{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:24:59Z","timestamp":1791822299088,"version":"4.3.4"},"reference-count":91,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2024ZFJH01-01"],"award-info":[{"award-number":["2024ZFJH01-01"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2023ZFJH01-01"],"award-info":[{"award-number":["2023ZFJH01-01"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82090033"],"award-info":[{"award-number":["82090033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100814"],"award-info":[{"award-number":["32100814"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571195"],"award-info":[{"award-number":["32571195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2293733"],"award-info":[{"award-number":["T2293733"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82288101"],"award-info":[{"award-number":["82288101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2023-PT310-01"],"award-info":[{"award-number":["2023-PT310-01"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2022C03034"],"award-info":[{"award-number":["2022C03034"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2025ZD0215000"],"award-info":[{"award-number":["2025ZD0215000"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2021ZD0203400"],"award-info":[{"award-number":["2021ZD0203400"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2021ZD0200408"],"award-info":[{"award-number":["2021ZD0200408"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LZ22H090001"],"award-info":[{"award-number":["LZ22H090001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.neuron.2026.04.041","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:14:10Z","timestamp":1779290050000},"page":"3665-3683.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Slow-wave sleep engages brainstem circuitry to prevent stress-induced anxiety"],"prefix":"10.1016","volume":"114","author":[{"given":"Xiang","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunting","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochuang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenggang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiadong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Qin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2026.04.041_bib1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neuron.2017.01.014","article-title":"Neural Circuitry of Wakefulness and Sleep","volume":"93","author":"Scammell","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2026.04.041_bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-neuro-080317-061813","article-title":"A Motor Theory of Sleep-Wake Control: Arousal-Action Circuit","volume":"42","author":"Liu","year":"2019","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrn3945","article-title":"Neuronal circuits for fear and anxiety","volume":"16","author":"Tovote","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib4","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/nn.4101","article-title":"Resolving the neural circuits of anxiety","volume":"18","author":"Calhoon","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41574-022-00746-8","article-title":"The multiple roles of life stress in metabolic disorders","volume":"19","author":"Kivim\u00e4ki","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.neuron.2026.04.041_bib6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00213-012-2754-5","article-title":"Chronic social defeat stress model: behavioral features, antidepressant action, and interaction with biological risk factors","volume":"224","author":"Venzala","year":"2012","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.neuron.2026.04.041_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neubiorev.2007.06.001","article-title":"Stress-induced changes in sleep in rodents: models and mechanisms","volume":"32","author":"Pawlyk","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuron.2026.04.041_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.00322","article-title":"Acute Social Defeat Stress Increases Sleep in Mice","volume":"13","author":"Fujii","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2017.00227","article-title":"Effects of Social Defeat Stress on Sleep in Mice","volume":"11","author":"Henderson","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib10","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s12264-020-00473-y","article-title":"Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice","volume":"36","author":"Feng","year":"2020","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.neuron.2026.04.041_bib11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1126\/science.abn0853","article-title":"A specific circuit in the midbrain detects stress and induces restorative sleep","volume":"377","author":"Yu","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.neuron.2026.04.041_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbr.2017.03.022","article-title":"Chronic social stress leads to altered sleep homeostasis in mice","volume":"327","author":"Olini","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuron.2026.04.041_bib13","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.80206","article-title":"Non-rapid eye movement sleep determines resilience to social stress","volume":"11","author":"Bush","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2026.04.041_bib14","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s12264-024-01270-7","article-title":"Behavioral Animal Models and Neural-Circuit Framework of Depressive Disorder","volume":"41","author":"Tian","year":"2025","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.neuron.2026.04.041_bib15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cell.2018.02.012","article-title":"Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability","volume":"173","author":"Hultman","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2026.04.041_bib16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41591-018-0299-9","article-title":"Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior","volume":"25","author":"Shen","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2026.04.041_bib17","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1016\/j.cub.2024.06.010","article-title":"A REM-active basal ganglia circuit that regulates anxiety","volume":"34","author":"Ba","year":"2024","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2026.04.041_bib18","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1037\/a0026871","article-title":"Sleep deprivation and stressors: evidence for elevated negative affect in response to mild stressors when sleep deprived","volume":"12","author":"Minkel","year":"2012","journal-title":"Emotion"},{"key":"10.1016\/j.neuron.2026.04.041_bib19","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrn.2017.55","article-title":"The sleep-deprived human brain","volume":"18","author":"Krause","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuron.2023.10.002","article-title":"Dopamine pathways mediating affective state transitions after sleep loss","volume":"112","author":"Wu","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2026.04.041_bib21","doi-asserted-by":"crossref","first-page":"17970","DOI":"10.1523\/JNEUROSCI.0620-12.2012","article-title":"Identification and characterization of a sleep-active cell group in the rostral medullary brainstem","volume":"32","author":"Anaclet","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib22","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/nn.3789","article-title":"The GABAergic parafacial zone is a medullary slow wave sleep-promoting center","volume":"17","author":"Anaclet","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/npp.2017.152","article-title":"Activation of the GABAergic Parafacial Zone Maintains Sleep and Counteracts the Wake-Promoting Action of the Psychostimulants Armodafinil and Caffeine","volume":"43","author":"Anaclet","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuron.2026.04.041_bib24","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.bja.2025.02.035","article-title":"Parafacial GABAergic neurone ablation induces behavioural resistance to volatile anaesthetic-induced hypnosis without reducing sleep","volume":"134","author":"Imamura","year":"2025","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.neuron.2026.04.041_bib25","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s12264-018-0303-x","article-title":"A Critical Time-Window for the Selective Induction of Hippocampal Memory Consolidation by a Brief Episode of Slow-Wave Sleep","volume":"34","author":"Lu","year":"2018","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.neuron.2026.04.041_bib26","doi-asserted-by":"crossref","first-page":"7627","DOI":"10.1523\/JNEUROSCI.0173-13.2013","article-title":"Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal","volume":"33","author":"Kaur","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib27","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1016\/j.cub.2016.07.054","article-title":"Stimulation of the Pontine Parabrachial Nucleus Promotes Wakefulness via Extra-thalamic Forebrain Circuit Nodes","volume":"26","author":"Qiu","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2026.04.041_bib28","article-title":"Ventral Tegmental Area Dopamine Neurons Regulated by the Parabrachial Nucleus Mediate Long-Term Aversive Memory","author":"Osnaya-Ramirez","year":"2025","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2026.04.041_bib29","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.neuron.2020.03.014","article-title":"Divergent Neural Pathways Emanating from the Lateral Parabrachial Nucleus Mediate Distinct Components of the Pain Response","volume":"106","author":"Chiang","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2026.04.041_bib30","doi-asserted-by":"crossref","first-page":"6340","DOI":"10.1523\/JNEUROSCI.2780-17.2018","article-title":"Brain Circuits Mediating Opposing Effects on Emotion and Pain","volume":"38","author":"Cai","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib31","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.neuron.2021.11.029","article-title":"Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions","volume":"110","author":"Liu","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2026.04.041_bib32","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s12264-022-00994-8","article-title":"Control of Emotion and Wakefulness by Neurotensinergic Neurons in the Parabrachial Nucleus","volume":"39","author":"Chen","year":"2023","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.neuron.2026.04.041_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd3666","article-title":"Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding","volume":"7","author":"Luskin","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neuron.2026.04.041_bib34","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tins.2018.03.007","article-title":"The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm","volume":"41","author":"Palmiter","year":"2018","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib35","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.neuron.2018.09.032","article-title":"Parabrachial CGRP Neurons Establish and Sustain Aversive Taste Memories","volume":"100","author":"Chen","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2026.04.041_bib36","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.neuron.2020.06.017","article-title":"The Parabrachial Nucleus Directly Channels Spinal Nociceptive Signals to the Intralaminar Thalamic Nuclei, but Not the Amygdala","volume":"107","author":"Deng","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2026.04.041_bib37","doi-asserted-by":"crossref","first-page":"e61135","DOI":"10.7554\/eLife.61135","article-title":"A spinoparabrachial circuit defined by Tacr1 expression drives pain","volume":"10","author":"Barik","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2026.04.041_bib38","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cell.2018.02.057","article-title":"A Neural Circuit for the Suppression of Pain by a Competing Need State","volume":"173","author":"Alhadeff","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2026.04.041_bib39","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/s41593-017-0012-1","article-title":"A craniofacial-specific monosynaptic circuit enables heightened affective pain","volume":"20","author":"Rodriguez","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19767-w","article-title":"Parabrachial nucleus circuit governs neuropathic pain-like behavior","volume":"11","author":"Sun","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2026.04.041_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-36603-z","article-title":"Parabrachial tachykinin1-expressing neurons involved in state-dependent breathing control","volume":"14","author":"Arthurs","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2026.04.041_bib42","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/s41593-023-01562-7","article-title":"A molecularly defined amygdala-independent tetra-synaptic forebrain-to-hindbrain pathway for odor-driven innate fear and anxiety","volume":"27","author":"Wang","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib43","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59799","article-title":"Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons","volume":"9","author":"Bowen","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2026.04.041_bib44","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81868","article-title":"Molecular and anatomical characterization of parabrachial neurons and their axonal projections","volume":"11","author":"Pauli","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2026.04.041_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113401","article-title":"Cell-type diversity in the bed nucleus of the stria terminalis to regulate motivated behaviors","volume":"411","author":"Ortiz-Juza","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuron.2026.04.041_bib46","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1523\/JNEUROSCI.3729-14.2015","article-title":"Parabrachial calcitonin gene-related peptide neurons mediate conditioned taste aversion","volume":"35","author":"Carter","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib47","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nature25511","article-title":"Encoding of danger by parabrachial CGRP neurons","volume":"555","author":"Campos","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2026.04.041_bib48","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nn.4574","article-title":"Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus","volume":"20","author":"Campos","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib49","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature12596","article-title":"Genetic identification of a neural circuit that suppresses appetite","volume":"503","author":"Carter","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2026.04.041_bib50","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cell.2015.05.057","article-title":"Elucidating an Affective Pain Circuit that Creates a Threat Memory","volume":"162","author":"Han","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2026.04.041_bib51","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nature12018","article-title":"Diverging neural pathways assemble a behavioural state from separable features in anxiety","volume":"496","author":"Kim","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2026.04.041_bib52","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/mp.2016.1","article-title":"Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders","volume":"21","author":"Lebow","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2026.04.041_bib53","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.pnpbp.2009.06.022","article-title":"Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses","volume":"33","author":"Walker","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2026.04.041_bib54","doi-asserted-by":"crossref","first-page":"8225","DOI":"10.1523\/JNEUROSCI.1162-19.2019","article-title":"Parabrachial Complex: A Hub for Pain and Aversion","volume":"39","author":"Chiang","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib55","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.scib.2020.03.028","article-title":"Anxiety-related cell-type-specific neural circuits in the anterior-dorsal bed nucleus of the stria terminalis","volume":"65","author":"Wang","year":"2020","journal-title":"Sci. Bull. (Beijing)"},{"key":"10.1016\/j.neuron.2026.04.041_bib56","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nn.3972","article-title":"NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking","volume":"18","author":"Pleil","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2020.100247","article-title":"BNST transient activity associates with approach behavior in a stressful environment and is modulated by the parabrachial nucleus","volume":"13","author":"Jaramillo","year":"2020","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.neuron.2026.04.041_bib58","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s12031-021-01946-z","article-title":"Activation of Lateral Parabrachial Nucleus (LPBn) PACAP-Expressing Projection Neurons to the Bed Nucleus of the Stria Terminalis (BNST) Enhances Anxiety-like Behavior","volume":"72","author":"Boucher","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108757","article-title":"Danger and distress: Parabrachial-extended amygdala circuits","volume":"198","author":"Jaramillo","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuron.2026.04.041_bib60","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nn.4208","article-title":"Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear","volume":"19","author":"Yang","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib61","doi-asserted-by":"crossref","first-page":"R774","DOI":"10.1016\/j.cub.2013.07.025","article-title":"Sleep, plasticity and memory from molecules to whole-brain networks","volume":"23","author":"Abel","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2026.04.041_bib62","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsy130","article-title":"Characteristics of sleep-active neurons in the medullary parafacial zone in rats","volume":"41","author":"Alam","year":"2018","journal-title":"Sleep"},{"key":"10.1016\/j.neuron.2026.04.041_bib63","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cell.2007.09.018","article-title":"Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions","volume":"131","author":"Krishnan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2026.04.041_bib64","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature19773","article-title":"Circuit-based interrogation of sleep control","volume":"538","author":"Weber","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2026.04.041_bib65","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/s41593-018-0198-x","article-title":"Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states","volume":"21","author":"Giardino","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib66","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav8736","article-title":"Amygdala ensembles encode behavioral states","volume":"364","author":"Gr\u00fcndemann","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.neuron.2026.04.041_bib67","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature09820","article-title":"Amygdala circuitry mediating reversible and bidirectional control of anxiety","volume":"471","author":"Tye","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2026.04.041_bib68","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.neuron.2013.06.016","article-title":"BLA to vHPC inputs modulate anxiety-related behaviors","volume":"79","author":"Felix-Ortiz","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2026.04.041_bib69","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.neuron.2018.01.016","article-title":"Anxiety Cells in a Hippocampal-Hypothalamic Circuit","volume":"97","author":"Jimenez","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2026.04.041_bib70","doi-asserted-by":"crossref","DOI":"10.1172\/JCI188246","article-title":"A noncanonical parasubthalamic nucleus-to-extended amygdala circuit converts chronic social stress into anxiety","volume":"135","author":"Liu","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.neuron.2026.04.041_bib71","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12727","article-title":"Sensitive red protein calcium indicators for imaging neural activity","volume":"5","author":"Dana","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2026.04.041_bib72","doi-asserted-by":"crossref","first-page":"7164","DOI":"10.1523\/JNEUROSCI.0245-17.2017","article-title":"Excitation of GABAergic Neurons in the Bed Nucleus of the Stria Terminalis Triggers Immediate Transition from Non-Rapid Eye Movement Sleep to Wakefulness in Mice","volume":"37","author":"Kodani","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108362","article-title":"Prepronociceptin-Expressing Neurons in the Extended Amygdala Encode and Promote Rapid Arousal Responses to Motivationally Salient Stimuli","volume":"33","author":"Rodriguez-Romaguera","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2026.04.041_bib74","article-title":"BNST GABAergic neurons modulate wakefulness over sleep and anesthesia","volume":"7","author":"Li","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.neuron.2026.04.041_bib75","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature09553","article-title":"Genetic dissection of an amygdala microcircuit that gates conditioned fear","volume":"468","author":"Haubensak","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2026.04.041_bib76","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/nn.3767","article-title":"Central amygdala PKC-delta(+) neurons mediate the influence of multiple anorexigenic signals","volume":"17","author":"Cai","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111824","article-title":"A paraventricular thalamus to central amygdala neural circuit modulates acute stress-induced heightened wakefulness","volume":"41","author":"Zhao","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2026.04.041_bib78","doi-asserted-by":"crossref","first-page":"S399","DOI":"10.1016\/S0924-977X(99)00051-6","article-title":"Limitations on the use of benzodiazepines in anxiety and insomnia: are they justified?","volume":"9","author":"Lader","year":"1999","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuron.2026.04.041_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108505","article-title":"GABAergic modulation of sleep-wake states","volume":"249","author":"Oishi","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neuron.2026.04.041_bib80","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neubiorev.2016.06.028","article-title":"Effects of experimental sleep deprivation on anxiety-like behavior in animal research: Systematic review and meta-analysis","volume":"68","author":"Pires","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuron.2026.04.041_bib81","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41583-024-00799-w","article-title":"Overnight neuronal plasticity and adaptation to emotional distress","volume":"25","author":"Cabrera","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib82","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.smrv.2005.05.002","article-title":"Sleep function and synaptic homeostasis","volume":"10","author":"Tononi","year":"2006","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.neuron.2026.04.041_bib83","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuron.2013.12.025","article-title":"Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration","volume":"81","author":"Tononi","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2026.04.041_bib84","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nmeth.2836","article-title":"Independent optical excitation of distinct neural populations","volume":"11","author":"Klapoetke","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2026.04.041_bib85","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1172\/JCI46229","article-title":"Rapid, reversible activation of AgRP neurons drives feeding behavior in mice","volume":"121","author":"Krashes","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.neuron.2026.04.041_bib86","unstructured":"Franklin, K.B., and Paxinos, G. (2008) The Mouse Brain in Stereotaxic Coordinates."},{"key":"10.1016\/j.neuron.2026.04.041_bib87","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cub.2014.02.011","article-title":"Selective activation of cholinergic basal forebrain neurons induces immediate sleep-wake transitions","volume":"24","author":"Han","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuron.2026.04.041_bib88","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/nprot.2011.361","article-title":"A standardized protocol for repeated social defeat stress in mice","volume":"6","author":"Golden","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuron.2026.04.041_bib89","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1073\/pnas.1400113111","article-title":"Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorder","volume":"111","author":"Cho","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2026.04.041_bib90","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41593-018-0288-9","article-title":"GABA and glutamate neurons in the VTA regulate sleep and wakefulness","volume":"22","author":"Yu","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2026.04.041_bib91","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.neuron.2017.05.020","article-title":"Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli","volume":"94","author":"Cho","year":"2017","journal-title":"Neuron"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627326003363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627326003363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:56:20Z","timestamp":1791420980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627326003363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":91,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0896627326003363"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2026.04.041","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Slow-wave sleep engages brainstem circuitry to prevent stress-induced anxiety","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2026.04.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}