{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:42:15Z","timestamp":1773661335133,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.neuropharm.2008.09.007","type":"journal-article","created":{"date-parts":[[2008,9,26]],"date-time":"2008-09-26T08:30:35Z","timestamp":1222417835000},"page":"368-378","source":"Crossref","is-referenced-by-count":19,"title":["N-type and P\/Q-type calcium channels regulate differentially the release of noradrenaline, ATP and \u03b2-NAD in blood vessels"],"prefix":"10.1016","volume":"56","author":[{"given":"Lisa M.","family":"Smyth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilia A.","family":"Yamboliev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta N.","family":"Mutafova-Yambolieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2008.09.007_bib1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1161\/01.HYP.0000203160.80972.47","article-title":"Coexpression of voltage-dependent calcium channels Cav1.2, 2.1a, and 2.1b in vascular myocytes","volume":"47","author":"Andreasen","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.neuropharm.2008.09.007_bib2","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1053\/j.gastro.2008.02.018","article-title":"Characterization of fetal and postnatal enteric neuronal cell lines with improvement in intestinal neural function","volume":"134","author":"Anitha","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neuropharm.2008.09.007_bib3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/abio.2002.5667","article-title":"High-performance liquid chromatographic technique for detection of a fluorescent analogue of ADP-ribose in isolated blood vessel preparations","volume":"305","author":"Bobalova","year":"2002","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1046\/j.1440-1681.2001.03460.x","article-title":"Co-release of endogenous ATP and noradrenaline from guinea-pig mesenteric veins exceeds co-release from mesenteric arteries","volume":"28","author":"Bobalova","year":"2001","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1365-2680.2001.00207.x","article-title":"Presynaptic alpha2-adrenoceptor-mediated modulation of adenosine 5\u2032 triphosphate and noradrenaline corelease: differences in canine mesenteric artery and vein","volume":"21","author":"Bobalova","year":"2001","journal-title":"J. Auton. Pharmacol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1046\/j.1440-1681.2003.03808.x","article-title":"Membrane-bound and releasable nucleotidase activities: differences in canine mesenteric artery and vein","volume":"30","author":"Bobalova","year":"2003","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejphar.2006.02.049","article-title":"Activation of the adenylyl cyclase\/protein kinase A pathway facilitates neural release of beta-nicotinamide adenine dinucleotide in canine mesenteric artery","volume":"536","author":"Bobalova","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib8","doi-asserted-by":"crossref","first-page":"L43","DOI":"10.1152\/ajplung.00460.2001","article-title":"Role of CaM kinase II and ERK activation in thrombin-induced endothelial cell barrier dysfunction","volume":"285","author":"Borbiev","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/8070","article-title":"Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels","volume":"2","author":"Bourinet","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib10","doi-asserted-by":"crossref","first-page":"F486","DOI":"10.1152\/ajprenal.00314.2005","article-title":"{beta}-NAD is a novel nucleotide released on stimulation of nerve terminals in human urinary bladder detrusor muscle","volume":"290","author":"Breen","year":"2006","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.bjp.0702256","article-title":"Effects of Ca2+ concentration and Ca2+ channel blockers on noradrenaline release and purinergic neuroeffector transmission in rat tail artery","volume":"126","author":"Brock","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib12","first-page":"7","article-title":"The fifth Heymans memorial lecture \u2013 Ghent, February 17, 1990. Co-transmission","volume":"304","author":"Burnstock","year":"1990","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.coph.2003.08.001","article-title":"Cotransmission","volume":"4","author":"Burnstock","year":"2004","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib14","doi-asserted-by":"crossref","first-page":"9569","DOI":"10.1073\/pnas.89.20.9569","article-title":"Large and small vertebrate sensory neurons express different Na and K channel subtypes","volume":"89","author":"Campbell","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1749-6632.1999.tb11284.x","article-title":"Interactions of presynaptic Ca2+ channels and snare proteins in neurotransmitter release","volume":"868","author":"Catterall","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.cellbio.16.1.521","article-title":"Structure and regulation of voltage-gated Ca2+ channels","volume":"16","author":"Catterall","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/978-1-4419-8632-0_45","article-title":"Modulatory role of GTP-binding proteins in the endogenous ADP-ribosylation of cytosolic proteins","volume":"419","author":"Di Girolamo","year":"1997","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib18","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1161\/01.RES.50.6.799","article-title":"High force development and crossbridge attachment in smooth muscle from swine carotid arteries","volume":"50","author":"Dillon","year":"1982","journal-title":"Circ. Res."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib19","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0896-6273(00)81057-0","article-title":"Nomenclature of voltage-gated calcium channels","volume":"25","author":"Ertel","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2008.09.007_bib20","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1042\/BJ20040979","article-title":"Extracellular NAD+ regulates intracellular free calcium concentration in human monocytes","volume":"382","author":"Gerth","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0028-3908(97)00046-4","article-title":"Identification of pore-forming subunit of P-type calcium channels: an antisense study on rat cerebellar Purkinje cells in culture","volume":"36","author":"Gillard","year":"1997","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2008.09.007_bib22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1161\/01.RES.33.3.275","article-title":"Length-tension relationship of smooth muscle of the hog carotid artery","volume":"33","author":"Herlihy","year":"1973","journal-title":"Circ. Res."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib23","doi-asserted-by":"crossref","first-page":"302","DOI":"10.5483\/BMBRep.2007.40.3.302","article-title":"A proteomic screen for presynaptic terminal N-type calcium channel (CaV2.2) binding partners","volume":"40","author":"Khanna","year":"2007","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1540\/jsmr.39.269","article-title":"Properties of the venous and arterial innervation in the mesentery","volume":"39","author":"Kreulen","year":"2003","journal-title":"J. Smooth Muscle Res."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0306-4522(94)90223-2","article-title":"Co-release of noradrenaline and ATP from cultured sympathetic neurons","volume":"61","author":"von Kugelgen","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2008.09.007_bib26","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.pharmtox.41.1.317","article-title":"Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers","volume":"41","author":"Lee","year":"2001","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib27","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/0028-3908(93)90010-Z","article-title":"Block of calcium channels in rat neurons by synthetic omega-Aga-IVA","volume":"32","author":"Mintz","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2008.09.007_bib28","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/355827a0","article-title":"P-type calcium channels blocked by the spider toxin [omega]-Aga-IVA","volume":"355","author":"Mintz","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2008.09.007_bib29","doi-asserted-by":"crossref","first-page":"31419","DOI":"10.1074\/jbc.M606625200","article-title":"Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes","volume":"281","author":"Moreschi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib30","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0306-3623(00)00054-9","article-title":"Multiple P2Y receptors mediate contraction in guinea pig mesenteric vein","volume":"34","author":"Mutafova-Yambolieva","year":"2000","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib31","doi-asserted-by":"crossref","first-page":"16359","DOI":"10.1073\/pnas.0705510104","article-title":"beta-Nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle","volume":"104","author":"Mutafova-Yambolieva","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0008-6363(02)00648-X","article-title":"Involvement of cyclic AMP-mediated pathway in neural release of noradrenaline in canine isolated mesenteric artery and vein","volume":"57","author":"Mutafova-Yambolieva","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib33","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1021\/bi00317a001","article-title":"Purification and sequence of a presynaptic peptide toxin from Conus geographus venom","volume":"23","author":"Olivera","year":"1984","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2008.09.007_bib34","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1146\/annurev.bi.63.070194.004135","article-title":"Calcium channel diversity and neurotransmitter release: the \u03c9-conotoxins and \u03c9-agatoxins","volume":"63","author":"Olivera","year":"1994","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib35","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1523\/JNEUROSCI.15-04-02995.1995","article-title":"Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons","volume":"15","author":"Randall","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib36","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1006\/bbrc.2001.5325","article-title":"Extracellular NAD(+) induces calcium signaling and apoptosis in human osteoblastic cells","volume":"285","author":"Romanello","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib37","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1152\/physrev.1983.63.4.1281","article-title":"Reflex control of veins and vascular capacitance","volume":"63","author":"Rothe","year":"1983","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1566-0702(00)00203-4","article-title":"Cotransmission from sympathetic vasoconstrictor neurons: differences in guinea-pig mesenteric artery and vein","volume":"86","author":"Smyth","year":"2000","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib39","doi-asserted-by":"crossref","first-page":"48893","DOI":"10.1074\/jbc.M407266200","article-title":"Release of {beta}-nicotinamide adenine dinucleotide upon stimulation of postganglionic nerve terminals in blood vessels and urinary bladder","volume":"279","author":"Smyth","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib40","doi-asserted-by":"crossref","first-page":"H1818","DOI":"10.1152\/ajpheart.01062.2005","article-title":"Nicotinamide adenine dinucleotide (NAD) is released from sympathetic nerve terminals via a botulinum neurotoxin A mediated mechanism in canine mesenteric artery","volume":"290","author":"Smyth","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib41","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.neuroscience.2006.01.043","article-title":"Novel localization of CD38 in perivascular sympathetic nerve terminals","volume":"139","author":"Smyth","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2008.09.007_bib42","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1038\/sj.bjp.0702954","article-title":"Significant role of neuronal non-N-type calcium channels in the sympathetic neurogenic contraction of rat mesenteric artery","volume":"128","author":"Tanaka","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib43","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/387076a0","article-title":"Neuronal release of soluble nucleotidases and their role in neurotransmitter inactivation","volume":"387","author":"Todorov","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2008.09.007_bib44","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0022-3565(24)34890-6","article-title":"Differential cotransmission in sympathetic nerves: role of frequency of stimulation and prejunctional autoreceptors","volume":"290","author":"Todorov","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib45","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1152\/jn.2001.85.1.164","article-title":"Agatoxin-IVA-sensitive calcium channels mediate the presynaptic and postsynaptic nicotinic activation of cardiac vagal neurons","volume":"85","author":"Wang","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib46","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/sj.bjp.0700948","article-title":"Role of N-, P- and Q-type voltage-gated calcium channels in transmitter release from sympathetic neurones in the mouse isolated vas deferens","volume":"120","author":"Waterman","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib47","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0301-0082(99)00025-8","article-title":"Voltage-gated calcium channels in autonomic neuroeffector transmission","volume":"60","author":"Waterman","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib48","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1523\/JNEUROSCI.16-13-04155.1996","article-title":"Multiple subtypes of voltage-gated calcium channel mediate transmitter release from parasympathetic neurons in the mouse bladder","volume":"16","author":"Waterman","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib49","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1474-8673.1996.tb00061.x","article-title":"Differences between the regulation of noradrenaline and ATP release","volume":"16","author":"Westfall","year":"1996","journal-title":"J. Auton. Pharmacol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib50","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/sj.bjp.0704943","article-title":"Involvement of T-type calcium channels in excitatory junction potentials in rat resistance mesenteric arteries","volume":"137","author":"Xi","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1472-6793-2-17","article-title":"Canine mesenteric artery and vein convey no difference in the content of major contractile proteins","volume":"2","author":"Yamboliev","year":"2002","journal-title":"BMC Physiol."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib52","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1042\/BJ20041217","article-title":"NAD+ surfaces again","volume":"382","author":"Ziegler","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuropharm.2008.09.007_bib53","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s002100000309","article-title":"Extracellular metabolism of ATP and other nucleotides","volume":"362","author":"Zimmermann","year":"2000","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390808004139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390808004139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T02:46:41Z","timestamp":1738378001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390808004139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0028390808004139"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2008.09.007","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}