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Pharmacol."},{"key":"10.1016\/j.neuron.2025.09.022_bib79","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.stem.2020.10.016","article-title":"Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-alpha Receptor Signaling","volume":"28","author":"Belenguer","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neuron.2025.09.022_bib80","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.7150\/jca.61556","article-title":"INHBA is a novel mediator regulating cellular senescence and immune evasion in colorectal cancer","volume":"12","author":"Chen","year":"2021","journal-title":"J. Cancer"},{"key":"10.1016\/j.neuron.2025.09.022_bib81","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13719","article-title":"Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence","volume":"7","author":"Revandkar","year":"2016","journal-title":"Nat. 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Neurol."},{"key":"10.1016\/j.neuron.2025.09.022_bib88","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1084\/jem.20080383","article-title":"Transcriptional role of p53 in interferon-mediated antiviral immunity","volume":"205","author":"Mu\u00f1oz-Fontela","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neuron.2025.09.022_bib89","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2013452118","article-title":"E2A-regulated epigenetic landscape promotes memory CD8 T cell differentiation","volume":"118","author":"Schauder","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2025.09.022_bib90","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.18632\/aging.101328","article-title":"TNFalpha-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion","volume":"9","author":"Kandhaya-Pillai","year":"2017","journal-title":"Aging (Albany, NY)"},{"key":"10.1016\/j.neuron.2025.09.022_bib91","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-020-0336-2","article-title":"A scalable SCENIC workflow for single-cell gene regulatory network analysis","volume":"15","author":"Van de Sande","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuron.2025.09.022_bib92","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/nyas.13533","article-title":"Revisiting the genomic hypomethylation hypothesis of aging","volume":"1418","author":"Unnikrishnan","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuron.2025.09.022_bib93","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/s41586-024-07187-5","article-title":"Disease-associated astrocyte epigenetic memory promotes CNS pathology","volume":"667","author":"Lee","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2025.09.022_bib94","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-022-01397-2","article-title":"Whole-blood methylation signatures are associated with and accurately classify multiple sclerosis disease severity","volume":"14","author":"Campagna","year":"2022","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.neuron.2025.09.022_bib95","doi-asserted-by":"crossref","first-page":"15134","DOI":"10.18632\/aging.103612","article-title":"Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis","volume":"12","author":"Wilkins","year":"2020","journal-title":"Aging (Albany, NY)"},{"key":"10.1016\/j.neuron.2025.09.022_bib96","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0784-9","article-title":"L1 drives IFN in senescent cells and promotes age-associated inflammation","volume":"566","author":"De Cecco","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2025.09.022_bib97","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-022-00583-3","article-title":"Glial interference: impact of type I interferon in neurodegenerative diseases","volume":"17","author":"Roy","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuron.2025.09.022_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111017","article-title":"Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction","volume":"39","author":"Rasa","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2025.09.022_bib99","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS-STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2025.09.022_bib100","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-020-2496-1","article-title":"A single-cell transcriptomic atlas characterizes ageing tissues in the mouse","volume":"583","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2025.09.022_bib101","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s43587-022-00337-2","article-title":"Activation of innate immune cGAS-STING pathway contributes to Alzheimer\u2019s pathogenesis in 5xFAD mice","volume":"3","author":"Xie","year":"2023","journal-title":"Nat Aging"},{"key":"10.1016\/j.neuron.2025.09.022_bib102","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2204058119","article-title":"Alpha-synuclein-mediated DNA damage, STING activation, and neuroinflammation in Parkinson\u2019s disease","volume":"119","author":"Standaert","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2025.09.022_bib103","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-018-0543-y","article-title":"Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline","volume":"562","author":"Bussian","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2025.09.022_bib104","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.neuron.2022.12.029","article-title":"Virus exposure and neurodegenerative disease risk across national biobanks","volume":"111","author":"Levine","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2025.09.022_bib105","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.neuron.2025.09.022_bib106","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.molmed.2018.02.007","article-title":"Human Endogenous Retroviruses in Neurological Diseases","volume":"24","author":"K\u00fcry","year":"2018","journal-title":"Trends Mol. 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Neuroimmunol. 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(2019). Package \u2018visnetwork\u2019: Network Visualization using \u2018vis.js\u2019 Library. https:\/\/cran.r-project.org\/web\/packages\/visNetwork\/index.html."},{"key":"10.1016\/j.neuron.2025.09.022_bib137","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. 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