{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:45:02Z","timestamp":1792025102417,"version":"4.4.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004189","name":"Max Planck Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.neuron.2022.11.007","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T03:55:44Z","timestamp":1668052544000},"page":"3919-3935.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients"],"prefix":"10.1016","volume":"110","author":[{"given":"Mona","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marnick","family":"Clijsters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumin","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wout","family":"Backaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Claerhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floor","family":"Couvreur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Van Breda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Bourgeois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kato","family":"Speleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Van Laethem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gill","family":"Verstappen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse Sumeyra","family":"Dereli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Jun","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuc Nguyen","family":"Dan Do","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Jochmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lies","family":"Laenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Debaveye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"De Munter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gunst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Jorissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Lagrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Meersseman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Neyts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar Rudolf","family":"Thal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat","family":"Topsakal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Vandenbriele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Wauters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8082-4971","authenticated-orcid":false,"given":"Peter","family":"Mombaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Van Gerven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2022.11.007_bib1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0140-6736(20)30185-9","article-title":"A novel coronavirus outbreak of global health concern","volume":"395","author":"Wang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.neuron.2022.11.007_bib2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41579-022-00713-0","article-title":"SARS-CoV-2 pathogenesis","volume":"20","author":"Lamers","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.neuron.2022.11.007_bib3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00428-022-03319-2","article-title":"Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?","volume":"481","author":"Jonigk","year":"2022","journal-title":"Virchows Arch."},{"key":"10.1016\/j.neuron.2022.11.007_bib4","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1126\/science.abm8108","article-title":"The immunology and immunopathology of COVID-19","volume":"375","author":"Merad","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.neuron.2022.11.007_bib5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s13054-022-04080-3","article-title":"Neurologic manifestations of COVID-19 in critically ill patients: results of the prospective multicenter registry PANDEMIC","volume":"26","author":"Dimitriadis","year":"2022","journal-title":"Crit. Care"},{"key":"10.1016\/j.neuron.2022.11.007_bib6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41593-020-00758-5","article-title":"Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19","volume":"24","author":"Meinhardt","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2022.11.007_bib7","doi-asserted-by":"crossref","first-page":"e20202135","DOI":"10.1084\/jem.20202135","article-title":"Neuroinvasion of SARS-CoV-2 in human and mouse brain","volume":"218","author":"Song","year":"2021","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neuron.2022.11.007_bib8","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.tins.2022.02.006","article-title":"The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2","volume":"45","author":"Bauer","year":"2022","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2022.11.007_bib9","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/s41591-022-01780-9","article-title":"Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults","volume":"28","author":"Killingley","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2022.11.007_bib10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuron.2020.06.032","article-title":"COVID-19 and the chemical senses: supporting players take center stage","volume":"107","author":"Cooper","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2022.11.007_bib11","article-title":"Decreasing incidence of chemosensory changes by COVID-19 variant","author":"Coelho","year":"2022","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.neuron.2022.11.007_bib12","article-title":"The Omicron variant of SARS-CoV-2 and its effect on the olfactory system","author":"Dehgani-Mobaraki","year":"2022","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.neuron.2022.11.007_bib13","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S0140-6736(22)00327-0","article-title":"Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study","volume":"399","author":"Menni","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.neuron.2022.11.007_bib14","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00401-021-02314-2","article-title":"The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models","volume":"141","author":"Butowt","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2022.11.007_bib15","first-page":"E3","article-title":"Expanded endonasal approach: the rostrocaudal axis. Part I. Crista galli to the sella turcica","volume":"19","author":"Kassam","year":"2005","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.neuron.2022.11.007_bib16","doi-asserted-by":"crossref","first-page":"5932","DOI":"10.1016\/j.cell.2021.10.027","article-title":"Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb","volume":"184","author":"Khan","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2022.11.007_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jmoldx.2011.08.002","article-title":"RNAscope: a novel in\u00a0situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues","volume":"14","author":"Wang","year":"2012","journal-title":"J.\u00a0Mol. Diagn."},{"key":"10.1016\/j.neuron.2022.11.007_bib18","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1056\/NEJMe2203329","article-title":"Covid-19 boosters - where from here?","volume":"386","author":"Offit","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuron.2022.11.007_bib19","doi-asserted-by":"crossref","first-page":"eabq2427","DOI":"10.1126\/sciimmunol.abq2427","article-title":"Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes","volume":"7","author":"Quandt","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.neuron.2022.11.007_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-virology-100114-055218","article-title":"Continuous and discontinuous RNA synthesis in coronaviruses","volume":"2","author":"Sola","year":"2015","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.neuron.2022.11.007_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-micro-110520-023212","article-title":"Similarities and dissimilarities of COVID-19 and other coronavirus diseases","volume":"75","author":"Fung","year":"2021","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.neuron.2022.11.007_bib22","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/ar.1092100214","article-title":"The glial cells in the nerve fiber layer of the rat olfactory bulb","volume":"210","author":"Doucette","year":"1984","journal-title":"Anat. Rec."},{"key":"10.1016\/j.neuron.2022.11.007_bib23","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/brain\/123.8.1581","article-title":"Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons","volume":"123","author":"Barnett","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2022.11.007_bib24","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/02688690701883442","article-title":"Olfactory ensheathing cells in the nasal mucosa of the rat and human","volume":"22","author":"Choi","year":"2008","journal-title":"Br. J. Neurosurg."},{"key":"10.1016\/j.neuron.2022.11.007_bib25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1023\/B:NEUR.0000010089.37032.48","article-title":"Ensheathment of the olfactory nerves in the adult rat","volume":"32","author":"Field","year":"2003","journal-title":"J.\u00a0Neurocytol."},{"key":"10.1016\/j.neuron.2022.11.007_bib26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/cne.20588","article-title":"Ultrastructural study of the primary olfactory pathway in Macaca fascicularis","volume":"488","author":"Herrera","year":"2005","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2022.11.007_bib27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/glia.20241","article-title":"Olfactory ensheathing cells and olfactory nerve fibroblasts maintain continuous open channels for regrowth of olfactory nerve fibres","volume":"52","author":"Li","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.neuron.2022.11.007_bib28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1089\/neu.2008.0709","article-title":"Technical strategies to isolate olfactory ensheathing cells for intraspinal implantation","volume":"26","author":"Kawaja","year":"2009","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuron.2022.11.007_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainres.2009.06.011","article-title":"A comparative examination of biomarkers for olfactory ensheathing cells in cats and guinea pigs","volume":"1284","author":"Smithson","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2022.11.007_bib30","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/jnr.22254","article-title":"Microglial\/macrophage cells in mammalian olfactory nerve fascicles","volume":"88","author":"Smithson","year":"2010","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.neuron.2022.11.007_bib31","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/ar.23816","article-title":"Cranial pair I: the olfactory nerve","volume":"302","author":"Crespo","year":"2019","journal-title":"Anat. Rec."},{"key":"10.1016\/j.neuron.2022.11.007_bib32","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/alr.21711","article-title":"Office-based olfactory mucosa biopsies","volume":"6","author":"Holbrook","year":"2016","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.neuron.2022.11.007_bib33","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1007\/s00429-016-1313-y","article-title":"Common olfactory ensheathing glial markers in the developing human olfactory system","volume":"222","author":"Oprych","year":"2017","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neuron.2022.11.007_bib34","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1097\/01.MLG.0000181493.83661.CE","article-title":"Abnormalities of axon growth in human olfactory mucosa","volume":"115","author":"Holbrook","year":"2005","journal-title":"Laryngoscope"},{"key":"10.1016\/j.neuron.2022.11.007_bib35","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/lary.21856","article-title":"Immunohistochemical characterization of human olfactory tissue","volume":"121","author":"Holbrook","year":"2011","journal-title":"Laryngoscope"},{"key":"10.1016\/j.neuron.2022.11.007_bib36","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/BF01960918","article-title":"Ueber die Erweiterung kleinerer Gef\u00e4sse","volume":"3","author":"Virchow","year":"1851","journal-title":"Archiv f. pathol. Anat."},{"key":"10.1016\/j.neuron.2022.11.007_bib37","first-page":"537","article-title":"Recherches sur quelques particularit\u00e9s de la structure des capillaires de l'enc\u00e9phale","volume":"2","author":"Robin","year":"1859","journal-title":"J.\u00a0Physiol. Homme Anim."},{"key":"10.1016\/j.neuron.2022.11.007_bib38","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1016\/j.neuron.2022.10.024","article-title":"Perivascular spaces and their role in neuroinflammation","volume":"110","author":"Ineichen","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2022.11.007_bib39","doi-asserted-by":"crossref","first-page":"105122","DOI":"10.1016\/j.antiviral.2021.105122","article-title":"A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents","volume":"192","author":"Do","year":"2021","journal-title":"Antiviral Res."},{"key":"10.1016\/j.neuron.2022.11.007_bib40","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3390\/v14050951","article-title":"SARS-CoV-2 virion infectivity and cytokine production in primary human airway epithelial cells","volume":"14","author":"Do","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.neuron.2022.11.007_bib41","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41467-022-28354-0","article-title":"The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern","volume":"13","author":"Abdelnabi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2022.11.007_bib42","doi-asserted-by":"crossref","first-page":"7163","DOI":"10.1038\/s41598-021-86500-y","article-title":"The impact of viremia on organ failure, biomarkers and mortality in a Swedish cohort of critically ill COVID-19 patients","volume":"11","author":"J\u00e4rhult","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2022.11.007_bib43","doi-asserted-by":"crossref","first-page":"e0031121","DOI":"10.1128\/mSphere.00311-21","article-title":"Temporal kinetics of RNAemia and associated systemic cytokines in hospitalized COVID-19 patients","volume":"6","author":"van Riel","year":"2021","journal-title":"mSphere"},{"key":"10.1016\/j.neuron.2022.11.007_bib44","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41586-021-03710-0","article-title":"Dysregulation of brain and choroid plexus cell types in severe COVID-19","volume":"595","author":"Yang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2022.11.007_bib45","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.immuni.2022.06.013","article-title":"What SARS-CoV-2 does to our brains","volume":"55","author":"Aschman","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.neuron.2022.11.007_bib46","doi-asserted-by":"crossref","first-page":"104193","DOI":"10.1016\/j.ebiom.2022.104193","article-title":"Assessing and improving the validity of COVID-19 autopsy studies - A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analyses","volume":"83","author":"Krasemann","year":"2022","journal-title":"eBioMedicine"},{"key":"10.1016\/j.neuron.2022.11.007_bib47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41586-020-2739-1","article-title":"The coding capacity of SARS-CoV-2","volume":"589","author":"Finkel","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2022.11.007_bib48","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/physrev.00031.2020","article-title":"Fluid transport in the brain","volume":"102","author":"Rasmussen","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuron.2022.11.007_bib49","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.addr.2011.11.002","article-title":"Intranasal delivery of biologics to the central nervous system","volume":"64","author":"Lochhead","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.neuron.2022.11.007_bib50","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.immuni.2022.04.012","article-title":"Immunological defense of CNS barriers against infections","volume":"55","author":"Ampie","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.neuron.2022.11.007_bib51","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.chom.2013.03.010","article-title":"Virus infections in the nervous system","volume":"13","author":"Koyuncu","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.neuron.2022.11.007_bib52","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/jnen\/nlac056","article-title":"SARS-CoV-2 brain regional detection, histopathology, gene expression, and immunomodulatory changes in decedents with COVID-19","volume":"81","author":"Serrano","year":"2022","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neuron.2022.11.007_bib53","doi-asserted-by":"crossref","first-page":"R1371","DOI":"10.1016\/j.cub.2021.08.026","article-title":"The glymphatic system","volume":"31","author":"Hablitz","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2022.11.007_bib54","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.neuron.2018.09.022","article-title":"The meningeal lymphatic system: a new player in neurophysiology","volume":"100","author":"Da Mesquita","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2022.11.007_bib55","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41593-018-0234-x","article-title":"The role of brain vasculature in neurodegenerative disorders","volume":"21","author":"Sweeney","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2022.11.007_bib56","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1016\/j.neuron.2022.10.006","article-title":"The neurobiology of long COVID","volume":"110","author":"Monje","year":"2022","journal-title":"Neuron"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627322010285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627322010285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:41:37Z","timestamp":1760254897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627322010285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":56,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0896627322010285"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2022.11.007","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2022.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}