{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:13:18Z","timestamp":1793445198684,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":383,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000053","name":"NEI","doi-asserted-by":"publisher","award":["R01EY033994"],"award-info":[{"award-number":["R01EY033994"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"NEI","doi-asserted-by":"publisher","award":["K99EY033909"],"award-info":[{"award-number":["K99EY033909"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["RF1AG078352"],"award-info":[{"award-number":["RF1AG078352"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["R21 NS130265"],"award-info":[{"award-number":["R21 NS130265"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R33HL159949"],"award-info":[{"award-number":["R33HL159949"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["R21EY034696"],"award-info":[{"award-number":["R21EY034696"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["RG-1901-33218"],"award-info":[{"award-number":["RG-1901-33218"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010956","name":"State University of New York Upstate Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014434","name":"Irving Medical Center, Columbia University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.neuron.2024.03.011","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T10:47:16Z","timestamp":1712659636000},"page":"1978-1996.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin\/\u03b2-catenin signaling"],"prefix":"10.1016","volume":"112","author":[{"given":"Saptarshi","family":"Biswas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjid","family":"Shahriar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Bachay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panos","family":"Arvanitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Jamoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Brunken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5375-4143","authenticated-orcid":false,"given":"Dritan","family":"Agalliu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2024.03.011_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.preteyeres.2013.02.001","article-title":"Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions","volume":"34","author":"Klaassen","year":"2013","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.neuron.2024.03.011_bib2","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cell.2015.10.067","article-title":"Establishment and dysfunction of the blood-brain barrier","volume":"163","author":"Zhao","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.03.011_bib3","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.tins.2015.08.003","article-title":"The molecular constituents of the blood-brain barrier","volume":"38","author":"Chow","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2024.03.011_bib4","doi-asserted-by":"crossref","DOI":"10.1242\/dev.182279","article-title":"Neuronal and glial regulation of CNS angiogenesis and barriergenesis","volume":"147","author":"Biswas","year":"2020","journal-title":"Development"},{"key":"10.1016\/j.neuron.2024.03.011_bib5","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1167\/iovs.12-10825","article-title":"Loss of scotopic contrast sensitivity in the optomotor response of diabetic mice","volume":"54","author":"Umino","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuron.2024.03.011_bib6","doi-asserted-by":"crossref","DOI":"10.1167\/tvst.3.3.6","article-title":"Rodent hyperglycemia-induced inner retinal deficits are mirrored in human diabetes","volume":"3","author":"Pardue","year":"2014","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.neuron.2024.03.011_bib7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/nyas.12412","article-title":"Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment","volume":"1311","author":"Abcouwer","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuron.2024.03.011_bib8","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1167\/iovs.04-1361","article-title":"Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes","volume":"46","author":"Feit-Leichman","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuron.2024.03.011_bib9","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1126\/science.272.5265.1182","article-title":"Requirement for cholinergic synaptic transmission in the propagation of spontaneous retinal waves","volume":"272","author":"Feller","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.neuron.2024.03.011_bib10","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1523\/JNEUROSCI.18-11-04155.1998","article-title":"Direct participation of starburst amacrine cells in spontaneous rhythmic activities in the developing mammalian retina","volume":"18","author":"Zhou","year":"1998","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.03.011_bib11","doi-asserted-by":"crossref","first-page":"7672","DOI":"10.1523\/JNEUROSCI.20-20-07672.2000","article-title":"Mice lacking specific nicotinic acetylcholine receptor subunits exhibit dramatically altered spontaneous activity patterns and reveal a limited role for retinal waves in forming ON and OFF circuits in the inner retina","volume":"20","author":"Bansal","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.03.011_bib12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neuron.2009.03.015","article-title":"Synaptic and extrasynaptic factors governing glutamatergic retinal waves","volume":"62","author":"Blankenship","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.03.011_bib13","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuron.2018.10.011","article-title":"Light prior to eye opening promotes retinal waves and eye-specific segregation","volume":"100","author":"Tiriac","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.03.011_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10219-8","article-title":"Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation","volume":"10","author":"Weiner","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2024.03.011_bib15","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1080\/02713683.2018.1433859","article-title":"The development of mid-wavelength photoresponsivity in the mouse retina","volume":"43","author":"Bonezzi","year":"2018","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.neuron.2024.03.011_bib16","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1167\/iovs.10-5176","article-title":"The mouse retina as an angiogenesis model","volume":"51","author":"Stahl","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuron.2024.03.011_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature11823","article-title":"A direct and melanopsin-dependent fetal light response regulates mouse eye development","volume":"494","author":"Rao","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.03.011_bib18","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41556-019-0301-x","article-title":"An opsin 5\u2013dopamine pathway mediates light-dependent vascular development in the eye","volume":"21","author":"Nguyen","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neuron.2024.03.011_bib19","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1167\/iovs.05-0174","article-title":"Role of the Norrie disease pseudoglioma gene in sprouting angiogenesis during development of the retinal vasculature","volume":"46","author":"Luhmann","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuron.2024.03.011_bib20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2009.07.047","article-title":"Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization","volume":"139","author":"Ye","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.03.011_bib21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2009.07.048","article-title":"TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4\/\u03b2-catenin signaling","volume":"139","author":"Junge","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.03.011_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011676","article-title":"LRP5 is required for vascular development in deeper layers of the retina","volume":"5","author":"Xia","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2024.03.011_bib23","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1093\/hmg\/dds087","article-title":"Norrin stimulates cell proliferation in the superficial retinal vascular plexus and is pivotal for the recruitment of mural cells","volume":"21","author":"Zuercher","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2024.03.011_bib24","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1167\/iovs.10-7146","article-title":"Frizzled 4 is required for retinal angiogenesis and maintenance of the blood-retina barrier","volume":"52","author":"Paes","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuron.2024.03.011_bib25","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2012.10.042","article-title":"Norrin\/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity","volume":"151","author":"Wang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.03.011_bib26","doi-asserted-by":"crossref","first-page":"13913","DOI":"10.1073\/pnas.250478897","article-title":"Phototransduction in transgenic mice after targeted deletion of the rod transducin \u03b1-subunit","volume":"97","author":"Calvert","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2024.03.011_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00203","article-title":"The roles of rods, cones, and melanopsin in photoresponses of M4 intrinsically photosensitive retinal ganglion cells (ipRGCs) and optokinetic visual behavior","volume":"12","author":"Schroeder","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2024.03.011_bib28","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/j.cub.2008.10.029","article-title":"ATP consumption by mammalian rod photoreceptors in darkness and in light","volume":"18","author":"Okawa","year":"2008","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2024.03.011_bib29","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/cne.10838","article-title":"Expression of vesicular glutamate transporter 1 in the mouse retina reveals temporal ordering in development of rod vs. cone and ON vs. OFF circuits","volume":"465","author":"Sherry","year":"2003","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2024.03.011_bib30","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.devcel.2021.06.021","article-title":"Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation","volume":"56","author":"Zarkada","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuron.2024.03.011_bib31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1369\/0022155412467635","article-title":"Endothelial tip cells in ocular angiogenesis: potential target for anti-angiogenesis therapy","volume":"61","author":"Siemerink","year":"2013","journal-title":"J.\u00a0Histochem. Cytochem."},{"key":"10.1016\/j.neuron.2024.03.011_bib32","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nature05571","article-title":"Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis","volume":"445","author":"Hellstr\u00f6m","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.03.011_bib33","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1073\/pnas.0611177104","article-title":"The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching","volume":"104","author":"Suchting","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2024.03.011_bib34","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1242\/dev.110296","article-title":"Multiple endothelial cells constitute the tip of developing blood vessels and polarize to promote lumen formation","volume":"141","author":"Pelton","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.neuron.2024.03.011_bib35","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.neuron.2017.02.043","article-title":"Gradual suppression of transcytosis governs functional blood-retinal barrier formation","volume":"93","author":"Chow","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.03.011_bib36","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.neuron.2017.10.025","article-title":"The Wnt inhibitor Apcdd1 coordinates vascular remodeling and barrier maturation of retinal blood vessels","volume":"96","author":"Mazzoni","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.03.011_bib37","doi-asserted-by":"crossref","DOI":"10.1242\/dev.200610","article-title":"Mural Wnt\/\u03b2-catenin signaling regulates Lama2 expression to promote neurovascular unit maturation","volume":"149","author":"Biswas","year":"2022","journal-title":"Development"},{"key":"10.1016\/j.neuron.2024.03.011_bib38","doi-asserted-by":"crossref","DOI":"10.1186\/s12987-018-0109-2","article-title":"The role of plasmalemma vesicle-associated protein in pathological breakdown of blood-brain and blood-retinal barriers: potential novel therapeutic target for cerebral edema and diabetic macular edema","volume":"15","author":"Bosma","year":"2018","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.neuron.2024.03.011_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-4614-3209-8_3","article-title":"Spatial and temporal localization of caveolin-1 protein in the developing retina","volume":"801","author":"Gu","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.neuron.2024.03.011_bib40","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ajpath.2013.10.022","article-title":"Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement, and mural cell alteration","volume":"184","author":"Gu","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neuron.2024.03.011_bib41","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1523\/JNEUROSCI.4443-07.2008","article-title":"Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma","volume":"28","author":"Buckingham","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.03.011_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46879-1","article-title":"Detailed evaluation of possible ganglion cell loss in the retina of Zucker diabetic fatty (ZDF) rats","volume":"9","author":"Hajd\u00fa","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2024.03.011_bib43","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1172\/JCI80297","article-title":"Neurovascular crosstalk between interneurons and capillaries is required for vision","volume":"125","author":"Usui","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2024.03.011_bib44","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/cne.21746","article-title":"Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in M\u00fcller glial cell development","volume":"510","author":"Poch\u00e9","year":"2008","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2024.03.011_bib45","doi-asserted-by":"crossref","first-page":"5996","DOI":"10.1523\/JNEUROSCI.0551-18.2018","article-title":"Laminin \u03b22 chain regulates retinal progenitor cell mitotic spindle orientation via dystroglycan","volume":"38","author":"Serjanov","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.03.011_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120415","article-title":"M\u00fcller glia activation in response to inherited retinal degeneration is highly varied and disease-specific","volume":"10","author":"Hippert","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2024.03.011_bib47","article-title":"Differential response of M\u00fcller cells and microglia in a mouse retinal detachment model and its implications in detached and non-detached regions","volume":"10","author":"Lee","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.neuron.2024.03.011_bib48","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2015.05.002","article-title":"Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets","volume":"161","author":"Macosko","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.03.011_bib49","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0169-328X(03)00030-5","article-title":"Glutamate stimulates neurotrophin expression in cultured M\u00fcller cells","volume":"111","author":"Taylor","year":"2003","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neuron.2024.03.011_bib50","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1167\/iovs.03-0948","article-title":"Glutamate-induced glutamine synthetase expression in retinal M\u00fcller cells after short-term ocular hypertension in the rat","volume":"45","author":"Shen","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuron.2024.03.011_bib51","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1073\/pnas.95.8.4663","article-title":"Functions of the two glutamate transporters GLAST and GLT-1 in the retina","volume":"95","author":"Harada","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2024.03.011_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069250","article-title":"Impairment of neuronal glutamate uptake and modulation of the glutamate transporter GLT-1 induced by retinal ischemia","volume":"8","author":"Russo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2024.03.011_bib53","doi-asserted-by":"crossref","first-page":"13094","DOI":"10.1073\/pnas.2000339117","article-title":"Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies","volume":"117","author":"Cheng","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2024.03.011_bib54","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1242\/dev.072348","article-title":"Diverse roles for VEGF-A in the nervous system","volume":"139","author":"Mackenzie","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.neuron.2024.03.011_bib55","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.cell.2014.09.025","article-title":"Neurons limit angiogenesis by titrating VEGF in retina","volume":"159","author":"Okabe","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.03.011_bib56","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1160\/TH08-12-0830","article-title":"The VEGF-induced transcriptional response comprises gene clusters at the crossroad of angiogenesis and inflammation","volume":"102","author":"Schweighofer","year":"2009","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.neuron.2024.03.011_bib57","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1161\/01.RES.77.3.638","article-title":"Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5\u2032 enhancer","volume":"77","author":"Liu","year":"1995","journal-title":"Circ. Res."},{"key":"10.1016\/j.neuron.2024.03.011_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108540","article-title":"Retinal hypoxia and angiogenesis with methamphetamine","volume":"206","author":"Lee","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.neuron.2024.03.011_bib59","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/dvdy.24614","article-title":"Transient phenotypic changes in endothelial cells and pericytes in neonatal mouse retina following short-term blockade of vascular endothelial growth factor receptors","volume":"247","author":"Morita","year":"2018","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.neuron.2024.03.011_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aag2476","article-title":"Gene expression profiles of brain endothelial cells during embryonic development at bulk and single-cell levels","volume":"10","author":"Hupe","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.neuron.2024.03.011_bib61","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1471-4159.2012.07694.x","article-title":"Glial glutamate transporter and glutamine synthetase regulate GABAergic synaptic strength in the spinal dorsal horn","volume":"121","author":"Jiang","year":"2012","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuron.2024.03.011_bib62","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1111\/j.1471-4159.2010.07077.x","article-title":"AMPA receptor mediated D-serine release from retinal glial cells","volume":"115","author":"Sullivan","year":"2010","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuron.2024.03.011_bib63","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1124\/mol.65.4.1008","article-title":"Characterization of novel L-threo-\u03b2-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters","volume":"65","author":"Shimamoto","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuron.2024.03.011_bib64","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/CIRCRESAHA.118.313316","article-title":"Fine-tuning of Sox17 and canonical Wnt coordinates the permeability properties of the blood-brain barrier","volume":"124","author":"Corada","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.neuron.2024.03.011_bib65","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nature03875","article-title":"Common mechanisms of nerve and blood vessel wiring","volume":"436","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.03.011_bib66","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1182\/blood-2012-04-396846","article-title":"Eyeing central neurons in vascular growth and reparative angiogenesis","volume":"120","author":"Sapieha","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.neuron.2024.03.011_bib67","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nm.4059","article-title":"Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1","volume":"22","author":"Joyal","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2024.03.011_bib68","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nm.1873","article-title":"The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis","volume":"14","author":"Sapieha","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2024.03.011_bib69","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1016\/j.cub.2023.07.040","article-title":"Dopamine signaling from ganglion cells directs layer-specific angiogenesis in the retina","volume":"33","author":"Liang","year":"2023","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2024.03.011_bib70","article-title":"Retinal glutamate neurotransmission: from physiology to pathophysiological mechanisms of retinal ganglion cell degeneration","volume":"12","author":"Boccuni","year":"2022","journal-title":"Life (Basel)"},{"key":"10.1016\/j.neuron.2024.03.011_bib71","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1126\/science.1097468","article-title":"Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites","volume":"304","author":"Fremeau","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.neuron.2024.03.011_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-28785-9","article-title":"Endothelial Unc5B controls blood-brain barrier integrity","volume":"13","author":"Boy\u00e9","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2024.03.011_bib73","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.exer.2016.03.018","article-title":"Retinal remodeling in human retinitis pigmentosa","volume":"150","author":"Jones","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.neuron.2024.03.011_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2016.00103","article-title":"Retinal remodeling and metabolic alterations in human AMD","volume":"10","author":"Jones","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2024.03.011_bib75","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.exer.2016.04.022","article-title":"M\u00fcller cell metabolic chaos during retinal degeneration","volume":"150","author":"Pfeiffer","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.neuron.2024.03.011_bib76","first-page":"2148","article-title":"Degeneration of astrocytes in feline retinopathy of prematurity causes failure of the blood-retinal barrier","volume":"33","author":"Chan-Ling","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuron.2024.03.011_bib77","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000329603","article-title":"Epidemiology of major eye diseases leading to blindness in Europe: a literature review","volume":"47","author":"Prokofyeva","year":"2012","journal-title":"Ophthal. Res."},{"key":"10.1016\/j.neuron.2024.03.011_bib78","first-page":"91","article-title":"Retinopathy of prematurity: the need for prevention","volume":"8","author":"Liegl","year":"2016","journal-title":"Eye Brain"},{"key":"10.1016\/j.neuron.2024.03.011_bib79","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.neuron.2014.07.034","article-title":"Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex","volume":"83","author":"Lacoste","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.03.011_bib80","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature25739","article-title":"A molecular atlas of cell types and zonation in the brain vasculature","volume":"554","author":"Vanlandewijck","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.03.011_bib81","doi-asserted-by":"crossref","DOI":"10.1038\/srep33883","article-title":"An automated microwell platform for large-scale single cell RNA-seq","volume":"6","author":"Yuan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2024.03.011_bib82","doi-asserted-by":"crossref","DOI":"10.1186\/s13073-018-0567-9","article-title":"Single-cell transcriptome analysis of lineage diversity in high-grade glioma","volume":"10","author":"Yuan","year":"2018","journal-title":"Genome Med."},{"key":"10.1016\/j.neuron.2024.03.011_bib83","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.03.011_bib84","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/bfgp\/elx044","article-title":"Clustering single cells: a review of approaches on high-and low-depth single-cell RNA-seq data","volume":"17","author":"Menon","year":"2018","journal-title":"Brief. Funct. Genomics"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089662732400165X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089662732400165X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:17:59Z","timestamp":1777580279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089662732400165X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":84,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S089662732400165X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2024.03.011","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.07.10.548410","asserted-by":"object"}]},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin\/\u03b2-catenin signaling","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2024.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}