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Dermatol."},{"key":"10.1016\/j.neuron.2025.12.039_bib103","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-3-662-46450-2_14","article-title":"Itch and Pain Differences and Commonalities","volume":"227","author":"Schmelz","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.neuron.2025.12.039_bib104","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neuron.2014.02.046","article-title":"Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord","volume":"82","author":"Kardon","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2025.12.039_bib105","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52316-0","article-title":"Pain Inhibits GRPR Neurons via GABAergic Signaling in the Spinal Cord","volume":"9","author":"Bardoni","year":"2019","journal-title":"Sci. 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Adv."},{"key":"10.1016\/j.neuron.2025.12.039_bib109","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.neuron.2017.01.012","article-title":"Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord","volume":"93","author":"Sun","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2025.12.039_bib110","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1212\/WNL.62.2.212","article-title":"Painful stimuli evoke itch in patients with chronic pruritus: Central sensitization for itch","volume":"62","author":"Ikoma","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2025.12.039_bib111","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1097\/ALN.0000000000000850","article-title":"Spinal IL-33\/ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKII\u2013CREB and Astroglial JAK2\u2013STAT3 Cascades in Mice","volume":"123","author":"Liu","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuron.2025.12.039_bib112","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-021-02198-9","article-title":"Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-\u03b1 through activating ERK, p38 MAPK, and JAK2\/STAT3","volume":"18","author":"Li","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.neuron.2025.12.039_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115143","article-title":"IL-33\/ST2 signaling in pain and itch: Cellular and molecular mechanisms and therapeutic potentials","volume":"165","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.neuron.2025.12.039_bib114","article-title":"Expansion of OSMR expression and signaling in the human dorsal root ganglion links OSM to neuropathic pain","author":"Mwirigi","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.neuron.2025.12.039_bib115","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41423-023-00992-4","article-title":"The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment","volume":"20","author":"Facheris","year":"2023","journal-title":"Cell. Mol. 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