{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:09:23Z","timestamp":1789826963944,"version":"4.0.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82350710222"],"award-info":[{"award-number":["82350710222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471439"],"award-info":[{"award-number":["82471439"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P30NS055077"],"award-info":[{"award-number":["P30NS055077"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007623","name":"School of Medicine, Emory University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007623","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016220","name":"Georgia Clinical and Translational Science Alliance","doi-asserted-by":"publisher","award":["UL1TR002378"],"award-info":[{"award-number":["UL1TR002378"]}],"id":[{"id":"10.13039\/100016220","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002378"],"award-info":[{"award-number":["UL1TR002378"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"publisher","award":["JCYJ20230807140806015"],"award-info":[{"award-number":["JCYJ20230807140806015"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"publisher","award":["KQTD20221101093608028"],"award-info":[{"award-number":["KQTD20221101093608028"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.neuron.2024.12.015","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T10:53:36Z","timestamp":1736852016000},"page":"719-736.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["ApoE3 R136S binds to Tau and blocks its propagation, suppressing neurodegeneration in mice with Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"113","author":[{"given":"Guiqin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhentao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Ki","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hee","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Su","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keqiang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2024.12.015_bib1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/00019052-199608000-00002","article-title":"Presenile because of presenilin: the presenilin genes and early onset Alzheimer\u2019s disease","volume":"9","author":"Haass","year":"1996","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.neuron.2024.12.015_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2022.101594","article-title":"APOE mediated neuroinflammation and neurodegeneration in Alzheimer\u2019s disease","volume":"59","author":"Parhizkar","year":"2022","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.neuron.2024.12.015_bib3","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.neuron.2022.03.004","article-title":"ApoE Cascade Hypothesis in the pathogenesis of Alzheimer\u2019s disease and related dementias","volume":"110","author":"Martens","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2024.12.015_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027037","article-title":"Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia","volume":"6","author":"Georgiadou","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuron.2024.12.015_bib5","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1038\/s41591-019-0611-3","article-title":"Resistance to autosomal dominant Alzheimer\u2019s disease in an APOE3 Christchurch homozygote: a case report","volume":"25","author":"Arboleda-Velasquez","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2024.12.015_bib6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00401-022-02467-8","article-title":"Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer\u2019s dementia","volume":"144","author":"Sepulveda-Falla","year":"2022","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2024.12.015_bib7","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/nm.3700","article-title":"Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer\u2019s disease","volume":"20","author":"Zhang","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2024.12.015_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms9762","article-title":"Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer\u2019s disease","volume":"6","author":"Zhang","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2024.12.015_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-019-0179-3","article-title":"delta-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities","volume":"9","author":"Zhang","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.neuron.2024.12.015_bib10","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1172\/JCI130513","article-title":"Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus","volume":"130","author":"Kang","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2024.12.015_bib11","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41594-022-00745-3","article-title":"Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation","volume":"29","author":"Kang","year":"2022","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.neuron.2024.12.015_bib12","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/brain\/awz346","article-title":"Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology","volume":"143","author":"Blennow","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2024.12.015_bib13","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s13195-022-01142-0","article-title":"CSF tau368\/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals","volume":"14","author":"Simr\u00e9n","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neuron.2024.12.015_bib14","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/WCO.0b013e32835a3432","article-title":"Where, when, and in what form does sporadic Alzheimer\u2019s disease begin?","volume":"25","author":"Braak","year":"2012","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.neuron.2024.12.015_bib15","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years","volume":"70","author":"Braak","year":"2011","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neuron.2024.12.015_bib16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.neurobiolaging.2006.02.007","article-title":"Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer\u2019s disease","volume":"28","author":"Grudzien","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2024.12.015_bib17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41586-020-2156-5","article-title":"LRP1 is a master regulator of tau uptake and spread","volume":"580","author":"Rauch","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.12.015_bib18","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1016\/S0021-9258(18)68957-4","article-title":"Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions","volume":"263","author":"Lalazar","year":"1988","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2024.12.015_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2174\/1567205017666200212155234","article-title":"Microglia in Alzheimer\u2019s Disease","volume":"17","author":"S\u00fc\u00df","year":"2020","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neuron.2024.12.015_bib20","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.3390\/biomedicines10081800","article-title":"Abeta and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer\u2019s Disease","volume":"10","author":"Zhao","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.neuron.2024.12.015_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abc9375","article-title":"APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia","volume":"13","author":"Liu","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuron.2024.12.015_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104518","article-title":"Asparagine endopeptidase cleaves tau at N167 after uptake into microglia","volume":"130","author":"Behrendt","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuron.2024.12.015_bib23","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nn.4132","article-title":"Depletion of microglia and inhibition of exosome synthesis halt tau propagation","volume":"18","author":"Asai","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.12.015_bib24","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1007\/s12035-021-02547-y","article-title":"Brain Exosomes: Friend or Foe in Alzheimer\u2019s Disease?","volume":"58","author":"Kaur","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuron.2024.12.015_bib25","doi-asserted-by":"crossref","first-page":"E12427","DOI":"10.1073\/pnas.1815915115","article-title":"Spatiotemporal activation of the C\/EBP\u03b2\/\u03b4-secretase axis regulates the pathogenesis of Alzheimer\u2019s disease","volume":"115","author":"Wang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2024.12.015_bib26","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.cell.2020.07.011","article-title":"Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c\/EBPbeta in Microglia","volume":"182","author":"Ndoja","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.12.015_bib27","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.neurobiolaging.2014.02.012","article-title":"Exosome reduction in\u00a0vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer\u2019s disease","volume":"35","author":"Dinkins","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2024.12.015_bib28","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.259324","article-title":"Neutral sphingomyelinase 2 controls exosome secretion by counteracting V-ATPase-mediated endosome acidification","volume":"135","author":"Choezom","year":"2022","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.neuron.2024.12.015_bib29","doi-asserted-by":"crossref","first-page":"200.e13","DOI":"10.1016\/j.neurobiolaging.2016.02.024","article-title":"Assessment of the genetic variance of late-onset Alzheimer\u2019s disease","volume":"41","author":"Ridge","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2024.12.015_bib30","article-title":"Netrin-1 receptor UNC5C cleavage by active \u03b4-secretase enhances neurodegeneration, promoting Alzheimer\u2019s disease pathologies","volume":"7","author":"Chen","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neuron.2024.12.015_bib31","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41586-022-04463-0","article-title":"FSH blockade improves cognition in mice with Alzheimer\u2019s disease","volume":"603","author":"Xiong","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2024.12.015_bib32","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/s41419-020-03270-7","article-title":"Delta-secretase triggers Alzheimer\u2019s disease pathologies in wild-type hAPP\/hMAPT double transgenic mice","volume":"11","author":"Wu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neuron.2024.12.015_bib33","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1038\/s41380-022-01600-z","article-title":"High-fat diet-induced diabetes couples to Alzheimer\u2019s disease through inflammation-activated C\/EBP\u03b2\/AEP pathway","volume":"27","author":"Liu","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2024.12.015_bib34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00401-021-02315-1","article-title":"ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer\u2019s disease","volume":"142","author":"Kang","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2024.12.015_bib35","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/bpa.12289","article-title":"Precortical Phase of Alzheimer\u2019s Disease (AD)-Related Tau Cytoskeletal Pathology","volume":"26","author":"Stratmann","year":"2016","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neuron.2024.12.015_bib36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13195-019-0511-2","article-title":"An experimental model of Braak\u2019s pretangle proposal for the origin of Alzheimer\u2019s disease: the role of locus coeruleus in early symptom development","volume":"11","author":"Ghosh","year":"2019","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neuron.2024.12.015_bib37","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00401-015-1458-4","article-title":"Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC\u2019s afferent and efferent connections","volume":"130","author":"Iba","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2024.12.015_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn7273","article-title":"Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes","volume":"14","author":"Montal","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuron.2024.12.015_bib39","doi-asserted-by":"crossref","first-page":"7364","DOI":"10.1523\/JNEUROSCI.0639-16.2016","article-title":"In\u00a0Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain","volume":"36","author":"Sepulcre","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.12.015_bib40","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1038\/s41591-018-0206-4","article-title":"Neurogenetic contributions to amyloid beta and tau spreading in the human cortex","volume":"24","author":"Sepulcre","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2024.12.015_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau5732","article-title":"Prospective longitudinal atrophy in Alzheimer\u2019s disease correlates with the intensity and topography of baseline tau-PET","volume":"12","author":"La Joie","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuron.2024.12.015_bib42","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ana.25395","article-title":"The impact of amyloid-beta and tau on prospective cognitive decline in older individuals","volume":"85","author":"Sperling","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuron.2024.12.015_bib43","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13195-020-00765-5","article-title":"Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer\u2019s disease: findings from the Colombia-Boston (COLBOS) biomarker study","volume":"13","author":"Sanchez","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neuron.2024.12.015_bib44","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00401-020-02249-0","article-title":"A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer\u2019s disease","volume":"141","author":"Sepulveda-Falla","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2024.12.015_bib45","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1038\/s41593-023-01480-8","article-title":"The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation","volume":"26","author":"Nelson","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2024.12.015_bib46","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2023.11.029","article-title":"APOE3ch alters microglial response and suppresses Abeta-induced tau seeding and spread","volume":"187","author":"Chen","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2024.12.015_bib47","article-title":"APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition","author":"Naguib","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.neuron.2024.12.015_bib48","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1038\/s41380-024-02565-x","article-title":"Thy1-ApoE4\/C\/EBPbeta double transgenic mice act as a sporadic model with Alzheimer\u2019s disease","volume":"29","author":"Qian","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2024.12.015_bib49","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0304-3940(95)11649-H","article-title":"ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation","volume":"192","author":"Huang","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2024.12.015_bib50","article-title":"APOE3 Christchurch heterozygosity delays clinical onset in autosomal dominant Alzheimer\u2019s disease","volume":"19","author":"Quiroz","year":"2023","journal-title":"Alzheimers Dem."},{"key":"10.1016\/j.neuron.2024.12.015_bib51","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1056\/NEJMoa2308583","article-title":"APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer\u2019s Disease","volume":"390","author":"Quiroz","year":"2024","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuron.2024.12.015_bib52","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1016\/S0021-9258(18)68778-2","article-title":"Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains","volume":"263","author":"Wetterau","year":"1988","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2024.12.015_bib53","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.1016\/S0021-9258(18)68779-4","article-title":"Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains","volume":"263","author":"Aggerbeck","year":"1988","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2024.12.015_bib54","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.abb.2012.10.007","article-title":"Biochemical and biophysical characterization of recombinant rat apolipoprotein E: similarities to human apolipoprotein E3","volume":"529","author":"Tran","year":"2013","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.neuron.2024.12.015_bib55","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.1073\/pnas.1507125112","article-title":"A survey of human brain transcriptome diversity at the single cell level","volume":"112","author":"Darmanis","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2024.12.015_bib56","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0002-9440(10)65305-9","article-title":"Specific regional transcription of apolipoprotein E in human brain neurons","volume":"154","author":"Xu","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neuron.2024.12.015_bib57","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1523\/JNEUROSCI.5476-05.2006","article-title":"Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus","volume":"26","author":"Xu","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2024.12.015_bib58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/exnr.1994.1108","article-title":"Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer\u2019s disease and in age-matched controls","volume":"128","author":"Han","year":"1994","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2024.12.015_bib59","doi-asserted-by":"crossref","first-page":"6002","DOI":"10.1038\/s41380-020-00956-4","article-title":"C\/EBP\u03b2 is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer\u2019s disease","volume":"26","author":"Xia","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2024.12.015_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102032","article-title":"ApoE4 activates C\/EBP\u03b2\/\u03b4-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer\u2019s disease","volume":"202","author":"Wang","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuron.2024.12.015_bib61","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/S0022-2275(20)32417-2","article-title":"Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes","volume":"40","author":"Mahley","year":"1999","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.neuron.2024.12.015_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-24904-z","article-title":"Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)","volume":"8","author":"Rauch","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2024.12.015_bib63","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1021\/bi8003999","article-title":"Role of the N- and C-terminal domains in binding of apolipoprotein E isoforms to heparan sulfate and dermatan sulfate: a surface plasmon resonance study","volume":"47","author":"Yamauchi","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuron.2024.12.015_bib64","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1172\/JCI118096","article-title":"Dominant expression of type III hyperlipoproteinemia. Pathophysiological insights derived from the structural and kinetic characteristics of ApoE-1 (Lys146-->Glu)","volume":"96","author":"Mann","year":"1995","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2024.12.015_bib65","doi-asserted-by":"crossref","first-page":"14782","DOI":"10.1074\/jbc.M213207200","article-title":"Characterization of the heparin binding sites in human apolipoprotein E","volume":"278","author":"Saito","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2024.12.015_bib66","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106320","article-title":"Gut inflammation triggers C\/EBP\u03b2\/\u03b4-secretase-dependent gut-to-brain propagation of A\u03b2 and Tau fibrils in Alzheimer\u2019s disease","volume":"40","author":"Chen","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2024.12.015_bib67","first-page":"35","article-title":"Purification of recombinant tau protein and preparation of Alzheimer-paired helical filaments in\u00a0vitro","volume":"299","author":"Barghorn","year":"2005","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.neuron.2024.12.015_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/npjamd.2016.19","article-title":"Extracellular Vesicle-Associated A\u03b2 Mediates Trans-Neuronal Bioenergetic and Ca2+-Handling Deficits in Alzheimer\u2019s Disease Models","volume":"2","author":"Eitan","year":"2016","journal-title":"NPJ Aging Mech. Dis."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627324009140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627324009140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T03:53:56Z","timestamp":1772682836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627324009140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0896627324009140"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2024.12.015","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ApoE3 R136S binds to Tau and blocks its propagation, suppressing neurodegeneration in mice with Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2024.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}