{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:28:56Z","timestamp":1770751736910,"version":"3.50.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.neuropharm.2005.06.016","type":"journal-article","created":{"date-parts":[[2005,8,12]],"date-time":"2005-08-12T11:38:04Z","timestamp":1123846684000},"page":"1160-1169","source":"Crossref","is-referenced-by-count":39,"title":["Effects of opioid antagonists and morphine in a hippocampal hypoxia\/hypoglycemia model"],"prefix":"10.1016","volume":"49","author":[{"given":"S.","family":"Ammon-Treiber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Stolze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Loh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"H\u00f6llt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2005.06.016_bib1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0169-328X(03)00057-3","article-title":"Microarray analysis of genes expressed in the frontal cortex of rats chronically treated with morphine and after naloxone precipitated withdrawal","volume":"112","author":"Ammon","year":"2003","journal-title":"Molecular Brain Research"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib2","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1379\/CSC-42.1","article-title":"Rapid, transient, and dose-dependent expression of hsp70 messenger RNA in the rat brain after morphine treatment","volume":"9","author":"Ammon-Treiber","year":"2004","journal-title":"Cell Stress & Chaperones"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s002100000244","article-title":"Morphine self-administration in mu-opioid receptor-deficient mice","volume":"361","author":"Becker","year":"2000","journal-title":"Naunyn-Schmiedeberg's Archives of Pharmacology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s00210-002-0533-2","article-title":"Rewarding effects of ethanol and cocaine in mu opioid receptor-deficient mice","volume":"365","author":"Becker","year":"2002","journal-title":"Naunyn-Schmiedeberg's Archives of Pharmacology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib5","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1097\/00000542-199210000-00020","article-title":"Physical and chemical properties of drug molecules governing their diffusion through the spinal membranes","volume":"77","author":"Bernards","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0306-4522(00)00304-3","article-title":"K(ATP) channel openers, adenosine agonists and epileptic preconditioning are stress signals inducing hippocampal neuroprotection","volume":"100","author":"Blondeau","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib7","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/sj.bjp.0704364","article-title":"Chronic morphine induces up-regulation of the pro-apoptotic Fas receptor and down-regulation of the anti-apoptotic Bcl-2 oncoprotein in rat brain","volume":"134","author":"Boronat","year":"2001","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib8","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1213\/00000539-199807000-00015","article-title":"The effect of fentanyl on electrophysiologic recovery of CA 1 pyramidal cells from anoxia in the rat hippocampal slice","volume":"87","author":"Charchaflieh","year":"1998","journal-title":"Anesthesia & Analgesia"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0165-6147(00)01560-1","article-title":"Neuronal ischaemic preconditioning","volume":"21","author":"Dawson","year":"2000","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib10","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3171\/jns.1990.72.3.0458","article-title":"Alterations in Na(+)\u2013K(+)-ATPase activity and beta-endorphin content in acute ischemic brain with and without naloxone treatment","volume":"72","author":"Furui","year":"1990","journal-title":"Journal of Neurosurgery"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00004647-199903000-00011","article-title":"Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning","volume":"19","author":"Gidday","year":"1999","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"issue":"1","key":"10.1016\/j.neuropharm.2005.06.016_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00007691-199101000-00001","article-title":"Clinical pharmacokinetics of morphine","volume":"13","author":"Glare","year":"1991","journal-title":"Therapeutic Drug Monitoring"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib13","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1213\/00000539-199911000-00023","article-title":"Acute decreases in cerebrospinal fluid glutathione levels after intracerebroventricular morphine for cancer pain","volume":"89","author":"Goudas","year":"1999","journal-title":"Anesthesia & Analgesia"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00210-004-0870-4","article-title":"Accelerated kindling development in mu-opioid receptor deficient mice","volume":"369","author":"Grecksch","year":"2004","journal-title":"Naunyn-Schmiedeberg's Archives of Pharmacology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/exnr.1998.6788","article-title":"Opioids disrupt Ca2+ homeostasis and induce carbonyl oxyradical production in mouse astrocytes in vitro: transient increases and adaptation to sustained exposure","volume":"151","author":"Hauser","year":"1998","journal-title":"Experimental Neurolology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib16","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1073\/pnas.92.10.4666","article-title":"Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K+ channels in cerebral ischemic preconditioning","volume":"92","author":"Heurteaux","year":"1995","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.6274019","article-title":"Reversal of induced ischemic neurologic deficit in gerbils by the opiate antagonist naloxone","volume":"215","author":"Hosobuchi","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib18","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0028-3908(02)00030-8","article-title":"Morphine induces apoptosis of human microglia and neurons","volume":"42","author":"Hu","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib19","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0006-8993(91)90831-F","article-title":"Temporal profile of the effects of pretreatment with brief cerebral ischemia on the neuronal damage following secondary ischemic insult in the gerbil: cumulative damage and protective effects","volume":"553","author":"Kato","year":"1991","journal-title":"Brain Research"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.brainres.2004.06.038","article-title":"Sevoflurane-induced preconditioning of rat brain in vitro and the role of KATP channels","volume":"1021","author":"Kehl","year":"2004","journal-title":"Brain Research"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/jcbfm.1991.62","article-title":"Induced tolerance to ischemia in gerbil hippocampal neurons","volume":"11","author":"Kirino","year":"1991","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib22","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1046\/j.1471-4159.2003.02072.x","article-title":"Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons","volume":"87","author":"Kis","year":"2003","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0006-8993(90)90189-I","article-title":"\u2018Ischemic tolerance\u2019 phenomenon found in the brain","volume":"528","author":"Kitagawa","year":"1990","journal-title":"Brain Research"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib24","series-title":"Clinical Anesthesia Practice","first-page":"597","article-title":"Intravenous agents","author":"Koska","year":"1994"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0165-0173(02)00157-1","article-title":"Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities","volume":"39","author":"Leker","year":"2002","journal-title":"Brain Research. Brain Research Reviews"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib26","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1161\/01.RES.84.12.1396","article-title":"Direct preconditioning of cardiac myocytes via opioid receptors and KATP channels","volume":"84","author":"Liang","year":"1999","journal-title":"Circulation Research"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0304-3940(03)00540-8","article-title":"Neuroprotection of naloxone against ischemic injury in rats: role of mu receptor antagonism","volume":"345","author":"Liao","year":"2003","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib28","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/00000542-200403000-00015","article-title":"Morphine preconditions Purkinje cells against cell death under in vitro simulated ischemia-reperfusion conditions","volume":"100","author":"Lim","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib29","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0006-8993(92)91380-W","article-title":"Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia","volume":"586","author":"Liu","year":"1992","journal-title":"Brain Research"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0169-328X(97)00353-7","article-title":"mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality","volume":"54","author":"Loh","year":"1998","journal-title":"Molecular Brain Research"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib31","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/00000542-200303000-00019","article-title":"Morphine enhances pharmacological preconditioning by isoflurane: role of mitochondrial K(ATP) channels and opioid receptors","volume":"98","author":"Ludwig","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1113\/jphysiol.1988.sp017033","article-title":"Enkephalin hyperpolarizes interneurones in the rat hippocampus","volume":"398","author":"Madison","year":"1988","journal-title":"Journal of Physiology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib33","doi-asserted-by":"crossref","first-page":"7650","DOI":"10.1523\/JNEUROSCI.22-17-07650.2002","article-title":"Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism","volume":"22","author":"Mao","year":"2002","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib34","first-page":"1056","article-title":"Effects of infusion rate of intravenously administered morphine on physiological, psychomotor, and self-reported measures in humans","volume":"299","author":"Marsch","year":"2001","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib35","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1161\/01.CIR.103.2.290","article-title":"Morphine mimics preconditioning via free radical signals and mitochondrial K(ATP) channels in myocytes","volume":"103","author":"McPherson","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib36","first-page":"753","article-title":"Morphine-induced excitation of pyramidal neurons is inhibited by cholecystokinin in the CA1 region of the rat hippocampal slice","volume":"268","author":"Miller","year":"1994","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib37","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib38","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/jnr.20120","article-title":"Diazoxide preconditioning protects against neuronal cell death by attenuation of oxidative stress upon glutamate stimulation","volume":"76","author":"Nagy","year":"2004","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib39","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/287022a0","article-title":"Enkephalin blocks inhibitory pathways in the vertebrate CNS","volume":"287","author":"Nicoll","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib40","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1749-6632.2002.tb04190.x","article-title":"Toxic effects of opioid and stimulant drugs on undifferentiated PC12 cells","volume":"965","author":"Oliveira","year":"2002","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib41","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.bjp.0705442","article-title":"Brief, repeated, oxygen-glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors","volume":"140","author":"Pugliese","year":"2003","journal-title":"British Journal of Pharmacolology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib42","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3233\/RNN-1999-00110","article-title":"Conditioning hypoxia causes protection against ischemia in the CA 1-region of hippocampal slices","volume":"15","author":"R\u00fcthrich","year":"1999","journal-title":"Restorative Neurology and Neuroscience"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0006-8993(01)03163-8","article-title":"Early effects on restoration of evoked field potentials in the hippocampal CA(1) region after reversible hypoxia\/hypoglycemia by the radical scavenger N-tert.-butyl-alpha-phenylnitron","volume":"922","author":"R\u00fcthrich","year":"2001","journal-title":"Brain Research"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib44","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/01.RES.78.6.1100","article-title":"Morphine mimics the cardioprotective effect of ischemic preconditioning via a glibenclamide-sensitive mechanism in the rat heart","volume":"78","author":"Schultz","year":"1996","journal-title":"Circulation Research"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib45","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1006\/jmcc.1997.0454","article-title":"Ischemic preconditioning and morphine-induced cardioprotection involve the delta (delta)-opioid receptor in the intact rat heart","volume":"29","author":"Schultz","year":"1997","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib46","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1161\/01.CIR.97.13.1282","article-title":"Ischemic preconditioning in the intact rat heart is mediated by delta1- but not mu- or kappa-opioid receptors","volume":"97","author":"Schultz","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib47","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1038\/sj.emboj.7600334","article-title":"Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375","volume":"23","author":"Schulz","year":"2004","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib48","first-page":"1059","article-title":"Cardioprotective effects of morphine on rat heart suffering from ischemia and reperfusion","volume":"116","author":"Shi","year":"2003","journal-title":"Chinese Medical Journal"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib49","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1046\/j.1440-1681.2000.03290.x","article-title":"Neuroexcitatory effects of morphine and hydromorphone: evidence implicating the 3-glucuronide metabolites","volume":"27","author":"Smith","year":"2000","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib50","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/cne.10997","article-title":"Neuronal types expressing mu- and delta-opioid receptor mRNA in the rat hippocampal formation","volume":"469","author":"Stumm","year":"2004","journal-title":"Journal of Comparative Neurology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib51","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/01.WCB.0000122742.72175.1B","article-title":"Adenosine A(1) receptor antagonist and mitochondrial ATP-sensitive potassium channel blocker attenuate the tolerance to focal cerebral ischemia in rats","volume":"24","author":"Yoshida","year":"2004","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib52","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/978-1-4615-0123-7_10","article-title":"Heat shock proteins and neuroprotection","volume":"513","author":"Yenari","year":"2002","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.neuropharm.2005.06.016_bib53","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1126\/science.451610","article-title":"Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons","volume":"205","author":"Zieglg\u00e4nsberger","year":"1979","journal-title":"Science"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002839080500239X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002839080500239X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T12:10:42Z","timestamp":1735906242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002839080500239X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S002839080500239X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2005.06.016","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}