{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:11:43Z","timestamp":1791418303537,"version":"4.3.3"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.neuropharm.2010.12.007","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T09:20:46Z","timestamp":1293009646000},"page":"593-601","source":"Crossref","is-referenced-by-count":37,"title":["Oleoylethanolamide: Effects on hypothalamic transmitters and gut peptides regulating food intake"],"prefix":"10.1016","volume":"60","author":[{"given":"Antonia","family":"Serrano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Pav\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulay","family":"Tovar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Casanueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Se\u00f1ar\u00eds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Di\u00e9guez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rodr\u00edguez de Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2010.12.007_bib1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/nature00887","article-title":"Gut hormone PYY (3-36) physiologically inhibits food intake","volume":"418","author":"Battherham","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib2","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/90992","article-title":"The adipocyte-secreted protein Acrp30 enhances hepatic insulin action","volume":"7","author":"Berg","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/cne.903010107","article-title":"Simultaneous labeling of vagal innervation of the gut and afferent projections from the visceral forebrain with dil injected into the dorsal vagal complex in the rat","volume":"301","author":"Berthoud","year":"1990","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejphar.2005.07.008","article-title":"Peptide YY (3-36) inhibits dopamine and norepinephrine release in the hypothalamus","volume":"519","author":"Brunetti","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0014-2999(00)00783-4","article-title":"Cocaine- and amphetamine - regulated transcript peptide (55-102) and thyrotropin releasing hormone inhibit hypothalamic dopamine release","volume":"409","author":"Brunetti","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0014-2999(99)00255-1","article-title":"Leptin inhibits norepinephrine and dopamine release from rat hypothalamic neuronal endings","volume":"372","author":"Brunetti","year":"1999","journal-title":"Eur. J.\u00a0Pharmacol."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib7","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1523\/JNEUROSCI.17-04-01226.1997","article-title":"Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain","volume":"17","author":"Cadas","year":"1997","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1079\/BJN20041256","article-title":"Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide","volume":"92","author":"Cani","year":"2004","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib9","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.2337\/diabetes.50.8.1714","article-title":"A\u00a0preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans","volume":"50","author":"Cummings","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib10","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/372686a0","article-title":"Formation and inactivation of endogenous cannabinoid anandamide in central neurons","volume":"372","author":"Di Marzo","year":"1994","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.neuropharm.2010.12.007_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.1085","article-title":"Characterization of CART neurons in the rat and human hypothalamus","volume":"432","author":"Elias","year":"2001","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0896-6273(00)81084-3","article-title":"From lesions to leptin: hypothalamic control of food intake and body weight","volume":"22","author":"Elmquist","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1753-4887.1998.tb01685.x","article-title":"Leptin, leptin receptors and the control of body weight","volume":"56","author":"Friedman","year":"1998","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib14","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1073\/pnas.041591798","article-title":"Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice","volume":"98","author":"Fruebis","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.neuropharm.2010.12.007_bib15","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1074\/jbc.M607809200","article-title":"Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine","volume":"282","author":"Fu","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature01921","article-title":"Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-\u03b1","volume":"425","author":"Fu","year":"2003","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.neuropharm.2010.12.007_bib17","doi-asserted-by":"crossref","first-page":"8096","DOI":"10.1523\/JNEUROSCI.0036-10.2010","article-title":"The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin","volume":"30","author":"Gaetani","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib18","doi-asserted-by":"crossref","first-page":"9612","DOI":"10.1523\/JNEUROSCI.22-21-09612.2002","article-title":"A\u00a0peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding","volume":"22","author":"G\u00f3mez","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib19","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1152\/ajpendo.00555.2004","article-title":"Oleylethanolamide impairs glucose tolerance and inhibits insulin-stimulated glucose uptake in rat adipocytes through p38 and JNK MAPK pathways","volume":"289","author":"Gonz\u00e1lez-Yanes","year":"2005","journal-title":"Am. J.\u00a0Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib20","doi-asserted-by":"crossref","first-page":"27849","DOI":"10.1074\/jbc.M404087200","article-title":"Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor \u03b1 (PPAR- \u03b1)","volume":"279","author":"Guzm\u00e1n","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib21","doi-asserted-by":"crossref","first-page":"10697","DOI":"10.1074\/jbc.271.18.10697","article-title":"AdipoQ is a novel adipose-specific gene dysregulated in obesity","volume":"271","author":"Hu","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1210\/er.20.1.68","article-title":"Interacting appetite-regulating pathways in the hypothalamic regulation of body weight","volume":"20","author":"Kalra","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib23","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib25","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/29993","article-title":"Hypothalamic CART is a new anorectic peptide regulated by leptin","volume":"393","author":"Kristensen","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000048219","article-title":"Neuropeptide Y, but not agouti-related peptide or melanin-concentrating hormone, is a target peptide for orexin-A feeding actions in the rat hypothalamus","volume":"75","author":"L\u00f3pez","year":"2002","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib28","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s00424-005-0034-5","article-title":"Resistin as a putative modulator of insulin action in the daily feeding\/fasting rhythm","volume":"452","author":"Oliver","year":"2006","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2006.02.004","article-title":"Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small molecule hypophagic agents","volume":"3","author":"Overton","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib30","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"issue":"3","key":"10.1016\/j.neuropharm.2010.12.007_bib31","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1152\/ajpregu.00029.2005","article-title":"Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity","volume":"289","author":"Proulx","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.nut.2004.06.021","article-title":"Neuropeptide Y, alpha-melanocyte-stimulating hormone, and monoamines in food intake regulation","volume":"21","author":"Ramos","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib33","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1053\/meta.2000.6251","article-title":"Peripheral versus central effects of glucagon-like peptide-1 receptor agonists on satiety and body weight loss in Zucker obese rats","volume":"49","author":"Rodriquez de Fonseca","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/35102582","article-title":"An anorexic lipid mediator regulated by feeding","volume":"414","author":"Rodr\u00edguez de Fonseca","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib35","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1159\/000126899","article-title":"Differential effects of chronic treatment with either dopamine D1 or D2 receptor agonist on the acute neuroendocrine actions of the highly potent synthetic cannabinoid HU-210 in male rats","volume":"61","author":"Rodr\u00edguez de Fonseca","year":"1995","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/cne.902180202","article-title":"The organization of forebrain afferents to the paraventricular and supraoptic nuclei of the rat","volume":"218","author":"Sawchenko","year":"1983","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib37","doi-asserted-by":"crossref","first-page":"26746","DOI":"10.1074\/jbc.270.45.26746","article-title":"A\u00a0novel serum protein similar to C1q, produced exclusively in adipocytes","volume":"270","author":"Scherer","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib38","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib39","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1210\/en.137.12.5236","article-title":"Regulation of hypothalamic somatostatin, growth hormone-releasing hormone, and growth hormone receptor messenger ribonucleic acid by glucocorticoids","volume":"137","author":"Se\u00f1ar\u00eds","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib40","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.neuropharm.2007.03.007","article-title":"The cannabinoid CB1 receptor antagonist SR141716A (Rimonabant) enhances the metabolic benefits of long-term treatment with oleoylethanolamide in Zucker rats","volume":"54","author":"Serrano","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib41","first-page":"76","article-title":"Oleoylethanolamide, a ligand of the peroxisome proliferators - activated receptor alpha, prevents liver injury and oxidative stress induced by Tween 20","volume":"4-1","author":"Serrano","year":"2008","journal-title":"Obe. Metab."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib42","first-page":"155","article-title":"Oleoylethanolamide regulates level of fatty acid in rats via down regulation of liver desaturases mRNA expression","volume":"2-3","author":"Serrano","year":"2006","journal-title":"Obe. Metab."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib43","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/oby.2007.564","article-title":"Circadian expression of genes regulating food intake","volume":"15","author":"Stutz","year":"2007","journal-title":"Obesity"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib44","doi-asserted-by":"crossref","first-page":"20869","DOI":"10.1074\/jbc.M110813200","article-title":"Astrocytes in culture produce anandamide and other acylethanolamides","volume":"277","author":"Walter","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib45","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/nm788","article-title":"Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase","volume":"8","author":"Yamauchi","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2010.12.007_bib46","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1388-1981(02)00298-6","article-title":"Regulation of adiponectin and leptin gene expression in white and brown adipose tissues: influence of beta3-adrenergic agonists, retinoic acid, leptin and fasting","volume":"1584","author":"Zhang","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib47","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2010.12.007_bib48","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1210\/en.2003-0241","article-title":"Minireview: from anorexia to obesity-the yin and yang of body weight control","author":"Zigman","year":"2003","journal-title":"Endocrinology"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390810003321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390810003321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T07:27:02Z","timestamp":1559892422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390810003321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0028390810003321"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2010.12.007","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}