{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:15:20Z","timestamp":1792818920218,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":379,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.neuron.2022.03.034","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T11:19:34Z","timestamp":1650367174000},"page":"1932-1943.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":203,"title":["Regional A\u03b2-tau interactions promote onset and acceleration of Alzheimer\u2019s disease tau spreading"],"prefix":"10.1016","volume":"110","author":[{"given":"Wha Jin","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Ryun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"La Joie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Hyoung","family":"Lyoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil D.","family":"Rabinovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon-Kyung","family":"Seong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Seeley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2022.03.034_bib1","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1001\/archneur.65.11.1509","article-title":"Frequent amyloid deposition without significant cognitive impairment Among the elderly","volume":"65","author":"Aizenstein","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neuron.2022.03.034_bib2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers. Dement."},{"key":"10.1016\/j.neuron.2022.03.034_bib3","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1007\/s00259-020-04773-3","article-title":"Temporal trajectories of in\u00a0vivo tau and amyloid-\u03b2 accumulation in Alzheimer\u2019s disease","volume":"47","author":"Baek","year":"2020","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.neuron.2022.03.034_bib4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/nbm.782","article-title":"The basis of anisotropic water diffusion in the nervous system \u2013 a technical review","volume":"15","author":"Beaulieu","year":"2002","journal-title":"NMR Biomed."},{"key":"10.1016\/j.neuron.2022.03.034_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J.\u00a0R. Stat. Soc. B Methodol."},{"key":"10.1016\/j.neuron.2022.03.034_bib6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2022.03.034_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2022.03.034_bib8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00401-011-0825-z","article-title":"Alzheimer\u2019s pathogenesis: is there neuron-to-neuron propagation?","volume":"121","author":"Braak","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2022.03.034_bib9","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.neuron.2019.08.037","article-title":"Patient-tailored, connectivity-based forecasts of spreading brain atrophy","volume":"104","author":"Brown","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2022.03.034_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/ana.24711","article-title":"In\u00a0vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum","volume":"80","author":"Cho","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuron.2022.03.034_bib11","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.2967\/jnumed.118.221697","article-title":"Progressive tau accumulation in Alzheimer disease: 2-year follow-up study","volume":"60","author":"Cho","year":"2019","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.neuron.2022.03.034_bib12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2967\/jnumed.117.195248","article-title":"Off-target 18F-AV-1451 binding in the basal ganglia correlates with age-related iron accumulation","volume":"59","author":"Choi","year":"2018","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.neuron.2022.03.034_bib13","doi-asserted-by":"crossref","first-page":"9535","DOI":"10.1073\/pnas.1301175110","article-title":"Brain homogenates from human tauopathies induce tau inclusions in mouse brain","volume":"110","author":"Clavaguera","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2022.03.034_bib14","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00401-014-1349-0","article-title":"Primary age-related tauopathy (PART): a common pathology associated with human aging","volume":"128","author":"Crary","year":"2014","journal-title":"Acta neuropathol."},{"key":"10.1016\/j.neuron.2022.03.034_bib15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/alz.12444","article-title":"Aducanumab: appropriate use recommendations","volume":"18","author":"Cummings","year":"2021","journal-title":"Alzheimers Dem."},{"key":"10.1016\/j.neuron.2022.03.034_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neurobiolaging.2018.01.024","article-title":"Longitudinal and cross-sectional structural magnetic resonance imaging correlates of AV-1451 uptake","volume":"66","author":"Das","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2022.03.034_bib17","first-page":"879","article-title":"Corpus callosum diffusion anisotropy correlates with neuropsychological outcomes in twins disconcordant for traumatic brain injury","volume":"27","author":"Ewing-Cobbs","year":"2006","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.neuron.2022.03.034_bib18","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1093\/cercor\/bhw157","article-title":"The human Brainnetome atlas: A new brain atlas based on connectional architecture","volume":"26","author":"Fan","year":"2016","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neuron.2022.03.034_bib19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41467-019-14159-1","article-title":"Functional brain architecture is associated with the rate of tau accumulation in Alzheimer\u2019s disease","volume":"11","author":"Franzmeier","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2022.03.034_bib20","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/j.neuropsychologia.2007.04.011","article-title":"Speed of lexical decision correlates with diffusion anisotropy in left parietal and frontal white matter: evidence from diffusion tensor imaging","volume":"45","author":"Gold","year":"2007","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.neuron.2022.03.034_bib21","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1212\/WNL.0000000000004643","article-title":"In\u00a0vivo staging of regional amyloid deposition","volume":"89","author":"Grothe","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2022.03.034_bib22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nm.4443","article-title":"Amyloid-beta plaques enhance Alzheimer\u2019s brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation","volume":"24","author":"He","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2022.03.034_bib23","series-title":"Understanding Robust and Exploratory Data Analysis","author":"Hoaglin","year":"2000"},{"key":"10.1016\/j.neuron.2022.03.034_bib24","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.6474172","article-title":"Alzheimer\u2019s disease: cell-specific pathology isolates the hippocampal formation","volume":"225","author":"Hyman","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.neuron.2022.03.034_bib25","series-title":"Medical Biostatistics","author":"Indrayan","year":"2017"},{"key":"10.1016\/j.neuron.2022.03.034_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003956","article-title":"Epidemic spreading model to characterize misfolded proteins propagation in aging and associated neurodegenerative disorders","volume":"10","author":"Iturria-Medina","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.neuron.2022.03.034_bib27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuron.2022.03.034_bib28","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1212\/WNL.49.3.786","article-title":"Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease","volume":"49","author":"Jack","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2022.03.034_bib29","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41583-018-0067-3","article-title":"Imaging the evolution and pathophysiology of Alzheimer disease","volume":"19","author":"Jagust","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2022.03.034_bib30","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jalz.2015.05.001","article-title":"The Alzheimer\u2019s disease neuroimaging initiative 2 PET core: 2015","volume":"11","author":"Jagust","year":"2015","journal-title":"Alzheimers. Dement."},{"key":"10.1016\/j.neuron.2022.03.034_bib31","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/ana.24546","article-title":"Tau positron emission tomographic imaging in aging and early Alzheimer disease","volume":"79","author":"Johnson","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuron.2022.03.034_bib32","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2967\/jnumed.111.090340","article-title":"Performance characteristics of amyloid PET with florbetapir F 18 in patients with Alzheimer\u2019s disease and cognitively normal subjects","volume":"53","author":"Joshi","year":"2012","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.neuron.2022.03.034_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00401-019-02075-z","article-title":"Evidence of corticofugal tau spreading in patients with frontotemporal dementia","volume":"139","author":"Kim","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2022.03.034_bib34","doi-asserted-by":"crossref","first-page":"16265","DOI":"10.1523\/JNEUROSCI.2170-12.2012","article-title":"Region-specific hierarchy between atrophy, hypometabolism, and \u03b2-amyloid (A\u03b2) load in Alzheimer\u2019s disease dementia","volume":"32","author":"La Joie","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2022.03.034_bib35","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.dadm.2018.01.007","article-title":"Tau positron emission tomography imaging in tauopathies: the added hurdle of off-target binding","volume":"10","author":"Lemoine","year":"2018","journal-title":"Alzheimers. Dement. (Amst)"},{"key":"10.1016\/j.neuron.2022.03.034_bib36","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/s41380-018-0342-8","article-title":"Tau PET imaging in neurodegenerative tauopathies\u2014still a challenge","volume":"24","author":"Leuzy","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2022.03.034_bib37","article-title":"Trans-synaptic spread of tau pathology in\u00a0vivo","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2022.03.034_bib38","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1212\/WNL.0000000000003724","article-title":"Elevated (18)F-AV-1451 PET tracer uptake detected in incidental imaging findings","volume":"88","author":"Lockhart","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2022.03.034_bib39","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.neuroimage.2017.05.058","article-title":"Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease","volume":"157","author":"Maass","year":"2017","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuron.2022.03.034_bib40","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/s41467-017-01285-x","article-title":"The challenge of mapping the human connectome based on diffusion tractography","volume":"8","author":"Maier-Hein","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2022.03.034_bib41","doi-asserted-by":"crossref","first-page":"e1295","DOI":"10.1212\/WNL.0000000000006277","article-title":"Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease","volume":"91","author":"Mcdade","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2022.03.034_bib42","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers. Dement."},{"key":"10.1016\/j.neuron.2022.03.034_bib43","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa2100708","article-title":"Donanemab in early Alzheimer\u2019s disease","volume":"384","author":"Mintun","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuron.2022.03.034_bib44","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/WCO.0b013e32835a30f4","article-title":"Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement","volume":"25","author":"Musiek","year":"2012","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.neuron.2022.03.034_bib45","doi-asserted-by":"crossref","first-page":"101848","DOI":"10.1016\/j.nicl.2019.101848","article-title":"Tau covariance patterns in Alzheimer\u2019s disease patients match intrinsic connectivity networks in the healthy brain","volume":"23","author":"Ossenkoppele","year":"2019","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.neuron.2022.03.034_bib46","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1093\/brain\/awv191","article-title":"The behavioural\/dysexecutive variant of Alzheimer\u2019s disease: clinical, neuroimaging and pathological features","volume":"138","author":"Ossenkoppele","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2022.03.034_bib47","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1212\/WNL.0b013e3181cb3e25","article-title":"Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI): clinical characterization","volume":"74","author":"Petersen","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2022.03.034_bib48","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.neuron.2011.12.040","article-title":"A network diffusion model of disease progression in dementia","volume":"73","author":"Raj","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2022.03.034_bib49","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.celrep.2014.12.034","article-title":"Network diffusion model of progression predicts longitudinal patterns of atrophy and metabolism in Alzheimer\u2019s disease","volume":"10","author":"Raj","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2022.03.034_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abc0655","article-title":"The cortical origin and initial spread of medial temporal tauopathy in Alzheimer\u2019s disease assessed with positron emission tomography","volume":"13","author":"Sanchez","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuron.2022.03.034_bib51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13195-020-00765-5","article-title":"Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer\u2019s disease: findings from the Colombia-Boston (COLBOS) biomarker study","volume":"13","author":"Sanchez","year":"2021","journal-title":"Alzheimer\u2019s Res. Therapy"},{"key":"10.1016\/j.neuron.2022.03.034_bib52","doi-asserted-by":"crossref","first-page":"116991","DOI":"10.1016\/j.neuroimage.2020.116991","article-title":"Inferior temporal tau is associated with accelerated prospective cortical thinning in clinically normal older adults","volume":"220","author":"Scott","year":"2020","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuron.2022.03.034_bib53","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1038\/s41591-018-0206-4","article-title":"Neurogenetic contributions to amyloid beta and tau spreading in the human cortex","volume":"24","author":"Sepulcre","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2022.03.034_bib54","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2022.03.034_bib55","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13195-019-0470-7","article-title":"18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes","volume":"11","author":"Tsai","year":"2019","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neuron.2022.03.034_bib56","doi-asserted-by":"crossref","first-page":"15775","DOI":"10.1523\/JNEUROSCI.3539-11.2011","article-title":"Rich-club organization of the human connectome","volume":"31","author":"Van Den Heuvel","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2022.03.034_bib57","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1038\/s41467-020-15701-2","article-title":"Spread of pathological tau proteins through communicating neurons in human Alzheimer\u2019s disease","volume":"11","author":"Vogel","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2022.03.034_bib58","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41591-021-01309-6","article-title":"Four distinct trajectories of tau deposition identified in Alzheimer\u2019s disease","volume":"27","author":"Vogel","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2022.03.034_bib59","first-page":"3720","article-title":"Diffusion toolkit: a software package for diffusion imaging data processing and tractography","volume":"15","author":"Wang","year":"2007","journal-title":"Proc. Int. Soc. Magn. Reson. Med."},{"key":"10.1016\/j.neuron.2022.03.034_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015709","article-title":"The concentration of soluble extracellular amyloid-\u03b2 protein in acute brain slices from CRND8 mice","volume":"5","author":"Waters","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.neuron.2022.03.034_bib61","series-title":"Introduction to Graph Theory","author":"Wilson","year":"1979"},{"key":"10.1016\/j.neuron.2022.03.034_bib62","doi-asserted-by":"crossref","first-page":"10256","DOI":"10.1073\/pnas.1001412107","article-title":"Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional\u2013executive network function in Alzheimer\u2019s disease","volume":"107","author":"Wolk","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2022.03.034_bib63","doi-asserted-by":"crossref","first-page":"10057","DOI":"10.1038\/srep10057","article-title":"A network flow-based analysis of cognitive reserve in normal ageing and Alzheimer\u2019s disease","volume":"5","author":"Wook Yoo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2022.03.034_bib64","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.neuron.2012.03.004","article-title":"Predicting regional neurodegeneration from the healthy brain functional connectome","volume":"73","author":"Zhou","year":"2012","journal-title":"Neuron"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627322003051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627322003051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:39:16Z","timestamp":1760254756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627322003051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":64,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0896627322003051"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2022.03.034","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regional A\u03b2-tau interactions promote onset and acceleration of Alzheimer\u2019s disease tau spreading","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2022.03.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}