{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:48:11Z","timestamp":1791578891432,"version":"4.3.4"},"reference-count":88,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","award":["629287"],"award-info":[{"award-number":["629287"]}],"id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018074","name":"University of California San Francisco Weill Institute for Neurosciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32 MH125536"],"award-info":[{"award-number":["F32 MH125536"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH125978"],"award-info":[{"award-number":["R01 MH125978"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99 MH135209"],"award-info":[{"award-number":["K99 MH135209"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008484","name":"BioMarin Pharmaceutical Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008484","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100028885","name":"FamilieSCN2A Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100028885","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014370","name":"Simons Foundation Autism Research Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.neuron.2024.01.029","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T10:34:02Z","timestamp":1708943642000},"page":"1444-1455.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD"],"prefix":"10.1016","volume":"112","author":[{"given":"Chenyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly D.","family":"Derderian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Kyoung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadav","family":"Ahituv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Bouvier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-1532","authenticated-orcid":false,"given":"Kevin J.","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2024.01.029_bib1","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s10803-006-0218-7","article-title":"Describing the sensory abnormalities of children and adults with autism","volume":"37","author":"Leekam","year":"2007","journal-title":"J.\u00a0Autism Dev. Disord."},{"key":"10.1016\/j.neuron.2024.01.029_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bandc.2005.12.013","article-title":"Tactile sensitivity in Asperger syndrome","volume":"61","author":"Blakemore","year":"2006","journal-title":"Brain Cogn."},{"key":"10.1016\/j.neuron.2024.01.029_bib3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.5014\/ajot.61.2.190","article-title":"Sensory processing in children with and without autism: a comparative study using the short sensory profile","volume":"61","author":"Tomchek","year":"2007","journal-title":"Am. J. Occup. Ther."},{"key":"10.1016\/j.neuron.2024.01.029_bib4","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s10803-009-0711-x","article-title":"Brief report: Sensory abnormalities as distinguishing symptoms of autism spectrum disorders in young children","volume":"39","author":"Wiggins","year":"2009","journal-title":"J.\u00a0Autism Dev. Disord."},{"key":"10.1016\/j.neuron.2024.01.029_bib5","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s41593-020-0598-6","article-title":"Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD","volume":"23","author":"Chen","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib6","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrn.2017.112","article-title":"Sensory perception in autism","volume":"18","author":"Robertson","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib7","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.neuron.2019.09.040","article-title":"Combinatorial Targeting of Distributed Forebrain Networks Reverses Noise Hypersensitivity in a Model of Autism Spectrum Disorder","volume":"104","author":"Nakajima","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.01.029_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11920-019-1122-0","article-title":"Mechanisms of Tactile Sensory Phenotypes in Autism: Current Understanding and Future Directions for Research","volume":"21","author":"Schaffler","year":"2019","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.neuron.2024.01.029_bib9","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.cell.2019.07.024","article-title":"Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models","volume":"178","author":"Orefice","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.01.029_bib10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/aur.1642","article-title":"Vestibulo-ocular reflex function in children with high-functioning autism spectrum disorders","volume":"10","author":"Carson","year":"2017","journal-title":"Autism Res."},{"key":"10.1016\/j.neuron.2024.01.029_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fnint.2021.743561","article-title":"Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder","volume":"15","author":"Mansour","year":"2021","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib12","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/aur.1481","article-title":"Visual and Vestibular Induced Eye Movements in Verbal Children and Adults with Autism","volume":"8","author":"Furman","year":"2015","journal-title":"Autism Res."},{"key":"10.1016\/j.neuron.2024.01.029_bib13","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.cell.2019.12.036","article-title":"Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism","volume":"180","author":"Satterstrom","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.01.029_bib14","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/s41588-022-01104-0","article-title":"Rare coding variation provides insight into the genetic architecture and phenotypic context of autism","volume":"54","author":"Fu","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2024.01.029_bib15","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.tins.2018.03.011","article-title":"Progress in Understanding and Treating SCN2A-Mediated Disorders","volume":"41","author":"Sanders","year":"2018","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib16","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.neuron.2019.05.037","article-title":"The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex","volume":"103","author":"Spratt","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.01.029_bib17","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1126\/science.1187958","article-title":"Molecular Identity of Dendritic Voltage-Gated Sodium Channels","volume":"328","author":"Lorincz","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.neuron.2024.01.029_bib18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12311-012-0387-1","article-title":"Polarised Localisation of the Voltage-Gated Sodium Channel Nav1.2 in Cerebellar Granule Cells","volume":"12","author":"Mart\u00ednez-Hern\u00e1ndez","year":"2013","journal-title":"Cerebellum"},{"key":"10.1016\/j.neuron.2024.01.029_bib19","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nn.2359","article-title":"Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation","volume":"12","author":"Hu","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib20","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.celrep.2013.03.023","article-title":"Silencing the Majority of Cerebellar Granule Cells Uncovers Their Essential Role in Motor Learning and Consolidation","volume":"3","author":"Galliano","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2024.01.029_bib21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0896-6273(00)80990-3","article-title":"Expression of a protein kinase C inhibitor in purkinje cells blocks cerebellar LTD and adaptation of the vestibulo-ocular reflex","volume":"20","author":"De Zeeuw","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.01.029_bib22","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.neuron.2006.08.026","article-title":"Selective Engagement of Plasticity Mechanisms for Motor Memory Storage","volume":"51","author":"Boyden","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.01.029_bib23","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.neuron.2010.07.009","article-title":"Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning","volume":"67","author":"Schonewille","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.01.029_bib24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41583-020-00392-x","article-title":"Bidirectional learning in upbound and downbound microzones of the cerebellum","volume":"22","author":"De Zeeuw","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib25","doi-asserted-by":"crossref","first-page":"7979","DOI":"10.1523\/JNEUROSCI.2215-05.2005","article-title":"The site of a motor memory shifts with consolidation","volume":"25","author":"Kassardjian","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib26","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.neuroscience.2005.12.035","article-title":"Memory trace of motor learning shifts transsynaptically from cerebellar cortex to nuclei for consolidation","volume":"139","author":"Shutoh","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2024.01.029_bib27","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1113\/JP274346","article-title":"Mechanisms underlying vestibulo-cerebellar motor learning in mice depend on movement direction","volume":"595","author":"Voges","year":"2017","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2024.01.029_bib28","doi-asserted-by":"crossref","first-page":"36131","DOI":"10.1038\/srep36131","article-title":"Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments","volume":"6","author":"Badura","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2024.01.029_bib29","doi-asserted-by":"crossref","first-page":"11065","DOI":"10.1523\/JNEUROSCI.2162-07.2007","article-title":"Reduced Sodium Current in Purkinje Neurons from NaV1.1 Mutant Mice: Implications for Ataxia in Severe Myoclonic Epilepsy in Infancy","volume":"27","author":"Kalume","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/(SICI)1096-9861(20000619)422:1<123::AID-CNE8>3.0.CO;2-X","article-title":"Distribution of voltage-gated sodium channel \u03b1-subunit and \u03b2-subunit mRNAs in human hippocampal formation, cortex, and cerebellum","volume":"422","author":"Whitaker","year":"2000","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2024.01.029_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4522(02)00943-0","article-title":"Differential distribution of vesicular glutamate transporters in the rat cerebellar cortex","volume":"117","author":"Hioki","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2024.01.029_bib32","doi-asserted-by":"crossref","first-page":"e02076","DOI":"10.7554\/eLife.02076","article-title":"Gating of neural error signals during motor learning","volume":"3","author":"Kimpo","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2024.01.029_bib33","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1523\/JNEUROSCI.0731-22.2022","article-title":"Expression of a Form of Cerebellar Motor Memory Requires Learned Alterations to the Activity of Inhibitory Molecular Layer Interneurons","volume":"43","author":"Bonnan","year":"2023","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib34","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0896-6273(00)80099-9","article-title":"Cyclic AMP mediates a presynaptic form of LTP at cerebellar parallel fiber synapses","volume":"16","author":"Salin","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.01.029_bib35","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1523\/JNEUROSCI.5252-10.2011","article-title":"Calcium Microdomains Near R-Type Calcium Channels Control the Induction of Presynaptic Long-Term Potentiation at Parallel Fiber to Purkinje Cell Synapses","volume":"31","author":"Myoga","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib36","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nn.2791","article-title":"D-Serine regulates cerebellar LTD and motor coordination through the \u03b42 glutamate receptor","volume":"14","author":"Kakegawa","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib37","doi-asserted-by":"crossref","first-page":"14126","DOI":"10.1073\/pnas.0904284106","article-title":"Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule","volume":"106","author":"Bidoret","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2024.01.029_bib38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0896-6273(01)00568-2","article-title":"Involvement of Presynaptic N-Methyl-D-Aspartate Receptors in Cerebellar Long-Term Depression","volume":"33","author":"Casado","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.01.029_bib39","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0896-6273(00)80969-1","article-title":"Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice","volume":"19","author":"Raman","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.01.029_bib40","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nature02442","article-title":"Integration of quanta in cerebellar granule cells during sensory processing","volume":"428","author":"Chadderton","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.01.029_bib41","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12916","article-title":"Multimodal sensory integration in single cerebellar granule cells in\u00a0vivo","volume":"4","author":"Ishikawa","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2024.01.029_bib42","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.neuron.2016.11.046","article-title":"Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3","volume":"93","author":"Gutierrez-Castellanos","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.01.029_bib43","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2102635118","article-title":"NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning","volume":"118","author":"Schonewille","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2024.01.029_bib44","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.celrep.2016.03.004","article-title":"Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors","volume":"15","author":"Bouvier","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2024.01.029_bib45","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.neuron.2018.07.024","article-title":"Graded Control of Climbing-Fiber-Mediated Plasticity and Learning by Inhibition in the Cerebellum","volume":"99","author":"Rowan","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.01.029_bib46","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nn.3678","article-title":"A supercritical density of Na+ channels ensures fast signaling in GABAergic interneuron axons","volume":"17","author":"Hu","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib47","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.neuron.2015.02.013","article-title":"Control of inhibitory synaptic outputs by low excitability of axon terminals revealed by direct recording","volume":"85","author":"Kawaguchi","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.01.029_bib48","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/gene.10204","article-title":"Cerebellar granule cell Cre recombinase expression","volume":"36","author":"Aller","year":"2003","journal-title":"Genesis"},{"key":"10.1016\/j.neuron.2024.01.029_bib49","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fnmol.2019.00145","article-title":"Scn2a haploinsufficiency in mice suppresses hippocampal neuronal excitability, excitatory synaptic drive, and long-term potentiation, and spatial learning and memory","volume":"12","author":"Shin","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib50","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/s41593-018-0163-8","article-title":"Altered hippocampal replay is associated with memory impairment in mice heterozygous for the scn2a gene","volume":"21","author":"Middleton","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib51","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12725","article-title":"Generation and basic characterization of a gene-trap knockout mouse model of Scn2a with a substantial reduction of voltage-gated sodium channel Nav1.2 expression","volume":"20","author":"Eaton","year":"2021","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.neuron.2024.01.029_bib52","article-title":"CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder","author":"Tamura","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.neuron.2024.01.029_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau0629","article-title":"CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency","volume":"363","author":"Matharu","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.neuron.2024.01.029_bib54","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ajo.2020.08.048","article-title":"Prevalence of Ophthalmologic Diagnoses in Children With Autism Spectrum Disorder Using the Optum Dataset: APopulation-Based Study","volume":"221","author":"Chang","year":"2021","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.neuron.2024.01.029_bib55","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1023\/A:1005631225367","article-title":"Evidence of Normal Cerebellar Control of the Vestibulo-Ocular Reflex (VOR) in Children with High-Functioning Autism","volume":"30","author":"Goldberg","year":"2000","journal-title":"J.\u00a0Autism Dev. Disord."},{"key":"10.1016\/j.neuron.2024.01.029_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci10110887","article-title":"Vestibular Functioning in Children with Neurodevelopmental Disorders Using the Functional Head Impulse Test","volume":"10","author":"Caldani","year":"2020","journal-title":"Brain Sci."},{"key":"10.1016\/j.neuron.2024.01.029_bib57","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1055\/s-2008-1052354","article-title":"Development of the dynamic characteristics of the horizontal vestibulo-ocular reflex in infancy","volume":"15","author":"Cioni","year":"1984","journal-title":"Neuropediatrics."},{"key":"10.1016\/j.neuron.2024.01.029_bib58","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1212\/WNL.39.4.534","article-title":"Maturation of the vestibulo-ocular reflex in normal infants during the first 2\u00a0months of life","volume":"39","author":"Weissman","year":"1989","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2024.01.029_bib59","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-069500","article-title":"Diagnostic delay in children with neurodevelopmental conditions attending a publicly funded developmental assessment service: findings from the Sydney Child Neurodevelopment Research Registry","volume":"13","author":"Boulton","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.neuron.2024.01.029_bib60","article-title":"Identification, evaluation, and management of children with autism spectrum disorder","volume":"145","author":"Hyman","year":"2020","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuron.2024.01.029_bib61","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0166-4328(84)90163-3","article-title":"Development of vertical vestibulo-ocular reflex characteristics in intact and flocculectomized rabbits visually deprived from birth","volume":"13","author":"Favilla","year":"1984","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuron.2024.01.029_bib62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF00238748","article-title":"The eye movements of the dark-reared cat","volume":"44","author":"Harris","year":"1981","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neuron.2024.01.029_bib63","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1152\/jn.2001.85.3.1119","article-title":"Visual Influences on the Development and Recovery of the Vestibuloocular Reflex in the Chicken","volume":"85","author":"Goode","year":"2001","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2024.01.029_bib64","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neuropharm.2007.05.029","article-title":"Timing dependence of the induction of cerebellar LTD","volume":"54","author":"Safo","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuron.2024.01.029_bib65","doi-asserted-by":"crossref","first-page":"9620","DOI":"10.1523\/JNEUROSCI.23-29-09620.2003","article-title":"Receptive Field Plasticity Profoundly Alters the Cutaneous Parallel Fiber Synaptic Input to Cerebellar Interneurons In\u00a0Vivo","volume":"23","author":"J\u00f6rntell","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib66","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nn1698","article-title":"Synapse-specific plasticity and compartmentalized signaling in cerebellar stellate cells","volume":"9","author":"Soler-Llavina","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib67","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nature11310","article-title":"Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice","volume":"488","author":"Tsai","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.01.029_bib68","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.celrep.2018.09.039","article-title":"Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors","volume":"25","author":"Tsai","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2024.01.029_bib69","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1176\/jnp.16.3.367","article-title":"Disorders of the Cerebellum: Ataxia, Dysmetria of Thought, and the Cerebellar Cognitive Affective Syndrome","volume":"16","author":"Schmahmann","year":"2004","journal-title":"J.\u00a0Neuropsychiatr."},{"key":"10.1016\/j.neuron.2024.01.029_bib70","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neulet.2018.07.005","article-title":"The cerebellum and cognition","volume":"688","author":"Schmahmann","year":"2019","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.neuron.2024.01.029_bib71","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1080\/14734220701490995","article-title":"The neuropsychiatry of the cerebellum - Insights from the clinic","volume":"6","author":"Schmahmann","year":"2007","journal-title":"Cerebellum"},{"key":"10.1016\/j.neuron.2024.01.029_bib72","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/s41593-020-0665-z","article-title":"Regulation of autism-relevant behaviors by cerebellar\u2013prefrontal cortical circuits","volume":"23","author":"Kelly","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib73","doi-asserted-by":"crossref","first-page":"20302","DOI":"10.1073\/pnas.1311686110","article-title":"T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learning","volume":"110","author":"Ly","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2024.01.029_bib74","doi-asserted-by":"crossref","first-page":"108932","DOI":"10.1016\/j.celrep.2021.108932","article-title":"The autism-associated protein CHD8 is required for cerebellar development and motor function","volume":"35","author":"Kawamura","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2024.01.029_bib75","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fnsys.2013.00083","article-title":"New roles for the cerebellum in health and disease","volume":"7","author":"Reeber","year":"2013","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib76","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.36401","article-title":"Normal cognitive and social development require posterior cerebellar activity","volume":"7","author":"Badura","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2024.01.029_bib77","doi-asserted-by":"crossref","first-page":"e06085","DOI":"10.7554\/eLife.06085","article-title":"Cerebellar associative sensory learning defects in five mouse autism models","volume":"4","author":"Kloth","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2024.01.029_bib78","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.1038\/ncomms6586","article-title":"Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism","volume":"5","author":"Piochon","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2024.01.029_bib79","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1093\/brain\/awx054","article-title":"Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders","volume":"140","author":"Wolff","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2024.01.029_bib80","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1016\/S0006-3495(00)76829-9","article-title":"Neuronal death and perinatal lethality in voltage-gated sodium channel \u03b1(II)-deficient mice","volume":"78","author":"Planells-Cases","year":"2000","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuron.2024.01.029_bib81","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/s41593-018-0209-y","article-title":"DeepLabCut: markerless pose estimation of user-defined body parts with deep learning","volume":"21","author":"Mathis","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.01.029_bib82","article-title":"Solving the spike sorting problem with Kilosort","author":"Pachitariu","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.neuron.2024.01.029_bib83","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.neuron.2020.07.004","article-title":"Head movements control the activity of primary visual cortex in a luminance-dependent manner","volume":"108","author":"Bouvier","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.01.029_bib84","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nature19818","article-title":"Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour","volume":"538","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.01.029_bib85","doi-asserted-by":"crossref","first-page":"9417","DOI":"10.1073\/pnas.94.17.9417","article-title":"Directing gene expression to cerebellar granule cells using \u03b3-aminobutyric acid type A receptor \u03b16 subunit transgenes","volume":"94","author":"Bahn","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2024.01.029_bib86","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/laban0511-155","article-title":"Retro-orbital injections in mice","volume":"40","author":"Yardeni","year":"2011","journal-title":"Lab Anim. (NY)"},{"key":"10.1016\/j.neuron.2024.01.029_bib87","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71464","article-title":"Cerebellum encodes and influences the initiation, performance, and termination of discontinuous movements in mice","volume":"11","author":"Gaffield","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2024.01.029_bib88","doi-asserted-by":"crossref","first-page":"e57669","DOI":"10.1371\/journal.pone.0057669","article-title":"Probabilistic Identification of Cerebellar Cortical Neurones across Species","volume":"8","author":"van Dijck","year":"2013","journal-title":"PLOS One"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627324000552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627324000552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T04:21:04Z","timestamp":1762316464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627324000552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":88,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S0896627324000552"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2024.01.029","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2024.01.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}