{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:14:51Z","timestamp":1791015291728,"version":"4.1.0"},"reference-count":96,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.neuropharm.2007.02.007","type":"journal-article","created":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T12:02:06Z","timestamp":1173355326000},"page":"1426-1437","source":"Crossref","is-referenced-by-count":32,"title":["A novel dual inhibitor of calpains and lipid peroxidation (BN82270) rescues the cochlea from sound trauma"],"prefix":"10.1016","volume":"52","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Pignol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Etienne","family":"Chabrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi","family":"Saido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lenoir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Puel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2007.02.007_bib1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1056-8719(97)00033-6","article-title":"Morphological and biochemical characterization and analysis of apoptosis","volume":"37","author":"Allen","year":"1997","journal-title":"Pharmacol. J. Toxicol. Methods"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib2","first-page":"29","article-title":"Ultrastructural changes in the receptor portion of the vestibular apparatus in response to noise","volume":"89","author":"Anichin","year":"1985","journal-title":"Arkh. Anat. Gistol. Embriol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00016488209108895","article-title":"The comparative ototoxicities of gentamicin, tobramycin and dibekacin in the guinea pig. A functional and morphological cochlear and vestibular study","volume":"390","author":"Aran","year":"1982","journal-title":"Acta Otolaryngol. Suppl."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0378-5955(94)90165-1","article-title":"Localization of F-actin and fodrin along the organ of Corti in the chinchilla","volume":"81","author":"Attanasio","year":"1994","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib5","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/000164801300366598","article-title":"Laser Doppler measurement of cochlear blood flow changes during conditioning noise exposure","volume":"121","author":"Attanasio","year":"2001","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib6","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1016\/j.bmcl.2004.04.105","article-title":"Novel dual inhibitors of calpain and lipid peroxidation","volume":"14","author":"Auvin","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib7","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.bmcl.2005.12.036","article-title":"Novel dual inhibitors of calpains and lipid peroxidation with enhanced cellular activity","volume":"16","author":"Auvin","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib8","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0006-8993(95)00398-A","article-title":"Degradation of fodrin and MAP 2 after neonatal cerebral hypoxic-ischemia","volume":"684","author":"Blomgren","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2337\/diabetes.50.1.77","article-title":"Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death","volume":"50","author":"Bonny","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/(SICI)1097-4547(19991001)58:1<167::AID-JNR16>3.0.CO;2-K","article-title":"Caspase and calpain substrates: roles in synaptic plasticity and cell death","volume":"58","author":"Chan","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib11","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0006-8993(99)01983-6","article-title":"Calpain inhibitors protect auditory sensory cells from hypoxia and neurotrophin-withdrawal induced apoptosis","volume":"850","author":"Cheng","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/01.moo.0000186799.45377.63","article-title":"Mechanisms of hair cell\u00a0death and protection","volume":"13","author":"Cheng","year":"2005","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0165-3806(88)90135-6","article-title":"Calbindin (CaBP 28kDa) appearance and distribution during development of the mouse inner ear","volume":"468","author":"Dechesne","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib14","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/0896-6273(95)90010-1","article-title":"Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links","volume":"15","author":"Denk","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0378-5955(01)00417-8","article-title":"Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity","volume":"164","author":"Ding","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib16","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0167-4889(92)90048-G","article-title":"Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry","volume":"1133","author":"Dive","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib17","series-title":"Handbook of Sensory Physiology","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/978-3-642-65829-7_17","article-title":"Inner Ear-Cochlear mechanics and cochlear potentials","volume":"vol. V\/1","author":"Eldredge","year":"1974"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib18","first-page":"1","article-title":"Stereocilia of sensory cells in normal and hearing impaired ears. A morphological, physiological and behavioural study","volume":"19","author":"Engstrom","year":"1983","journal-title":"Scand. Audiol. Suppl."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib19","series-title":"Structural Pattern of the Organ of Corti","author":"Engstrom","year":"1966"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0378-5955(83)90110-7","article-title":"Ultrastructural studies of stereocilia in noise-exposed rabbits","volume":"12","author":"Engstrom","year":"1983","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib21","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1080\/00016489850183430","article-title":"An in vitro model for acoustic overstimulation","volume":"118","author":"Fridberger","year":"1998","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib22","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1128\/MCB.24.6.2499-2512.2004","article-title":"Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation","volume":"24","author":"Glading","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib23","first-page":"219","article-title":"Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques","volume":"71","author":"Gold","year":"1994","journal-title":"Lab. Invest."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib24","first-page":"1465","article-title":"In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note","volume":"21","author":"Grasl-Kraupp","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/cne.903000202","article-title":"Cochlear innervation in the developing rat: an immunocytochemical study of neurofilament and spectrin proteins","volume":"300","author":"Hafidi","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib26","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00003643-199605000-00006","article-title":"Efficacy and mechanisms of action of the cytoprotective lipid peroxidation inhibitor tirilazad mesylate in subarachnoid haemorrhage","volume":"13","author":"Hall","year":"1996","journal-title":"Eur. J. Anaesthesiol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/(SICI)1097-4547(19960501)44:3<293::AID-JNR10>3.0.CO;2-6","article-title":"Inhibition of lipid peroxidation attenuates axotomy-induced apoptotic degeneration of facial motor neurons in neonatal rats","volume":"44","author":"Hall","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1523\/JNEUROSCI.22-01-00103.2002","article-title":"Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons","volume":"22","author":"Harris","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib29","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1749-6632.1999.tb08655.x","article-title":"The role of antioxidants in protection from impulse noise","volume":"884","author":"Henderson","year":"1999","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.aud.0000191942.36672.f3","article-title":"The role of oxidative stress in noise-induced hearing loss","volume":"27","author":"Henderson","year":"2006","journal-title":"Ear Hear."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib31","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1242\/jcs.96.2.283","article-title":"Spectrin, actin and the structure of the cortical lattice in mammalian cochlear outer hair cells","volume":"96","author":"Holley","year":"1990","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000275253","article-title":"Attachment of the inner sensory cell hairs to the tectorial membrane. A scanning electron microscopic study. ORL J","volume":"38","author":"Hoshino","year":"1976","journal-title":"Otorhinolaryngol. Relat. Spec."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/000164800760370774","article-title":"Intense noise-induced apoptosis in hair cells of guinea pig cochleae","volume":"120","author":"Hu","year":"2000","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib34","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0378-5955(02)00286-1","article-title":"Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise","volume":"166","author":"Hu","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib35","first-page":"422","article-title":"Inner ear correlates in acoustic trauma","volume":"84","author":"Hunter-Duvar","year":"1977","journal-title":"Trans. Sect. Otolaryngol. Am. Acad. Ophthalmol. Otolaryngol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0378-5955(88)90081-0","article-title":"Ionic changes in cochlear endolymph of the guinea pig induced by acoustic injury","volume":"32","author":"Ikeda","year":"1988","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1749-6632.1999.tb08641.x","article-title":"A radical demise. Toxins and trauma share common pathways in hair cell death","volume":"884","author":"Kopke","year":"1999","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib38","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0378-5955(95)00021-U","article-title":"The arrangements of F-actin, tubulin and fodrin in the organ of Corti of the horseshoe bat (Rhinolophus rouxi) and the gerbil (Meriones unguiculatus)","volume":"84","author":"Kuhn","year":"1995","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib39","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/cne.20252","article-title":"Calpain activity in the amikacin-damaged rat cochlea","volume":"477","author":"Ladrech","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib40","first-page":"1","article-title":"Pathways for protection from noise induced hearing loss","volume":"5","author":"Le Prell","year":"2003","journal-title":"Noise Health"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib41","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000079329","article-title":"Mechanisms of apoptosis induced by cisplatin in marginal cells in mouse stria vascularis","volume":"66","author":"Lee","year":"2004","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib42","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF00309683","article-title":"Stereocilia and tectorial membrane development in the rat cochlea. A SEM study","volume":"175","author":"Lenoir","year":"1987","journal-title":"Anat. Embryol. (Berl.)"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib43","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1001\/archotol.1971.00770070486002","article-title":"Acoustic damage of the cochlea. A scanning and transmission electron microscopic observation","volume":"94","author":"Lim","year":"1971","journal-title":"Arch. Otolaryngol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib44","doi-asserted-by":"crossref","first-page":"10297","DOI":"10.1073\/pnas.92.22.10297","article-title":"Detection of Ca2+ entry through mechanosensitive channels localizes the site of mechanoelectrical transduction in hair cells","volume":"92","author":"Lumpkin","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib45","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0378-5955(98)00164-6","article-title":"Ultrastructural localisation of spectrin in sensory and supporting cells of guinea-pig organ of Corti","volume":"126","author":"Mahendrasingam","year":"1998","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib46","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1046\/j.1471-4159.2002.01057.x","article-title":"Calpain activates caspase-3 during UV-induced neuronal death but only calpain is necessary for death","volume":"82","author":"McCollum","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib47","first-page":"150","article-title":"Cell-penetrating inhibitors of calpin","volume":"16","author":"Mehdi","year":"1991","journal-title":"TIBS"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002329900181","article-title":"Calpain: a cytosolic proteinase active at the membranes","volume":"156","author":"Molinari","year":"1997","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib49","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1042\/bj3190683","article-title":"Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis","volume":"319","author":"Nath","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib50","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s10162-002-3038-2","article-title":"The caspase pathway in noise-induced apoptosis of the chinchilla cochlea","volume":"4","author":"Nicotera","year":"2003","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib51","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0378-5955(93)90220-U","article-title":"Fodrin is\u00a0a\u00a0constituent of the cortical lattice in outer hair cells of the guinea pig cochlea: immunocytochemical evidence","volume":"65","author":"Nishida","year":"1993","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-5955(99)00163-X","article-title":"Histopathological differences between temporary and permanent threshold shift","volume":"139","author":"Nordmann","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib53","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0006-8993(00)02733-5","article-title":"Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea","volume":"878","author":"Ohinata","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib54","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000013846","article-title":"Early elevation of cochlear reactive oxygen species following noise exposure","volume":"4","author":"Ohlemiller","year":"1999","journal-title":"Audiol. Neurootol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib55","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1113\/jphysiol.1988.sp017071","article-title":"Mechanical stimulation and Fura-2 fluorescence in the hair bundle of dissociated hair cells of the chick","volume":"399","author":"Ohmori","year":"1988","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib56","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0378-5955(95)00173-5","article-title":"Cytoskeletal and calcium-binding proteins in the mammalian organ of Corti: cell type-specific proteins displaying longitudinal and radial gradients","volume":"91","author":"Pack","year":"1995","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib57","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000275850","article-title":"Velocity and displacement coupling of mammalian inner hair cells and the mechanical resonance of the free-standing stereocilia. ORL J","volume":"48","author":"Patuzzi","year":"1986","journal-title":"Otorhinolaryngol. Relat. Spec."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib58","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0378-5955(87)90186-9","article-title":"The low-frequency response of inner hair cells in the guinea pig cochlea: implications for fluid coupling and resonance of the stereocilia","volume":"30","author":"Patuzzi","year":"1987","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib59","first-page":"6","article-title":"Apoptosis\u2013selected methods of detection of apoptosis and associated regulatory factors on tissue sections of tumors","volume":"39","author":"Pavlovsky","year":"2003","journal-title":"Cesk Patol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib60","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/j.1471-4159.2006.03952.x","article-title":"Calpain inhibitors and antioxidants act synergistically to prevent cell necrosis. Effects of the novel dual inhibitors (cysteine protease inhibitor and antioxidant) BN 82204 and its pro-drug BN 82270","volume":"98","author":"Pignol","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib61","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1523\/JNEUROSCI.20-01-00043.2000","article-title":"Rescue of hearing, auditory hair cells, and neurons by CEP-1347\/KT7515, an inhibitor of c-Jun N-terminal kinase activation","volume":"20","author":"Pirvola","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib62","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0378-5955(03)00039-X","article-title":"Cochlear damage caused by continuous and intermittent noise exposure","volume":"178","author":"Pourbakht","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib63","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/cne.903410209","article-title":"Excitatory amino acids antagonists protect cochlear auditory neurons from excitotoxicity","volume":"341","author":"Puel","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib64","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0304-3940(02)00063-0","article-title":"Calpain activation and alpha-spectrin cleavage in rat brain by ethanol","volume":"321","author":"Rajgopal","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib65","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0378-5955(94)90098-1","article-title":"F-actin, tubulin and spectrin in the organ of Corti: comparative distribution in different cell types and mammalian species","volume":"76","author":"Raphael","year":"1994","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib66","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0090-4295(00)00960-2","article-title":"Apoptosis as a biomarker in chemoprevention trials","volume":"57","author":"Riss","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib67","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/aja.1001390402","article-title":"The tectorial membrane of the rat","volume":"139","author":"Ross","year":"1974","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib68","first-page":"1313","article-title":"Ototoxicity: therapeutic opportunities. Drug Discov","volume":"10","author":"Rybak","year":"2005","journal-title":"Today"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib69","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0378-5955(91)90218-X","article-title":"Atrophy of outer hair cell stereocilia and hearing loss in hydropic cochleae","volume":"53","author":"Rydmarker","year":"1991","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib70","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1016\/S0021-9258(19)74593-1","article-title":"Spatial resolution of fodrin proteolysis in postischemic brain","volume":"268","author":"Saido","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib71","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1096\/fasebj.8.11.8070630","article-title":"Calpain: new perspectives in molecular diversity and physiological-pathological involvement","volume":"8","author":"Saido","year":"1994","journal-title":"FASEB J."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib72","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/mcbr.2001.0271","article-title":"PD98059 attenuates hydrogen peroxide-induced cell death through inhibition of Jun N-Terminal Kinase in HT29 cells","volume":"4","author":"Salh","year":"2000","journal-title":"Mol. Cell Biol. Res. Commun."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib73","first-page":"229","article-title":"Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance","volume":"2","author":"Searle","year":"1982","journal-title":"Pathol. Annu."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(02)04090-8","article-title":"Upregulated iNOS and oxidative damage to the cochlear stria vascularis due to noise stress","volume":"967","author":"Shi","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib75","doi-asserted-by":"crossref","first-page":"11486","DOI":"10.1073\/pnas.96.20.11486","article-title":"A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain","volume":"96","author":"Shields","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib76","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0304-3940(02)00059-9","article-title":"Expression of c-Fos after noise-induced temporary threshold shift in the guinea pig cochlea","volume":"320","author":"Shizuki","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib77","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1073\/pnas.81.11.3572","article-title":"Brain fodrin: substrate for calpain I, an endogenous calcium-activated protease","volume":"81","author":"Siman","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib78","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0378-5955(92)90152-D","article-title":"Actin-binding and microtubuleassociated proteins in the organ of Corti","volume":"57","author":"Slepecky","year":"1992","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib79","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.heares.2005.01.011","article-title":"Protective effect of T-type calcium channel blocker flunarizine on cisplatin-induced death of auditory cells","volume":"204","author":"So","year":"2005","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib80","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0065-227X(96)81667-4","article-title":"Structure and physiological functions of ubiquitous and tissue-specific calpain species. Muscle-specific calpain, p94, interacts with connectin\/titin","volume":"33","author":"Sorimachi","year":"1996","journal-title":"Adv. Biophys."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib81","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1042\/bj3280721","article-title":"Structure and physiological function of calpains","volume":"328","author":"Sorimachi","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib82","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3109\/00016487309139699","article-title":"Relation of structural damage to exposure time and intensity in acoustic trauma","volume":"75","author":"Spoendlin","year":"1973","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib83","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jcp.1041590206","article-title":"Calpain activation in apoptosis","volume":"159","author":"Squier","year":"1994","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib84","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/abbi.1996.0300","article-title":"Maitotoxin induces calpain activation in SH-SY5Y neuroblastoma cells and cerebrocortical cultures","volume":"331","author":"Wang","year":"1996","journal-title":"Biochem. Biophys."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib85","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/00001756-199903170-00027","article-title":"Leupeptin\u00a0protects sensory hair cells from acoustic trauma","volume":"10","author":"Wang","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib86","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0306-4522(02)00004-0","article-title":"Riluzole rescues cochlear sensory cells from acoustic trauma in the guinea-pig","volume":"111","author":"Wang","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib87","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1523\/JNEUROSCI.23-24-08596.2003","article-title":"A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss","volume":"23","author":"Wang","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib88","doi-asserted-by":"crossref","first-page":"8309","DOI":"10.1074\/jbc.274.12.8309","article-title":"Caspase-dependent activation of calpain during drug-induced apoptosis","volume":"274","author":"Wood","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib89","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/sj.onc.1202034","article-title":"Bax cleavage is mediated by calpain during drug-induced apoptosis","volume":"17","author":"Wood","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib90","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0074-7696(08)62312-8","article-title":"Cell death: the significance of apoptosis","volume":"68","author":"Wyllie","year":"1980","journal-title":"Int. Rev. Cyt."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib91","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/BF02114761","article-title":"Appearance of free radicals in the guinea pig inner ear after noise-induced acoustic trauma","volume":"252","author":"Yamane","year":"1995","journal-title":"Arch. Otorhinolaryngol."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib92","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ceca.2004.03.001","article-title":"Ca2+-dependent proteases in ischemic neuronal death: a conserved \u201ccalpain-cathepsin cascade\u201d from nematodes to primates","volume":"36","author":"Yamashima","year":"2004","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib93","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1046\/j.1460-9568.1998.00184.x","article-title":"Inhibition of ischaemic hippocampal neuronal death in primates with cathepsinBinhibitorCA-074: a novel strategy for neuroprotection based on \u201ccalpain-cathepsin hypothesis.\u201d","volume":"10","author":"Yamashima","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib94","first-page":"2719","article-title":"AIF and EndoG in noise-induced hearing loss","volume":"15","author":"Yamashita","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2007.02.007_bib95","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0006-8993(98)00660-X","article-title":"Influence of intense sound exposure on glutathione synthesis in the cochlea","volume":"804","author":"Yamasoba","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2007.02.007_bib96","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0378-5955(90)90228-H","article-title":"Nonerythroid spectrin (fodrin) is a prominent component of the cochlear hair cells","volume":"43","author":"Ylikoski","year":"1990","journal-title":"Hear. Res."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390807000494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390807000494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T20:52:09Z","timestamp":1628542329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390807000494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":96,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0028390807000494"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2007.02.007","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}