{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:19:05Z","timestamp":1790835545276,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.neuron.2022.09.028","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T10:33:23Z","timestamp":1666175603000},"page":"3318-3338.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures"],"prefix":"10.1016","volume":"110","author":[{"given":"Nan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Langfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Stricos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalini","family":"Ramanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B.","family":"Richman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Vaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Plascencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Katherine","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koliane","family":"Ouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid V.","family":"Ivanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing Richard","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Jennifer","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Colwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Aaronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Rosinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3705-7935","authenticated-orcid":false,"given":"X. William","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2022.09.028_bib1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-neuro-091819-094557","article-title":"The glial perspective on sleep and circadian rhythms","volume":"43","author":"Artiushin","year":"2020","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2022.09.028_bib2","doi-asserted-by":"crossref","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.neuron.2022.09.028_bib3","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.neuron.2016.10.064","article-title":"Phosphodiesterase 10A inhibition improves cortico-basal ganglia function in huntington's disease models","volume":"92","author":"Beaumont","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2022.09.028_bib4","doi-asserted-by":"crossref","first-page":"14288","DOI":"10.1523\/JNEUROSCI.5102-12.2013","article-title":"Effects of sleep and wake on oligodendrocytes and their precursors","volume":"33","author":"Bellesi","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2022.09.028_bib5","doi-asserted-by":"crossref","first-page":"36804","DOI":"10.1038\/srep36804","article-title":"Contribution of sleep to the repair of neuronal DNA double-strand breaks: evidence from flies and mice","volume":"6","author":"Bellesi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2022.09.028_bib6","doi-asserted-by":"crossref","first-page":"8606","DOI":"10.1523\/JNEUROSCI.2660-04.2004","article-title":"ATP excites interneurons and astrocytes to increase synaptic inhibition in neuronal networks","volume":"24","author":"Bowser","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2022.09.028_bib7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.neuron.2022.09.028_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.conb.2017.03.016","article-title":"Sleep, synaptic homeostasis and neuronal firing rates","volume":"44","author":"Cirelli","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuron.2022.09.028_bib9","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1002\/glia.23667","article-title":"The role of sleep and wakefulness in myelin plasticity","volume":"67","author":"de Vivo","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.neuron.2022.09.028_bib10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1126\/science.aai8355","article-title":"Homer1a drives homeostatic scaling-down of excitatory synapses during sleep","volume":"355","author":"Diering","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.neuron.2022.09.028_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1752-0509-1-24","article-title":"Understanding network concepts in modules","volume":"1","author":"Dong","year":"2007","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.neuron.2022.09.028_bib12","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.cell.2008.10.029","article-title":"Application of a translational profiling approach for the comparative analysis of CNS cell types","volume":"135","author":"Doyle","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2022.09.028_bib13","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.neuron.2013.10.035","article-title":"The neuron identity problem: form meets function","volume":"80","author":"Fishell","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2022.09.028_bib14","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2019.06.036","article-title":"CAG Repeat Not Polyglutamine Length Determines Timing of Huntington's Disease Onset","volume":"178","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2022.09.028_bib87","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol"},{"key":"10.1016\/j.neuron.2022.09.028_bib15","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nature08537","article-title":"Neuroscience in the era of functional genomics and systems biology","volume":"461","author":"Geschwind","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2022.09.028_bib16","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.celrep.2016.06.059","article-title":"Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq","volume":"16","author":"Gokce","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2022.09.028_bib17","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/hmg\/ddy375","article-title":"FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat","volume":"28","author":"Goold","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2022.09.028_bib18","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1523\/JNEUROSCI.0857-08.2008","article-title":"Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice","volume":"28","author":"Gray","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2022.09.028_bib19","doi-asserted-by":"crossref","first-page":"a021691","DOI":"10.1101\/cshperspect.a021691","article-title":"The striatum: where skills and habits meet","volume":"7","author":"Graybiel","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuron.2022.09.028_bib20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.immuni.2018.11.004","article-title":"Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes","volume":"50","author":"Hammond","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.neuron.2022.09.028_bib21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature11405","article-title":"An anatomically comprehensive atlas of the adult human brain transcriptome","volume":"489","author":"Hawrylycz","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2022.09.028_bib22","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.neuron.2016.11.044","article-title":"lncRNA functional networks in oligodendrocytes reveal stage-specific myelination control by an lncOL1\/Suz12 complex in the CNS","volume":"93","author":"He","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2022.09.028_bib23","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.cell.2008.10.028","article-title":"A translational profiling approach for the molecular characterization of CNS cell types","volume":"135","author":"Heiman","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2022.09.028_bib24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.cell.2016.01.046","article-title":"Neuronal firing rate homeostasis is inhibited by sleep and promoted by wake","volume":"165","author":"Hengen","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2022.09.028_bib25","doi-asserted-by":"crossref","first-page":"e0175075","DOI":"10.1371\/journal.pone.0175075","article-title":"Dynamic glucocorticoid-dependent regulation of Sgk1 expression in oligodendrocytes of adult male rat brain by acute stress and time of day","volume":"12","author":"Hinds","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2022.09.028_bib26","doi-asserted-by":"crossref","first-page":"25773","DOI":"10.1073\/pnas.1910590116","article-title":"Sleep-wake-driven and circadian contributions to daily rhythms in gene expression and chromatin accessibility in the murine cortex","volume":"116","author":"Hor","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2022.09.028_bib27","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/0748730410379711","article-title":"JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets","volume":"25","author":"Hughes","year":"2010","journal-title":"J.\u00a0Biol. Rhythms"},{"key":"10.1016\/j.neuron.2022.09.028_bib28","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/mp.2016.259","article-title":"A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder","volume":"23","author":"Ikeda","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2022.09.028_bib29","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.cell.2013.08.004","article-title":"The CRTC1-SIK1 pathway regulates entrainment of the circadian clock","volume":"154","author":"Jagannath","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2022.09.028_bib30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1471-4159.2007.05089.x","article-title":"Molecular correlates of sleep and wakefulness in the brain of the white-crowned sparrow","volume":"105","author":"Jones","year":"2008","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuron.2022.09.028_bib31","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4103\/1673-5374.235214","article-title":"Neuroplasticity, limbic neuroblastosis and neuro-regenerative disorders","volume":"13","author":"Kandasamy","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neuron.2022.09.028_bib32","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/s41593-018-0216-z","article-title":"Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes","volume":"21","author":"Kelley","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2022.09.028_bib33","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of alzheimer's disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2022.09.028_bib34","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature09033","article-title":"Widespread transcription at neuronal activity-regulated enhancers","volume":"465","author":"Kim","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2022.09.028_bib35","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.neuron.2008.11.005","article-title":"Striatal plasticity and basal ganglia circuit function","volume":"60","author":"Kreitzer","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2022.09.028_bib36","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.neuron.2022.09.028_bib37","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nn.4256","article-title":"Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice","volume":"19","author":"Langfelder","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2022.09.028_bib38","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1752-0509-1-54","article-title":"Eigengene networks for studying the relationships between co-expression modules","volume":"1","author":"Langfelder","year":"2007","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.neuron.2022.09.028_bib39","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.neuron.2022.09.028_bib86","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v046.i11","article-title":"Fast R Functions for Robust Correlations and Hierarchical Clustering","volume":"46","author":"Langfelder","year":"2012","journal-title":"J Stat Softw"},{"key":"10.1016\/j.neuron.2022.09.028_bib40","doi-asserted-by":"crossref","first-page":"e1001057","DOI":"10.1371\/journal.pcbi.1001057","article-title":"Is my network module preserved and reproducible?","volume":"7","author":"Langfelder","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.neuron.2022.09.028_bib41","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1371\/journal.pgen.0030161","article-title":"Capturing heterogeneity in gene expression studies by surrogate variable analysis","volume":"3","author":"Leek","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neuron.2022.09.028_bib42","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/s41386-020-00788-4","article-title":"Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder","volume":"46","author":"Li","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuron.2022.09.028_bib43","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1038\/srep02054","article-title":"Cold-induced RNA-binding proteins regulate circadian gene expression by controlling alternative polyadenylation","volume":"3","author":"Liu","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2022.09.028_bib44","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nn1654","article-title":"FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains","volume":"9","author":"Lobo","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2022.09.028_bib45","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41583-018-0088-y","article-title":"Rhythms of life: circadian disruption and brain disorders across the lifespan","volume":"20","author":"Logan","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2022.09.028_bib46","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0896-6273(02)00828-0","article-title":"Function and regulation of CREB family transcription factors in the nervous system","volume":"35","author":"Lonze","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2022.09.028_bib47","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.neuron.2022.09.028_bib48","doi-asserted-by":"crossref","first-page":"20090","DOI":"10.1073\/pnas.0710131104","article-title":"Homer1a is a core brain molecular correlate of sleep loss","volume":"104","author":"Maret","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2022.09.028_bib49","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0006-8993(99)01451-1","article-title":"Instability of the CAG repeat in immortalized fibroblast cell cultures from Huntington's disease transgenic mice","volume":"835","author":"Manley","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2022.09.028_bib50","series-title":"UMAP: uniform manifold approximation and projection for dimension reduction","author":"McInnes","year":"2018"},{"key":"10.1016\/j.neuron.2022.09.028_bib51","doi-asserted-by":"crossref","first-page":"8868","DOI":"10.1038\/s41598-018-27293-5","article-title":"Brain cell type specific gene expression and co-expression network architectures","volume":"8","author":"McKenzie","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2022.09.028_bib52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fnsyn.2018.00045","article-title":"Astrocyte-neuron networks: a multilane highway of signaling for homeostatic brain function","volume":"10","author":"Mederos","year":"2018","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.neuron.2022.09.028_bib53","doi-asserted-by":"crossref","first-page":"R585","DOI":"10.1016\/j.cub.2019.05.018","article-title":"Sleep: DNA repair function for better neuronal aging?","volume":"29","author":"Mourrain","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2022.09.028_bib54","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1038\/ncomms4339","article-title":"Genome-wide association study reveals two new risk loci for bipolar disorder","volume":"5","author":"M\u00fchleisen","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2022.09.028_bib55","doi-asserted-by":"crossref","first-page":"eaao0318","DOI":"10.1126\/science.aao0318","article-title":"Diurnal transcriptome atlas of a primate across major neural and peripheral tissues","volume":"359","author":"Mure","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.neuron.2022.09.028_bib56","doi-asserted-by":"crossref","first-page":"eaav2642","DOI":"10.1126\/science.aav2642","article-title":"The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep","volume":"366","author":"Noya","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.neuron.2022.09.028_bib57","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/nn.2207","article-title":"Functional organization of the transcriptome in human brain","volume":"11","author":"Oldham","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2022.09.028_bib58","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1752-0509-6-63","article-title":"Network methods for describing sample relationships in genomic datasets: application to Huntington's disease","volume":"6","author":"Oldham","year":"2012","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.neuron.2022.09.028_bib59","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1126\/science.aah4967","article-title":"Circadian physiology of metabolism","volume":"354","author":"Panda","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neuron.2022.09.028_bib60","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrg3934","article-title":"Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders","volume":"16","author":"Parikshak","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.neuron.2022.09.028_bib61","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2022.09.028_bib62","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13073-019-0704-0","article-title":"Genomics of circadian rhythms in health and disease","volume":"11","author":"Rijo-Ferreira","year":"2019","journal-title":"Genome Med."},{"key":"10.1016\/j.neuron.2022.09.028_bib63","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.cell.2018.07.028","article-title":"Molecular diversity and specializations among the cells of the adult mouse brain","volume":"174","author":"Saunders","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2022.09.028_bib64","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nn.3000","article-title":"TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3","volume":"15","author":"Shigetomi","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2022.09.028_bib65","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s41588-019-0397-8","article-title":"Genome-wide association study identifies 30 loci associated with bipolar disorder","volume":"51","author":"Stahl","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2022.09.028_bib66","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1126\/science.1087447","article-title":"A gene-coexpression network for global discovery of conserved genetic modules","volume":"302","author":"Stuart","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neuron.2022.09.028_bib67","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nn.3356","article-title":"Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-beta","volume":"16","author":"Suberbielle","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2022.09.028_bib68","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A next generation connectivity map: L1000 platform and the first 1, 000, 000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2022.09.028_bib69","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuron.2022.09.028_bib70","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.neuron.2022.09.028_bib71","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neuron.2020.11.001","article-title":"Sleep Promotes downward firing rate homeostasis","volume":"109","author":"Torrado Pacheco","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2022.09.028_bib72","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.tins.2020.01.003","article-title":"Astrocytes and microglia: In sickness and in health","volume":"43","author":"Vainchtein","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2022.09.028_bib73","first-page":"2579","article-title":"Visualizing data using t-SNE","volume":"9","author":"Van der Maaten","year":"2008","journal-title":"Journal of machine learning research"},{"key":"10.1016\/j.neuron.2022.09.028_bib74","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/35088082","article-title":"Spred is a sprouty-related suppressor of Ras signalling","volume":"412","author":"Wakioka","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2022.09.028_bib75","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/nm.3514","article-title":"Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease","volume":"20","author":"Wang","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2022.09.028_bib88","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fnins.2017.00149","article-title":"Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington\u2019s, Parkinson\u2019s, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated Datasets","volume":"11","author":"Wang","year":"2017","journal-title":"Front Neurosci"},{"key":"10.1016\/j.neuron.2022.09.028_bib76","doi-asserted-by":"crossref","first-page":"4854732","DOI":"10.1155\/2018\/4854732","article-title":"Disruption of the circadian clock alters antioxidative defense via the SIRT1-BMAL1 pathway in 6-OHDA-induced models of Parkinson's disease","volume":"2018","author":"Wang","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.neuron.2022.09.028_bib77","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3233\/JHD-200426","article-title":"Modifiers of CAG\/CTG Repeat Instability: Insights from Mammalian Models","volume":"10","author":"Wheeler","year":"2021","journal-title":"J.\u00a0Huntingtons Dis."},{"key":"10.1016\/j.neuron.2022.09.028_bib78","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1177\/0748730418790401","article-title":"Circadian-based treatment strategy effective in the BACHD mouse model of huntington's disease","volume":"33","author":"Whittaker","year":"2018","journal-title":"J.\u00a0Biol. Rhythms"},{"key":"10.1016\/j.neuron.2022.09.028_bib79","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/msb.2009.46","article-title":"The organization of the transcriptional network in specific neuronal classes","volume":"5","author":"Winden","year":"2009","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.neuron.2022.09.028_bib80","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/bioinformatics\/btp618","article-title":"Phenopedia and Genopedia: disease-centered and gene-centered views of the evolving knowledge of human genetic associations","volume":"26","author":"Yu","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2022.09.028_bib81","doi-asserted-by":"crossref","first-page":"4979","DOI":"10.1016\/j.molcel.2021.10.026","article-title":"Parp1 promotes sleep, which enhances DNA repair in neurons","volume":"81","author":"Zada","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neuron.2022.09.028_bib82","doi-asserted-by":"crossref","first-page":"Article17","DOI":"10.2202\/1544-6115.1128","article-title":"A general framework for weighted gene co-expression network analysis","volume":"4","author":"Zhang","year":"2005","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"10.1016\/j.neuron.2022.09.028_bib83","doi-asserted-by":"crossref","first-page":"16219","DOI":"10.1073\/pnas.1408886111","article-title":"A circadian gene expression atlas in mammals: implications for biology and medicine","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2022.09.028_bib84","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.neuron.2007.01.025","article-title":"Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death","volume":"53","author":"Zhang","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2022.09.028_bib85","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J.\u00a0Neurosci."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627322008674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627322008674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:40:46Z","timestamp":1760254846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627322008674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":88,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0896627322008674"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2022.09.028","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2022.09.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}