3","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.bbamcr.2018.07.002","article-title":"Calcium signaling defects underlying salivary gland dysfunction","volume":"1865","author":"Ambudkar","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.neuron.2020.08.024_bib4","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.bbagen.2012.05.012","article-title":"Correlation of serotonin levels in CSF, platelets, plasma, and urine","volume":"1820","author":"Audhya","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuron.2020.08.024_bib5","series-title":"Spatial Point Patterns: Methodology and Applications with R","author":"Baddedy","year":"2015"},{"key":"10.1016\/j.neuron.2020.08.024_bib6","doi-asserted-by":"crossref","first-page":"42786","DOI":"10.1038\/srep42786","article-title":"Calcium spikes, waves and oscillations in a large, patterned epithelial tissue","volume":"7","author":"Balaji","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2020.08.024_bib7","doi-asserted-by":"crossref","first-page":"534","DOI":"10.4103\/1673-5374.180372","article-title":"The choroid plexus-cerebrospinal fluid interface in Alzheimer\u2019s disease: more than just a barrier","volume":"11","author":"Balusu","year":"2016","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neuron.2020.08.024_bib8","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.15252\/emmm.201606271","article-title":"Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles","volume":"8","author":"Balusu","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.neuron.2020.08.024_bib9","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1182\/blood-2012-02-413047","article-title":"Platelets can enhance vascular permeability","volume":"120","author":"Cloutier","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.neuron.2020.08.024_bib10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.cell.2012.05.047","article-title":"The first five seconds in the life of a clathrin-coated pit","volume":"150","author":"Cocucci","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2020.08.024_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ceca.2016.12.004","article-title":"Regulation of epithelial ion transport in exocrine glands by store-operated Ca2+ entry","volume":"63","author":"Concepcion","year":"2017","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neuron.2020.08.024_bib12","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1111\/j.1471-4159.1986.tb13085.x","article-title":"Agonist-induced phosphoinositide hydrolysis in choroid plexus","volume":"47","author":"Conn","year":"1986","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuron.2020.08.024_bib13","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.celrep.2018.06.100","article-title":"The ESCRT-III protein CHMP1A mediates secretion of sonic hedgehog on a distinctive subtype of extracellular vesicles","volume":"24","author":"Coulter","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2020.08.024_bib14","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1177\/153537020523001011","article-title":"The choroid plexus removes beta-amyloid from brain cerebrospinal fluid","volume":"230","author":"Crossgrove","year":"2005","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.neuron.2020.08.024_bib15","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1152\/physrev.00004.2013","article-title":"Cerebrospinal fluid secretion by the choroid plexus","volume":"93","author":"Damkier","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuron.2020.08.024_bib16","article-title":"A cellular and spatial map of the choroid plexus across brain ventricles and ages","author":"Dani","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.neuron.2020.08.024_bib17","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nn1472","article-title":"ATP mediates rapid microglial response to local brain injury in\u00a0vivo","volume":"8","author":"Davalos","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2020.08.024_bib18","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nbt.3437","article-title":"Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9","volume":"34","author":"Doench","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neuron.2020.08.024_bib19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuron.2007.08.003","article-title":"Imaging large-scale neural activity with cellular resolution in awake, mobile mice","volume":"56","author":"Dombeck","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2020.08.024_bib20","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1038\/nn.2648","article-title":"Functional imaging of hippocampal place cells at cellular resolution during virtual navigation","volume":"13","author":"Dombeck","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2020.08.024_bib21","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1523\/JNEUROSCI.12-12-04775.1992","article-title":"Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium","volume":"12","author":"Esterle","year":"1992","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.08.024_bib22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.devcel.2020.01.027","article-title":"Emergence and developmental roles of the cerebrospinal fluid system","volume":"52","author":"Fame","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuron.2020.08.024_bib23","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.bbagen.2015.05.003","article-title":"Apocrine secretion: new insights into an old phenomenon","volume":"1850","author":"Farka\u0161","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuron.2020.08.024_bib24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00401-018-1807-1","article-title":"Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease","volume":"135","author":"Ghersi-Egea","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2020.08.024_bib25","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1038\/nprot.2014.165","article-title":"Removable cranial windows for long-term imaging in awake mice","volume":"9","author":"Goldey","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuron.2020.08.024_bib26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2202-12-4","article-title":"Targeting choroid plexus epithelia and ventricular ependyma for drug delivery to the central nervous system","volume":"12","author":"Gonzalez","year":"2011","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neuron.2020.08.024_bib27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0040-8166(87)90061-9","article-title":"Protein secretion by choroid plexus: isolated apical fragments synthesize protein in\u00a0vitro","volume":"19","author":"Gudeman","year":"1987","journal-title":"Tissue Cell"},{"key":"10.1016\/j.neuron.2020.08.024_bib28","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/jnr.490240209","article-title":"Release from live choroid plexus of apical fragments and electrophoretic characterization of their synthetic products","volume":"24","author":"Gudeman","year":"1989","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.neuron.2020.08.024_bib29","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1364\/OL.33.002668","article-title":"Direct image reconstruction from a Fourier intensity pattern using HERALDO","volume":"33","author":"Guizar-Sicairos","year":"2008","journal-title":"Opt. Lett."},{"key":"10.1016\/j.neuron.2020.08.024_bib30","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1038\/mtna.2013.27","article-title":"Fetal brain-directed AAV gene therapy results in rapid, robust, and persistent transduction of mouse choroid plexus epithelia","volume":"2","author":"Haddad","year":"2013","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.neuron.2020.08.024_bib31","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/s41593-018-0242-x","article-title":"Microglia in neurodegeneration","volume":"21","author":"Hickman","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2020.08.024_bib32","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3389\/fnagi.2018.00218","article-title":"In\u00a0vivo imaging of microglia with multiphoton microscopy","volume":"10","author":"Hierro-Bujalance","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuron.2020.08.024_bib33","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuron.2019.02.017","article-title":"Therapeutic AAV gene transfer to the nervous system: a clinical reality","volume":"101","author":"Hudry","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2020.08.024_bib34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/cne.901150206","article-title":"The development of the vascular pattern of the choroid plexus of the lateral ventricles","volume":"115","author":"Hudson","year":"1960","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2020.08.024_bib35","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1109\/TMI.2016.2550102","article-title":"Enhancement of vascular structures in 3D and 2D angiographic images","volume":"35","author":"Jerman","year":"2016","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.neuron.2020.08.024_bib36","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","article-title":"Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion","volume":"20","author":"Jung","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neuron.2020.08.024_bib37","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nm.4361","article-title":"Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus","volume":"23","author":"Karimy","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2020.08.024_bib38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41583-019-0201-x","article-title":"Macrophages at CNS interfaces: ontogeny and function in health and disease","volume":"20","author":"Kierdorf","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2020.08.024_bib39","doi-asserted-by":"crossref","first-page":"e964","DOI":"10.1038\/tp.2016.229","article-title":"Transcriptome sequencing of the choroid plexus in schizophrenia","volume":"6","author":"Kim","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuron.2020.08.024_bib40","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.neuron.2011.01.023","article-title":"The cerebrospinal fluid provides a proliferative niche for neural progenitor cells","volume":"69","author":"Lehtinen","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2020.08.024_bib41","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2020.08.024_bib42","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nri.2017.125","article-title":"Microglia and macrophages in brain homeostasis and disease","volume":"18","author":"Li","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neuron.2020.08.024_bib43","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.cell.2018.04.041","article-title":"A fine-scale functional logic to convergence from retina to thalamus","volume":"173","author":"Liang","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2020.08.024_bib44","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-\u0394 \u0394 C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.neuron.2020.08.024_bib45","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1523\/JNEUROSCI.3081-14.2015","article-title":"Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production","volume":"35","author":"Lun","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.08.024_bib46","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrn3921","article-title":"Development and functions of the choroid plexus-cerebrospinal fluid system","volume":"16","author":"Lun","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2020.08.024_bib47","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.neuron.2015.02.022","article-title":"Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance","volume":"85","author":"Madisen","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2020.08.024_bib48","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/jcbfm.2009.15","article-title":"Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation","volume":"29","author":"Marques","year":"2009","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuron.2020.08.024_bib49","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1750-1326-8-38","article-title":"Blood-brain-barriers in aging and in Alzheimer\u2019s disease","volume":"8","author":"Marques","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuron.2020.08.024_bib50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nature14306","article-title":"Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool","volume":"522","author":"Mesa","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2020.08.024_bib51","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.1088417","article-title":"Inflammatory blockade restores adult hippocampal neurogenesis","volume":"302","author":"Monje","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neuron.2020.08.024_bib52","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bbi.2019.02.004","article-title":"Choroid plexus transcriptome and ultrastructure analysis reveals a TLR2-specific chemotaxis signature and cytoskeleton remodeling in leukocyte trafficking","volume":"79","author":"Mottahedin","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuron.2020.08.024_bib53","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neuron.2009.08.009","article-title":"Automated analysis of cellular signals from large-scale calcium imaging data","volume":"63","author":"Mukamel","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2020.08.024_bib54","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.neuropharm.2008.08.020","article-title":"Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs)","volume":"55","author":"Narboux-N\u00eame","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuron.2020.08.024_bib55","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.bpj.2017.05.051","article-title":"Release of applied mechanical loading stimulates intercellular calcium waves in Drosophila wing discs","volume":"113","author":"Narciso","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuron.2020.08.024_bib56","series-title":"The Choroid Plexus in Health and Disease","author":"Netsky","year":"1975"},{"key":"10.1016\/j.neuron.2020.08.024_bib57","doi-asserted-by":"crossref","first-page":"e55523","DOI":"10.7554\/eLife.55523","article-title":"A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons","volume":"9","author":"Okaty","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2020.08.024_bib58","doi-asserted-by":"crossref","first-page":"eaaz5626","DOI":"10.1126\/science.aaz5626","article-title":"Human CNS barrier-forming organoids with cerebrospinal fluid production","volume":"369","author":"Pellegrini","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.neuron.2020.08.024_bib59","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fnmol.2015.00012","article-title":"Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC:G5-tdT reporter mouse","volume":"8","author":"Pozner","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neuron.2020.08.024_bib60","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ni.1716","article-title":"C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE","volume":"10","author":"Reboldi","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.neuron.2020.08.024_bib61","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1126\/science.aaf7012","article-title":"Spatiotemporal coordination of stem cell commitment during epidermal homeostasis","volume":"352","author":"Rompolas","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neuron.2020.08.024_bib62","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.brainres.2005.12.052","article-title":"Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503","volume":"1073\u20131074","author":"Rosenzweig-Lipson","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2020.08.024_bib63","doi-asserted-by":"crossref","first-page":"20150424","DOI":"10.1098\/rstb.2015.0424","article-title":"Store-operated Ca2+ channels in airway epithelial cell function and implications for asthma","volume":"371","author":"Samanta","year":"2016","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.neuron.2020.08.024_bib64","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/S0022-3565(25)20218-X","article-title":"Serotonin1c receptor reserve in choroid plexus masks receptor subsensitivity","volume":"252","author":"Sanders-Bush","year":"1990","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuron.2020.08.024_bib65","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/S0006-3495(00)76468-X","article-title":"The use of pHluorins for optical measurements of presynaptic activity","volume":"79","author":"Sankaranarayanan","year":"2000","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuron.2020.08.024_bib66","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1113\/JP275376","article-title":"Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain","volume":"596","author":"Saunders","year":"2018","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2020.08.024_bib67","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/embj.201386609","article-title":"The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus","volume":"33","author":"Schwartz","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2020.08.024_bib68","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.immuni.2013.02.012","article-title":"Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus","volume":"38","author":"Shechter","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.neuron.2020.08.024_bib69","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.stem.2016.06.013","article-title":"Age-dependent niche signals from the choroid plexus regulate adult neural stem cells","volume":"19","author":"Silva-Vargas","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neuron.2020.08.024_bib70","doi-asserted-by":"crossref","first-page":"646","DOI":"10.2174\/1389200220666190725115503","article-title":"The relationship between the serotonin metabolism, gut-microbiota and the gut-brain axis","volume":"20","author":"Stasi","year":"2019","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.neuron.2020.08.024_bib71","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1523\/JNEUROSCI.19-15-06275.1999","article-title":"Demonstration of a coupled metabolism-efflux process at the choroid plexus as a mechanism of brain protection toward xenobiotics","volume":"19","author":"Strazielle","year":"1999","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.08.024_bib72","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.devcel.2013.09.002","article-title":"Birth regulates the initiation of sensory map formation through serotonin signaling","volume":"27","author":"Toda","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuron.2020.08.024_bib73","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.stem.2014.01.014","article-title":"Axonal control of the adult neural stem cell niche","volume":"14","author":"Tong","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neuron.2020.08.024_bib74","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1083\/jcb.201709064","article-title":"Spatiotemporal organization of exocytosis emerges during neuronal shape change","volume":"217","author":"Urbina","year":"2018","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2020.08.024_bib75","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41593-019-0393-4","article-title":"A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment","volume":"22","author":"Van Hove","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2020.08.024_bib76","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41592-018-0115-y","article-title":"Three-photon imaging of mouse brain structure and function through the intact skull","volume":"15","author":"Wang","year":"2018","journal-title":"Nat. Methods"},{"issue":"6,\u00a0Suppl","key":"10.1016\/j.neuron.2020.08.024_bib77","first-page":"475","article-title":"Comparison of endoscopic third ventriculostomy alone and combined with choroid plexus cauterization in infants younger than 1 year of age: a prospective study in 550 African children","volume":"103","author":"Warf","year":"2005","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.neuron.2020.08.024_bib78","doi-asserted-by":"crossref","first-page":"15934","DOI":"10.1523\/JNEUROSCI.3227-12.2012","article-title":"BMP4 sufficiency to induce choroid plexus epithelial fate from embryonic stem cell-derived neuroepithelial progenitors","volume":"32","author":"Watanabe","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2020.08.024_bib79","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0143-4160(95)90081-0","article-title":"Serotonin elevates intracellular Ca2+ in rat choroid plexus epithelial cells by acting on 5-HT2C receptors","volume":"17","author":"Watson","year":"1995","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neuron.2020.08.024_bib80","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.cell.2019.03.011","article-title":"Volumetric Ca(2+) imaging in the mouse brain using hybrid multiplexed sculpted light microscopy","volume":"177","author":"Weisenburger","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2020.08.024_bib81","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1165\/rcmb.2006-0475RC","article-title":"A transgenic FOXJ1-Cre system for gene inactivation in ciliated epithelial cells","volume":"36","author":"Zhang","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.neuron.2020.08.024_bib82","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0006-8993(02)03683-1","article-title":"Establishment and characterization of an immortalized Z310 choroidal epithelial cell line from murine choroid plexus","volume":"958","author":"Zheng","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2020.08.024_bib83","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11626-998-0051-8","article-title":"Primary culture of choroidal epithelial cells: characterization of an in\u00a0vitro model of blood-CSF barrier","volume":"34","author":"Zheng","year":"1998","journal-title":"In\u00a0Vitro Cell. Dev. Biol. Anim."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627320306553?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627320306553?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:29:25Z","timestamp":1760254165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627320306553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":83,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0896627320306553"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2020.08.024","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2020.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}