{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:10:25Z","timestamp":1793247025583,"version":"4.5.0"},"reference-count":107,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-15-1-0360"],"award-info":[{"award-number":["W81XWH-15-1-0360"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002426","name":"Telethon Foundation","doi-asserted-by":"publisher","award":["GGP20137"],"award-info":[{"award-number":["GGP20137"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014370","name":"Simons Foundation Autism Research Initiative","doi-asserted-by":"publisher","award":["529085"],"award-info":[{"award-number":["529085"]}],"id":[{"id":"10.13039\/100014370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004727","name":"Vlaams Instituut voor Biotechnologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001703","name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012695","name":"Beatrice and Samuel A. Seaver Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013134","name":"US Department of Defense Military Health System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013134","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202932"],"award-info":[{"award-number":["202932"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Governo Italiano Ministero dell&apos;Istruzione dell&apos;Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"SNSF","doi-asserted-by":"publisher","award":["51NF40-158776"],"award-info":[{"award-number":["51NF40-158776"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007277","name":"Icahn School of Medicine at Mount Sinai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["695568"],"award-info":[{"award-number":["695568"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.neuron.2023.03.008","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T10:32:22Z","timestamp":1680085942000},"page":"1760-1775.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Altered striatal actin dynamics drives behavioral inflexibility in a mouse model of fragile X syndrome"],"prefix":"10.1016","volume":"111","author":[{"given":"Valentina","family":"Mercaldo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbora","family":"Vidimova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Gastaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian C.","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Cencelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Pedini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"De Rubeis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Klann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"August B.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth G.N.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilmann","family":"Achsel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bagni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2023.03.008_bib1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/jnc.14056","article-title":"Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes","volume":"142","author":"Frank","year":"2017","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuron.2023.03.008_bib2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1242\/jcs.052696","article-title":"The architecture of an excitatory synapse","volume":"123","author":"Chua","year":"2010","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.neuron.2023.03.008_bib3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/msb.2009.27","article-title":"Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins","volume":"5","author":"Fern\u00e1ndez","year":"2009","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.neuron.2023.03.008_bib4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/76615","article-title":"Proteomic analysis of NMDA receptor-adhesion protein signaling complexes","volume":"3","author":"Husi","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib5","doi-asserted-by":"crossref","first-page":"a005694","DOI":"10.1101\/cshperspect.a005694","article-title":"Synaptic cell adhesion","volume":"4","author":"Missler","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuron.2023.03.008_bib6","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neuron.2018.01.036","article-title":"Alpha-actinin Anchors PSD-95 at Postsynaptic Sites","volume":"97","author":"Matt","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.03.008_bib7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0959-4388(99)00018-5","article-title":"Postsynaptic actin and neuronal plasticity","volume":"9","author":"Matus","year":"1999","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuron.2023.03.008_bib8","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1523\/JNEUROSCI.5479-03.2004","article-title":"Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP\/Shank family","volume":"24","author":"Qualmann","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nn.2719","article-title":"Characterization of the proteome, diseases and evolution of the human postsynaptic density","volume":"14","author":"Bay\u00e9s","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib10","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.conb.2012.02.002","article-title":"Synaptopathies: diseases of the synaptome","volume":"22","author":"Grant","year":"2012","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuron.2023.03.008_bib11","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s10072-017-2974-x","article-title":"Autism, epilepsy, and synaptopathies: a not rare association","volume":"38","author":"Keller","year":"2017","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.neuron.2023.03.008_bib12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.pnpbp.2017.12.001","article-title":"Neurodevelopmental synaptopathies: insights from behaviour in rodent models of synapse gene mutations","volume":"84","author":"Luo","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2023.03.008_bib13","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.neuron.2019.02.041","article-title":"A synaptic perspective of fragile X syndrome and autism spectrum disorders","volume":"101","author":"Bagni","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.03.008_bib14","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1093\/cercor\/bhv031","article-title":"Age-dependent long-term potentiation deficits in the prefrontal cortex of the Fmr1 knockout mouse model of fragile X syndrome","volume":"26","author":"Martin","year":"2016","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neuron.2023.03.008_bib15","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.cell.2014.08.035","article-title":"SnapShot: FMRP mRNA targets and diseases","volume":"158","author":"Pasciuto","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.03.008_bib16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev-neuro-060909-153138","article-title":"The pathophysiology of fragile X (and what it teaches us about synapses)","volume":"35","author":"Bhakar","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib17","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.2741\/3785","article-title":"Fragile X syndrome: from gene discovery to therapy","volume":"16","author":"Heulens","year":"2011","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.neuron.2023.03.008_bib18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-pathol-011811-132457","article-title":"Molecular mechanisms of fragile X syndrome: a twenty-year perspective","volume":"7","author":"Santoro","year":"2012","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.neuron.2023.03.008_bib19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41583-021-00428-w","article-title":"Cognitive and behavioural flexibility: neural mechanisms and clinical considerations","volume":"22","author":"Uddin","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib20","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.03.008_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/proteomes6030031","article-title":"Regional diversity in the postsynaptic proteome of the mouse brain","volume":"6","author":"Roy","year":"2018","journal-title":"Proteomes"},{"key":"10.1016\/j.neuron.2023.03.008_bib22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41593-017-0025-9","article-title":"Proteomic analysis of postsynaptic proteins in regions of the human neocortex","volume":"21","author":"Roy","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1126\/science.aba3163","article-title":"A brainwide atlas of synapses across the mouse life span","volume":"369","author":"Cizeron","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.03.008_bib24","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.neuron.2018.07.007","article-title":"Architecture of the mouse brain synaptome","volume":"99","author":"Zhu","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.03.008_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neuron.2019.05.002","article-title":"Syngo: an evidence-based, expert-curated knowledge base for the synapse","volume":"103","author":"Koopmans","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.03.008_bib26","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.03.008_bib27","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuron.2023.03.008_bib28","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.mcn.2018.07.001","article-title":"Regulation of actin dynamics during structural plasticity of dendritic spines: signaling messengers and actin-binding proteins","volume":"91","author":"Borovac","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev.cellbio.15.1.185","article-title":"Proteins of the ADF\/cofilin family: essential regulators of actin dynamics","volume":"15","author":"Bamburg","year":"1999","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.neuron.2023.03.008_bib30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3389\/fnmol.2018.00143","article-title":"The role of actin cytoskeleton in dendritic spines in the maintenance of long-term memory","volume":"11","author":"Basu","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib31","doi-asserted-by":"crossref","first-page":"e0170113","DOI":"10.1371\/journal.pone.0170113","article-title":"Biophysical model of the role of actin remodeling on dendritic spine morphology","volume":"12","author":"Miermans","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2023.03.008_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2011.05.029","article-title":"An embryonic culture system for the investigation of striatal medium spiny neuron dendritic spine development and plasticity","volume":"200","author":"Penrod","year":"2011","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.neuron.2023.03.008_bib33","doi-asserted-by":"crossref","first-page":"10377","DOI":"10.1038\/s41598-019-46682-y","article-title":"Fluorescence imaging of actin turnover parses early stem cell lineage divergence and senescence","volume":"9","author":"Mishra","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2023.03.008_bib34","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature09823","article-title":"Local, persistent activation of Rho GTPases during plasticity of single dendritic spines","volume":"472","author":"Murakoshi","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.03.008_bib35","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/gbb.12301","article-title":"Cognitive flexibility deficits in a mouse model for the absence of full-length dystrophin","volume":"15","author":"Remmelink","year":"2016","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.neuron.2023.03.008_bib36","doi-asserted-by":"crossref","first-page":"a021691","DOI":"10.1101\/cshperspect.a021691","article-title":"The striatum: where skills and habits meet","volume":"7","author":"Graybiel","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuron.2023.03.008_bib37","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.biopsych.2018.01.025","article-title":"Habits are negatively regulated by histone deacetylase 3 in the dorsal striatum","volume":"84","author":"Malvaez","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2023.03.008_bib38","doi-asserted-by":"crossref","first-page":"14613","DOI":"10.1038\/srep14613","article-title":"Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene","volume":"5","author":"Nithianantharajah","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2023.03.008_bib39","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbr.2013.05.060","article-title":"Effects of stimulus salience on touchscreen serial reversal learning in a mouse model of fragile X syndrome","volume":"252","author":"Dickson","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuron.2023.03.008_bib40","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0143-15.2016","article-title":"Normal performance of Fmr1 mice on a touchscreen delayed nonmatching to position working memory task","volume":"3","author":"Leach","year":"2016","journal-title":"eNeuro"},{"key":"10.1016\/j.neuron.2023.03.008_bib41","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.bbr.2007.10.004","article-title":"Stimulus specific deficit on visual reversal learning after lesions of medial prefrontal cortex in the mouse","volume":"187","author":"Brigman","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuron.2023.03.008_bib42","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neulet.2017.04.049","article-title":"Acquisition and reversal of visual discrimination learning in APPSwDI\/Nos2(-\/-) (CVN) mice","volume":"650","author":"Piiponniemi","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2023.03.008_bib43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fnbeh.2016.00015","article-title":"Editorial: Avoidance: from basic science to psychopathology","volume":"10","author":"Servatius","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib44","doi-asserted-by":"crossref","first-page":"634493","DOI":"10.3389\/fncel.2021.634493","article-title":"Roles for the dorsal striatum in aversive behavior","volume":"15","author":"Stanley","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib45","doi-asserted-by":"crossref","first-page":"10274","DOI":"10.1523\/JNEUROSCI.1842-16.2016","article-title":"Basal ganglia output controls active avoidance behavior","volume":"36","author":"Hormigo","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib46","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.biopsych.2010.09.033","article-title":"Contributions of striatal dopamine signaling to the modulation of cognitive flexibility","volume":"69","author":"Darvas","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2023.03.008_bib47","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnsys.2019.00028","article-title":"Dorsal striatal circuits for habits, compulsions and addictions","volume":"13","author":"Lipton","year":"2019","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib48","doi-asserted-by":"crossref","first-page":"e0224715","DOI":"10.1371\/journal.pone.0224715","article-title":"Lesion of striatal patches disrupts habitual behaviors and increases behavioral variability","volume":"15","author":"Nadel","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2023.03.008_bib49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1037\/0735-7044.116.1.105","article-title":"Role of the dorsomedial striatum in behavioral flexibility for response and visual cue discrimination learning","volume":"116","author":"Ragozzino","year":"2002","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib50","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fnins.2016.00027","article-title":"Striatal circuits as a common node for autism pathophysiology","volume":"10","author":"Fuccillo","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib51","doi-asserted-by":"crossref","first-page":"e61882","DOI":"10.7554\/eLife.61882","article-title":"Defective memory engram reactivation underlies impaired fear memory recall in fragile X syndrome","volume":"9","author":"Li","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2023.03.008_bib52","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/B978-0-12-418675-0.00004-3","article-title":"Structural and functional organization of the postsynaptic density","author":"Verpelli","year":"2014","journal-title":"The Synapse: Struct. Funct."},{"key":"10.1016\/j.neuron.2023.03.008_bib53","doi-asserted-by":"crossref","first-page":"a009886","DOI":"10.1101\/cshperspect.a009886","article-title":"Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities","volume":"4","author":"Zoghbi","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuron.2023.03.008_bib54","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.crstbi.2021.10.001","article-title":"Role of actin cytoskeleton in the organization and function of ionotropic glutamate receptors","volume":"3","author":"Dutta","year":"2021","journal-title":"Curr. Res Struct. Biol."},{"key":"10.1016\/j.neuron.2023.03.008_bib55","doi-asserted-by":"crossref","first-page":"9565","DOI":"10.1523\/JNEUROSCI.17-24-09565.1997","article-title":"Isoform specificity in the relationship of actin to dendritic spines","volume":"17","author":"Kaech","year":"1997","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib56","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuron.2005.12.017","article-title":"A critical role for myosin IIb in dendritic spine morphology and synaptic function","volume":"49","author":"Ryu","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.03.008_bib57","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.3390\/cells9061458","article-title":"Linking the landscape of MYH9-related diseases to the molecular mechanisms that control non-muscle myosin II-A function in cells","volume":"9","author":"Asensio-Ju\u00e1rez","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.neuron.2023.03.008_bib58","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0284-20.2020","article-title":"Myosin Va brain-specific mutation alters mouse behavior and disrupts hippocampal synapses","volume":"7","author":"Pandian","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.neuron.2023.03.008_bib59","doi-asserted-by":"crossref","first-page":"15909","DOI":"10.1074\/jbc.M115.640136","article-title":"Actinin-4 governs dendritic spine dynamics and promotes their remodeling by metabotropic glutamate receptors","volume":"290","author":"Kalinowska","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2023.03.008_bib60","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1093\/emboj\/17.5.1362","article-title":"Gelsolin is a downstream effector of rac for fibroblast motility","volume":"17","author":"Azuma","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2023.03.008_bib61","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.ajhg.2017.11.006","article-title":"ACTB loss-of-function mutations result in a pleiotropic developmental disorder","volume":"101","author":"Cuvertino","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuron.2023.03.008_bib62","doi-asserted-by":"crossref","first-page":"e1004772","DOI":"10.1371\/journal.pgen.1004772","article-title":"De novo mutations in moderate or severe intellectual disability","volume":"10","author":"Hamdan","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neuron.2023.03.008_bib63","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/ng.1091","article-title":"De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome","volume":"44","author":"Rivi\u00e8re","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2023.03.008_bib64","doi-asserted-by":"crossref","first-page":"e26144","DOI":"10.4161\/rdis.26144","article-title":"A human de novo mutation in MYH10 phenocopies the loss of function mutation in mice","volume":"1","author":"Tuzovic","year":"2013","journal-title":"Rare Dis."},{"key":"10.1016\/j.neuron.2023.03.008_bib65","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/hmg\/ddi077","article-title":"FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts","volume":"14","author":"Castets","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2023.03.008_bib66","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.cub.2005.05.050","article-title":"The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain","volume":"15","author":"Reeve","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2023.03.008_bib67","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1113\/JP275571","article-title":"Imbalance of synaptic actin dynamics as a key to fragile X syndrome?","volume":"596","author":"Michaelsen-Preusse","year":"2018","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2023.03.008_bib68","doi-asserted-by":"crossref","first-page":"eaan0852","DOI":"10.1126\/scisignal.aan0852","article-title":"Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome","volume":"10","author":"Pyronneau","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.neuron.2023.03.008_bib69","doi-asserted-by":"crossref","first-page":"eaan0665","DOI":"10.1126\/scisignal.aan0665","article-title":"Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice","volume":"10","author":"Santini","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.neuron.2023.03.008_bib70","doi-asserted-by":"crossref","first-page":"6586","DOI":"10.1523\/JNEUROSCI.23-16-06586.2003","article-title":"Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis","volume":"23","author":"Takahashi","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib71","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fnmol.2020.00161","article-title":"The fragile X mental retardation protein regulates striatal medium spiny neuron synapse density and dendritic spine morphology","volume":"13","author":"Huebschman","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib72","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.neuroscience.2007.06.044","article-title":"Cortical regulation of dopamine depletion-induced dendritic spine loss in striatal medium spiny neurons","volume":"149","author":"Neely","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2023.03.008_bib73","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1523\/JNEUROSCI.1377-18.2018","article-title":"Dopamine restores limbic memory loss, dendritic spine structure, and NMDAR-dependent LTD in the nucleus accumbens of alcohol-withdrawn rats","volume":"39","author":"Cannizzaro","year":"2019","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib74","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.3390\/cells9112441","article-title":"Changes in striatal medium spiny neuron morphology resulting from dopamine depletion are reversible","volume":"9","author":"Witzig","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.neuron.2023.03.008_bib75","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1021\/cn100032f","article-title":"Dopamine release and uptake impairments and behavioral alterations observed in mice that model fragile X mental retardation syndrome","volume":"1","author":"Fulks","year":"2010","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib76","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1176\/ajp.2006.163.7.1252","article-title":"Volumetric analysis and three-dimensional glucose metabolic mapping of the striatum and thalamus in patients with autism spectrum disorders","volume":"163","author":"Haznedar","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuron.2023.03.008_bib77","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.biopsych.2005.03.040","article-title":"Striatal volume on magnetic resonance imaging and repetitive behaviors in autism","volume":"58","author":"Hollander","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2023.03.008_bib78","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13041-020-00624-2","article-title":"Pathological alterations in striatal compartments in the human brain of autism spectrum disorder","volume":"13","author":"Kuo","year":"2020","journal-title":"Mol. Brain"},{"key":"10.1016\/j.neuron.2023.03.008_bib79","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.biopsych.2009.03.017","article-title":"Changes in the developmental trajectories of striatum in autism","volume":"66","author":"Langen","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2023.03.008_bib80","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.biopsych.2007.09.008","article-title":"Abnormal striatal GABA transmission in the mouse model for the fragile X syndrome","volume":"63","author":"Centonze","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2023.03.008_bib81","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/ncomms2045","article-title":"Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome","volume":"3","author":"Jung","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.03.008_bib82","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13041-020-00649-7","article-title":"Altered dopaminergic pathways and therapeutic effects of intranasal dopamine in two distinct mouse models of autism","volume":"13","author":"Chao","year":"2020","journal-title":"Mol. Brain"},{"key":"10.1016\/j.neuron.2023.03.008_bib83","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1101\/lm.035956.114","article-title":"Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us","volume":"21","author":"Santos","year":"2014","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuron.2023.03.008_bib84","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.celrep.2015.04.064","article-title":"Autism-like deficits in Shank3-deficient mice are rescued by targeting actin regulators","volume":"11","author":"Duffney","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2023.03.008_bib85","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1515\/revneuro-2013-0017","article-title":"The role of the actin cytoskeleton in regulating Drosophila behavior","volume":"24","author":"Ojelade","year":"2013","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib86","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neubiorev.2015.12.001","article-title":"The stressed cytoskeleton: how actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior","volume":"62","author":"van der Kooij","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuron.2023.03.008_bib87","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tcb.2006.08.006","article-title":"Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking","volume":"16","author":"Ridley","year":"2006","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.neuron.2023.03.008_bib88","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0896-6273(00)80376-1","article-title":"Regulation of Dendritic Growth and Remodeling by Rho, Rac, and Cdc42","volume":"19","author":"Threadgill","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.03.008_bib89","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.1073\/pnas.1602152113","article-title":"Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes","volume":"113","author":"Dong","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.03.008_bib90","first-page":"191","article-title":"Rho proteins, mental retardation and the cellular basis of cognition","volume":"25","author":"Ramakers","year":"2002","journal-title":"Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib91","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.neuron.2011.05.021","article-title":"Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses","volume":"70","author":"Gilman","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.03.008_bib92","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.cell.2019.12.036","article-title":"Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism","volume":"180","author":"Satterstrom","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.03.008_bib93","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature12929","article-title":"De novo mutations in schizophrenia implicate synaptic networks","volume":"506","author":"Fromer","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.03.008_bib94","first-page":"22","article-title":"The Dutch-Belgian fragile X Fmr1 knockout mice: a model to study fragile X mental retardation","volume":"78","author":"Bakker","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.03.008_bib95","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2023.03.008_bib96","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.03.008_bib97","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2023.03.008_bib98","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.21105\/joss.02286","article-title":"spam: software for Practical Analysis of Materials","volume":"5","author":"Stamati","year":"2020","journal-title":"J.\u00a0Open Source Software"},{"key":"10.1016\/j.neuron.2023.03.008_bib99","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1152\/jn.1999.82.6.3196","article-title":"Cross talk between A(1) and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats","volume":"82","author":"Lopes","year":"1999","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2023.03.008_bib100","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41419-022-05019-w","article-title":"FMRP modulates the Wnt signalling pathway in glioblastoma","volume":"13","author":"Pedini","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neuron.2023.03.008_bib101","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.mcn.2006.11.015","article-title":"The fragile X mental retardation protein-RNP granules show an mGluR-dependent localization in the post-synaptic spines","volume":"34","author":"Ferrari","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2023.03.008_bib102","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3389\/fgene.2018.00442","article-title":"FXS-like phenotype in two unrelated patients carrying a methylated premutation of the FMR1 gene","volume":"9","author":"Fern\u00e1ndez","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.neuron.2023.03.008_bib103","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.neuron.2023.03.008_bib104","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","volume":"7","author":"Carpenter","year":"2006","journal-title":"Genome Biol."},{"key":"10.1016\/j.neuron.2023.03.008_bib105","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.neuron.2018.06.007","article-title":"Mettl14 is essential for epitranscriptomic regulation of striatal function and learning","volume":"99","author":"Koranda","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.03.008_bib106","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1073\/pnas.0511244103","article-title":"Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens","volume":"103","author":"Lee","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.03.008_bib107","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neuron.2019.01.025","article-title":"Punishment-predictive cues guide avoidance through potentiation of hypothalamus-to-habenula synapses","volume":"102","author":"Trusel","year":"2019","journal-title":"Neuron"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627323002040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627323002040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:17:00Z","timestamp":1777580220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627323002040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":107,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S0896627323002040"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2023.03.008","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered striatal actin dynamics drives behavioral inflexibility in a mouse model of fragile X syndrome","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2023.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}