{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:19:31Z","timestamp":1790770771147,"version":"4.1.0"},"reference-count":92,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005310","name":"Klarman Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018644","name":"Boston Nutrition Obesity Research Center, Boston University","doi-asserted-by":"publisher","award":["P30 DK046200"],"award-info":[{"award-number":["P30 DK046200"]}],"id":[{"id":"10.13039\/100018644","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005270","name":"McKnight Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP1 AT010971"],"award-info":[{"award-number":["DP1 AT010971"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK109930"],"award-info":[{"award-number":["R01 DK109930"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 NS007484"],"award-info":[{"award-number":["T32 NS007484"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32 DK112589"],"award-info":[{"award-number":["F32 DK112589"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH12343"],"award-info":[{"award-number":["R01 MH12343"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.neuron.2024.03.027","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T14:56:34Z","timestamp":1713538594000},"page":"2130-2141.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Repeated stress triggers seeking of a starvation-like state in anxiety-prone female mice"],"prefix":"10.1016","volume":"112","author":[{"given":"Hakan","family":"Kucukdereli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Amsalem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trent","family":"Pottala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilani","family":"Potgieter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Hasbrouck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lutas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9882-933X","authenticated-orcid":false,"given":"Mark L.","family":"Andermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2024.03.027_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.physbeh.2007.11.037","article-title":"Neurobiology of anorexia and bulimia nervosa","volume":"94","author":"Kaye","year":"2008","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuron.2024.03.027_bib2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.tins.2013.01.003","article-title":"Nothing tastes as good as skinny feels: The neurobiology of anorexia nervosa","volume":"36","author":"Kaye","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2024.03.027_bib3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/eat.20244","article-title":"Habit learning and anorexia nervosa: A cognitive neuroscience hypothesis","volume":"39","author":"Steinglass","year":"2006","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.neuron.2024.03.027_bib4","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.biopsych.2006.03.040","article-title":"The prevalence and correlates of eating disorders in the national comorbidity survey replication","volume":"61","author":"Hudson","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2024.03.027_bib5","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1176\/appi.ajp.161.12.2215","article-title":"Comorbidity of anxiety disorders with anorexia and bulimia nervosa","volume":"161","author":"Kaye","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuron.2024.03.027_bib6","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s11920-012-0282-y","article-title":"Epidemiology of\u00a0eating disorders: Incidence, prevalence and mortality rates","volume":"14","author":"Smink","year":"2012","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.neuron.2024.03.027_bib7","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1001\/archgenpsychiatry.2011.74","article-title":"Mortality rates\u00a0in patients with anorexia nervosa and other eating disorders. A\u00a0meta-analysis of 36 studies","volume":"68","author":"Arcelus","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neuron.2024.03.027_bib8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrn2682","article-title":"New insights into symptoms and neurocircuit function of anorexia nervosa","volume":"10","author":"Kaye","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2024.03.027_bib9","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.2147\/NDT.S108912","article-title":"Historical evolution of the concept of anorexia nervosa and relationships with orthorexia nervosa, autism, and obsessive-compulsive spectrum","volume":"12","author":"Dell\u2019Osso","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.neuron.2024.03.027_bib10","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/eat.23265","article-title":"Habits are stronger with longer duration of illness and greater severity in anorexia nervosa","volume":"53","author":"Davis","year":"2020","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.neuron.2024.03.027_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/eat.22345","article-title":"Restrictive food intake as a choice\u2014A paradigm for study","volume":"48","author":"Steinglass","year":"2015","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.neuron.2024.03.027_bib12","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.biopsych.2021.06.020","article-title":"A framework for developing translationally relevant animal models of stress-induced changes in eating behavior","volume":"91","author":"Fran\u00e7ois","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2024.03.027_bib13","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1037\/h0025205","article-title":"Self-starvation of rats living in activity wheels on a restricted feeding schedule","volume":"64","author":"Routtenberg","year":"1967","journal-title":"J.\u00a0Comp. Physiol. Psychol."},{"key":"10.1016\/j.neuron.2024.03.027_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fnut.2019.00069","article-title":"Activity based anorexia as an animal model for anorexia nervosa\u2013a systematic review","volume":"6","author":"Schalla","year":"2019","journal-title":"Front. Nutr."},{"key":"10.1016\/j.neuron.2024.03.027_bib15","doi-asserted-by":"crossref","first-page":"e776","DOI":"10.1038\/tp.2016.35","article-title":"BDNF-Val66Met variant and adolescent stress interact to promote susceptibility to anorexic behavior in mice","volume":"6","author":"Madra","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuron.2024.03.027_bib16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1126\/science.1129663","article-title":"Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior","volume":"314","author":"Chen","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.neuron.2024.03.027_bib17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neulet.2011.07.044","article-title":"Evidence of association between Val66Met polymorphism at BDNF gene and anxiety disorders in a community sample of children and adolescents","volume":"502","author":"Tocchetto","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2024.03.027_bib18","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/sj.mp.4001281","article-title":"Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type","volume":"8","author":"Ribas\u00e9s","year":"2003","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2024.03.027_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11920-022-01319-2","article-title":"Rethinking the approach to preclinical models of anorexia nervosa","volume":"24","author":"Fran\u00e7ois","year":"2022","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.neuron.2024.03.027_bib20","doi-asserted-by":"crossref","first-page":"596381","DOI":"10.3389\/fnhum.2020.596381","article-title":"Animal models for anorexia nervosa\u2014a systematic review","volume":"14","author":"Scharner","year":"2020","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.neuron.2024.03.027_bib21","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/HRP.0000000000000111","article-title":"Interacting neural processes of feeding, hyperactivity, stress, reward, and the utility of the activity-based anorexia model of anorexia nervosa","volume":"24","author":"Ross","year":"2016","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.neuron.2024.03.027_bib22","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nn.2739","article-title":"AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training","volume":"14","author":"Aponte","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.03.027_bib23","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1172\/JCI46229","article-title":"Rapid, reversible activation of AgRP neurons drives feeding behavior in mice","volume":"121","author":"Krashes","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2024.03.027_bib24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature14416","article-title":"Neurons for hunger and thirst transmit a negative-valence teaching signal","volume":"521","author":"Betley","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.03.027_bib25","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-physiol-021115-104948","article-title":"Three pillars for the neural control of appetite","volume":"79","author":"Sternson","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.neuron.2024.03.027_bib26","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nn.2139","article-title":"The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress","volume":"11","author":"Lutter","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.03.027_bib27","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.cell.2015.02.024","article-title":"Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding","volume":"160","author":"Dietrich","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.03.027_bib28","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/nn.4274","article-title":"Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state","volume":"19","author":"Padilla","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.03.027_bib29","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1016\/j.cub.2016.07.019","article-title":"Preemptive stimulation of AgRP neurons in fed mice enables conditioned food seeking under threat","volume":"26","author":"Jikomes","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2024.03.027_bib30","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.44527","article-title":"Need-based prioritization of behavior","volume":"8","author":"Burnett","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2024.03.027_bib31","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1038\/s41593-019-0506-0","article-title":"State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala","volume":"22","author":"Lutas","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.03.027_bib32","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.neuron.2016.03.014","article-title":"Feeding state modulates behavioral choice and processing of prey stimuli in the zebrafish tectum","volume":"90","author":"Filosa","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.03.027_bib33","doi-asserted-by":"crossref","first-page":"10701","DOI":"10.1523\/JNEUROSCI.3464-14.2015","article-title":"Negative energy balance blocks neural and behavioral responses to acute stress by \u201csilencing\u201d central glucagon-like peptide 1 signaling in rats","volume":"35","author":"Maniscalco","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.03.027_bib34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nm0196-21","article-title":"Anorexia nervosa, self\u2013starvation and the reward of stress","volume":"2","author":"Bergh","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2024.03.027_bib35","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neubiorev.2015.02.012","article-title":"A reward-centred model of anorexia nervosa: A focussed narrative review of the neurological and psychophysiological literature","volume":"52","author":"O\u2019Hara","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuron.2024.03.027_bib36","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/cts.13196","article-title":"Fear and food: anxiety-like behavior and the susceptibility to weight loss in an activity-based anorexia rat model","volume":"15","author":"Schwenzer","year":"2022","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.neuron.2024.03.027_bib37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.psychres.2019.05.010","article-title":"A systematic review of studies probing longitudinal associations between anxiety and anorexia nervosa","volume":"276","author":"Lloyd","year":"2019","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neuron.2024.03.027_bib38","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nn.2167","article-title":"Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance","volume":"11","author":"Tong","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.03.027_bib39","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nn.3078","article-title":"A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing","volume":"15","author":"Madisen","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.03.027_bib40","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.18640","article-title":"Hunger neurons drive feeding through a sustained, positive reinforcement signal","volume":"5","author":"Chen","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2024.03.027_bib41","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1469-7793.1998.605bk.x","article-title":"The arginine vasopressin and corticotrophin-releasing hormone gene transcription responses to varied frequencies of repeated stress in rats","volume":"510","author":"Ma","year":"1998","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2024.03.027_bib42","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0031-9384(87)90282-4","article-title":"Effects of chronic stress on plasma corticosterone, ACTH and prolactin","volume":"40","author":"Kant","year":"1987","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuron.2024.03.027_bib43","doi-asserted-by":"crossref","first-page":"12245","DOI":"10.1038\/s41598-020-69132-6","article-title":"Stress and behavioral correlates in the head-fixed method: stress measurements, habituation dynamics, locomotion, and motor-skill learning in mice","volume":"10","author":"Juczewski","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2024.03.027_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.07122","article-title":"Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales","volume":"4","author":"Mandelblat-Cerf","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2024.03.027_bib45","series-title":"Principles of Behavior: an Introduction to Behavior Theory","author":"Hull","year":"1943"},{"key":"10.1016\/j.neuron.2024.03.027_bib46","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.physbeh.2004.02.004","article-title":"Motivation concepts in behavioral neuroscience","volume":"81","author":"Berridge","year":"2004","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuron.2024.03.027_bib47","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41398-019-0438-1","article-title":"AGRP neurons modulate fasting-induced anxiolytic effects","volume":"9","author":"Li","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuron.2024.03.027_bib48","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0031-9384(86)90301-X","article-title":"Stress selectively influences center region activity of mice in an open field","volume":"37","author":"Lee","year":"1986","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuron.2024.03.027_bib49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuron.2024.03.027_bib50","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/s41588-019-0439-2","article-title":"Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa","volume":"51","author":"Watson","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2024.03.027_bib51","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.3390\/ijerph19031471","article-title":"Resilience is associated with less eating disorder symptoms in the NutriNet-Sant\u00e9 Cohort Study","volume":"19","author":"Robert","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.neuron.2024.03.027_bib52","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuron.2024.03.027_bib53","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbr.2004.05.018","article-title":"Correlations between behaviours in the elevated plus-maze and sensitivity to unpredictable subchronic mild stress: evidence from inbred strains of mice","volume":"156","author":"Ducottet","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuron.2024.03.027_bib54","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0031-9384(71)90050-3","article-title":"Variations in food and water intake in the normal and acyclic female rat","volume":"7","author":"Tarttelin","year":"1971","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuron.2024.03.027_bib55","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.physbeh.2011.04.014","article-title":"The ovarian hormone estradiol plays a crucial role in the control of food intake in females","volume":"104","author":"Eckel","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuron.2024.03.027_bib56","doi-asserted-by":"crossref","first-page":"15932","DOI":"10.1073\/pnas.0904747106","article-title":"Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake","volume":"106","author":"Olofsson","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2024.03.027_bib57","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1677\/joe.0.0180102","article-title":"Occurrence of anoestrus in mice caged in groups","volume":"18","author":"Whitten","year":"1959","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.neuron.2024.03.027_bib58","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1095\/biolreprod14.3.292","article-title":"Estrous Cycles in the Mouse: Relative Influence of Continuous Light and the Presence of a Male","volume":"14","author":"Campbell","year":"1976","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.neuron.2024.03.027_bib59","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.70271","article-title":"Assessing the effects of stress on feeding behaviors in laboratory mice","volume":"11","author":"Francois","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2024.03.027_bib60","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.cub.2023.02.035","article-title":"Mouse spontaneous behavior reflects individual variation rather than estrous state","volume":"33","author":"Levy","year":"2023","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2024.03.027_bib61","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.aaz9468","article-title":"Facial expressions of emotion states and their neuronal correlates in mice","volume":"368","author":"Dolensek","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.neuron.2024.03.027_bib62","doi-asserted-by":"crossref","first-page":"930005","DOI":"10.3389\/fvets.2022.930005","article-title":"Grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats\u2014A systematic review","volume":"9","author":"Aulehner","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.neuron.2024.03.027_bib63","doi-asserted-by":"crossref","first-page":"105369","DOI":"10.1016\/j.archoralbio.2022.105369","article-title":"Encoding signs of orofacial neuropathic pain from facial expressions in mice","volume":"135","author":"Andrade-Gonz\u00e1lez","year":"2022","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.neuron.2024.03.027_bib64","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.physbeh.2012.03.024","article-title":"Facial expressions of mice in aggressive and fearful contexts","volume":"107","author":"Defensor","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuron.2024.03.027_bib65","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0349-22.2022","article-title":"A new tool for quantifying mouse facial expressions","volume":"10","author":"Le Mo\u00ebne","year":"2023","journal-title":"eNeuro"},{"key":"10.1016\/j.neuron.2024.03.027_bib66","series-title":"Advances in Neural Information Processing Systems","first-page":"4766","article-title":"A unified approach to interpreting model predictions","author":"Lundberg","year":"2017"},{"key":"10.1016\/j.neuron.2024.03.027_bib67","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cell.2018.02.057","article-title":"A neural circuit for the suppression of pain by a competing need state","volume":"173","author":"Alhadeff","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.03.027_bib68","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1038\/s41380-022-01932-w","article-title":"AgRP neurons coordinate the mitigation of activity-based anorexia","volume":"28","author":"Sutton Hickey","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2024.03.027_bib69","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/sj.npp.1301443","article-title":"Altered insula response to taste stimuli in individuals recovered from restricting-type anorexia nervosa","volume":"33","author":"Wagner","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuron.2024.03.027_bib70","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/npp.2015.174","article-title":"Altered insula activity during visceral interoception in weight-restored patients with anorexia nervosa","volume":"41","author":"Kerr","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuron.2024.03.027_bib71","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1176\/appi.ajp.2019.19030261","article-title":"Neural insensitivity to the effects of hunger in women remitted from anorexia nervosa","volume":"177","author":"Kaye","year":"2020","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuron.2024.03.027_bib72","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neuron.2019.12.027","article-title":"Estimation of current and future physiological states in insular cortex","volume":"105","author":"Livneh","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.03.027_bib73","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0896-6273(03)00679-2","article-title":"Both of us disgusted in my insula","volume":"40","author":"Wicker","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.03.027_bib74","doi-asserted-by":"crossref","first-page":"15539","DOI":"10.1038\/s41598-019-51727-3","article-title":"Diverging roles of the anterior insula in trauma-exposed individuals vulnerable or resilient to posttraumatic stress disorder","volume":"9","author":"Jeong","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2024.03.027_bib75","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.abj8817","article-title":"Fear balance is maintained by bodily feedback to the insular cortex in mice","volume":"374","author":"Klein","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.neuron.2024.03.027_bib76","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1038\/s41380-020-01004-x","article-title":"Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity","volume":"26","author":"Fang","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2024.03.027_bib77","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/s41380-022-01872-5","article-title":"Increased intrinsic and synaptic excitability of hypothalamic POMC neurons underlies chronic stress-induced behavioral deficits","volume":"28","author":"Fang","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2024.03.027_bib78","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/35078085","article-title":"Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus","volume":"411","author":"Cowley","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.03.027_bib79","doi-asserted-by":"crossref","DOI":"10.1177\/1744806918763658","article-title":"A deep neural network to assess spontaneous pain from mouse facial expressions","volume":"14","author":"Tuttle","year":"2018","journal-title":"Mol. Pain"},{"key":"10.1016\/j.neuron.2024.03.027_bib80","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nmeth.1455","article-title":"Coding of facial expressions of pain in the laboratory mouse","volume":"7","author":"Langford","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2024.03.027_bib81","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/39051","article-title":"A specific neural substrate for perceiving facial expressions of disgust","volume":"389","author":"Phillips","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.03.027_bib82","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.neuron.2014.08.042","article-title":"Engagement of neural circuits underlying 2D spatial navigation in a rodent virtual reality system","volume":"84","author":"Aronov","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.03.027_bib83","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","article-title":"SciPy 1.0: fundamental algorithms for scientific computing in Python","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2024.03.027_bib84","first-page":"2825","article-title":"Scikit-learn: Machine Learning in Python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J.\u00a0Mach. Learn. Res."},{"key":"10.1016\/j.neuron.2024.03.027_bib85","article-title":"PyTorch: An Imperative Style, High-Performance Deep Learning Library","author":"Paszke","year":"2019","journal-title":"arXiv"},{"key":"10.1016\/j.neuron.2024.03.027_bib86","series-title":"Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition","first-page":"770","article-title":"Deep residual learning for image recognition","author":"He","year":"2016"},{"key":"10.1016\/j.neuron.2024.03.027_bib87","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/s41593-018-0209-y","article-title":"DeepLabCut: Markerless pose estimation of user-defined body parts with deep learning","volume":"21","author":"Mathis","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.03.027_bib88","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41593-022-01050-4","article-title":"Hippocampal place codes are gated by behavioral engagement","volume":"25","author":"Pettit","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.03.027_bib89","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.neuron.2015.11.031","article-title":"Mapping sub-second structure in mouse behavior","volume":"88","author":"Wiltschko","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.03.027_bib90","series-title":"Proceedings of the 3rd International Conference on Learning Representations, ICLR 2015","article-title":"Adam: A method for stochastic optimization","author":"Kingma","year":"2015"},{"key":"10.1016\/j.neuron.2024.03.027_bib91","series-title":"Constructive Theory of Functions of Several Variables. Lecture Notes in Mathematics","article-title":"Splines minimizing rotation-invariant semi-norms in Sobolev spaces","author":"Duchon","year":"1977"},{"key":"10.1016\/j.neuron.2024.03.027_bib92","series-title":"Proceedings of the International Symposium on Biomedical Imaging","first-page":"1123","article-title":"Robust registration of calcium images by learned contrast synthesis","author":"Bogovic","year":"2016"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627324002344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627324002344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T12:35:46Z","timestamp":1751546146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627324002344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":92,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S0896627324002344"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2024.03.027","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repeated stress triggers seeking of a starvation-like state in anxiety-prone female mice","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2024.03.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}