{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:19:11Z","timestamp":1792124351132,"version":"4.4.0"},"reference-count":105,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01NS15276"],"award-info":[{"award-number":["R01NS15276"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01GM137428"],"award-info":[{"award-number":["R01GM137428"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007557","name":"California Institute of Regenerative Medicine","doi-asserted-by":"publisher","award":["EDUC4-12752"],"award-info":[{"award-number":["EDUC4-12752"]}],"id":[{"id":"10.13039\/100007557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100023065","name":"State of California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100023065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.neuron.2024.04.006","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T10:48:42Z","timestamp":1714560522000},"page":"2157-2176.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size"],"prefix":"10.1016","volume":"112","author":[{"given":"Lin","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingrong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhelin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Li","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren P.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheela P.","family":"Pokharel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Blue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene W.","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0573-4981","authenticated-orcid":false,"given":"Sika","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2024.04.006_bib1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrm4063","article-title":"Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes","volume":"16","author":"Lykke-Andersen","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neuron.2024.04.006_bib2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev-genet-112414-054639","article-title":"Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story","volume":"49","author":"He","year":"2015","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.neuron.2024.04.006_bib3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1101\/gad.1389006","article-title":"Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay","volume":"20","author":"Kashima","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.neuron.2024.04.006_bib4","doi-asserted-by":"crossref","first-page":"7483","DOI":"10.1128\/MCB.24.17.7483-7490.2004","article-title":"SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans","volume":"24","author":"Grimson","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neuron.2024.04.006_bib5","doi-asserted-by":"crossref","first-page":"9447","DOI":"10.1093\/nar\/gku578","article-title":"Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6","volume":"42","author":"Chakrabarti","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuron.2024.04.006_bib6","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0092-8674(00)00214-2","article-title":"Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon","volume":"103","author":"Lykke-Andersen","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.04.006_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0060111","article-title":"A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay","volume":"6","author":"Singh","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neuron.2024.04.006_bib8","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ceb.2009.02.007","article-title":"Execution of nonsense-mediated mRNA decay: what defines a substrate?","volume":"21","author":"Rebbapragada","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.neuron.2024.04.006_bib9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-genet-111212-133424","article-title":"Organizing principles of mammalian nonsense-mediated mRNA decay","volume":"47","author":"Popp","year":"2013","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.neuron.2024.04.006_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.biochem.76.050106.093909","article-title":"The nonsense-mediated decay RNA surveillance pathway","volume":"76","author":"Chang","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.neuron.2024.04.006_bib11","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1093\/hmg\/ddt035","article-title":"Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders","volume":"22","author":"Nguyen","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2024.04.006_bib12","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/ng2100","article-title":"Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation","volume":"39","author":"Tarpey","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2024.04.006_bib13","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/mp.2010.59","article-title":"A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders","volume":"16","author":"Addington","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2024.04.006_bib14","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/mp.2009.14","article-title":"Mutations of the UPF3B gene, which encodes a protein widely expressed in neurons, are associated with nonspecific mental retardation with or without autism","volume":"15","author":"Laumonnier","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2024.04.006_bib15","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/hmg\/ddt315","article-title":"The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth","volume":"22","author":"Jolly","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2024.04.006_bib16","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.celrep.2014.01.028","article-title":"Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway","volume":"6","author":"Lou","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2024.04.006_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13041-015-0122-1","article-title":"Full UPF3B function is critical for neuronal differentiation of neural stem cells","volume":"8","author":"Alrahbeni","year":"2015","journal-title":"Mol. Brain"},{"key":"10.1016\/j.neuron.2024.04.006_bib18","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1038\/mp.2017.173","article-title":"A Upf3b-mutant mouse model with behavioral and neurogenesis defects","volume":"23","author":"Huang","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2024.04.006_bib19","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1242\/dev.090571","article-title":"Neural progenitors, neurogenesis and the evolution of the neocortex","volume":"141","author":"Florio","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.neuron.2024.04.006_bib20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.conb.2020.10.017","article-title":"Behavior and lineage progression of neural progenitors in the mammalian cortex","volume":"66","author":"Lin","year":"2021","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuron.2024.04.006_bib21","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/35055553","article-title":"Neurons derived from radial glial cells establish radial units in neocortex","volume":"409","author":"Noctor","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.04.006_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nn1172","article-title":"Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases","volume":"7","author":"Noctor","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.04.006_bib23","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.tins.2020.07.009","article-title":"Basal Progenitor Morphology and Neocortex Evolution","volume":"43","author":"Kalebic","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2024.04.006_bib24","first-page":"616","article-title":"Intermediate progenitors and Tbr2 in cortical development","volume":"235","author":"Hevner","year":"2019","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.neuron.2024.04.006_bib25","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0896-6273(00)80621-2","article-title":"Pax6 controls radial glia differentiation in the cerebral cortex","volume":"21","author":"G\u00f6tz","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.04.006_bib26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1523\/JNEUROSCI.2899-04.2005","article-title":"Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex","volume":"25","author":"Englund","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.04.006_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cell.2015.09.004","article-title":"Molecular identity of human outer radial glia during cortical development","volume":"163","author":"Pollen","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.04.006_bib28","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aap8809","article-title":"Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex","volume":"358","author":"Nowakowski","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.neuron.2024.04.006_bib29","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1016\/j.celrep.2017.12.017","article-title":"Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling","volume":"21","author":"Yuzwa","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2024.04.006_bib30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41593-017-0056-2","article-title":"Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing","volume":"21","author":"Hochgerner","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.04.006_bib31","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41586-019-0969-x","article-title":"The single-cell transcriptional landscape of mammalian organogenesis","volume":"566","author":"Cao","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.04.006_bib32","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.cell.2020.06.027","article-title":"Origins and Proliferative States of Human Oligodendrocyte Precursor Cells","volume":"182","author":"Huang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.04.006_bib33","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41586-021-03910-8","article-title":"An atlas of cortical arealization identifies dynamic molecular signatures","volume":"598","author":"Bhaduri","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.04.006_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/science.adf0834","article-title":"Single-cell analysis of prenatal and postnatal human cortical development","volume":"382","author":"Velmeshev","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.neuron.2024.04.006_bib35","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.15252\/embj.201796764","article-title":"Epigenome profiling and editing of neocortical progenitor cells during development","volume":"36","author":"Albert","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2024.04.006_bib36","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrn4021","article-title":"Proliferation control in neural stem and progenitor cells","volume":"16","author":"Homem","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2024.04.006_bib37","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2014.10.027","article-title":"Deterministic progenitor behavior and unitary production of neurons in the neocortex","volume":"159","author":"Gao","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.04.006_bib38","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1523\/JNEUROSCI.16-19-06183.1996","article-title":"The leaving or Q fraction of the murine cerebral proliferative epithelium: a general model of neocortical neuronogenesis","volume":"16","author":"Takahashi","year":"1996","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.04.006_bib39","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cell.2016.02.046","article-title":"The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay","volume":"165","author":"Shum","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.04.006_bib40","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/hmg\/10.2.99","article-title":"Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability","volume":"10","author":"Medghalchi","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2024.04.006_bib41","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.15252\/embj.201489947","article-title":"Smg6\/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay","volume":"34","author":"Li","year":"2015","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2024.04.006_bib42","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1101\/gad.468808","article-title":"NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements","volume":"22","author":"Weischenfeldt","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.neuron.2024.04.006_bib43","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1523\/JNEUROSCI.22-15-06309.2002","article-title":"Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage","volume":"22","author":"Gorski","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.04.006_bib44","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1006\/bbrc.2000.2870","article-title":"Specificity and efficiency of Cre-mediated recombination in Emx1-Cre knock-in mice","volume":"273","author":"Guo","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuron.2024.04.006_bib45","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/dvg.20256","article-title":"Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice","volume":"44","author":"Goebbels","year":"2006","journal-title":"Genesis"},{"key":"10.1016\/j.neuron.2024.04.006_bib46","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/12703","article-title":"Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety","volume":"23","author":"Tronche","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2024.04.006_bib47","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1261\/rna.058040.116","article-title":"Inhibition of nonsense-mediated RNA decay by ER stress","volume":"23","author":"Li","year":"2017","journal-title":"RNA"},{"key":"10.1016\/j.neuron.2024.04.006_bib48","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.omtn.2021.12.003","article-title":"Molecular profiling of individual FDA-approved clinical drugs identifies modulators of nonsense-mediated mRNA decay","volume":"27","author":"Zhao","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.neuron.2024.04.006_bib49","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41580-019-0126-2","article-title":"Quality and quantity control of gene expression by nonsense-mediated mRNA decay","volume":"20","author":"Kurosaki","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neuron.2024.04.006_bib50","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12876","article-title":"Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability","volume":"5","author":"Nelson","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2024.04.006_bib51","doi-asserted-by":"crossref","first-page":"599","DOI":"10.15252\/embr.201439696","article-title":"The unfolded protein response is shaped by the NMD pathway","volume":"16","author":"Karam","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.neuron.2024.04.006_bib52","doi-asserted-by":"crossref","first-page":"6632","DOI":"10.1038\/ncomms7632","article-title":"Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics","volume":"6","author":"Popp","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2024.04.006_bib53","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF01190834","article-title":"Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population","volume":"18","author":"Nowakowski","year":"1989","journal-title":"J.\u00a0Neurocytol."},{"key":"10.1016\/j.neuron.2024.04.006_bib54","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.1523\/JNEUROSCI.15-09-06046.1995","article-title":"The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall","volume":"15","author":"Takahashi","year":"1995","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.04.006_bib55","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ydbio.2006.08.035","article-title":"Pax6 controls cerebral cortical cell number by regulating exit from the cell cycle and specifies cortical cell identity by a cell autonomous mechanism","volume":"302","author":"Quinn","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.neuron.2024.04.006_bib56","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1242\/dev.022616","article-title":"Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis","volume":"135","author":"Kawaguchi","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.neuron.2024.04.006_bib57","doi-asserted-by":"crossref","first-page":"9122","DOI":"10.1523\/JNEUROSCI.0791-13.2013","article-title":"Dynamic interactions between intermediate neurogenic progenitors and radial glia in embryonic mouse neocortex: potential role in Dll1-Notch signaling","volume":"33","author":"Nelson","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.04.006_bib58","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neuron.2008.09.020","article-title":"Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex","volume":"60","author":"Farkas","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.04.006_bib59","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuron.2008.09.028","article-title":"Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex","volume":"60","author":"Sessa","year":"2008","journal-title":"Neuron"},{"issue":"Suppl 1","key":"10.1016\/j.neuron.2024.04.006_bib60","doi-asserted-by":"crossref","first-page":"i138","DOI":"10.1093\/cercor\/bhj168","article-title":"A role for proneural genes in the maturation of cortical progenitor cells","volume":"16","author":"Britz","year":"2006","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neuron.2024.04.006_bib61","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1038\/s41467-021-24324-0","article-title":"High-resolution characterization of gene function using single-cell CRISPR tiling screen","volume":"12","author":"Yang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2024.04.006_bib62","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1186\/s13059-014-0554-4","article-title":"MAGeCK enables robust identification of essential genes from genome-scale CRISPR\/Cas9 knockout screens","volume":"15","author":"Li","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.neuron.2024.04.006_bib63","doi-asserted-by":"crossref","first-page":"8812","DOI":"10.1074\/jbc.M610443200","article-title":"An essential role of human Ada3 in p53 acetylation","volume":"282","author":"Nag","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2024.04.006_bib64","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/3207","article-title":"ATM: the p53 booster","volume":"4","author":"Nakamura","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2024.04.006_bib65","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1038\/sj.onc.1204665","article-title":"Activation of p53 transcriptional activity requires ATM\u2019s kinase domain and multiple N-terminal serine residues of p53","volume":"20","author":"Turenne","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.neuron.2024.04.006_bib66","doi-asserted-by":"crossref","first-page":"14188","DOI":"10.1073\/pnas.1005960107","article-title":"The ATM\u2013p53 pathway suppresses aneuploidy-induced tumorigenesis","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2024.04.006_bib67","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2015.05.002","article-title":"Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets","volume":"161","author":"Macosko","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.04.006_bib68","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/nsmb.2635","article-title":"Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3\u2032 UTRs","volume":"20","author":"Z\u00fcnd","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.neuron.2024.04.006_bib69","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.molcel.2015.06.036","article-title":"Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity","volume":"59","author":"Lee","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neuron.2024.04.006_bib70","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1101\/gr.157354.113","article-title":"Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay","volume":"23","author":"Hurt","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.neuron.2024.04.006_bib71","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2024.04.006_bib72","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrc2657","article-title":"p21 in cancer: intricate networks and multiple activities","volume":"9","author":"Abbas","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.neuron.2024.04.006_bib73","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1101\/gad.9.8.935","article-title":"p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage","volume":"9","author":"Macleod","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.neuron.2024.04.006_bib74","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1128\/MCB.18.1.629","article-title":"Effects of p21(Cip1\/Waf1) at both the G1\/S and the G2\/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication","volume":"18","author":"Niculescu","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neuron.2024.04.006_bib75","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3390\/cells11081366","article-title":"Tet1 Suppresses p21 to Ensure Proper Cell Cycle Progression in Embryonic Stem Cells","volume":"11","author":"Chrysanthou","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.neuron.2024.04.006_bib76","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1038\/s41467-018-07901-8","article-title":"Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities","volume":"9","author":"Sanson","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2024.04.006_bib77","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.cell.2017.09.003","article-title":"Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation","volume":"171","author":"Yoon","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.04.006_bib78","doi-asserted-by":"crossref","first-page":"17535","DOI":"10.1038\/s41598-017-17283-4","article-title":"Identification of nonsense-mediated mRNA decay pathway as a critical regulator of p53 isoform \u03b2","volume":"7","author":"Cowen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2024.04.006_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101163","article-title":"Inhibition of nonsense-mediated decay rescues p53\u03b2\/\u03b3 isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancers","volume":"297","author":"Gudikote","year":"2021","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2024.04.006_bib80","doi-asserted-by":"crossref","first-page":"8612","DOI":"10.1128\/MCB.22.24.8612-8625.2002","article-title":"Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence","volume":"22","author":"Inga","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neuron.2024.04.006_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003726","article-title":"Characterization of the p53 cistrome--DNA binding cooperativity dissects p53\u2019s tumor suppressor functions","volume":"9","author":"Schlereth","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neuron.2024.04.006_bib82","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jmb.2004.06.071","article-title":"Cooperative binding of tetrameric p53 to DNA","volume":"341","author":"Weinberg","year":"2004","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.neuron.2024.04.006_bib83","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.dnarep.2016.04.008","article-title":"Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage","volume":"42","author":"Karimian","year":"2016","journal-title":"DNA Repair"},{"key":"10.1016\/j.neuron.2024.04.006_bib84","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1261\/rna.030122.111","article-title":"The role of mRNA decay in p53-induced gene expression","volume":"17","author":"Melanson","year":"2011","journal-title":"RNA"},{"key":"10.1016\/j.neuron.2024.04.006_bib85","first-page":"5187","article-title":"p21 is necessary for the p53-mediated G1 arrest in human cancer cells","volume":"55","author":"Waldman","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.neuron.2024.04.006_bib86","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14728","article-title":"DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression","volume":"8","author":"Barr","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2024.04.006_bib87","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/cdd.2017.172","article-title":"Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM","volume":"25","author":"Engeland","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neuron.2024.04.006_bib88","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1093\/emboj\/20.17.4987","article-title":"The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay","volume":"20","author":"Le Hir","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2024.04.006_bib89","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/j.celrep.2018.11.046","article-title":"The Exon Junction Complex Undergoes a Compositional Switch that Alters mRNP Structure and Nonsense-Mediated mRNA Decay Activity","volume":"25","author":"Mabin","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2024.04.006_bib90","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nn.2527","article-title":"The exon junction complex component Magoh controls brain size by regulating neural stem cell division","volume":"13","author":"Silver","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.04.006_bib91","doi-asserted-by":"crossref","first-page":"7003","DOI":"10.1523\/JNEUROSCI.0018-15.2015","article-title":"Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly","volume":"35","author":"Mao","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.04.006_bib92","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006282","article-title":"Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly","volume":"12","author":"Mao","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neuron.2024.04.006_bib93","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41398-020-01065-0","article-title":"Full function of exon junction complex factor, Rbm8a, is critical for interneuron development","volume":"10","author":"McSweeney","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuron.2024.04.006_bib94","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuron.2015.12.007","article-title":"Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain","volume":"89","author":"Pilaz","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.04.006_bib95","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nn.3026","article-title":"PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2","volume":"15","author":"Zheng","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.04.006_bib97","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.neuron.2020.06.036","article-title":"Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon","volume":"107","author":"Lin","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.04.006_bib96","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nm1228","article-title":"An essential function for NBS1 in the prevention of ataxia and cerebellar defects","volume":"11","author":"Frappart","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2024.04.006_bib98","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1091\/mbc.02-02-0030","article-title":"Identification of genes periodically expressed in the human cell cycle and their expression in tumors","volume":"13","author":"Whitfield","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neuron.2024.04.006_bib99","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/s41596-022-00680-z","article-title":"Transcriptome-wide identification of RNA-binding protein binding sites using seCLIP-seq","volume":"17","author":"Blue","year":"2022","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuron.2024.04.006_bib100","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1101\/gr.209601.116","article-title":"UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy","volume":"27","author":"Smith","year":"2017","journal-title":"Genome Res."},{"key":"10.1016\/j.neuron.2024.04.006_bib101","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet.journal"},{"key":"10.1016\/j.neuron.2024.04.006_bib102","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2024.04.006_bib103","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nmeth.3810","article-title":"Robust transcriptome-wide discovery\u00a0of RNA-binding protein binding sites with enhanced CLIP (eCLIP)","volume":"13","author":"Van Nostrand","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2024.04.006_bib104","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19760","article-title":"Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation","volume":"5","author":"Horlbeck","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.neuron.2024.04.006_bib105","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41375-021-01378-z","article-title":"3-Ketodihydrosphingosine reductase maintains ER homeostasis and unfolded protein response in leukemia","volume":"36","author":"Liu","year":"2022","journal-title":"Leukemia"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627324002447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627324002447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T08:34:30Z","timestamp":1751531670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627324002447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":105,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S0896627324002447"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2024.04.006","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2024.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}