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Neurosci."},{"key":"10.1016\/j.neuron.2021.05.002_bib68","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2105-7-123","article-title":"Detecting outliers when fitting data with nonlinear regression - a new method based on robust nonlinear regression and the false discovery rate","volume":"7","author":"Motulsky","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.neuron.2021.05.002_bib69","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/sj.npp.1300456","article-title":"Increases in dopamine D3 receptor binding in rats receiving a cocaine challenge at various time points after cocaine self-administration: implications for cocaine-seeking behavior","volume":"29","author":"Neisewander","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuron.2021.05.002_bib70","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuron.2019.01.016","article-title":"The Molecular Basis of Drug Addiction: Linking Epigenetic to Synaptic and Circuit Mechanisms","volume":"102","author":"Nestler","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2021.05.002_bib71","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/nprot.2013.094","article-title":"Design and generation of recombinant rabies virus vectors","volume":"8","author":"Osakada","year":"2013","journal-title":"Nat. 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