{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:32:59Z","timestamp":1790911979953,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1016\/j.neuropharm.2004.04.002","type":"journal-article","created":{"date-parts":[[2004,6,11]],"date-time":"2004-06-11T12:44:35Z","timestamp":1086957875000},"page":"253-262","source":"Crossref","is-referenced-by-count":44,"title":["Chloride transport inhibitors influence recovery from oxygen\u2013glucose deprivation-induced cellular injury in adult hippocampus"],"prefix":"10.1016","volume":"47","author":[{"given":"Brooks B","family":"Pond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Galeffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Ahrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle D","family":"Schwartz-Bloom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2004.04.002_BIB1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1113\/jphysiol.1993.sp019683","article-title":"Cell volume regulation in rat thymocytes","volume":"465","author":"Arrazola","year":"1993","journal-title":"Journal of Physiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB2","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1523\/JNEUROSCI.23-12-05061.2003","article-title":"Na\u2013K\u2013Cl cotransporter contributes to glutamate-mediated excitotoxicity","volume":"23","author":"Beck","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB3","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/jcp.1041640209","article-title":"Swelling activates chloride current and increases internal calcium in nonpigmented epithelial cells from the rabbit ciliary body","volume":"164","author":"Botchkin","year":"1995","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.ne.13.030190.001131","article-title":"The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death","volume":"13","author":"Choi","year":"1990","journal-title":"Annals Review Neuroscience"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB5","doi-asserted-by":"crossref","first-page":"8069","DOI":"10.1523\/JNEUROSCI.20-21-08069.2000","article-title":"Potassium-coupled chloride cotransport controls intracellular chloride in rat neocortical pyramidal neurons","volume":"20","author":"DeFazio","year":"2000","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB6","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1124\/mol.52.4.714","article-title":"The role of alpha1 and alpha6 subtype amino-terminal domains in allosteric regulation of gamma-aminobutyric acida receptors","volume":"523","author":"Fisher","year":"1997","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0168-0102(98)00099-6","article-title":"Simultaneous optical imaging of intracellular Cl\u2212 in neurons in different layers of rat neocortical slices: advantages and limitations","volume":"32","author":"Fukuda","year":"1998","journal-title":"Neuroscience Research"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB37","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.1523\/JNEUROSCI.0755-04.2004","article-title":"Changes in intracellular chloride after oxygen-glucose deprivation in the adult hippocampal slice: Effect of diazepam","volume":"24","author":"Galeffi","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB8","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1046\/j.1471-4159.2000.0751242.x","article-title":"Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia","volume":"75","author":"Galeffi","year":"2000","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB9","first-page":"696","article-title":"Demonstration of a [K+,Cl\u2212]-cotransport system in human red cells by its sensitivity to [(dihydroindenyl)oxy]alkanoic acids: regulation of cell swelling and distinction from the bumetanide-sensitive [Na+, K+, Cl\u2212]-cotransport system","volume":"33","author":"Garay","year":"1988","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB10","doi-asserted-by":"crossref","first-page":"16237","DOI":"10.1074\/jbc.271.27.16237","article-title":"Molecular cloning and functional expression of the K\u2013Cl cotransporter from rabbit, rat, and human","volume":"271","author":"Gillen","year":"1996","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB11","first-page":"174","article-title":"Loop diuretics","volume":"10","author":"Greger","year":"1987","journal-title":"Renal Physiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1113\/jphysiol.1997.sp022052","article-title":"Run-down of the GABAA response under experimental ischaemia in acutely dissociated CA1 pyramidal neurons of the rat","volume":"500","author":"Harata","year":"1997","journal-title":"Journal of Physiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1152\/jn.1999.81.1.49","article-title":"Extracellular chloride and the maintenance of spontaneous epileptiform activity in rat hippocampal slices","volume":"81","author":"Hochman","year":"1999","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB14","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/1097-010X(20010401\/30)289:4<224::AID-JEZ3>3.0.CO;2-R","article-title":"Cl\u2212 ATPase in rat brain and kidney","volume":"289","author":"Inagaki","year":"2001","journal-title":"Journal of Experimental Zoology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB15","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1046\/j.1471-4159.1998.70062500.x","article-title":"Optical imaging of hippocampal neurons with a chloride-sensitive dye: early effects of in vitro ischemia","volume":"70","author":"Inglefield","year":"1998","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB16","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1476-5381.1988.tb10326.x","article-title":"Effects of diuretics on GABA-gated chloride current in frog isolated sensory neurons","volume":"93","author":"Inomata","year":"1988","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0304-3940(91)90512-R","article-title":"An ATP-driven Cl\u2212 pump regulates Cl\u2212 concentrations in rat hippocampal neurons","volume":"134","author":"Inoue","year":"1991","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB18","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1523\/JNEUROSCI.19-12-04695.1999","article-title":"A furosemide-sensitive K+\u2013Cl\u2212 cotransporter counteracts intracellular Cl\u2212 accumulation and depletion in cultured rat midbrain neurons","volume":"19","author":"Jarolimek","year":"1999","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1152\/jn.2000.84.1.281","article-title":"Reversibility and cation selectivity of the K+ Cl\u2212 cotransporter in rat central neurons","volume":"84","author":"Kakazu","year":"2000","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB20","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1113\/jphysiol.1982.sp014424","article-title":"Mechanisms involved in irreversible anoxic damage to the in vitro rat hippocampal slice","volume":"332","author":"Kass","year":"1982","journal-title":"Journal of Physiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB21","first-page":"363","article-title":"Brain anti-cytoxic edema agents","volume":"361","author":"Kimelberg","year":"1990","journal-title":"Progress in Clinical Biological Research"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB22","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0896-6273(00)00056-8","article-title":"A genetically encoded ratiometric indicator for choride: capturing chloride transients in cultured hippocampal neurons","volume":"27","author":"Kuner","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB23","first-page":"217","article-title":"Chloride transport blockers prevent N-methyl-d-aspartate receptor-channel complex activation","volume":"41","author":"Lerma","year":"1992","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB24","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1152\/physrev.1999.79.4.1431","article-title":"Ischemic cell death in brain neurons","volume":"79","author":"Lipton","year":"1999","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB25","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0306-4522(01)00035-5","article-title":"Effects of ion channel blockade on the distribution of Na, K, Ca and other elements in oxygen\u2013glucose deprived CA1 hippocampal neurons","volume":"103","author":"Lopachin","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0021-9258(18)51740-3","article-title":"Effect of ischemia on known substrates and cofactors of the glycolytic pathway in brain","volume":"239","author":"Lowry","year":"1964","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0165-0270(95)00020-U","article-title":"Effects of dextran on hippocampal brain slice water, extracellular space, calcium kinetics and histology","volume":"61","author":"Newman","year":"1995","journal-title":"Journal of Neuroscience Methods"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB28","doi-asserted-by":"crossref","first-page":"C1516","DOI":"10.1152\/ajpcell.1997.273.5.C1516","article-title":"Functional characterization of the neuronal-specific K\u2013Cl: implications for [K+]o regulation","volume":"273","author":"Payne","year":"1997","journal-title":"American Journal of Physiology: Cell Physiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0166-2236(03)00068-7","article-title":"Cation\u2013chloride co-transporters in neuronal communication, development and trauma","volume":"26","author":"Payne","year":"2003","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB30","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0306-4522(00)00442-5","article-title":"GABAA receptors: immunocytochemical distribution of 13 subunits in the adult rat brain","volume":"101","author":"Pirker","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB31","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1152\/jn.2001.86.6.2715","article-title":"Sodium influx blockade and hypoxic damage to CA1 pyramidal neurons in rat hippocampal slices","volume":"86","author":"Raley-Susman","year":"2001","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0014-4886(95)90015-2","article-title":"Effect of composition of experimental solutions on neuronal solutions on neuronal survival during rat brain slicing","volume":"131","author":"Richerson","year":"1995","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB33","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0006-8993(96)00804-9","article-title":"Reduction of NaCl increases survival of mammalian spinal neurons subjected to dendrite transection injury","volume":"734","author":"Rosenberg","year":"1997","journal-title":"Brain Research"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB34","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/jcbfm.1987.130","article-title":"Cerebral ischemia and reperfusion: prevention of brain mitochondrial injury by lidoflazine","volume":"7","author":"Rosenthal","year":"1987","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB35","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1523\/JNEUROSCI.05-06-01483.1985","article-title":"The neurotoxicity of excitatory amino acids is produced by passive chloride influx","volume":"5","author":"Rothman","year":"1985","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB36","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1152\/physrev.2000.80.1.211","article-title":"Sodium\u2013potassium\u2013chloride cotransport","volume":"80","author":"Russell","year":"2000","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(99)00107-X","article-title":"Differential effects of l-buthionine sulfoximine and ethacrynic acid on glutathione levels and mitochondrial function in PC12 cells","volume":"264","author":"Seyfried","year":"1999","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB39","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s004240000338","article-title":"Volume-sensitive KCl cotransport associated with human cervical carcinogenesis","volume":"440","author":"Shen","year":"2000","journal-title":"European Journal of Physiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB40","doi-asserted-by":"crossref","first-page":"C1710","DOI":"10.1152\/ajpcell.2000.279.6.C1710","article-title":"Regulation of Na+\u2013K+\u2013Cl\u2212 cotransporter in primary astrocytes by dibutyryl cAMP and high [K+]o","volume":"279","author":"Su","year":"2000","journal-title":"American Journal of Physiology: Cell Physiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB41","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1152\/ajpcell.00538.2001","article-title":"Astrocytes from Na+\u2013K+\u2013Cl\u2212 cotransporter-null mice exhibit absence of swelling and decrease in EAA release","volume":"282","author":"Su","year":"2002","journal-title":"American Journal of Physiology: Cell Physiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB42","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1152\/ajpcell.00478.2001","article-title":"Contribution of Na+\u2013K+\u2013Cl\u2212 cotransporter to high-[K+]o-induced swelling and EAA release in astrocytes","volume":"282","author":"Su","year":"2002","journal-title":"American Journal of Physiology: Cell Physiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB43","doi-asserted-by":"crossref","first-page":"C772","DOI":"10.1152\/ajpcell.1998.275.3.C772","article-title":"Stimulation of Na+\u2013K+\u20132Cl\u2212 cotransporter in neuronal cells by excitatory neurotransmitter glutamate","volume":"275","author":"Sun","year":"1998","journal-title":"American Journal of Physiology: Cell Physiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s004240051128","article-title":"Evidence for the involvement of K+ channels and K+\u2013Cl\u2212 cotransport in the regulatory volume decrease of newborn rat cardiomyocytes","volume":"439","author":"Taouil","year":"1999","journal-title":"European Journal of Physiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB45","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1523\/JNEUROSCI.19-02-00619.1999","article-title":"Oxygen\/glucose deprivation in hippocampal slices: altered intraneuronal elemental composition predicts structural and functional damage","volume":"19","author":"Taylor","year":"1999","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB46","first-page":"670","article-title":"Functional characterization of human \u03b3-aminobutyric acidA receptors containing the \u03b14 subunit","volume":"50","author":"Wafford","year":"1996","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB47","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0168-0102(00)00221-2","article-title":"Optical imaging reveals cation\u2013Cl\u2212 cotransporter-mediated transient rapid decrease in intracellular Cl\u2212 concentration induced by oxygen\u2013glucose deprivation in rat neocortical slices","volume":"39","author":"Yamada","year":"2001","journal-title":"Neuroscience Research"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB48","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1152\/jn.1997.78.2.903","article-title":"Factors that reverse the persistent depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro","volume":"78","author":"Yamamoto","year":"1997","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB49","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/00004647-200106000-00009","article-title":"Na+\u2013K+\u2013Cl\u2212 cotransporter in rat focal cerebral ischemia","volume":"21","author":"Yan","year":"2001","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.neuropharm.2004.04.002_BIB50","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0006-8993(02)03832-5","article-title":"Inhibition of Na+\u2013K+\u2013Cl\u2212 cotransporter during focal cerebral ischemia decreases edema and neuronal damage","volume":"961","author":"Yan","year":"2003","journal-title":"Brain Research"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390804001066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390804001066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T11:49:33Z","timestamp":1705146573000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390804001066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S0028390804001066"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2004.04.002","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}