{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:04:55Z","timestamp":1779275095372,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1016\/j.neuropharm.2004.06.034","type":"journal-article","created":{"date-parts":[[2005,1,31]],"date-time":"2005-01-31T18:49:44Z","timestamp":1107197384000},"page":"1102-1112","source":"Crossref","is-referenced-by-count":18,"title":["Modulation of voltage-dependent sodium channels by the \u03b4-agonist SNC80 in acutely isolated rat hippocampal neurons"],"prefix":"10.1016","volume":"47","author":[{"given":"Christina","family":"Remy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Remy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Swandulla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2004.06.034_BIB1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0304-3940(01)01895-X","article-title":"Two mutations in the IV\/S4-S5 segment of the human skeletal muscle Na+ channel disrupt fast and enhance slow inactivation","volume":"306","author":"Alekov","year":"2001","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1085\/jgp.70.5.549","article-title":"Inactivation of the sodium channel. I. Sodium current experiments","volume":"70","author":"Bezanilla","year":"1977","journal-title":"J. Gen. Physiol"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB3","first-page":"359","article-title":"SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist","volume":"273","author":"Bilsky","year":"1995","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB4","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1021\/jm960319n","article-title":"Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands","volume":"40","author":"Calderon","year":"1997","journal-title":"J. Med. Chem"},{"issue":"Suppl.","key":"10.1016\/j.neuropharm.2004.06.034_BIB5","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1152\/physrev.1992.72.suppl_4.S15","article-title":"Cellular and molecular biology of voltage-gated sodium channels","volume":"72","author":"Catterall","year":"1992","journal-title":"Physiol. Rev"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB6","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1046\/j.1440-1681.2000.03291.x","article-title":"Cellular actions of opioids and other analgesics: implications for synergism in pain relief","volume":"27","author":"Christie","year":"2000","journal-title":"Clin. Exp. Pharmacol. Physiol"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB7","doi-asserted-by":"crossref","first-page":"6512","DOI":"10.1523\/JNEUROSCI.17-17-06512.1997","article-title":"Slow recovery from inactivation of Na+ channels underlies the activity-dependent attenuation of dendritic action potentials in hippocampal CA1 pyramidal neurons","volume":"17","author":"Colbert","year":"1997","journal-title":"J. Neurosci"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0006-3495(96)79219-6","article-title":"Impaired slow inactivation in mutant sodium channels","volume":"71","author":"Cummins","year":"1996","journal-title":"Biophys. J"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1469-7793.2001.0385f.x","article-title":"Slow recovery from inactivation regulates the availability of voltage-dependent Na+ channels in hippocampal granule cells, hilar neurons and basket cells","volume":"532","author":"Ellerkmann","year":"2001","journal-title":"J. Physiol"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB10","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1152\/jn.1996.76.3.2125","article-title":"Kinetics of slow inactivation of persistent sodium current in layer V neurons of mouse neocortical slices","volume":"76","author":"Fleidervish","year":"1996","journal-title":"J. Neurophysiol"},{"issue":"Pt. 1","key":"10.1016\/j.neuropharm.2004.06.034_BIB11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1113\/jphysiol.1996.sp021366","article-title":"Slow inactivation of Na+ current and slow cumulative spike adaptation in mouse and guinea-pig neocortical neurones in slices","volume":"493","author":"Fleidervish","year":"1996","journal-title":"J. Physiol"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB12","first-page":"1193","article-title":"Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu\/delta\/kappa-opioid receptor knockout mice reveal a nonopioid activity","volume":"298","author":"Gaveriaux-Ruff","year":"2001","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB13","first-page":"125","article-title":"Opiate receptors and analgesia: an update","volume":"6","author":"Hayes","year":"1991","journal-title":"J. Post Anesth. Nurs"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB14","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0006-3495(97)78768-X","article-title":"Slow inactivation differs among mutant Na+ channels associated with myotonia and periodic paralysis","volume":"72","author":"Hayward","year":"1997","journal-title":"Biophys. J"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB15","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/bja\/81.6.925","article-title":"Opioid receptor independent effects of morphine on membrane currents in single cardiac myocytes","volume":"81","author":"Hung","year":"1998","journal-title":"Br. J. Anaesth"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-6147(98)01279-6","article-title":"Opioids: first lessons from knockout mice","volume":"20","author":"Kieffer","year":"1999","journal-title":"Trends Pharmacol. Sci"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0301-0082(02)00008-4","article-title":"Exploring the opioid system by gene knockout","volume":"66","author":"Kieffer","year":"2002","journal-title":"Prog. Neurobiol"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB18","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1152\/physrev.1999.79.4.1317","article-title":"Voltage-gated ion channels and hereditary disease","volume":"79","author":"Lehmann-Horn","year":"1999","journal-title":"Physiol. Rev"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s002329900318","article-title":"Slow changes in the availability of voltage-gated ion channels: effects on the dynamics of excitable membranes","volume":"161","author":"Marom","year":"1998","journal-title":"J. Membr. Biol"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB20","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1469-7793.1997.593ba.x","article-title":"Functional differences in Na+ channel gating between fast-spiking interneurones and principal neurones of rat hippocampus","volume":"505","author":"Martina","year":"1997","journal-title":"J. Physiol"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/bse0330065","article-title":"A molecular basis for opiate action","volume":"33","author":"Massotte","year":"1998","journal-title":"Essays Biochem"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s004240050900","article-title":"A global defect in scaling relationship between electrical activity and availability of muscle sodium channels in hyperkalemic periodic paralysis","volume":"438","author":"Melamed-Frank","year":"1999","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB23","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1085\/jgp.115.6.707","article-title":"Role of domain 4 in sodium channel slow inactivation","volume":"115","author":"Mitrovic","year":"2000","journal-title":"J. Gen. Physiol"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0165-0173(97)00054-4","article-title":"Sodium channels as molecular targets for antiepileptic drugs","volume":"26","author":"Ragsdale","year":"1998","journal-title":"Brain Res. Brain Res. Rev"},{"issue":"Pt. 1","key":"10.1016\/j.neuropharm.2004.06.034_BIB25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1469-7793.1998.139bo.x","article-title":"Electrophysiological characterization of Na+ currents in acutely isolated human hippocampal dentate granule cells","volume":"509","author":"Reckziegel","year":"1998","journal-title":"J. Physiol"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB26","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1046\/j.1460-9568.2003.02710.x","article-title":"Anticonvulsant pharmacology of voltage-gated sodium channels in hippocampal neurons of control and chronically epileptic rats","volume":"17","author":"Remy","year":"2003","journal-title":"Eur. J. Neurosci"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB27","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0006-3495(92)81901-X","article-title":"Steady-state availability of sodium channels. Interactions between activation and slow inactivation","volume":"61","author":"Ruben","year":"1992","journal-title":"Biophys. J"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1978.sp012485","article-title":"Slow inactivation of the sodium conductance in squid giant axons. Pronase resistance","volume":"283","author":"Rudy","year":"1978","journal-title":"J. Physiol"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1085\/jgp.20028672","article-title":"Slow inactivation does not block the aqueous accessibility to the outer pore of voltage-gated Na+ channels","volume":"120","author":"Struyk","year":"2002","journal-title":"J. Gen. Physiol"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/339597a0","article-title":"Structural parts involved in activation and inactivation of the sodium channel","volume":"339","author":"St\u00fchmer","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB31","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1152\/jn.00624.2001","article-title":"Sodium channel blocking actions of the kappa-opioid receptor agonist U50,488 contribute to its visceral antinociceptive effects","volume":"87","author":"Su","year":"2002","journal-title":"J. Neurophysiol"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB32","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1523\/JNEUROSCI.18-05-01893.1998","article-title":"Interaction between duration of activity and time course of recovery from slow inactivation in mammalian brain Na+ channels","volume":"18","author":"Toib","year":"1998","journal-title":"J. Neurosci"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1385\/CBB:35:2:171","article-title":"Slow inactivation in voltage-gated sodium channels: molecular substrates and contributions to channelopathies","volume":"35","author":"Vilin","year":"2001","journal-title":"Cell Biochem. Biophys"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB34","doi-asserted-by":"crossref","first-page":"10910","DOI":"10.1073\/pnas.89.22.10910","article-title":"A cluster of hydrophobic amino acid residues required for fast Na(+)- channel inactivation","volume":"89","author":"West","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1085\/jgp.200308881","article-title":"Molecular motions of the outer ring of charge of the sodium channel: do they couple to slow inactivation?","volume":"122","author":"Xiong","year":"2003","journal-title":"J. Gen. Physiol"},{"key":"10.1016\/j.neuropharm.2004.06.034_BIB36","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0006-8993(99)02360-4","article-title":"Blockade of U50488H on sodium currents in acutely isolated mice hippocampal CA3 pyramidal neurons","volume":"855","author":"Zou","year":"2000","journal-title":"Brain Res"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390804002503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390804002503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T01:24:03Z","timestamp":1548811443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390804002503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S0028390804002503"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2004.06.034","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}