{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:17:05Z","timestamp":1790018225159,"version":"4.0.1"},"reference-count":56,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.neuropharm.2005.11.023","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T07:41:25Z","timestamp":1137742885000},"page":"661-670","source":"Crossref","is-referenced-by-count":36,"title":["Modulation of \u03949-THC-induced increase of cortical and hippocampal acetylcholine release by \u03bc opioid and D1 dopamine receptors"],"prefix":"10.1016","volume":"50","author":[{"given":"A.","family":"Pisanu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Acquas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Fenu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Di Chiara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2005.11.023_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0014-2999(94)90013-2","article-title":"The potent and selective dopamine D1 receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the rat","volume":"260","author":"Acquas","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/BF02249415","article-title":"Chronic lithium attenuates dopamine D1-receptor mediated increases in acetylcholine release in rat frontal cortex","volume":"125","author":"Acquas","year":"1996","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2005.11.023_bib3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0014-2999(00)00403-9","article-title":"Cannabinoid CB1 receptor agonists increase rat cortical and hippocampal acetylcholine release in vivo","volume":"401","author":"Acquas","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0014-2999(01)00967-0","article-title":"Delta9-tetrahydrocannabinol enhances cortical and hippocampal acetylcholine release in vivo: a microdialysis study","volume":"419","author":"Acquas","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib5","series-title":"Dopamine in the CNS II","first-page":"85","article-title":"Dopamine\u2013acetylcholine interactions","author":"Acquas","year":"2002"},{"key":"10.1016\/j.neuropharm.2005.11.023_bib6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0014-2999(01)00766-X","article-title":"Intracerebral self-administration of the cannabinoid receptor agonist CP 55,940 in the rat: interaction with the opioid system","volume":"413","author":"Braida","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejphar.2004.10.043","article-title":"Delta9-tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in rats","volume":"506","author":"Braida","year":"2004","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.neuropharm.2005.11.023_bib8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s002130100875","article-title":"Behavioural sensitization after repeated exposure to Delta 9-tetrahydrocannabinol and cross-sensitization with morphine","volume":"158","author":"Cadoni","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2005.11.023_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(98)00738-0","article-title":"Inhibition of hippocampal acetylcholine release after acute and repeated Delta9-tetrahydrocannabinol in rats","volume":"809","author":"Carta","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib10","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0361-9230(86)90140-1","article-title":"Changes in cortical acetylcholine output induced by modulation of the nucleus basalis","volume":"16","author":"Casamenti","year":"1986","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib11","doi-asserted-by":"crossref","first-page":"L-43","DOI":"10.1016\/S0024-3205(97)00405-0","article-title":"Delta-9-tetrahydrocannabinol increases prodynorphin and proenkephalin gene expression in the spinal cord of the rat","volume":"61","author":"Corchero","year":"1997","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0014-2999(97)00144-1","article-title":"Delta 9-tetrahydrocannabinol increases proopiomelanocortin gene expression in the arcuate nucleus of the rat hypothalamus","volume":"323","author":"Corchero","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0166-4328(00)00311-9","article-title":"Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse","volume":"118","author":"Cossu","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0006-8993(89)91137-2","article-title":"Adaptation of the quantitative 2-[14C]deoxyglucose method for use in freely moving rats","volume":"499","author":"Crane","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib15","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1111\/j.1471-4159.1987.tb05695.x","article-title":"Measurement of acetylcholine release in freely moving rats by means of automated intracerebral dialysis","volume":"48","author":"Damsma","year":"1987","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib16","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0306-4522(93)90235-8","article-title":"Dopaminergic regulation of cortical acetylcholine release: effects of dopamine receptor agonists","volume":"54","author":"Day","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2005.11.023_bib17","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1046\/j.1471-4159.1994.63062086.x","article-title":"Dopaminergic regulation of septo-hippocampal cholinergic neurons","volume":"63","author":"Day","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/BF02244939","article-title":"On the preferential release of dopamine in the nucleus accumbens by amphetamine: further evidence obtained by vertically implanted concentric probes","volume":"112","author":"Di Chiara","year":"1993","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2005.11.023_bib19","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s002130100734","article-title":"Intravenous self-administration of the cannabinoid CB1 receptor agonist WIN 55,212-2 in rats","volume":"156","author":"Fattore","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2005.11.023_bib20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3940(97)00278-4","article-title":"\u03949-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors","volume":"226","author":"French","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/BF02431546","article-title":"Facilitation of brain stimulation reward by delta 9-tetrahydrocannabinol","volume":"96","author":"Gardner","year":"1988","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2005.11.023_bib22","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1006\/nbdi.1998.0219","article-title":"Cannabinoid transmission and reward-related events","volume":"5","author":"Gardner","year":"1998","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-2999(98)00486-5","article-title":"Cannabinoids decrease acetylcholine release in the medial-prefrontal cortex and hippocampus, reversal by SR 141716A","volume":"355","author":"Gessa","year":"1998","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.neuropharm.2005.11.023_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3940(98)00534-5","article-title":"Regulation of cannabinoid and mu opioid receptors in rat lumbar spinal cord following neonatal capsaicin treatment","volume":"252","author":"Hohmann","year":"1998","journal-title":"Neurosci. Lett."},{"issue":"1\u20132","key":"10.1016\/j.neuropharm.2005.11.023_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0006-8993(98)01321-3","article-title":"Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord","volume":"822","author":"Hohmann","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s00213-003-1693-6","article-title":"The opioid antagonist naltrexone reduces the reinforcing effects of Delta 9 tetrahydrocannabinol (THC) in squirrel monkeys","volume":"173","author":"Justinova","year":"2004","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.neuropharm.2005.11.023_bib27","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1523\/JNEUROSCI.12-02-00483.1992","article-title":"Opioids excite dopamine neurons by hyperpolarization of local interneurons","volume":"12","author":"Johnson","year":"1992","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.neuropharm.2005.11.023_bib28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0028-3908(01)00039-9","article-title":"Chronic treatment with Delta(9)-tetrahydrocannabinol enhances the locomotor response to amphetamine and heroin. Implications for vulnerability to drug addiction","volume":"41","author":"Lamarque","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2005.11.023_bib29","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1126\/science.283.5400.401","article-title":"Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice","volume":"283","author":"Ledent","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2005.11.023_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF02246347","article-title":"Delta 9-tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism","volume":"126","author":"Lichtman","year":"1996","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2005.11.023_bib31","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1111\/j.1471-4159.1991.tb06415.x","article-title":"[3H]SCH 39166, a new D1-selective radioligand: in vitro and in vivo binding analyses","volume":"57","author":"McQuade","year":"1991","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.neuropharm.2005.11.023_bib32","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0169-328X(97)00371-9","article-title":"Chronic administration of cannabinoids regulates proenkephalin mRNA levels in selected regions of the rat brain","volume":"55","author":"Manzanares","year":"1998","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"8","key":"10.1016\/j.neuropharm.2005.11.023_bib33","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1038\/sj.bjp.0703990","article-title":"Reduction of opioid dependence by the CB(1) antagonist SR141716A in mice: evaluation of the interest in pharmacotherapy of opioid addiction","volume":"132","author":"Mas-Nieto","year":"2001","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.neuropharm.2005.11.023_bib34","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0278-5846(00)00119-6","article-title":"Different mechanisms for dopaminergic excitation induced by opiates and cannabinoids in the rat midbrain","volume":"24","author":"Melis","year":"2000","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2005.11.023_bib35","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0024-3205(02)02274-9","article-title":"Involvement of reduced acetylcholine release in \u03949-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze","volume":"72","author":"Mishima","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib36","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0306-4522(98)00261-9","article-title":"Role of accumbens and cortical dopamine receptors in the regulation of cortical acetylcholine release","volume":"88","author":"Moore","year":"1999","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.neuropharm.2005.11.023_bib37","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/sj.bjp.0703413","article-title":"D(2) dopamine receptors enable delta(9)-tetrahydrocannabinol induced memory impairment and reduction of hippocampal extracellular acetylcholine concentration","volume":"130","author":"Nava","year":"2000","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.neuropharm.2005.11.023_bib38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF01675349","article-title":"Dopaminergic neurons: effect of acute and chronic morphine administration on single cell activity and transmitter metabolism","volume":"42","author":"Nowycky","year":"1978","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib39","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.neuropharm.2005.11.023_bib40","series-title":"A Stereotaxic Atlas of the Rat Brain","author":"Pellegrino","year":"1979"},{"issue":"1","key":"10.1016\/j.neuropharm.2005.11.023_bib41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neuroscience.2004.05.015","article-title":"Compartment-specific localization of cannabinoid 1 (CB1) and mu-opioid receptors in rat nucleus accumbens","volume":"127","author":"Pickel","year":"2004","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.neuropharm.2005.11.023_bib42","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1046\/j.1460-9568.2002.02019.x","article-title":"Cannabinoids inhibit excitatory inputs to neurons in the shell of the nucleus accumbens: an in vivo electrophysiological study","volume":"5","author":"Pistis","year":"2002","journal-title":"Eur. J. Neurosci."},{"issue":"3","key":"10.1016\/j.neuropharm.2005.11.023_bib43","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/S0014-2999(01)01056-1","article-title":"Behavioural sensitization to heroin by cannabinoid pre-treatment in the rat","volume":"421","author":"Pontieri","year":"2001","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.neuropharm.2005.11.023_bib44","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0006-8993(01)02158-8","article-title":"Behavioural sensitization to WIN55212.2 in rats pretreated with heroin","volume":"898","author":"Pontieri","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0166-4328(98)00065-5","article-title":"Spatial signal detection in rats is differentially disrupted by delta-9-tetrahydrocannabinol, scopolamine, and MK-801","volume":"99","author":"Presburger","year":"1999","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.neuropharm.2005.11.023_bib46","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1523\/JNEUROSCI.21-03-00823.2001","article-title":"Ultrastructural localization of the CB1 cannabinoid receptor in mu-opioid receptor patches of the rat caudate putamen nucleus","volume":"21","author":"Rodriguez","year":"2001","journal-title":"J. Neurosci."},{"issue":"17","key":"10.1016\/j.neuropharm.2005.11.023_bib47","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1097\/00001756-200112040-00017","article-title":"CB1-cannabinoid and mu-opioid receptor co-localization on postsynaptic target in the rat dorsal horn","volume":"12","author":"Salio","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2005.11.023_bib48","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1111\/j.0953-816X.2004.03420.x","article-title":"Beta-endorphin elevations in the ventral tegmental area regulate the discriminative effects of Delta-9-tetrahydrocannabinol","volume":"19","author":"Solinas","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib49","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1126\/science.276.5321.2048","article-title":"Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism","volume":"276","author":"Tanda","year":"1997","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.neuropharm.2005.11.023_bib50","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/80577","article-title":"Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys","volume":"3","author":"Tanda","year":"2000","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.neuropharm.2005.11.023_bib51","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00213-003-1485-z","article-title":"Cannabinoids: reward, dependence, and underlying neurochemical mechanisms \u2013 a review of recent preclinical data","volume":"169","author":"Tanda","year":"2003","journal-title":"Psychopharmacology"},{"issue":"28","key":"10.1016\/j.neuropharm.2005.11.023_bib52","doi-asserted-by":"crossref","first-page":"9374","DOI":"10.1523\/JNEUROSCI.23-28-09374.2003","article-title":"Biphasic effects of cannabinoids on acetylcholine release in the hippocampus: site and mechanism of action","volume":"23","author":"Tzavara","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib53","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1046\/j.0953-816x.2001.01558.x","article-title":"Delta9-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect","volume":"13","author":"Valverde","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2005.11.023_bib54","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0006-8993(95)00255-O","article-title":"Perinatal exposure to delta 9-tetrahydrocannabinol (delta 9-THC) leads to changes in opioid-related behavioral patterns in rats","volume":"680","author":"Vela","year":"1995","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.neuropharm.2005.11.023_bib55","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/syn.10202","article-title":"Systemic, but not local, administration of cannabinoid CB1 receptor agonists modulate prefrontal cortical acetylcholine efflux in the rat","volume":"48","author":"Verrico","year":"2003","journal-title":"Synapse"},{"issue":"7","key":"10.1016\/j.neuropharm.2005.11.023_bib56","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1111\/j.1460-9568.2004.03645.x","article-title":"Change in endocannabinoid levels in a rat model of behavioural sensitization to morphine","volume":"20","author":"Vigan\u00f2","year":"2004","journal-title":"Eur. J. Neurosci."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390805003977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390805003977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T15:29:46Z","timestamp":1555342186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390805003977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0028390805003977"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2005.11.023","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}