{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:49:42Z","timestamp":1789429782292,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.neuropharm.2007.04.019","type":"journal-article","created":{"date-parts":[[2007,5,15]],"date-time":"2007-05-15T09:30:32Z","timestamp":1179221432000},"page":"169-177","source":"Crossref","is-referenced-by-count":54,"title":["The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain"],"prefix":"10.1016","volume":"53","author":[{"given":"Ying-Ching","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiung-Chun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuei-Sen","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2007.04.019_bib1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0301-0082(98)00087-2","article-title":"The effects of cannabinoids on the brain","volume":"58","author":"Ameri","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib3","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/sj.bjp.0706798","article-title":"AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain","volume":"148","author":"Costa","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pain.2005.09.005","article-title":"Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat","volume":"118","author":"Elmes","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.pharmtox.38.1.179","article-title":"Cannabinoid receptors and their endogenous agonists","volume":"38","author":"Felder","year":"1998","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0304-3959(00)00474-7","article-title":"The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain","volume":"92","author":"Fox","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0733-8619(18)30815-6","article-title":"Trigeminal neuralgia and related disorders","volume":"7","author":"Fromm","year":"1989","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0306-4522(96)00428-9","article-title":"Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain","volume":"77","author":"Glass","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0304-3940(96)13308-5","article-title":"The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain","volume":"221","author":"Herzberg","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib11","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1073\/pnas.0409888102","article-title":"CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids","volume":"102","author":"Ibrahim","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pain.2005.12.018","article-title":"CB2 cannabinoid receptor mediation of antinociception","volume":"122","author":"Ibrahim","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib13","first-page":"39","article-title":"An Immunohistochemical Study of Trigeminal Mononeuropathy in Rats","author":"Imamura","year":"1993","journal-title":"Abstract of the 7th World Congress on Pain"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/PL00005748","article-title":"Characterization of heat-hyperalgesia\u00a0in an experimental trigeminal neuropathy in rats","volume":"116","author":"Imamura","year":"1997","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0304-3959(98)00263-2","article-title":"The cannabinoid receptor agonist WIN 55,212-2 mesylate blocks the development of hyperalgesia produced by capsaicin in rats","volume":"81","author":"Li","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib17","first-page":"507","article-title":"Therapeutic potential of cannabinoids in trigeminal neuralgia. Curr. Drug Targets CNS Neurol","volume":"3","author":"Liang","year":"2004","journal-title":"Disord."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1113\/jphysiol.2003.056986","article-title":"Cannabinoid-induced\u00a0presynaptic inhibition at the primary afferent trigeminal synapse of juvenile rat brainstem slices","volume":"555","author":"Liang","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib19","first-page":"517","article-title":"Spinal and supraspinal components of\u00a0cannabinoid-induced antinociception","volume":"258","author":"Lichtman","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0304-3959(03)00242-2","article-title":"Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats","volume":"105","author":"Lim","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0006-8993(03)02872-5","article-title":"Cannabinoid CB1 receptor protein expression in the rat hippocampus and entorhinal, perirhinal, postrhinal and temporal cortices: regional variations and age-related changes","volume":"979","author":"Liu","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib22","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1093\/brain\/124.12.2347","article-title":"Trigeminal neuralgia: pathology and pathogenesis","volume":"124","author":"Love","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0009-3084(02)00155-X","article-title":"Inhibition of pain responses by activation of CB2 cannabinoid receptors","volume":"121","author":"Malan","year":"2002","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0304-3959(99)00045-7","article-title":"Spinal cannabinoids are anti-allodynic in rats with persistent inflammation","volume":"82","author":"Martin","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib25","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/346561a0","article-title":"Structure of a cannabinoid receptor and functional expression of the cloned cDNA","volume":"346","author":"Matsuda","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/365061a0","article-title":"Molecular characterization of a peripheral receptor for cannabinoids","volume":"365","author":"Munro","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0304-3959(01)00403-1","article-title":"Induction of Fos protein-like immunoreactivity in the trigeminal spinal nucleus caudalis and upper cervical cord following noxious and non-noxious\u00a0mechanical stimulation of the whisker pad of the rat with an inferior alveolar nerve transection","volume":"95","author":"Nomura","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib28","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0028-3908(00)00160-X","article-title":"Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception","volume":"40","author":"Palazzo","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pain.2005.07.008","article-title":"A cannabinoid agonist, WIN 55,212-2, reduces neuropathic nociception induced by paclitaxel in rats","volume":"118","author":"Pascual","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib30","doi-asserted-by":"crossref","first-page":"11393","DOI":"10.1073\/pnas.0603861103","article-title":"The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin","volume":"103","author":"Patwardhan","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib31","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0301-0082(00)00031-9","article-title":"Cannabinoid receptors and pain","volume":"63","author":"Pertwee","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0306-4522(03)00333-6","article-title":"The\u00a0neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat","volume":"120","author":"Price","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib33","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/sj.bjp.0705778","article-title":"Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons","volume":"142","author":"Price","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0304-3959(94)90086-8","article-title":"Trigeminal neuralgia: the role of self-sustaining\u00a0discharge in the trigeminal ganglion","volume":"56","author":"Rappaport","year":"1994","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib35","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1460-9568.2005.04206.x","article-title":"Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats","volume":"22","author":"Sagar","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib36","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1016\/S0014-2999(01)00798-1","article-title":"Cannabinoid CB1 receptor upregulation in a rat model of chronic neuropathic pain","volume":"415","author":"Siegling","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib37","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0091-3057(97)00583-2","article-title":"Characterization of delta9-tetrahydrocannabinol and anandamide antinociception in nonarthritic and arthritic rats","volume":"60","author":"Smith","year":"1998","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib38","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1523\/JNEUROSCI.14-05-02708.1994","article-title":"Behavioral evidence of trigeminal neuropathic pain following chronic constriction injury to the rat's infraorbital nerve","volume":"14","author":"Vos","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib39","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/08990220050020535","article-title":"Changes in neuronal activities in the two ventral posterior medial thalamic nuclei in an experimental model of trigeminal pain in the rat by constriction of one infraorbital nerve","volume":"17","author":"Vos","year":"2000","journal-title":"Somatosens. Mot. Res."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib40","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0022-3565(24)37725-0","article-title":"Differential blockade of the antinociceptive effects of centrally administered cannabinoids by SR141716A","volume":"286","author":"Welch","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib41","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0030-4220(92)90292-X","article-title":"Drugs used in the management of trigeminal neuralgia","volume":"74","author":"Zakrzewska","year":"1992","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"10.1016\/j.neuropharm.2007.04.019_bib42","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0306-4522(97)00240-6","article-title":"Down-regulation of mu-opioid receptors in rat and monkey dorsal root ganglion neurons and spinal cord after peripheral axotomy","volume":"82","author":"Zhang","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2007.04.019_bib43","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/22761","article-title":"Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide","volume":"400","author":"Zygmunt","year":"1999","journal-title":"Nature"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390807001256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390807001256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T03:37:43Z","timestamp":1736998663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390807001256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0028390807001256"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2007.04.019","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}