{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:28:50Z","timestamp":1786994930744,"version":"build-2736575974"},"reference-count":121,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["P30AG10161"],"award-info":[{"award-number":["P30AG10161"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG10161"],"award-info":[{"award-number":["P30AG10161"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG61356"],"award-info":[{"award-number":["U01AG61356"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG72975"],"award-info":[{"award-number":["P30AG72975"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG15819"],"award-info":[{"award-number":["R01AG15819"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG17917"],"award-info":[{"award-number":["R01AG17917"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG46152"],"award-info":[{"award-number":["U01AG46152"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG068577"],"award-info":[{"award-number":["R01AG068577"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG054517"],"award-info":[{"award-number":["R01AG054517"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.neuron.2025.07.010","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T14:40:49Z","timestamp":1754491249000},"page":"2822-2838.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Reconstructed cell-type-specific rhythms in human brain link Alzheimer\u2019s pathology, circadian stress, and ribosomal disruption"],"prefix":"10.1016","volume":"113","author":[{"given":"Henry C.","family":"Hollis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Sheehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Leonard B.","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan A.","family":"Hammarlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilas","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik S.","family":"Musiek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-5854","authenticated-orcid":false,"given":"Ron C.","family":"Anafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2025.07.010_bib1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0092-8674(00)80566-8","article-title":"Molecular bases for circadian clocks","volume":"96","author":"Dunlap","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2025.07.010_bib2","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nrg2430","article-title":"The genetics of mammalian circadian order and disorder: implications for physiology and disease","volume":"9","author":"Takahashi","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.neuron.2025.07.010_bib3","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1126\/science.2305266","article-title":"Transplanted Suprachiasmatic Nucleus Determines Circadian Period","volume":"247","author":"Ralph","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.neuron.2025.07.010_bib4","doi-asserted-by":"crossref","first-page":"16219","DOI":"10.1073\/pnas.1408886111","article-title":"A circadian gene expression atlas in mammals: Implications for biology and medicine","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2025.07.010_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat8806","article-title":"A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine","volume":"10","author":"Ruben","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuron.2025.07.010_bib6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1126\/science.add0846","article-title":"Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans","volume":"379","author":"Talamanca","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.neuron.2025.07.010_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00002093-200210000-00001","article-title":"Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank","volume":"16","author":"Barker","year":"2002","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.neuron.2025.07.010_bib8","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1001\/jamaneurol.2017.4719","article-title":"Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease","volume":"75","author":"Musiek","year":"2018","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neuron.2025.07.010_bib9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jsmc.2009.01.009","article-title":"Circadian Rhythm Sleep Disorder: Irregular Sleep Wake Rhythm Type","volume":"4","author":"Zee","year":"2009","journal-title":"Sleep Med. Clin."},{"key":"10.1016\/j.neuron.2025.07.010_bib10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/ana.24548","article-title":"Melanopsin retinal ganglion cell loss in Alzheimer disease","volume":"79","author":"La Morgia","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuron.2025.07.010_bib11","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.5664\/jcsm.5100","volume":"11","author":"Auger","year":"2015","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.neuron.2025.07.010_bib12","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0197-4580(95)00059-N","article-title":"Circadian locomotor activity and core-body temperature rhythms in Alzheimer\u2019s disease","volume":"16","author":"Satlin","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2025.07.010_bib13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00019442-200505000-00004","article-title":"Disturbance of endogenous circadian rhythm in aging and Alzheimer disease","volume":"13","author":"Harper","year":"2005","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neuron.2025.07.010_bib14","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0006-8993(90)90214-V","article-title":"Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer\u2019s disease","volume":"528","author":"Skene","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2025.07.010_bib15","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jalz.2016.10.003","article-title":"Circadian alterations during early stages of Alzheimer\u2019s disease are associated with aberrant cycles of DNA methylation in BMAL1","volume":"13","author":"Cronin","year":"2017","journal-title":"Alzheimers. Dement."},{"key":"10.1016\/j.neuron.2025.07.010_bib16","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3389\/fnins.2020.00703","article-title":"Evaluating Circadian Dysfunction in Mouse Models of Alzheimer\u2019s Disease: Where Do We Stand?","volume":"14","author":"Sheehan","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuron.2025.07.010_bib17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neurobiolaging.2019.01.010","article-title":"Delayed daily activity and reduced NREM slow-wave power in the APPswe\/PS1dE9 mouse model of Alzheimer\u2019s disease","volume":"78","author":"Kent","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2025.07.010_bib18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cell.2009.08.031","article-title":"A genome-wide RNAi screen for modifiers of the circadian clock in human cells","volume":"139","author":"Zhang","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2025.07.010_bib19","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0197-4580(95)00043-E","article-title":"VIP neurons in the human SCN in relation to sex, age, and Alzheimer\u2019s disease","volume":"16","author":"Zhou","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2025.07.010_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0006-8993(85)91350-2","article-title":"The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia","volume":"342","author":"Swaab","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2025.07.010_bib21","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jalz.2019.06.3916","article-title":"Profound degeneration of wake-promoting neurons in Alzheimer\u2019s disease","volume":"15","author":"Oh","year":"2019","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neuron.2025.07.010_bib22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrneurol.2013.269","article-title":"Sleep and Alzheimer disease pathology\u2014a bidirectional relationship","volume":"10","author":"Ju","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuron.2025.07.010_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2014.121","article-title":"Sleep, circadian rhythms, and the pathogenesis of Alzheimer Disease","volume":"47","author":"Musiek","year":"2015","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.neuron.2025.07.010_bib24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jsmc.2015.08.004","article-title":"Consequences of Circadian Disruption on Neurologic Health","volume":"10","author":"Videnovic","year":"2015","journal-title":"Sleep Med. Clin."},{"key":"10.1016\/j.neuron.2025.07.010_bib25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nrm1980","article-title":"Metabolic cycles as an underlying basis of biological oscillations","volume":"7","author":"Tu","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neuron.2025.07.010_bib26","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.1222826","article-title":"Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons","volume":"337","author":"Wang","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.neuron.2025.07.010_bib27","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.1172\/JCI70317","article-title":"Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration","volume":"123","author":"Musiek","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neuron.2025.07.010_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbi.2014.11.009","article-title":"Microglia inflammatory responses are controlled by an intrinsic circadian clock","volume":"45","author":"Fonken","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuron.2025.07.010_bib29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s12974-019-1562-9","article-title":"An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain","volume":"16","author":"Ni","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuron.2025.07.010_bib30","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1080\/07420520600827087","article-title":"The Circadian Regulation of Presenilin-2 Gene Expression","volume":"23","author":"B\u00e9langer","year":"2006","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.neuron.2025.07.010_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003529","article-title":"Mapping the Road Forward in Alzheimer\u2019s Disease","volume":"3","author":"Holtzman","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuron.2025.07.010_bib32","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1126\/science.1180962","article-title":"Amyloid-\u03b2 Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle","volume":"326","author":"Kang","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuron.2025.07.010_bib33","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1073\/pnas.1508249112","article-title":"Effects of aging on circadian patterns of gene expression in the human prefrontal cortex","volume":"113","author":"Chen","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2025.07.010_bib34","doi-asserted-by":"crossref","first-page":"9950","DOI":"10.1073\/pnas.1305814110","article-title":"Circadian patterns of gene expression in the human brain and disruption in major depressive disorder","volume":"110","author":"Li","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2025.07.010_bib120","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/0748730410379711","article-title":"JTK_CYCLE: An Efficient Nonparametric Algorithm for Detecting Rhythmic Components in Genome-Scale Data Sets","volume":"25","author":"Hughes","year":"2010","journal-title":"J Biol Rhythms"},{"key":"10.1016\/j.neuron.2025.07.010_bib121","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/bioinformatics\/btw405","article-title":"MetaCycle: an integrated R package to evaluate periodicity in large scale data","volume":"32","author":"Wu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2025.07.010_bib35","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1073\/pnas.1619320114","article-title":"CYCLOPS reveals human transcriptional rhythms in health and disease","volume":"114","author":"Anafi","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2025.07.010_bib36","article-title":"Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer","volume":"121","author":"Li","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2025.07.010_bib37","article-title":"A glial circadian gene expression atlas reveals cell type and disease-specific reprogramming in response to amyloid pathology or aging","author":"Sheehan","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.neuron.2025.07.010_bib38","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.3233\/JAD-179939","article-title":"Religious Orders Study and Rush Memory and Aging Project","volume":"64","author":"Bennett","year":"2018","journal-title":"J. Alzheimers. Dis."},{"key":"10.1016\/j.neuron.2025.07.010_bib39","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41586-024-07871-6","article-title":"Cellular communities reveal trajectories of brain ageing and Alzheimer\u2019s disease","volume":"633","author":"Green","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2025.07.010_bib40","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.4327","article-title":"Evidence for widespread dysregulation of circadian clock progression in human cancer","volume":"6","author":"Shilts","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.neuron.2025.07.010_bib41","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.neuron.2025.07.010_bib42","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.neuron.2025.07.010_bib43","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuron.2025.07.010_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.90","article-title":"Gene Set Knowledge Discovery with Enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.neuron.2025.07.010_bib45","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neuron.2025.07.010_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf6295","article-title":"Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP\/PS1 mice","volume":"9","author":"Shi","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuron.2025.07.010_bib47","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1038\/s41598-018-19699-y","article-title":"Innate immune alterations are elicited in microglial cells before plaque deposition in the Alzheimer\u2019s disease mouse model 5xFAD","volume":"8","author":"Boza-Serrano","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2025.07.010_bib48","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3390\/cells8050425","article-title":"Genetic and Real-World Clinical Data, Combined with Empirical Validation, Nominate Jak-Stat Signaling as a Target for Alzheimer\u2019s Disease Therapeutic Development","volume":"8","author":"Nevado-Holgado","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.neuron.2025.07.010_bib49","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41586-023-05788-0","article-title":"Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy","volume":"615","author":"Chen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2025.07.010_bib50","series-title":"Chronobiology and Chronomedicine - From Molecular and Cellular Mechanisms to Whole Body: Interdigitating Networks","first-page":"610","article-title":"Identifying and Interpreting Rhythms in Biological Data","author":"Yoo","year":"2024"},{"key":"10.1016\/j.neuron.2025.07.010_bib51","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.1111\/febs.16095","article-title":"Venn diagram analysis overestimates the extent of circadian rhythm reprogramming","volume":"289","author":"Pelikan","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.neuron.2025.07.010_bib52","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2025.07.010_bib53","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1093\/nar\/gks042","article-title":"Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation","volume":"40","author":"McCarthy","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuron.2025.07.010_bib54","article-title":"From reads to genes to pathways: differential expression analysis of RNA-Seq experiments using Rsubread and the edgeR quasi-likelihood pipeline","volume":"5","author":"Chen","year":"2016","journal-title":"F1000Res"},{"key":"10.1016\/j.neuron.2025.07.010_bib55","article-title":"edgeR 4.0: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets","volume":"53","author":"Chen","year":"2024","journal-title":"Nucleic Acid Res."},{"key":"10.1016\/j.neuron.2025.07.010_bib56","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer\u2019s disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2025.07.010_bib57","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-020-01079-1","article-title":"Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation","volume":"8","author":"Wojtas","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neuron.2025.07.010_bib58","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-020-00416-1","article-title":"Astrocyte-derived clusterin suppresses amyloid formation in vivo","volume":"15","author":"Wojtas","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuron.2025.07.010_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107846","article-title":"The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress","volume":"32","author":"Kobiita","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2025.07.010_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.726479","article-title":"Astrocyte Heterogeneity in Multiple Sclerosis: Current Understanding and Technical Challenges","volume":"15","author":"Lo","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2025.07.010_bib61","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1126\/science.aaa1934","article-title":"Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq","volume":"347","author":"Zeisel","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.neuron.2025.07.010_bib62","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-017-0184-x","article-title":"Late onset Alzheimer\u2019s disease genetics implicates microglial pathways in disease risk","volume":"12","author":"Efthymiou","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuron.2025.07.010_bib63","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neurobiolaging.2014.09.027","article-title":"Alzheimer\u2019s disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes","volume":"36","author":"Sekar","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2025.07.010_bib64","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A Unique Microglia Type Associated with Restricting Development of Alzheimer\u2019s Disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2025.07.010_bib65","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20202717","article-title":"Microglia in Alzheimer\u2019s disease at single-cell level. Are there common patterns in humans and mice?","volume":"218","author":"Chen","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neuron.2025.07.010_bib66","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-021-00428-5","article-title":"Mammalian\/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration","volume":"16","author":"Querfurth","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuron.2025.07.010_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27702-w","article-title":"Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and A\u00df pathology","volume":"13","author":"Jiwaji","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2025.07.010_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.neuron.2025.07.010_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18115-2","article-title":"Circadian control of brain glymphatic and lymphatic fluid flow","volume":"11","author":"Hablitz","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2025.07.010_bib70","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/s41593-024-01638-y","article-title":"Brain clearance is reduced during sleep and anesthesia","volume":"27","author":"Miao","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2025.07.010_bib71","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41593-025-01897-3","article-title":"A curious concept of CNS clearance","volume":"28","author":"Pl\u00e1","year":"2025","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2025.07.010_bib72","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41593-025-01898-2","article-title":"Reply to: A curious concept of CNS clearance","volume":"28","author":"Franks","year":"2025","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2025.07.010_bib73","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature24482","article-title":"Visualization of chemical modifications in the human 80S ribosome structure","volume":"551","author":"Natchiar","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2025.07.010_bib74","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4792","article-title":"UCSF ChimeraX: Tools for structure building and analysis","volume":"32","author":"Meng","year":"2023","journal-title":"Protein Sci."},{"key":"10.1016\/j.neuron.2025.07.010_bib75","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/s43587-024-00719-8","article-title":"SEA-AD is a multimodal cellular atlas and resource for Alzheimer\u2019s disease","volume":"4","author":"Hawrylycz","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.neuron.2025.07.010_bib76","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/alz.12714","article-title":"The landscape of metabolic brain alterations in Alzheimer\u2019s disease","volume":"19","author":"Batra","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neuron.2025.07.010_bib77","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuron.2025.07.010_bib78","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1152\/physiolgenomics.00275.2006","article-title":"Macromolecule biosynthesis: a key function of sleep","volume":"31","author":"Mackiewicz","year":"2007","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.neuron.2025.07.010_bib79","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.162771","article-title":"Neuronal deletion of the circadian clock gene Bmal1 induces cell-autonomous dopaminergic neurodegeneration","volume":"9","author":"Kanan","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.neuron.2025.07.010_bib80","doi-asserted-by":"crossref","first-page":"R914","DOI":"10.1016\/j.cub.2006.09.058","article-title":"Chronic jet-lag increases mortality in aged mice","volume":"16","author":"Davidson","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2025.07.010_bib81","doi-asserted-by":"crossref","first-page":"5796","DOI":"10.4049\/jimmunol.1001026","article-title":"Dysregulation of inflammatory responses by chronic circadian disruption","volume":"185","author":"Castanon-Cervantes","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.neuron.2025.07.010_bib82","doi-asserted-by":"crossref","first-page":"5516","DOI":"10.1128\/MCB.20.15.5516-5528.2000","article-title":"Bop1 Is a Mouse WD40 Repeat Nucleolar Protein Involved in 28S and 5. 8S rRNA Processing and 60S Ribosome Biogenesis","volume":"20","author":"Strezoska","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neuron.2025.07.010_bib83","article-title":"QuAPPro: An R\/shiny app for Quantification and Alignment of Polysome Profiles","author":"Schiller","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.neuron.2025.07.010_bib84","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1529\/biophysj.104.040824","article-title":"Modeling Feedback Loops of the Mammalian Circadian Oscillator","volume":"87","author":"Becker-Weimann","year":"2004","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuron.2025.07.010_bib85","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1126\/science.1106914","article-title":"Gene Regulation at the Single-Cell Level","volume":"307","author":"Rosenfeld","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.neuron.2025.07.010_bib86","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-84738-0","article-title":"Variability in mRNA translation: a random matrix theory approach","volume":"11","author":"Margaliot","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2025.07.010_bib87","doi-asserted-by":"crossref","DOI":"10.1038\/nmicrobiol.2016.231","article-title":"Reduction of translating ribosomes enables Escherichia coli to maintain elongation rates during slow growth","volume":"2","author":"Dai","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.neuron.2025.07.010_bib88","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/s41564-018-0199-2","article-title":"Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions","volume":"3","author":"Li","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.neuron.2025.07.010_bib89","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14931","article-title":"Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer\u2019s disease","volume":"8","author":"Lim","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2025.07.010_bib90","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbr.2009.10.014","article-title":"Short-term total sleep deprivation in the rat increases antioxidant responses in multiple brain regions without impairing spontaneous alternation behavior","volume":"207","author":"Ramanathan","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuron.2025.07.010_bib91","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbr.2011.05.010","article-title":"Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: Potential role of oxidative stress mechanisms","volume":"224","author":"Vollert","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuron.2025.07.010_bib92","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1471-4159.2004.02952.x","article-title":"Sleep deprivation induces the unfolded protein response in mouse cerebral cortex","volume":"92","author":"Naidoo","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuron.2025.07.010_bib93","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aar8590","article-title":"Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans","volume":"4","author":"Cedernaes","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neuron.2025.07.010_bib94","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-14-362","article-title":"Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues","volume":"14","author":"Anafi","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.neuron.2025.07.010_bib95","doi-asserted-by":"crossref","first-page":"9171","DOI":"10.1523\/JNEUROSCI.3040-05.2005","article-title":"Ribosome dysfunction is an early event in Alzheimer\u2019s disease","volume":"25","author":"Ding","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2025.07.010_bib96","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s11064-006-9071-5","article-title":"Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer\u2019s disease","volume":"31","author":"Ding","year":"2006","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuron.2025.07.010_bib97","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001455","article-title":"The Circadian Clock Coordinates Ribosome Biogenesis","volume":"11","author":"Jouffe","year":"2013","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neuron.2025.07.010_bib98","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-26365-x","article-title":"Neuronal ribosomes exhibit dynamic and context-dependent exchange of ribosomal proteins","volume":"12","author":"Fusco","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2025.07.010_bib99","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.molcel.2017.05.021","article-title":"Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide","volume":"67","author":"Shi","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neuron.2025.07.010_bib100","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-021-00903-7","article-title":"The circadian rest-activity pattern predicts cognitive decline among mild-moderate Alzheimer\u2019s disease patients","volume":"13","author":"Targa","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neuron.2025.07.010_bib101","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/ana.26880","article-title":"Associations of 24-Hour Rest-Activity Rhythm Fragmentation, Cognitive Decline, and Postmortem Locus Coeruleus Hypopigmentation in Alzheimer\u2019s Disease","volume":"95","author":"Van Egroo","year":"2024","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuron.2025.07.010_bib102","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.cmet.2023.07.014","article-title":"Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer\u2019s disease","volume":"35","author":"Whittaker","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.neuron.2025.07.010_bib103","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.buildenv.2008.02.005","article-title":"Ambient bright light in dementia: Effects on behaviour and circadian rhythmicity","volume":"44","author":"van Hoof","year":"2009","journal-title":"Build. Environ."},{"key":"10.1016\/j.neuron.2025.07.010_bib104","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1073\/pnas.0408465102","article-title":"Stochastic simulation of the mammalian circadian clock","volume":"102","author":"Forger","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2025.07.010_bib105","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.neuron.2017.02.030","article-title":"Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling","volume":"93","author":"Brancaccio","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2025.07.010_bib106","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.cub.2017.02.037","article-title":"Astrocytes Regulate Daily Rhythms in the Suprachiasmatic Nucleus and Behavior","volume":"27","author":"Tso","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2025.07.010_bib107","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neuron.2025.07.010_bib108","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btad547","article-title":"PyDESeq2: a python package for bulk RNA-seq differential expression analysis","volume":"39","author":"Muzellec","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2025.07.010_bib109","doi-asserted-by":"crossref","DOI":"10.21105\/joss.00042","article-title":"Gillespie.jl: Stochastic Simulation Algorithm in Julia","volume":"1","author":"Frost","year":"2016","journal-title":"J. Open Source Softw."},{"key":"10.1016\/j.neuron.2025.07.010_bib110","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1389-0344(01)00067-3","article-title":"Co-expression of multiple transgenes in mouse CNS: a comparison of strategies","volume":"17","author":"Jankowsky","year":"2001","journal-title":"Biomol. Eng."},{"key":"10.1016\/j.neuron.2025.07.010_bib111","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddh019","article-title":"Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase","volume":"13","author":"Jankowsky","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2025.07.010_bib112","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41588-024-01685-y","article-title":"Cell subtype-specific effects of genetic variation in the Alzheimer\u2019s disease brain","volume":"56","author":"Fujita","year":"2024","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2025.07.010_bib113","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.jalz.2017.01.020","article-title":"Metabolic network failures in Alzheimer\u2019s disease: A biochemical road map","volume":"13","author":"Toledo","year":"2017","journal-title":"Alzheimers. Dement."},{"key":"10.1016\/j.neuron.2025.07.010_bib114","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-14959-w","article-title":"Sex and APOE \u03b54 genotype modify the Alzheimer\u2019s disease serum metabolome","volume":"11","author":"Arnold","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2025.07.010_bib115","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2017.140","article-title":"Targeted metabolomics and medication classification data from participants in the ADNI1 cohort","volume":"4","author":"St John-Williams","year":"2017","journal-title":"Sci. Data"},{"key":"10.1016\/j.neuron.2025.07.010_bib116","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2144\/04361RR04","article-title":"Estimation of ribosomal RNA transcription rate in situ","volume":"36","author":"Cui","year":"2004","journal-title":"BioTechniques"},{"key":"10.1016\/j.neuron.2025.07.010_bib117","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1126\/science.284.5423.2177","article-title":"Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker","volume":"284","author":"Czeisler","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.neuron.2025.07.010_bib118","doi-asserted-by":"crossref","first-page":"15602","DOI":"10.1073\/pnas.1010666108","article-title":"Sex difference in the near-24-hour intrinsic period of the human circadian timing system","volume":"108","author":"Duffy","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2025.07.010_bib119","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1084\/jem.103.2.273","article-title":"Clonal growth of mammalian cells in vitro; growth characteristics of colonies from single HeLa cells with and without a feeder layer","volume":"103","author":"Puck","year":"1956","journal-title":"J. Exp. Med."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627325005173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627325005173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:35:08Z","timestamp":1778546108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627325005173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":121,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0896627325005173"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2025.07.010","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.02.21.639499","asserted-by":"object"}]},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reconstructed cell-type-specific rhythms in human brain link Alzheimer\u2019s pathology, circadian stress, and ribosomal disruption","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2025.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}