{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:54:11Z","timestamp":1781711651776,"version":"3.54.5"},"reference-count":10,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.neuron.2026.04.030","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:49:26Z","timestamp":1781707766000},"page":"2073-2075","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Limiting neurodegeneration in ALS: A phosphatase paves the way"],"prefix":"10.1016","volume":"114","author":[{"given":"Elena I.","family":"Rugarli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-1462","authenticated-orcid":false,"given":"Thomas","family":"Langer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2026.04.030_bib1","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.neuron.2026.02.003","article-title":"Targeting PGAM5-driven mitochondrial integrated stress response slows ALS progression across subtypes","volume":"114","author":"Zheng","year":"2026","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2026.04.030_bib2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1083\/jcb.200906084","article-title":"Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1","volume":"187","author":"Ehses","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neuron.2026.04.030_bib3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41594-026-01756-0","article-title":"Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15","volume":"33","author":"Kroczek","year":"2026","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.neuron.2026.04.030_bib4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41586-020-2076-4","article-title":"A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol","volume":"579","author":"Fessler","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2026.04.030_bib5","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41586-020-2078-2","article-title":"Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway","volume":"579","author":"Guo","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2026.04.030_bib6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s12276-025-01391-7","article-title":"The dual role of PGAM5 in inflammation","volume":"57","author":"Qi","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.neuron.2026.04.030_bib7","doi-asserted-by":"crossref","first-page":"34635","DOI":"10.1074\/jbc.M112.357509","article-title":"Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5","volume":"287","author":"Sekine","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuron.2026.04.030_bib8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.nbd.2019.03.024","article-title":"The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS","volume":"127","author":"Dzhashiashvili","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuron.2026.04.030_bib9","doi-asserted-by":"crossref","first-page":"7690","DOI":"10.1038\/s41467-025-63031-y","article-title":"Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial","volume":"16","author":"Flores","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2026.04.030_bib10","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202403195","article-title":"Sephin1 reduces TDP-43 cytoplasmic mislocalization and improves motor neuron survival in ALS models","volume":"8","author":"Abgueguen","year":"2025","journal-title":"Life Sci. Alliance"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627326003259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627326003259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:19:09Z","timestamp":1781709549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627326003259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0896627326003259"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2026.04.030","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Limiting neurodegeneration in ALS: A phosphatase paves the way","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2026.04.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2026.02.003","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}