{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:39:55Z","timestamp":1792175995579,"version":"4.4.0"},"reference-count":193,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":386,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["AI151708"],"award-info":[{"award-number":["AI151708"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["NS117424"],"award-info":[{"award-number":["NS117424"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["NS122825"],"award-info":[{"award-number":["NS122825"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP220242"],"award-info":[{"award-number":["RP220242"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012207","name":"Grace Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012207","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.neuron.2023.10.014","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T09:28:11Z","timestamp":1699435691000},"page":"539-557","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges"],"prefix":"10.1016","volume":"112","author":[{"given":"Kun","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2023.10.014_bib1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41580-020-0244-x","article-title":"Molecular mechanisms and cellular functions of cGAS\u2013STING signalling","volume":"21","author":"Hopfner","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neuron.2023.10.014_bib2","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20220990","article-title":"STING trafficking as a new dimension of immune signaling","volume":"220","author":"Jeltema","year":"2023","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neuron.2023.10.014_bib3","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41577-021-00633-9","article-title":"The type I interferonopathies: 10 years on","volume":"22","author":"Crow","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib5","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/s41586-021-04059-0","article-title":"Disruption of mitochondrial complex I induces progressive parkinsonism","volume":"599","author":"Gonz\u00e1lez-Rodr\u00edguez","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib6","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.cell.2014.11.037","article-title":"Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA","volume":"159","author":"Rongvaux","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib7","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.cell.2014.11.036","article-title":"Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production","volume":"159","author":"White","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib8","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA stress primes the antiviral innate immune response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib10","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/ana.20256","article-title":"PINK1 mutations are associated with sporadic early-onset parkinsonism","volume":"56","author":"Valente","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuron.2023.10.014_bib11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson\u2019s disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.014_bib12","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41586-018-0448-9","article-title":"Parkin and PINK1 mitigate STING-induced inflammation","volume":"561","author":"Sliter","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib13","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1093\/hmg\/ddz004","article-title":"LRRK2 impairs PINK1\/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson\u2019s disease","volume":"28","author":"Bonello","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2023.10.014_bib14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/15548627.2019.1603548","article-title":"LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10","volume":"16","author":"Wauters","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.neuron.2023.10.014_bib15","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1093\/hmg\/ddz126","article-title":"Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts","volume":"28","author":"Korecka","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2023.10.014_bib16","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.stem.2016.08.002","article-title":"Functional impairment in Miro degradation and mitophagy is a shared feature in familial and sporadic Parkinson\u2019s disease","volume":"19","author":"Hsieh","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib17","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51071","article-title":"LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis","volume":"9","author":"Weindel","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2023.10.014_bib18","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nn.3489","article-title":"The Parkinson\u2019s disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy","volume":"16","author":"Burchell","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.10.014_bib19","doi-asserted-by":"crossref","first-page":"E4439","DOI":"10.1073\/pnas.1405752111","article-title":"Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation","volume":"111","author":"Wong","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.10.014_bib20","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202106046","article-title":"ER-lysosome lipid transfer protein VPS13C\/PARK23 prevents aberrant mtDNA-dependent STING signaling","volume":"221","author":"Hancock-Cerutti","year":"2022","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2023.10.014_bib21","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s43587-022-00337-2","article-title":"Activation of innate immune cGAS-STING pathway contributes to Alzheimer\u2019s pathogenesis in 5xFAD mice","volume":"3","author":"Xie","year":"2023","journal-title":"Nat Aging"},{"key":"10.1016\/j.neuron.2023.10.014_bib22","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2011226118","article-title":"NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer\u2019s disease via cGAS-STING","volume":"118","author":"Hou","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.10.014_bib23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41593-023-01315-6","article-title":"Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience","volume":"26","author":"Udeochu","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.10.014_bib24","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.cell.2020.09.020","article-title":"TDP-43 triggers mitochondrial DNA release via mPTP to activate cGAS\/STING in ALS","volume":"183","author":"Yu","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib25","doi-asserted-by":"crossref","first-page":"104404","DOI":"10.1016\/j.isci.2022.104404","article-title":"cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model","volume":"25","author":"Tan","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.neuron.2023.10.014_bib26","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.immuni.2015.01.012","article-title":"DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity","volume":"42","author":"H\u00e4rtlova","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.neuron.2023.10.014_bib27","doi-asserted-by":"crossref","first-page":"6378","DOI":"10.1523\/JNEUROSCI.0774-19.2019","article-title":"Accumulation of cytoplasmic DNA due to ATM deficiency activates the microglial viral response system with neurotoxic consequences","volume":"39","author":"Song","year":"2019","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.10.014_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13468","article-title":"Inhibition of the cGAS-STING pathway ameliorates the premature senescence hallmarks of ataxia-telangiectasia brain organoids","volume":"20","author":"Aguado","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature23449","article-title":"cGAS surveillance of micronuclei links genome instability to innate immunity","volume":"548","author":"Mackenzie","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib30","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1093\/hmg\/ddx283","article-title":"Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy","volume":"26","author":"Bartsch","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2023.10.014_bib31","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1016\/j.neuron.2021.09.040","article-title":"Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair","volume":"109","author":"Aditi","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.014_bib32","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41586-020-2625-x","article-title":"C9orf72 in myeloid cells suppresses STING-induced inflammation","volume":"585","author":"McCauley","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib33","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41586-021-03762-2","article-title":"Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C","volume":"596","author":"Chu","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib34","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1172\/JCI135026","article-title":"Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration","volume":"130","author":"Jauhari","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2023.10.014_bib35","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41586-022-04421-w","article-title":"The cGAS-STING pathway drives type I IFN immunopathology in COVID-19","volume":"603","author":"Domizio","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib36","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.celrep.2019.09.050","article-title":"Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury","volume":"29","author":"Maekawa","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2023.10.014_bib37","doi-asserted-by":"crossref","first-page":"680648","DOI":"10.3389\/fimmu.2021.680648","article-title":"Circulating mitochondrial DNA stimulates innate immune signaling pathways to mediate acute kidney injury","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib38","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41419-021-03961-9","article-title":"Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neuron.2023.10.014_bib39","doi-asserted-by":"crossref","first-page":"852243","DOI":"10.3389\/fnmol.2022.852243","article-title":"Type I interferon response is mediated by NLRX1-cGAS-STING signaling in brain injury","volume":"15","author":"Fritsch","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neuron.2023.10.014_bib40","doi-asserted-by":"crossref","first-page":"860977","DOI":"10.3389\/fimmu.2022.860977","article-title":"mtDNA-STING axis mediates microglial polarization via IRF3\/NF-\u03baB signaling after ischemic stroke","volume":"13","author":"Kong","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib41","doi-asserted-by":"crossref","first-page":"9644","DOI":"10.7150\/thno.47651","article-title":"HDAC3 inhibition ameliorates ischemia\/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway","volume":"10","author":"Liao","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.neuron.2023.10.014_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao6047","article-title":"BAK\/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis","volume":"359","author":"McArthur","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.10.014_bib43","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.aav4011","article-title":"VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease","volume":"366","author":"Kim","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.10.014_bib44","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108293","article-title":"Nuclear cGAS: guard or prisoner?","volume":"40","author":"de Oliveira Mann","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2023.10.014_bib45","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature23470","article-title":"Mitotic progression following DNA damage enables pattern recognition within micronuclei","volume":"548","author":"Harding","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib46","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ncb3586","article-title":"Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence","volume":"19","author":"Gl\u00fcck","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neuron.2023.10.014_bib47","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41586-018-0050-1","article-title":"SAMHD1 acts at stalled replication forks to prevent interferon induction","volume":"557","author":"Coquel","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib48","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.neuron.2014.06.034","article-title":"DNA damage and its links to neurodegeneration","volume":"83","author":"Madabhushi","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.014_bib49","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1101\/gad.301325.117","article-title":"Genome integrity and disease prevention in the nervous system","volume":"31","author":"McKinnon","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.neuron.2023.10.014_bib50","doi-asserted-by":"crossref","first-page":"5951","DOI":"10.1172\/JCI130445","article-title":"Inhibition of the ATM\/Chk2 axis promotes cGAS\/STING signaling in ARID1A-deficient tumors","volume":"130","author":"Wang","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2023.10.014_bib51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0006-8993(99)02004-1","article-title":"DNA strand breaks in Alzheimer\u2019s disease","volume":"849","author":"Adamec","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2023.10.014_bib52","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0197-4580(90)90542-8","article-title":"Increased levels of DNA breaks in cerebral cortex of Alzheimer\u2019s disease patients","volume":"11","author":"Mullaart","year":"1990","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2023.10.014_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbrainres.2004.05.023","article-title":"Deficiency of the Mre11 DNA repair complex in Alzheimer\u2019s disease brains","volume":"128","author":"Jacobsen","year":"2004","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neuron.2023.10.014_bib54","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.neurobiolaging.2005.03.009","article-title":"DNA end joining activity is reduced in Alzheimer\u2019s disease","volume":"27","author":"Shackelford","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2023.10.014_bib55","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nn.3356","article-title":"Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-\u03b2","volume":"16","author":"Suberbielle","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.10.014_bib56","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2118819119","article-title":"STING mediates neurodegeneration and neuroinflammation in nigrostriatal alpha-synucleinopathy","volume":"119","author":"Hinkle","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.10.014_bib57","doi-asserted-by":"crossref","first-page":"710608","DOI":"10.3389\/fimmu.2021.710608","article-title":"Traumatic brain injury induces cGAS activation and type I interferon signaling in aged mice","volume":"12","author":"Barrett","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib58","doi-asserted-by":"crossref","first-page":"1027116","DOI":"10.3389\/fnins.2022.1027116","article-title":"Neurons and glial cells acquire a senescent signature after repeated mild traumatic brain injury in a sex-dependent manner","volume":"16","author":"Schwab","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuron.2023.10.014_bib59","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201911002","article-title":"Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke","volume":"12","author":"Li","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.neuron.2023.10.014_bib60","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.stem.2017.07.009","article-title":"Modeling of TREX1-dependent autoimmune disease using human stem cells highlights L1 accumulation as a source of neuroinflammation","volume":"21","author":"Thomas","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib61","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.coi.2012.09.007","article-title":"Endogenous retroelements and autoimmune disease","volume":"24","author":"Stetson","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib62","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cell.2017.12.016","article-title":"Breaching self-tolerance to Alu duplex RNA underlies MDA5-mediated inflammation","volume":"172","author":"Ahmad","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib63","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1002\/1873-3468.14205","article-title":"Transposable elements as new players in neurodegenerative diseases","volume":"595","author":"Ravel-Godreuil","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuron.2023.10.014_bib64","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/ng1842","article-title":"Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Gouti\u00e8res syndrome and mimic congenital viral brain infection","volume":"38","author":"Crow","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2023.10.014_bib65","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.cell.2012.04.011","article-title":"Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development","volume":"149","author":"Reijns","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib66","doi-asserted-by":"crossref","first-page":"15989","DOI":"10.1073\/pnas.2002144117","article-title":"Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease","volume":"117","author":"Sharma","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.10.014_bib67","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1056\/NEJMoa1312625","article-title":"Activated STING in a vascular and pulmonary syndrome","volume":"371","author":"Liu","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuron.2023.10.014_bib68","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.chom.2015.07.001","article-title":"STING activation by translocation from the ER is associated with infection and autoinflammatory disease","volume":"18","author":"Dobbs","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.neuron.2023.10.014_bib69","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81943","article-title":"Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice","volume":"11","author":"Szego","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2023.10.014_bib70","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10875-021-00974-z","article-title":"STING-mediated lung inflammation and beyond","volume":"41","author":"Fr\u00e9mond","year":"2021","journal-title":"J.\u00a0Clin. Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib71","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jaip.2020.11.007","article-title":"Overview of STING-associated vasculopathy with onset in infancy (SAVI) among 21 patients","volume":"9","author":"Fr\u00e9mond","year":"2021","journal-title":"J.\u00a0Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.neuron.2023.10.014_bib72","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10875-016-0271-8","article-title":"Copa syndrome: a novel autosomal dominant immune dysregulatory disease","volume":"36","author":"Vece","year":"2016","journal-title":"J.\u00a0Clin. Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib73","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200600","article-title":"Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling","volume":"217","author":"Lepelley","year":"2020","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neuron.2023.10.014_bib74","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201045","article-title":"A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome","volume":"217","author":"Deng","year":"2020","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neuron.2023.10.014_bib75","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1038\/s41467-022-29946-6","article-title":"Deficiency in coatomer complex I causes aberrant activation of STING signalling","volume":"13","author":"Steiner","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.10.014_bib76","doi-asserted-by":"crossref","first-page":"6977","DOI":"10.1038\/s41467-022-33765-0","article-title":"Interruption of post-Golgi STING trafficking activates tonic interferon signaling","volume":"13","author":"Tu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.10.014_bib77","article-title":"ER-to-Golgi trafficking and its implication in neurological diseases","volume":"9","author":"Wang","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.neuron.2023.10.014_bib78","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12974-016-0570-2","article-title":"Induction of the type I interferon response in neurological forms of Gaucher disease","volume":"13","author":"Vitner","year":"2016","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.neuron.2023.10.014_bib79","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.imlet.2017.07.004","article-title":"Overview of immune abnormalities in lysosomal storage disorders","volume":"188","author":"Rigante","year":"2017","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.neuron.2023.10.014_bib80","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ajhg.2016.01.014","article-title":"Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1\/Parkin-dependent mitophagy","volume":"98","author":"Lesage","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuron.2023.10.014_bib81","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/cge.13124","article-title":"Diagnostic exome sequencing in early-onset Parkinson's disease confirms VPS13C as a rare cause of autosomal-recessive Parkinson's disease","volume":"93","author":"Schormair","year":"2018","journal-title":"Clin. Genet."},{"key":"10.1016\/j.neuron.2023.10.014_bib82","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1083\/jcb.201807019","article-title":"VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites","volume":"217","author":"Kumar","year":"2018","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2023.10.014_bib83","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.014_bib84","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.014_bib85","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1093\/hmg\/ddu068","article-title":"C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking","volume":"23","author":"Farg","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2023.10.014_bib86","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.cub.2018.03.063","article-title":"A C9orf72 ALS\/FTD ortholog acts in endolysosomal degradation and lysosomal homeostasis","volume":"28","author":"Corrionero","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2023.10.014_bib87","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1080\/15548627.2019.1580106","article-title":"C9orf72-dependent lysosomal functions regulate epigenetic control of autophagy and lipid metabolism","volume":"15","author":"Liu","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.neuron.2023.10.014_bib88","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1080\/15548627.2019.1703353","article-title":"C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis","volume":"16","author":"Shao","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.neuron.2023.10.014_bib89","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13126","article-title":"C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis","volume":"19","author":"Wang","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib90","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrn3961","article-title":"Compromised autophagy and neurodegenerative diseases","volume":"16","author":"Menzies","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2023.10.014_bib91","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.conb.2017.09.005","article-title":"Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases","volume":"48","author":"Wang","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuron.2023.10.014_bib92","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuron.2017.01.022","article-title":"Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities","volume":"93","author":"Menzies","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.014_bib93","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13024-019-0323-7","article-title":"Endo-lysosomal dysregulations and late-onset Alzheimer\u2019s disease: impact of genetic risk factors","volume":"14","author":"Van Acker","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuron.2023.10.014_bib94","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41577-021-00577-0","article-title":"Regulation of the nucleic acid-sensing toll-like receptors","volume":"22","author":"Lind","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib95","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.coi.2009.12.002","article-title":"Localisation and trafficking of toll-like receptors: an important mode of regulation","volume":"22","author":"McGettrick","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib96","doi-asserted-by":"crossref","DOI":"10.3390\/diseases4040031","article-title":"Mitochondrial dysfunction in lysosomal storage disorders","volume":"4","author":"de la Mata","year":"2016","journal-title":"Diseases"},{"key":"10.1016\/j.neuron.2023.10.014_bib97","article-title":"Mechanisms of mitochondrial dysfunction in lysosomal storage disorders: a review","volume":"9","author":"Stepien","year":"2020","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.neuron.2023.10.014_bib98","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fcell.2017.00110","article-title":"Crosstalk between lysosomes and mitochondria in Parkinson's disease","volume":"5","author":"Plotegher","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.neuron.2023.10.014_bib99","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.arr.2016.05.004","article-title":"Disorders of lysosomal acidification-the emerging role of v-ATPase in aging and neurodegenerative disease","volume":"32","author":"Colacurcio","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neuron.2023.10.014_bib100","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/jnc.14471","article-title":"Mitochondria, lysosomes, and dysfunction: their meaning in neurodegeneration","volume":"147","author":"Audano","year":"2018","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuron.2023.10.014_bib101","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51031","article-title":"Impaired lysosomal acidification triggers iron deficiency and inflammation in\u00a0vivo","volume":"8","author":"Yambire","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2023.10.014_bib102","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease","volume":"361","author":"Sidransky","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuron.2023.10.014_bib103","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S1474-4422(12)70190-4","article-title":"The link between the GBA gene and parkinsonism","volume":"11","author":"Sidransky","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuron.2023.10.014_bib104","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/s41467-021-22113-3","article-title":"Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson's disease","volume":"12","author":"Kim","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.10.014_bib105","doi-asserted-by":"crossref","first-page":"9879","DOI":"10.1073\/pnas.1004676107","article-title":"Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice","volume":"107","author":"Tong","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.10.014_bib106","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.neuron.2012.11.033","article-title":"RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk","volume":"77","author":"MacLeod","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.014_bib107","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077198","article-title":"LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization","volume":"8","author":"Migheli","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2023.10.014_bib108","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1016\/j.yexcr.2008.02.015","article-title":"LRRK2 regulates synaptic vesicle endocytosis","volume":"314","author":"Shin","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.neuron.2023.10.014_bib109","doi-asserted-by":"crossref","first-page":"6565","DOI":"10.1038\/s41467-021-26851-2","article-title":"Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.10.014_bib110","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.cell.2015.04.050","article-title":"PQBP1 is a proximal sensor of the cGAS-dependent innate response to HIV-1","volume":"161","author":"Yoh","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib111","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1021\/acscentsci.1c00440","article-title":"Human SLC46A2 is the dominant cGAMP importer in extracellular cGAMP-sensing macrophages and monocytes","volume":"7","author":"Cordova","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.neuron.2023.10.014_bib112","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s43018-020-0028-4","article-title":"Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity","volume":"1","author":"Carozza","year":"2020","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.neuron.2023.10.014_bib113","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.molcel.2020.10.021","article-title":"LRRC8A:C\/E heteromeric channels are ubiquitous transporters of cGAMP","volume":"80","author":"Lahey","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib114","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.molcel.2019.05.006","article-title":"SLC19A1 is an importer of the immunotransmitter cGAMP","volume":"75","author":"Ritchie","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib115","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/j.immuni.2022.08.006","article-title":"ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP","volume":"55","author":"Maltbaek","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.neuron.2023.10.014_bib116","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41590-021-01105-x","article-title":"The volume-regulated anion channel LRRC8C suppresses T\u00a0cell function by regulating cyclic dinucleotide transport and STING-p53 signaling","volume":"23","author":"Concepcion","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib117","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-019-1553-0","article-title":"SLC19A1 transports immunoreactive cyclic dinucleotides","volume":"573","author":"Luteijn","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib118","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature12640","article-title":"Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP","volume":"503","author":"Ablasser","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib119","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s12974-018-1354-7","article-title":"STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury","volume":"15","author":"Abdullah","year":"2018","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.neuron.2023.10.014_bib120","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41586-019-1006-9","article-title":"Autophagy induction via STING trafficking is a primordial function of the cGAS pathway","volume":"567","author":"Gui","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.09.039","article-title":"The DNA inflammasome in human myeloid cells is initiated by a STING-cell death program upstream of NLRP3","volume":"171","author":"Gaidt","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib122","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.immuni.2020.06.009","article-title":"Interferon-independent activities of mammalian STING mediate antiviral response and tumor immune evasion","volume":"53","author":"Wu","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.neuron.2023.10.014_bib123","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ncb3586","article-title":"Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence","volume":"19","author":"Gl\u00fcck","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neuron.2023.10.014_bib124","first-page":"E4612","article-title":"cGAS is essential for cellular senescence","volume":"9","author":"Yang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.10.014_bib125","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1084\/jem.20182192","article-title":"STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T\u00a0cell death","volume":"216","author":"Wu","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neuron.2023.10.014_bib126","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1038\/s41467-020-17156-x","article-title":"Interferon-independent STING signaling promotes resistance to HSV-1 in\u00a0vivo","volume":"11","author":"Yamashiro","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.10.014_bib127","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100225118","article-title":"TBK1 recruitment to STING activates both IRF3 and NF-\u03baB that mediate immune defense against tumors and viral infections","volume":"118","author":"Yum","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.10.014_bib128","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/glia.23592","article-title":"Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression","volume":"67","author":"Nazmi","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.neuron.2023.10.014_bib129","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS-STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1182\/blood.2020008913","article-title":"Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke","volume":"138","author":"Wang","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.neuron.2023.10.014_bib131","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/glia.22786","article-title":"DNA sensors are expressed in astrocytes and microglia in\u00a0vitro and are upregulated during gliosis in neurodegenerative disease","volume":"63","author":"Cox","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.neuron.2023.10.014_bib132","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2017.08.039","article-title":"Human microglia and astrocytes express cGAS-STING viral sensing components","volume":"658","author":"Jeffries","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2023.10.014_bib133","doi-asserted-by":"crossref","DOI":"10.1038\/s41418-023-01216-y","article-title":"The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse model of Parkinson's disease via LCN2-dependent astrocyte senescence","author":"Jiang","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neuron.2023.10.014_bib134","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1401334","article-title":"Phenotypic variation in Aicardi-Gouti\u00e8res syndrome explained by cell-specific IFN-stimulated gene response and cytokine release","volume":"194","author":"Cuadrado","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib135","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211121","article-title":"DNA damage contributes to neurotoxic inflammation in Aicardi-Goutieres syndrome astrocytes","volume":"219","author":"Giordano","year":"2022","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neuron.2023.10.014_bib136","doi-asserted-by":"crossref","first-page":"13348","DOI":"10.1038\/ncomms13348","article-title":"Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS","volume":"7","author":"Reinert","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.10.014_bib137","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib138","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/s41593-021-00905-6","article-title":"Neuroinflammatory astrocyte subtypes in the mouse brain","volume":"24","author":"Hasel","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.10.014_bib139","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.immuni.2022.03.018","article-title":"Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid beta plaques","volume":"55","author":"Roy","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.neuron.2023.10.014_bib140","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2015.08.069","article-title":"Lack of neuronal IFN-beta-IFNAR causes Lewy body- and Parkinson's disease-like dementia","volume":"163","author":"Ejlerskov","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib141","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106868","article-title":"IFN-beta rescues neurodegeneration by regulating mitochondrial fission via STAT5, PGAM5, and Drp1","volume":"40","author":"Tresse","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2023.10.014_bib142","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1523\/JNEUROSCI.0718-19.2019","article-title":"Aberrant ER stress induced neuronal-IFNbeta elicits white matter injury due to microglial activation and T-cell infiltration after TBI","volume":"40","author":"Sen","year":"2020","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.10.014_bib143","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/cns.14095","article-title":"PERK-STING-RIPK3 pathway facilitates cognitive impairment by inducing neuronal necroptosis in sepsis-associated encephalopathy","volume":"29","author":"Xiaofeng","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neuron.2023.10.014_bib144","doi-asserted-by":"crossref","first-page":"868484","DOI":"10.3389\/fnagi.2022.868484","article-title":"Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes\/TANK-binding kinase 1\/interferon regulatory factor 3 signaling","volume":"14","author":"Kang","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuron.2023.10.014_bib145","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41586-020-03151-1","article-title":"STING controls nociception via type I interferon signalling in sensory neurons","volume":"591","author":"Donnelly","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib146","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s11481-021-10031-6","article-title":"STING\/NF-\u03baB\/IL-6-mediated inflammation in microglia contributes to spared nerve injury (SNI)-induced pain initiation","volume":"17","author":"Sun","year":"2022","journal-title":"J.\u00a0Neuroimmune Pharmacol."},{"key":"10.1016\/j.neuron.2023.10.014_bib147","doi-asserted-by":"crossref","first-page":"109206","DOI":"10.1016\/j.neuropharm.2022.109206","article-title":"Pharmacological inhibition of the cGAS-STING signaling pathway suppresses microglial M1-polarization in the spinal cord and attenuates neuropathic pain","volume":"217","author":"Wu","year":"2022","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuron.2023.10.014_bib148","article-title":"STING contributes to cancer-induced bone pain by promoting M1 polarization of microglia in the medial prefrontal cortex","volume":"14","author":"Zhang","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.neuron.2023.10.014_bib149","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12974-023-02783-0","article-title":"STING controls opioid-induced itch and chronic itch via spinal tank-binding kinase 1-dependent type I interferon response in mice","volume":"20","author":"Li","year":"2023","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.neuron.2023.10.014_bib150","doi-asserted-by":"crossref","first-page":"16488","DOI":"10.1038\/s41598-022-20889-y","article-title":"Increased type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer's disease","volume":"12","author":"Jana","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2023.10.014_bib151","doi-asserted-by":"crossref","first-page":"2002117","DOI":"10.1002\/advs.202002117","article-title":"Deficiency of STING signaling in embryonic cerebral cortex leads to neurogenic abnormalities and autistic-like behaviors","volume":"7","author":"Zhang","year":"2020","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.neuron.2023.10.014_bib152","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/s41590-019-0433-y","article-title":"Mechanisms of immunotherapy resistance: lessons from glioblastoma","volume":"20","author":"Jackson","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib153","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ccell.2022.04.009","article-title":"Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition","volume":"40","author":"Low","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib154","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022111961","article-title":"DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma","volume":"42","author":"Taffoni","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2023.10.014_bib155","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2111003119","article-title":"STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models","volume":"119","author":"Berger","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.10.014_bib156","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1158\/1078-0432.CCR-21-1914","article-title":"Intratumoral delivery of STING agonist results in clinical responses in canine glioblastoma","volume":"27","author":"Boudreau","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.neuron.2023.10.014_bib157","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1039\/D0NH00446D","article-title":"Immunostimulatory silica nanoparticle boosts innate immunity in brain tumors","volume":"6","author":"Bielecki","year":"2021","journal-title":"Nanoscale Horiz."},{"key":"10.1016\/j.neuron.2023.10.014_bib158","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41467-023-37328-9","article-title":"STING agonist-loaded, CD47\/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.10.014_bib159","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1038\/s41467-023-36878-2","article-title":"Checkpoint kinase 1\/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade","volume":"14","author":"Dmello","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.10.014_bib160","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1038\/s41467-020-15129-8","article-title":"Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity","volume":"11","author":"von Roemeling","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.10.014_bib161","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1158\/0008-5472.CAN-22-3382","article-title":"PP2Ac deficiency enhances tumor immunogenicity by activating STING-type I interferon signaling in glioblastoma","volume":"83","author":"Mondal","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.neuron.2023.10.014_bib162","doi-asserted-by":"crossref","DOI":"10.1172\/JCI149258","article-title":"Tumor treating fields dually activate STING and AIM2 inflammasomes to induce adjuvant immunity in glioblastoma","volume":"132","author":"Chen","year":"2022","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2023.10.014_bib163","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41572-018-0055-y","article-title":"Brain metastases","volume":"5","author":"Achrol","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.neuron.2023.10.014_bib164","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41568-019-0220-y","article-title":"Brain metastasis","volume":"20","author":"Boire","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.neuron.2023.10.014_bib165","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature18268","article-title":"Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer","volume":"533","author":"Chen","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib166","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1038\/s41467-023-38252-8","article-title":"Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment","volume":"14","author":"Ma","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.10.014_bib167","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1093\/brain\/awaa246","article-title":"Mitochondrial damage-associated inflammation highlights biomarkers in PRKN\/PINK1 parkinsonism","volume":"143","author":"Borsche","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2023.10.014_bib168","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ana.410410211","article-title":"Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques","volume":"41","author":"Ginsberg","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuron.2023.10.014_bib169","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s004010050923","article-title":"RNA sequestration to pathological lesions of neurodegenerative diseases","volume":"96","author":"Ginsberg","year":"1998","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2023.10.014_bib170","doi-asserted-by":"crossref","first-page":"14550","DOI":"10.1073\/pnas.1206923109","article-title":"Nucleic acid-containing amyloid fibrils potently induce type I interferon and stimulate systemic autoimmunity","volume":"109","author":"Di Domizio","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.10.014_bib171","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1172\/JCI133737","article-title":"Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease","volume":"130","author":"Roy","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2023.10.014_bib172","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11051375","article-title":"STING-triggered CNS inflammation in human neurodegenerative diseases","volume":"11","author":"Ferecsk\u00f3","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.neuron.2023.10.014_bib173","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1111\/cns.14157","article-title":"Microglial cGAS drives neuroinflammation in the MPTP mouse models of Parkinson's disease","volume":"29","author":"Ma","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neuron.2023.10.014_bib174","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.neurobiolaging.2013.10.089","article-title":"Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease","volume":"35","author":"Taylor","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2023.10.014_bib175","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1002\/glia.23028","article-title":"Type-1 interferons contribute to the neuroinflammatory response and disease progression of the MPTP mouse model of Parkinson's disease","volume":"64","author":"Main","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.neuron.2023.10.014_bib176","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0128-15.2016","article-title":"Ablation of type-1 IFN signaling in hematopoietic cells confers protection following traumatic brain injury","volume":"3","author":"Karve","year":"2016","journal-title":"eNeuro"},{"key":"10.1016\/j.neuron.2023.10.014_bib177","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1038\/s41467-020-19737-2","article-title":"Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease","volume":"11","author":"Olah","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.10.014_bib178","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1080\/13543776.2022.2144220","article-title":"Recent advances in the development of STING inhibitors: an updated patent review","volume":"32","author":"Shen","year":"2022","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.neuron.2023.10.014_bib179","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS-STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib180","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41586-018-0287-8","article-title":"Targeting STING with covalent small-molecule inhibitors","volume":"559","author":"Haag","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib181","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/jnc.15678","article-title":"STING mediates neuroinflammatory response by activating NLRP3-related pyroptosis in severe traumatic brain injury","volume":"162","author":"Zhang","year":"2022","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuron.2023.10.014_bib182","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12974-020-01830-4","article-title":"Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage","volume":"17","author":"Peng","year":"2020","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.neuron.2023.10.014_bib183","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41586-022-04559-7","article-title":"Activation of STING by targeting a pocket in the transmembrane domain","volume":"604","author":"Lu","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib184","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1126\/science.adf8974","article-title":"Human STING is a proton channel","volume":"381","author":"Liu","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.10.014_bib185","article-title":"A conserved ion channel function of STING mediates non-canonical autophagy and cell death","author":"Xun","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.neuron.2023.10.014_bib186","doi-asserted-by":"crossref","first-page":"6593","DOI":"10.1021\/acs.jmedchem.1c01948","article-title":"Novel CRBN-recruiting proteolysis-targeting chimeras as degraders of stimulator of interferon genes with in\u00a0vivo anti-inflammatory efficacy","volume":"65","author":"Liu","year":"2022","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.neuron.2023.10.014_bib187","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.molcel.2019.09.009","article-title":"AUTACs: cargo-specific degraders using selective autophagy","volume":"76","author":"Takahashi","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neuron.2023.10.014_bib188","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2105465118","article-title":"STING inhibitors target the cyclic dinucleotide binding pocket","volume":"118","author":"Hong","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.10.014_bib189","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41586-019-0998-5","article-title":"Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP","volume":"567","author":"Shang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.014_bib190","doi-asserted-by":"crossref","first-page":"776","DOI":"10.4049\/jimmunol.1601585","article-title":"The Common R71H-G230A-R293Q human TMEM173 is a null allele","volume":"198","author":"Patel","year":"2017","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.neuron.2023.10.014_bib191","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/gene.2010.75","article-title":"Identification and characterization of a loss-of-function human MPYS variant","volume":"12","author":"Jin","year":"2011","journal-title":"Genes Immun."},{"key":"10.1016\/j.neuron.2023.10.014_bib192","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077846","article-title":"Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides","volume":"8","author":"Yi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2023.10.014_bib193","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41435-018-0029-9","article-title":"TMEM173 variants and potential importance to human biology and disease","volume":"20","author":"Patel","year":"2019","journal-title":"Genes Immun."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089662732300795X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089662732300795X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:48:36Z","timestamp":1760255316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089662732300795X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":193,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S089662732300795X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2023.10.014","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2023.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}