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Biol."},{"key":"10.1016\/j.neuron.2024.09.015_bib106","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41588-023-01584-8","article-title":"Multi-ancestry genome-wide association meta-analysis of Parkinson\u2019s disease","volume":"56","author":"Kim","year":"2024","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2024.09.015_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2023.168144","article-title":"Role of Autophagy Pathway in Parkinson\u2019s Disease and Related Genetic Neurological Disorders","volume":"435","author":"Themistokleous","year":"2023","journal-title":"J.\u00a0Mol. 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Disord."},{"key":"10.1016\/j.neuron.2024.09.015_bib111","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1083\/jcb.201003122","article-title":"alpha-Synuclein impairs macroautophagy: implications for Parkinson\u2019s disease","volume":"190","author":"Winslow","year":"2010","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2024.09.015_bib112","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s41419-021-04138-0","article-title":"Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion","volume":"12","author":"Tang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neuron.2024.09.015_bib113","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1126\/science.1101738","article-title":"Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy","volume":"305","author":"Cuervo","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.neuron.2024.09.015_bib114","doi-asserted-by":"crossref","first-page":"10814","DOI":"10.1074\/jbc.M110.132514","article-title":"Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy","volume":"286","author":"Choubey","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2024.09.015_bib115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1750-1326-9-47","article-title":"The role of the LRRK2 gene in Parkinsonism","volume":"9","author":"Li","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuron.2024.09.015_bib116","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1093\/hmg\/ddp346","article-title":"LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model","volume":"18","author":"Alegre-Abarrategui","year":"2009","journal-title":"Hum. Mol. 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Commun."},{"key":"10.1016\/j.neuron.2024.09.015_bib124","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cell.2011.02.010","article-title":"PARIS (ZNF746) repression of PGC-1\u03b1 contributes to neurodegeneration in Parkinson\u2019s disease","volume":"144","author":"Shin","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.09.015_bib125","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1016\/S0140-6736(09)60492-X","article-title":"Parkinson\u2019s disease","volume":"373","author":"Lees","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.neuron.2024.09.015_bib126","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5028","article-title":"iPSC-derived neurons from GBA1-associated Parkinson\u2019s disease patients show autophagic defects and impaired calcium homeostasis","volume":"5","author":"Sch\u00f6ndorf","year":"2014","journal-title":"Nat. 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