{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:23:02Z","timestamp":1792815782690,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG047644"],"award-info":[{"award-number":["AG047644"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS090934"],"award-info":[{"award-number":["NS090934"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U19AG069701"],"award-info":[{"award-number":["1U19AG069701"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.neuron.2023.10.023","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T10:45:53Z","timestamp":1700649953000},"page":"384-403.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":172,"title":["Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist"],"prefix":"10.1016","volume":"112","author":[{"given":"Alexandra","family":"Litvinchuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung H.","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing L.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonnet S.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nga","family":"Bien-Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Tycksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Travis","family":"Tabor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Remolina Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Manis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choonghee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enmanuel J.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla M.","family":"Yuede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil G.","family":"Cashikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Di Paolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2023.10.023_bib1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006312","article-title":"Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease","volume":"2","author":"Holtzman","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.neuron.2023.10.023_bib2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/s41577-018-0051-1","article-title":"Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight","volume":"18","author":"Shi","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neuron.2023.10.023_bib3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41593-019-0566-1","article-title":"Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain","volume":"23","author":"Marschallinger","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.10.023_bib4","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.neuron.2019.12.007","article-title":"TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge","volume":"105","author":"Nugent","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.023_bib5","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1016\/j.cell.2021.08.002","article-title":"Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic","volume":"184","author":"Logan","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.10.023_bib6","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.cell.2022.05.017","article-title":"Cholesterol and matrisome pathways dysregulated in astrocytes and microglia","volume":"185","author":"TCW","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.10.023_bib7","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.stem.2022.07.005","article-title":"Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity","volume":"29","author":"Victor","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neuron.2023.10.023_bib8","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.neuron.2018.05.008","article-title":"APOE4 causes widespread molecular and cellular alterations associated with Alzheimer\u2019s disease phenotypes in human iPSC-derived brain cell types","volume":"98","author":"Lin","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.023_bib9","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41586-022-05439-w","article-title":"APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes","volume":"611","author":"Blanchard","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.023_bib10","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1126\/science.aan4183","article-title":"Defective cholesterol clearance limits remyelination in the aged central nervous system","volume":"359","author":"Cantuti-Castelvetri","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.10.023_bib11","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.neuron.2020.09.029","article-title":"Emerging microglia biology defines novel therapeutic approaches for Alzheimer\u2019s disease","volume":"108","author":"Lewcock","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.023_bib12","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1016\/j.neuron.2022.10.015","article-title":"Microglial efferocytosis: diving into the Alzheimer\u2019s disease gene pool","volume":"110","author":"Romero-Molina","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.023_bib13","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1038\/s41588-022-01208-7","article-title":"Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer \u2019 s disease","volume":"54","author":"Holstege","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2023.10.023_bib14","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1523\/JNEUROSCI.4315-03.2004","article-title":"Neuron-specific apolipoprotein E4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice","volume":"24","author":"Brecht","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.10.023_bib15","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1073\/pnas.0812697106","article-title":"Apolipoprotein E \u03b54 is associated with disease-specific effects on brain\u00a0atrophy\u00a0in Alzheimer\u2019s disease and frontotemporal dementia","volume":"106","author":"Agosta","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.10.023_bib16","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature24016","article-title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","volume":"549","author":"Shi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.023_bib17","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1084\/jem.20190980","article-title":"Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model","volume":"216","author":"Shi","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neuron.2023.10.023_bib18","first-page":"1","article-title":"TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4","author":"Gratuze","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.023_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/science.add1236","article-title":"ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy","volume":"379","author":"Seo","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.10.023_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41593-021-00801-z","article-title":"Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia","volume":"24","author":"Dong","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.10.023_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.aaz4564","article-title":"APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia","volume":"13","author":"Sienski","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuron.2023.10.023_bib22","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41582-018-0058-z","article-title":"Neurofilaments as biomarkers in neurological disorders","volume":"14","author":"Khalil","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuron.2023.10.023_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.aag0481","article-title":"Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy","volume":"9","author":"DeVos","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuron.2023.10.023_bib24","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.neuron.2021.03.024","article-title":"Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia","volume":"109","author":"Wang","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.023_bib25","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/ana.26043","article-title":"Apolipoprotein E4 reduction with antisense oligonucleotides decreases neurodegeneration in a tauopathy model","volume":"89","author":"Litvinchuk","year":"2021","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuron.2023.10.023_bib26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1073\/pnas.98.2.507","article-title":"LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes","volume":"98","author":"Laffitte","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.10.023_bib27","doi-asserted-by":"crossref","first-page":"34144","DOI":"10.1074\/jbc.M110.108100","article-title":"ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein\/presenilin 1 mice","volume":"285","author":"Donkin","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2023.10.023_bib28","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.023_bib29","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.neuron.2018.10.031","article-title":"Complement C3aR inactivation attenuates tau pathology and reverses an immune network deregulated in tauopathy models and Alzheimer\u2019s disease","volume":"100","author":"Litvinchuk","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.023_bib30","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1093\/brain\/awz241","article-title":"CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice","volume":"142","author":"Mancuso","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2023.10.023_bib31","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41586-023-05788-0","article-title":"Microglia-mediated T\u00a0cell infiltration drives neurodegeneration in tauopathy","volume":"615","author":"Chen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.023_bib32","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2023.10.023_bib33","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neuron.2023.10.023_bib34","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","article-title":"The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases","volume":"47","author":"Krasemann","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.neuron.2023.10.023_bib35","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer\u2019s disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2023.10.023_bib36","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41593-020-0624-8","article-title":"Disease-associated astrocytes in Alzheimer\u2019s disease and aging","volume":"23","author":"Habib","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.10.023_bib37","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.neuron.2023.10.023_bib38","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"ClusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS A J. Integr. Biol."},{"key":"10.1016\/j.neuron.2023.10.023_bib39","first-page":"671","article-title":"Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease","volume":"118","author":"Wahrle","year":"2008","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2023.10.023_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-022-01881-6","article-title":"Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice","volume":"12","author":"Miranda","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuron.2023.10.023_bib41","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-022-00547-7","article-title":"Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia","volume":"17","author":"Xia","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuron.2023.10.023_bib42","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.tcb.2022.09.006","article-title":"Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia","volume":"33","author":"Simon","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.neuron.2023.10.023_bib43","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1074\/jbc.M111.274142","article-title":"Comparative lipidomic analysis of mouse and human brain with Alzheimer disease","volume":"287","author":"Chan","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2023.10.023_bib44","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.023_bib45","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41593-020-0650-6","article-title":"Alzheimer\u2019s-associated PLC\u03b32 is a signaling node required for both TREM2 function and the inflammatory response in human microglia","volume":"23","author":"Andreone","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2023.10.023_bib46","doi-asserted-by":"crossref","first-page":"10601","DOI":"10.1073\/pnas.0701096104","article-title":"Attenuation of neuroinflammation and Alzheimer\u2019s disease pathology by liver X receptors","volume":"104","author":"Zelcer","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2023.10.023_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172161","article-title":"Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice","volume":"12","author":"Carter","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2023.10.023_bib48","doi-asserted-by":"crossref","first-page":"7293","DOI":"10.1523\/JNEUROSCI.5198-13.2014","article-title":"Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene","volume":"34","author":"Boehm-Cagan","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.10.023_bib49","doi-asserted-by":"crossref","first-page":"6862","DOI":"10.1523\/JNEUROSCI.1051-10.2010","article-title":"Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice","volume":"30","author":"Fitz","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.10.023_bib50","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1194\/jlr.M800376-JLR200","article-title":"Synthetic LXR agonist attenuates plaque formation in apoE-\/-mice without inducing liver steatosis and hypertriglyceridemia","volume":"50","author":"Kratzer","year":"2009","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.neuron.2023.10.023_bib51","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nm820","article-title":"Reciprocal regulation of inflammation and lipid metabolism by liver X receptors","volume":"9","author":"Joseph","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2023.10.023_bib52","doi-asserted-by":"crossref","first-page":"6520","DOI":"10.4049\/jimmunol.1201393","article-title":"Reciprocal negative cross-talk between liver X receptors (LXRs) and STAT1: effects on IFN-\u03b3-induced inflammatory responses and LXR-dependent gene expression","volume":"190","author":"Pascual-Garc\u00eda","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.neuron.2023.10.023_bib53","article-title":"Microglial NF-\u03baB drives tau spreading and toxicity in a mouse model of tauopathy","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2023.10.023_bib54","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yexcr.2004.01.002","article-title":"Interleukin-6 induces Alzheimer-type phosphorylation of Tau protein by deregulating the cdk5\/p35 pathway","volume":"295","author":"Quintanilla","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.neuron.2023.10.023_bib55","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1523\/JNEUROSCI.23-05-01605.2003","article-title":"Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway","volume":"23","author":"Li","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2023.10.023_bib56","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41586-019-1769-z","article-title":"NLRP3 inflammasome activation drives tau pathology","volume":"575","author":"Ising","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2023.10.023_bib60","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-019-0337-1","article-title":"Lack of hepatic apoE does not influence early A\u03b2 deposition: observations from a new APOE knock-in model","volume":"14","author":"Huynh","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuron.2023.10.023_bib58","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nprot.2006.170","article-title":"Assessing nest building in mice","volume":"1","author":"Deacon","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuron.2023.10.023_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011374","article-title":"Behavioral consequences of NMDA antagonist-induced neuroapoptosis in the infant mouse brain","volume":"5","author":"Yuede","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2023.10.023_bib61","doi-asserted-by":"crossref","DOI":"10.3791\/56322-v","article-title":"In\u00a0vitro phagocytosis of myelin debris by bone marrow-derived macrophages","author":"Rolfe","year":"2017","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.neuron.2023.10.023_bib62","doi-asserted-by":"crossref","DOI":"10.3791\/51482-v","article-title":"An engulfment assay: A protocol to assess interactions between CNS phagocytes and neurons","author":"Schafer","year":"2014","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.neuron.2023.10.023_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.121109","article-title":"Concurrent cell type\u2013specific isolation and profiling of mouse brains in inflammation and Alzheimer\u2019s disease","volume":"3","author":"Swartzlander","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.neuron.2023.10.023_bib64","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-015-0844-5","article-title":"MAST: A flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data","volume":"16","author":"Finak","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.neuron.2023.10.023_bib65","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2023.10.023_bib66","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"FeatureCounts: an efficient general\u00a0purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2023.10.023_bib67","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon: fast and bias-aware quantification of transcript expression using dual-phase inference","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2023.10.023_bib68","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1093\/bioinformatics\/bts356","article-title":"RSeQC: quality control of RNA-seq experiments","volume":"28","author":"Wang","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2023.10.023_bib69","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: A Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2023.10.023_bib70","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuron.2023.10.023_bib71","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1371\/journal.pgen.0030161","article-title":"Capturing heterogeneity in gene expression studies by surrogate variable analysis","volume":"3","author":"Leek","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neuron.2023.10.023_bib72","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-10-161","article-title":"GAGE: generally applicable gene set enrichment for pathway analysis","volume":"10","author":"Luo","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.neuron.2023.10.023_bib73","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/986048","article-title":"Advanced heat map and clustering analysis using Heatmap3","volume":"2014","author":"Zhao","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.neuron.2023.10.023_bib74","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/bioinformatics\/btt285","article-title":"Pathview: an R\/Bioconductor package for pathway-based data integration and visualization","volume":"29","author":"Luo","year":"2013","journal-title":"Bioinformatics"}],"updated-by":[{"DOI":"10.1016\/j.neuron.2024.05.021","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000}}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627323008048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627323008048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T20:03:46Z","timestamp":1738872226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627323008048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":73,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S0896627323008048"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2023.10.023","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2023.10.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}