{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:15:37Z","timestamp":1792048537685,"version":"4.4.0"},"reference-count":120,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011878","name":"Vlaamse regering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016882","name":"European Resuscitation Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016882","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P40OD018537"],"award-info":[{"award-number":["P40OD018537"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019618","name":"Vlaams Supercomputer Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004727","name":"Vlaams Instituut voor Biotechnologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.neuron.2023.02.033","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T12:59:19Z","timestamp":1679403559000},"page":"1577-1590.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Neuronal identity defines \u03b1-synuclein and tau toxicity"],"prefix":"10.1016","volume":"111","author":[{"given":"Roman","family":"Praschberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Kuenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Schoovaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Kaempf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeevanjot","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Janssens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jef","family":"Swerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Nachman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Calatayud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein","family":"Aerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Poovathingal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5073-5393","authenticated-orcid":false,"given":"Patrik","family":"Verstreken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2023.02.033_bib1","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/s41593-018-0221-2","article-title":"Selective vulnerability in neurodegenerative diseases","volume":"21","author":"Fu","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.02.033_bib2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","article-title":"Association of missense and 5\u2032-splice-site mutations in tau with the inherited dementia FTDP-17","volume":"393","author":"Hutton","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.02.033_bib3","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the \u03b1-synuclein gene identified in families with Parkinson\u2019s disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.02.033_bib4","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/mds.27193","article-title":"Neuropathology of genetic synucleinopathies with parkinsonism: review of the literature","volume":"32","author":"Schneider","year":"2017","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neuron.2023.02.033_bib5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00005072-199904000-00004","article-title":"Tau pathology in a family with dementia and a P301L mutation in tau","volume":"58","author":"Mirra","year":"1999","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neuron.2023.02.033_bib6","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0002-9440(10)65721-5","article-title":"Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau","volume":"153","author":"Spillantini","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neuron.2023.02.033_bib7","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1440-1789.2006.00702.x","article-title":"Neuropathology of familial tauopathy","volume":"26","author":"Tsuboi","year":"2006","journal-title":"Neuropathology"},{"key":"10.1016\/j.neuron.2023.02.033_bib8","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/35006074","article-title":"A Drosophila model of Parkinson\u2019s disease","volume":"404","author":"Feany","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.02.033_bib9","doi-asserted-by":"crossref","first-page":"10328","DOI":"10.1073\/pnas.1604645113","article-title":"Mutations associated with familial Parkinson\u2019s disease alter the initiation and amplification steps of \u03b1-synuclein aggregation","volume":"113","author":"Flagmeier","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.02.033_bib10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0014-5793(99)00294-X","article-title":"Accelerated filament formation from Tau protein with specific FTDP-17 missense mutations","volume":"447","author":"Nacharaju","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuron.2023.02.033_bib11","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1523\/JNEUROSCI.20-16-06021.2000","article-title":"Neuropathology in mice expressing human \u03b1-synuclein","volume":"20","author":"Van Der Putten","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.02.033_bib12","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1126\/science.1062382","article-title":"Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles","volume":"293","author":"Wittmann","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.02.033_bib13","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.02.033_bib14","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.02.033_bib15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13059-014-0560-6","article-title":"Gateways to the FANTOM5 promoter level mammalian expression atlas","volume":"16","author":"Lizio","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.neuron.2023.02.033_bib16","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2018.06.021","article-title":"Molecular architecture of the mouse nervous system","volume":"174","author":"Zeisel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.02.033_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/ana.67","article-title":"Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr \u03b1-synuclein mutation","volume":"49","author":"Spira","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuron.2023.02.033_bib18","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1038\/s41467-020-17876-0","article-title":"A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders","volume":"11","author":"Agarwal","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.02.033_bib19","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.neuron.2021.10.036","article-title":"Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells","volume":"110","author":"Franjic","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.02.033_bib20","unstructured":"Allen Institute for Brain Science. Allen Brain Map: Cell Types Database - Human Multiple Cortical Areas. Available from https:\/\/portal.brain-map.org\/atlases-and-data\/rnaseq\/human-multiple-cortical-areas-smart-seq."},{"key":"10.1016\/j.neuron.2023.02.033_bib118","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41586-019-1506-7","article-title":"Conserved cell types with divergent features in human versus mouse cortex","volume":"573","author":"Hodge","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.02.033_bib119","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41586-021-03465-8","article-title":"Comparative cellular analysis of motor cortex in human, marmoset and mouse","volume":"598","author":"Bakken","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.02.033_bib21","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.cell.2018.05.057","article-title":"A single-cell transcriptome atlas of the aging drosophila brain","volume":"174","author":"Davie","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.02.033_bib22","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.celrep.2012.09.011","article-title":"A GAL4-driver line resource for drosophila neurobiology","volume":"2","author":"Jenett","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2023.02.033_bib23","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.cell.2018.05.021","article-title":"Phenotypic convergence: distinct transcription factors regulate common terminal features","volume":"174","author":"Konstantinides","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.02.033_bib24","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.neuron.2020.10.006","article-title":"Transcriptional programs of circuit assembly in the drosophila visual system","volume":"108","author":"Kurmangaliyev","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.02.033_bib25","doi-asserted-by":"crossref","first-page":"eabk2432","DOI":"10.1126\/science.abk2432","article-title":"Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly","volume":"375","author":"Li","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.02.033_bib26","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41586-020-2879-3","article-title":"Neuronal diversity and convergence in a visual system developmental atlas","volume":"589","author":"\u00d6zel","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.02.033_bib27","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1073\/pnas.97.10.5129","article-title":"Assembly of Tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure","volume":"97","author":"von Bergen","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.02.033_bib28","doi-asserted-by":"crossref","first-page":"48165","DOI":"10.1074\/jbc.M105196200","article-title":"Mutations of Tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure","volume":"276","author":"von Bergen","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2023.02.033_bib29","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1046\/j.1471-4159.2001.00408.x","article-title":"Identification of the region of non-A\u03b2 component (NAC) of Alzheimer\u2019s disease amyloid responsible for its aggregation and toxicity","volume":"78","author":"Bodles","year":"2001","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuron.2023.02.033_bib30","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nature15368","article-title":"Structure of the toxic core of \u03b1-synuclein from invisible crystals","volume":"525","author":"Rodriguez","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.02.033_bib31","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature05695","article-title":"Atomic structures of amyloid cross-\u03b2 spines reveal varied steric zippers","volume":"447","author":"Sawaya","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.02.033_bib33","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.cell.2010.02.025","article-title":"The Q system: A repressible binary system for transgene expression, lineage tracing, and mosaic analysis","volume":"141","author":"Potter","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.02.033_bib32","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nmeth.3250","article-title":"Improved and expanded Q-system reagents for genetic manipulations","volume":"12","author":"Riabinina","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2023.02.033_bib34","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1073\/pnas.0611511104","article-title":"An optimized transgenesis system for Drosophila using germ-line-specific \u03c6C31 integrases","volume":"104","author":"Bischof","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.02.033_bib35","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1126\/science.1134426","article-title":"P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster","volume":"314","author":"Venken","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.02.033_bib36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0896-6273(00)00084-2","article-title":"Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP","volume":"28","author":"Feng","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.02.033_bib37","doi-asserted-by":"crossref","first-page":"e2003026","DOI":"10.1371\/journal.pbio.2003026","article-title":"Ethoscopes: an open platform for high-throughput ethomics","volume":"15","author":"Geissmann","year":"2017","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neuron.2023.02.033_bib38","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1126\/science.1202249","article-title":"Inducing sleep by remote control facilitates memory consolidation in drosophila","volume":"332","author":"Donlea","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.02.033_bib39","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.neuron.2018.05.022","article-title":"ER lipid defects in neuropeptidergic neurons impair sleep patterns in Parkinson\u2019s disease","volume":"98","author":"Valadas","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.02.033_bib40","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.neuron.2023.02.033_bib42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: A Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2023.02.033_bib41","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuron.2013.05.024","article-title":"Contributions of the 12 neuron classes in the fly lamina to motion vision","volume":"79","author":"Tuthill","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.02.033_bib43","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/BF00612038","article-title":"The large monopolar cells L1 and L2 are responsible for ERG transients in Drosophila","volume":"159","author":"Coombe","year":"1986","journal-title":"J. Comp. Physiol."},{"key":"10.1016\/j.neuron.2023.02.033_bib45","doi-asserted-by":"crossref","first-page":"9089","DOI":"10.1074\/jbc.M710012200","article-title":"Mitochondrial import and accumulation of \u03b1-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain","volume":"283","author":"Devi","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2023.02.033_bib46","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/s41419-019-2091-2","article-title":"Mitochondrial damage by \u03b1-synuclein causes cell death in human dopaminergic neurons","volume":"10","author":"Ganjam","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neuron.2023.02.033_bib47","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuron.2011.06.031","article-title":"Selective neuronal vulnerability in neurodegenerative diseases: from stressor thresholds to degeneration","volume":"71","author":"Saxena","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.02.033_bib48","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/mds.25095","article-title":"Neuronal vulnerability, pathogenesis, and Parkinson\u2019s disease","volume":"28","author":"Sulzer","year":"2013","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neuron.2023.02.033_bib44","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fnins.2016.00016","article-title":"Identification of vulnerable cell types in major brain disorders using single cell transcriptomes and expression weighted cell type enrichment","volume":"10","author":"Skene","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuron.2023.02.033_bib49","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1523\/JNEUROSCI.16-14-04491.1996","article-title":"Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer\u2019s disease","volume":"16","author":"G\u00f3mez-Isla","year":"1996","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.02.033_bib50","doi-asserted-by":"crossref","first-page":"108190","DOI":"10.1155\/2010\/108190","article-title":"Selective vulnerability of neurons in layer II of the entorhinal cortex during aging and Alzheimer\u2019s disease","volume":"2010","author":"Stranahan","year":"2010","journal-title":"Neural Plast."},{"key":"10.1016\/j.neuron.2023.02.033_bib51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00401-020-02158-2","article-title":"Distribution patterns of tau pathology in progressive supranuclear palsy","volume":"140","author":"Kovacs","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2023.02.033_bib52","doi-asserted-by":"crossref","first-page":"9511","DOI":"10.1073\/pnas.0701055104","article-title":"Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies","volume":"104","author":"Luo","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.02.033_bib53","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.neuron.2018.01.022","article-title":"Synaptogyrin-3 mediates presynaptic dysfunction induced by tau","volume":"97","author":"McInnes","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.02.033_bib54","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.neuron.2020.12.016","article-title":"Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation","volume":"109","author":"Largo-Barrientos","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.02.033_bib55","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature23002","article-title":"Cryo-EM structures of tau filaments from Alzheimer\u2019s disease","volume":"547","author":"Fitzpatrick","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.02.033_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.36402","article-title":"Cryo-EM structure of alpha-synuclein fibrils","volume":"7","author":"Guerrero-Ferreira","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.neuron.2023.02.033_bib57","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1038\/s41467-018-05971-2","article-title":"Cryo-EM of full-length \u03b1-synuclein reveals fibril polymorphs with a common structural kernel","volume":"9","author":"Li","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.02.033_bib58","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41586-021-03911-7","article-title":"Structure-based classification of tauopathies","volume":"598","author":"Shi","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.02.033_bib59","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41422-020-0299-4","article-title":"Cryo-EM structure of full-length \u03b1-synuclein amyloid fibril with Parkinson\u2019s disease familial A53T mutation","volume":"30","author":"Sun","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.neuron.2023.02.033_bib60","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1750-1326-9-43","article-title":"Alpha-synuclein and tau: teammates in neurodegeneration?","volume":"9","author":"Moussaud","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuron.2023.02.033_bib61","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.semcdb.2018.05.005","article-title":"The interaction of \u03b1-synuclein and Tau: A molecular conspiracy in neurodegeneration?","volume":"99","author":"Yan","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.neuron.2023.02.033_bib62","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2023.02.033_bib63","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/brain\/122.8.1437","article-title":"The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson\u2019s disease","volume":"122","author":"Damier","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2023.02.033_bib64","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1136\/jnnp.54.5.388","article-title":"Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson\u2019s disease","volume":"54","author":"Gibb","year":"1991","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neuron.2023.02.033_bib65","first-page":"373","article-title":"Pathological changes in dendrites of substantia nigra neurons in Parkinson\u2019s disease: A Golgi study","volume":"6","author":"Patt","year":"1991","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.neuron.2023.02.033_bib66","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/s41593-022-01061-1","article-title":"Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson\u2019s disease","volume":"25","author":"Kamath","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.02.033_bib67","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrn.2016.178","article-title":"Selective neuronal vulnerability in Parkinson disease","volume":"18","author":"Surmeier","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2023.02.033_bib68","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/BF00307643","article-title":"Cortical Lewy body-containing neurons are pyramidal cells: laser confocal imaging of double-immunolabeled sections with anti-ubiquitin and SMI32","volume":"89","author":"Wakabayashi","year":"1995","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2023.02.033_bib69","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0140-6736(94)92338-8","article-title":"Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer\u2019s disease","volume":"344","author":"West","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.neuron.2023.02.033_bib70","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2023.02.033_bib71","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.neuron.2020.06.010","article-title":"Selective neuronal vulnerability in Alzheimer\u2019s disease: a network-based analysis","volume":"107","author":"Roussarie","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.02.033_bib72","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13195-019-0530-z","article-title":"Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer\u2019s disease: A preclinical study in rTg4510 mice","volume":"11","author":"Foster","year":"2019","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"10.1016\/j.neuron.2023.02.033_bib73","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00424-009-0736-1","article-title":"Calcium hypothesis of Alzheimer\u2019s disease","volume":"459","author":"Berridge","year":"2010","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.neuron.2023.02.033_bib74","doi-asserted-by":"crossref","first-page":"107900","DOI":"10.1016\/j.celrep.2020.107900","article-title":"Pathogenic tau causes a toxic depletion of nuclear calcium","volume":"32","author":"Mahoney","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2023.02.033_bib75","first-page":"433","article-title":"Early alterations of hippocampal neuronal firing induced by Abeta42","volume":"28","author":"Gavello","year":"2018","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neuron.2023.02.033_bib76","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuron.2008.06.008","article-title":"Abeta plaques lead to aberrant regulation of calcium homeostasis in\u00a0vivo resulting in structural and functional disruption of neuronal networks","volume":"59","author":"Kuchibhotla","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.02.033_bib77","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1523\/JNEUROSCI.12-02-00376.1992","article-title":"\u03b2-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity","volume":"12","author":"Mattson","year":"1992","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.02.033_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.50901","article-title":"A genetic, genomic, and computational resource for exploring neural circuit function","volume":"9","author":"Davis","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.neuron.2023.02.033_bib79","author":"Janssens"},{"key":"10.1016\/j.neuron.2023.02.033_bib80","doi-asserted-by":"crossref","first-page":"18054","DOI":"10.1523\/JNEUROSCI.2668-12.2012","article-title":"Abnormal synaptic vesicle biogenesis in Drosophila synaptogyrin mutants","volume":"32","author":"Stevens","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.02.033_bib81","doi-asserted-by":"crossref","first-page":"E2967","DOI":"10.1073\/pnas.1506763112","article-title":"Optimized tools for multicolor stochastic labeling reveal diverse stereotyped cell arrangements in the fly visual system","volume":"112","author":"Nern","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.02.033_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gigascience\/giaa151","article-title":"SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data","volume":"9","author":"Young","year":"2020","journal-title":"GigaScience"},{"key":"10.1016\/j.neuron.2023.02.033_bib83","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.neuron.2023.02.033_bib84","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"ClusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.neuron.2023.02.033_bib85","unstructured":"Carlson M. (2019). org.Dm.eg.db: Genome wide annotation for Fly. R package version 3.8.2."},{"key":"10.1016\/j.neuron.2023.02.033_bib86","unstructured":"Carlson M. (2019). GO.db: A set of annotation maps describing the entire Gene Ontology. R package version 3.8.2."},{"key":"10.1016\/j.neuron.2023.02.033_bib87","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1093\/bioinformatics\/btq064","article-title":"GOSemSim: an R package for measuring semantic similarity among GO terms and gene products","volume":"26","author":"Yu","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2023.02.033_bib88","unstructured":"Sayols S. (2020). rrvgo: a Bioconductor package to reduce and visualize Gene Ontology terms.https:\/\/ssayols.github.io\/rrvgo."},{"key":"10.1016\/j.neuron.2023.02.033_bib89","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13059-015-0844-5","article-title":"MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data","volume":"16","author":"Finak","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.neuron.2023.02.033_bib90","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/1471-2105-12-357","article-title":"An integrative approach to ortholog prediction for disease-focused and other functional studies","volume":"12","author":"Hu","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.neuron.2023.02.033_bib91","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2023.02.033_bib92","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2023.02.033_bib93","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2023.02.033_bib94","doi-asserted-by":"crossref","first-page":"e0209331","DOI":"10.1371\/journal.pone.0209331","article-title":"Rethomics: an R framework to analyse high-throughput behavioural data","volume":"14","author":"Geissmann","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2023.02.033_bib95","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.21105\/joss.01686","article-title":"Welcome to the Tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"J.\u00a0Open Source Softw."},{"key":"10.1016\/j.neuron.2023.02.033_bib96","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/bimj.200810425","article-title":"Simultaneous inference in general parametric models","volume":"50","author":"Hothorn","year":"2008","journal-title":"Biom. J."},{"key":"10.1016\/j.neuron.2023.02.033_bib97","doi-asserted-by":"crossref","first-page":"15295","DOI":"10.1038\/ncomms15295","article-title":"Tau association with synaptic vesicles causes presynaptic dysfunction","volume":"8","author":"Zhou","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.02.033_bib98","doi-asserted-by":"crossref","first-page":"e04577","DOI":"10.7554\/eLife.04577","article-title":"The neuronal architecture of the mushroom body provides a logic for associative learning","volume":"3","author":"Aso","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.neuron.2023.02.033_bib99","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21022","article-title":"Visual projection neurons in the Drosophila lobula link feature detection to distinct behavioral programs","volume":"5","author":"Wu","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.neuron.2023.02.033_bib100","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1523\/JNEUROSCI.3432-15.2016","article-title":"Shawn, the Drosophila homolog of SLC25A39\/40, is a mitochondrial carrier that promotes neuronal survival","volume":"36","author":"Slabbaert","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.02.033_bib101","doi-asserted-by":"crossref","first-page":"13853","DOI":"10.1523\/JNEUROSCI.2600-15.2015","article-title":"Chaperones in neurodegeneration","volume":"35","author":"Lindberg","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.02.033_bib102","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nmeth.1662","article-title":"MiMIC: A highly versatile transposon insertion resource for engineering Drosophila melanogaster genes","volume":"8","author":"Venken","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2023.02.033_bib103","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.celrep.2015.01.059","article-title":"Plug-and-play genetic access to drosophila cell types using exchangeable exon cassettes","volume":"10","author":"Diao","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2023.02.033_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.35574","article-title":"A gene-specific T2A-GAL4 library for drosophila","volume":"7","author":"Lee","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.neuron.2023.02.033_bib105","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.neuron.2017.09.026","article-title":"Detecting activated cell populations using single-cell RNA-seq","volume":"96","author":"Wu","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.02.033_bib106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.73971","article-title":"Hydrop enables droplet-based single-cell ATAC-seq and single-cell RNA-seq using dissolvable hydrogel beads","volume":"11","author":"De Rop","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.neuron.2023.02.033_bib107","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/s41587-020-0497-0","article-title":"Single-cell RNA counting at allele and isoform resolution using Smart-seq3","volume":"38","author":"Hagemann-Jensen","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neuron.2023.02.033_bib120","doi-asserted-by":"crossref","unstructured":"Hagemann-jensen, M., Ziegenhain, C., Chen, P., Ramsk\u00f6ld, D., Hendriks, G., Larsson, A.J.M., Faridani, O.R., and Sandberg, R. (2020). Smart-seq3 Protocol V.3. protocols.io, 1\u201319.","DOI":"10.17504\/protocols.io.bcq4ivyw"},{"key":"10.1016\/j.neuron.2023.02.033_bib108","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nprot.2014.006","article-title":"Full-length RNA-seq from single cells using Smart-seq2","volume":"9","author":"Picelli","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuron.2023.02.033_bib109","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neuron.2023.02.033_bib110","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1038\/s41598-019-41695-z","article-title":"From Louvain to Leiden: guaranteeing well-connected communities","volume":"9","author":"Traag","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2023.02.033_bib111","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.1038\/s41467-020-19894-4","article-title":"Muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data","volume":"11","author":"Crowell","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.02.033_bib112","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.1038\/s41467-021-25960-2","article-title":"Confronting false discoveries in single-cell differential expression","volume":"12","author":"Squair","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.02.033_bib113","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/s41467-021-21038-1","article-title":"A practical solution to pseudoreplication bias in single-cell studies","volume":"12","author":"Zimmerman","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.02.033_bib114","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1093\/nar\/gks042","article-title":"Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation","volume":"40","author":"McCarthy","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuron.2023.02.033_bib115","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1093\/bioinformatics\/btm087","article-title":"A new method to measure the semantic similarity of GO terms","volume":"23","author":"Wang","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2023.02.033_bib116","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00401-021-02343-x","article-title":"Cross-platform transcriptional profiling identifies common and\u00a0distinct molecular pathologies in Lewy body diseases","volume":"142","author":"Feleke","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2023.02.033_bib117","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1126\/science.287.5461.2185","article-title":"The genome sequence of Drosophila melanogaster","volume":"287","author":"Adams","year":"2000","journal-title":"Science"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627323001666?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627323001666?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T04:20:00Z","timestamp":1762316400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627323001666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":120,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S0896627323001666"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2023.02.033","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.06.24.496376","asserted-by":"object"}]},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuronal identity defines \u03b1-synuclein and tau toxicity","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2023.02.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}