{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:41:22Z","timestamp":1791427282597,"version":"4.3.3"},"reference-count":74,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["095317\/Z\/11\/Z"],"award-info":[{"award-number":["095317\/Z\/11\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["860035"],"award-info":[{"award-number":["860035"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016948","name":"Tau Consortium","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000320","name":"Alzheimer&apos;s Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["BRC-1215-20014"],"award-info":[{"award-number":["BRC-1215-20014"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.neuron.2023.04.006","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T10:28:03Z","timestamp":1682504883000},"page":"2021-2037.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":127,"title":["Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration"],"prefix":"10.1016","volume":"111","author":[{"given":"Beatrice Paola","family":"Festa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah H.","family":"Siddiqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Jimenez-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeran","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matea","family":"Rob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin","family":"Djajadikerta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanna","family":"Stamatakou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5002-5263","authenticated-orcid":false,"given":"David C.","family":"Rubinsztein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2023.04.006_bib1","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41593-018-0235-9","article-title":"Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases","volume":"21","author":"Soto","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.04.006_bib2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/cr.2013.168","article-title":"The machinery of macroautophagy","volume":"24","author":"Feng","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.neuron.2023.04.006_bib3","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuron.2017.01.022","article-title":"Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities","volume":"93","author":"Menzies","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.04.006_bib4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/hmg\/ddi458","article-title":"Rapamycin alleviates toxicity of different aggregate-prone proteins","volume":"15","author":"Berger","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2023.04.006_bib5","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.neuron.2022.01.017","article-title":"The different autophagy degradation pathways and neurodegeneration","volume":"110","author":"Fleming","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.04.006_bib6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fncel.2018.00323","article-title":"Bidirectional Microglia-Neuron Communication in Health and Disease","volume":"12","author":"Szepesi","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2023.04.006_bib7","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/brain\/awm044","article-title":"Microglial activation in presymptomatic Huntington\u2019s disease gene carriers","volume":"130","author":"Tai","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2023.04.006_bib8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JAD-2012-120787","article-title":"Microglial markers are elevated in the prodromal phase of Alzheimer\u2019s disease and vascular dementia","volume":"33","author":"Olsson","year":"2013","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neuron.2023.04.006_bib9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainresrev.2004.07.021","article-title":"Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases","volume":"48","author":"Cartier","year":"2005","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.neuron.2023.04.006_bib10","doi-asserted-by":"crossref","first-page":"480739","DOI":"10.1155\/2013\/480739","article-title":"Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain","volume":"2013","author":"Ramesh","year":"2013","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.neuron.2023.04.006_bib11","doi-asserted-by":"crossref","first-page":"dmm049349","DOI":"10.1242\/dmm.049349","article-title":"Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer\u2019s disease mouse models","volume":"15","author":"Monz\u00f3n-Sandoval","year":"2022","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.neuron.2023.04.006_bib12","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/s41593-019-0491-3","article-title":"Single-cell transcriptomic profiling of the aging mouse brain","volume":"22","author":"Ximerakis","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.04.006_bib13","doi-asserted-by":"crossref","first-page":"E598","DOI":"10.3390\/ijms18030598","article-title":"Autophagy and microglia: novel partners in neurodegeneration and aging","volume":"18","author":"Plaza-Zabala","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuron.2023.04.006_bib14","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41418-021-00903-y","article-title":"Vinexin contributes to autophagic decline in brain ageing across species","volume":"29","author":"Park","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neuron.2023.04.006_bib15","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cellsig.2004.04.007","article-title":"Chemokine receptor CCR5: insights into structure, function, and regulation","volume":"16","author":"Oppermann","year":"2004","journal-title":"Cell. Signal."},{"key":"10.1016\/j.neuron.2023.04.006_bib16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3940(01)02149-8","article-title":"Cellular expression of functional chemokine receptor CCR5 and CXCR4 in human embryonic neurons","volume":"311","author":"Boutet","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2023.04.006_bib17","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0165-5728(01)00457-X","article-title":"Developmental expression patterns of CCR5 and CXCR4 in the rhesus macaque brain","volume":"122","author":"Westmoreland","year":"2002","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.neuron.2023.04.006_bib18","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1161\/STROKEAHA.120.033285","article-title":"CCR5 activation promotes N LRP1-dependent neuronal pyroptosis via CCR5\/PKA\/CREB pathway after intracerebral hemorrhage","volume":"52","author":"Yan","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.neuron.2023.04.006_bib19","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.cell.2019.01.044","article-title":"CCR5 is a therapeutic target for recovery after stroke and traumatic brain injury","volume":"176","author":"Joy","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.04.006_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.neuron.2023.04.006_bib21","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/hmg\/11.9.1107","article-title":"Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy","volume":"11","author":"Ravikumar","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2023.04.006_bib22","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1186\/s12885-017-3817-0","article-title":"CCL5-CCR5 interactions modulate metabolic events during tumor onset to promote tumorigenesis","volume":"17","author":"Gao","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.neuron.2023.04.006_bib23","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.bbrc.2009.07.035","article-title":"CCL5 promotes proliferation of MCF-7 cells through mTOR-dependent mRNA translation","volume":"387","author":"Murooka","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuron.2023.04.006_bib24","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.4049\/jimmunol.1500704","article-title":"CCR5-dependent activation of mTORC1 regulates translation of inducible NO synthase and COX-2 during encephalomyocarditis virus infection","volume":"195","author":"Shaheen","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.neuron.2023.04.006_bib25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2023.04.006_bib26","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/nm1303","article-title":"CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection","volume":"11","author":"Tyner","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2023.04.006_bib27","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1128\/jvi.76.5.2245-2254.2002","article-title":"Interaction of the CC-chemokine RANTES with glycosaminoglycans activates a p44\/p42 mitogen-activated protein kinase-dependent signaling pathway and enhances human immunodeficiency virus type 1 infectivity","volume":"76","author":"Chang","year":"2002","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.neuron.2023.04.006_bib28","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","article-title":"TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neuron.2023.04.006_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1742-2094-11-12","article-title":"Morphometric characterization of microglial phenotypes in human cerebral cortex","volume":"11","author":"Torres-Platas","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuron.2023.04.006_bib30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/ng1362","article-title":"Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease","volume":"36","author":"Ravikumar","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2023.04.006_bib31","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.it.2015.04.007","article-title":"The choreography of neuroinflammation in Huntington\u2019s disease","volume":"36","author":"Crotti","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.neuron.2023.04.006_bib32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40478-016-0292-9","article-title":"Autophagic and lysosomal defects in human tauopathies: analysis of\u00a0post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy","volume":"4","author":"Piras","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neuron.2023.04.006_bib33","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2147\/NDT.S75717","article-title":"Activation of mTOR: a culprit of Alzheimer\u2019s disease?","volume":"11","author":"Cai","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.neuron.2023.04.006_bib34","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.3233\/JAD-160912","article-title":"Tau oligomers associate with inflammation in the brain and retina of tauopathy mice and in neurodegenerative diseases","volume":"55","author":"Nilson","year":"2017","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neuron.2023.04.006_bib35","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.1113694","article-title":"Tau suppression in a neurodegenerative mouse model improves memory function","volume":"309","author":"Santacruz","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.04.006_bib36","doi-asserted-by":"crossref","first-page":"10637","DOI":"10.1523\/JNEUROSCI.3279-05.2005","article-title":"Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)","volume":"25","author":"Ramsden","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.04.006_bib37","first-page":"1","article-title":"CCR5 Inhibitors and HIV-1 Infection","volume":"1","author":"Latinovic","year":"2019","journal-title":"J.\u00a0AIDS HIV Treat."},{"key":"10.1016\/j.neuron.2023.04.006_bib38","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1126\/science.1241475","article-title":"Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex","volume":"341","author":"Tan","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.04.006_bib39","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1083\/jcb.151.6.1281","article-title":"Endocytosis and recycling of the HIV coreceptor CCR5","volume":"151","author":"Signoret","year":"2000","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2023.04.006_bib40","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.devcel.2018.03.008","article-title":"The RAB11A-positive compartment is a primary platform for autophagosome assembly mediated by WIPI2 recognition of PI3P-RAB11A","volume":"45","author":"Puri","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuron.2023.04.006_bib41","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/WAD.0000000000000367","article-title":"Lack of association between the CCR5-delta32 polymorphism and neurodegenerative disorders","volume":"34","author":"Wojta","year":"2020","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.neuron.2023.04.006_bib42","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1196\/annals.1386.012","article-title":"Association between the polymorphism of CCR5 and Alzheimer\u2019s disease: results of a study performed on male and female patients from Northern Italy","volume":"1089","author":"Balistreri","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuron.2023.04.006_bib43","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.neulet.2004.05.058","article-title":"The chemokine receptor CCR5-Delta32 gene mutation is not protective against Alzheimer\u2019s disease","volume":"366","author":"Combarros","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2023.04.006_bib44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jns.2004.07.005","article-title":"CCR2-64I polymorphism and CCR5Delta32 deletion in patients with Alzheimer\u2019s disease","volume":"225","author":"Galimberti","year":"2004","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neuron.2023.04.006_bib45","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neulet.2004.08.016","article-title":"Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer\u2019s and Parkinson\u2019s disease","volume":"370","author":"Huerta","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2023.04.006_bib52","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1084\/jem.186.1.139","article-title":"HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication","volume":"186","author":"Amara","year":"1997","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neuron.2023.04.006_bib53","doi-asserted-by":"crossref","first-page":"11803","DOI":"10.1038\/ncomms11803","article-title":"The Parkinson\u2019s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway","volume":"7","author":"Bento","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.04.006_bib54","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.04.006_bib50","doi-asserted-by":"crossref","first-page":"13821","DOI":"10.1038\/ncomms13821","article-title":"CCT complex restricts neuropathogenic protein aggregation via\u00a0autophagy","volume":"7","author":"Pavel","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.04.006_bib61","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1136\/jmg.36.10.739","article-title":"A molecular investigation of true dominance in Huntington\u2019s disease","volume":"36","author":"Narain","year":"1999","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.neuron.2023.04.006_bib62","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1242\/jcs.00381","article-title":"Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate","volume":"116","author":"Mizushima","year":"2003","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.neuron.2023.04.006_bib63","doi-asserted-by":"crossref","first-page":"33889","DOI":"10.1074\/jbc.273.51.33889","article-title":"A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy","volume":"273","author":"Mizushima","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2023.04.006_bib64","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/sj.mt.6300163","article-title":"Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease","volume":"15","author":"Howarth","year":"2007","journal-title":"Mol. Ther."},{"key":"10.1016\/j.neuron.2023.04.006_bib73","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","volume":"7","author":"Carpenter","year":"2006","journal-title":"Genome Biol."},{"key":"10.1016\/j.neuron.2023.04.006_bib46","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/hmg\/8.3.397","article-title":"Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin","volume":"8","author":"Schilling","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2023.04.006_bib47","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1093\/hmg\/ddq093","article-title":"Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington\u2019s disease","volume":"19","author":"Rose","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2023.04.006_bib48","doi-asserted-by":"crossref","first-page":"16027","DOI":"10.1074\/jbc.M710606200","article-title":"Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice","volume":"283","author":"Orr","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2023.04.006_bib49","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.04.006_bib51","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0021-9150(02)00382-9","article-title":"CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice","volume":"167","author":"Kuziel","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.neuron.2023.04.006_bib55","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s003359900551","article-title":"Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment","volume":"8","author":"Rogers","year":"1997","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.neuron.2023.04.006_bib56","doi-asserted-by":"crossref","DOI":"10.3791\/55523","article-title":"Assessment of spontaneous alternation, novel object recognition and limb clasping in transgenic mouse models of amyloid-\u03b2 and Tau neuropathology","author":"Miedel","year":"2017","journal-title":"J.\u00a0Vis. Exp. JoVE."},{"key":"10.1016\/j.neuron.2023.04.006_bib57","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/2041-210X.12584","article-title":"BORIS: a free, versatile open-source event-logging software for video\/audio coding and live observations","volume":"7","author":"Friard","year":"2016","journal-title":"Methods Ecol. Evol."},{"key":"10.1016\/j.neuron.2023.04.006_bib58","doi-asserted-by":"crossref","first-page":"14338","DOI":"10.1038\/ncomms14338","article-title":"mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases","volume":"8","author":"Palmieri","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.04.006_bib59","doi-asserted-by":"crossref","first-page":"108564","DOI":"10.1016\/j.celrep.2020.108564","article-title":"mTORC2 assembly is regulated by USP9X-mediated deubiquitination of RICTOR","volume":"33","author":"Wrobel","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2023.04.006_bib60","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.devcel.2021.05.010","article-title":"Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner","volume":"56","author":"Karabiyik","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuron.2023.04.006_bib65","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature22078","article-title":"Polyglutamine tracts regulate beclin 1-dependent autophagy","volume":"545","author":"Ashkenazi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.04.006_bib66","doi-asserted-by":"crossref","first-page":"71","DOI":"10.7171\/jbt.18-2903-002","article-title":"Cytosolic and Transmembrane Protein Extraction Methods of Breast and Ovarian Cancer Cells: A Comparative Study","volume":"29","author":"Muinao","year":"2018","journal-title":"J.\u00a0Biomol. Tech."},{"key":"10.1016\/j.neuron.2023.04.006_bib67","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0006-291X(02)00908-7","article-title":"Chemokine receptor CCR5: polymorphism at protein level","volume":"296","author":"Suzuki","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuron.2023.04.006_bib68","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1600-0854.2005.00274.x","article-title":"Characterization of endocytic vesicles using magnetic microbeads coated with signalling ligands","volume":"6","author":"Li","year":"2005","journal-title":"Traffic"},{"key":"10.1016\/j.neuron.2023.04.006_bib69","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1177\/002215549904700601","article-title":"Reduction of\u00a0lipofuscin-like autofluorescence in fluorescently labeled tissue","volume":"47","author":"Schnell","year":"1999","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.neuron.2023.04.006_bib70","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1038\/s41467-019-09494-2","article-title":"Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing","volume":"10","author":"Siddiqi","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.04.006_bib71","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.aanat.2016.10.002","article-title":"Stereological investigation of the CA1 pyramidal cell layer in untreated and lithium-treated 3xTg-AD and wild-type mice","volume":"209","author":"Schaeffer","year":"2017","journal-title":"Ann. Anat. Anat. Anz. Off. Organ Anat. Ges."},{"key":"10.1016\/j.neuron.2023.04.006_bib72","series-title":"Paxinos and Franklin\u2019s, the Mouse Brain in Stereotaxic Coordinates - 5thEdition","author":"George","year":"2019"},{"key":"10.1016\/j.neuron.2023.04.006_bib74","article-title":"R: A language and environment for statistical computing","author":"Team","year":"2021","journal-title":"R Found. Stat. Comput."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627323002684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627323002684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:43:58Z","timestamp":1760255038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627323002684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":74,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S0896627323002684"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2023.04.006","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742625309.793599780","asserted-by":"object"}]},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2023.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}