{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:04:49Z","timestamp":1784912689457,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.neuropharm.2011.08.041","type":"journal-article","created":{"date-parts":[[2011,9,3]],"date-time":"2011-09-03T07:00:47Z","timestamp":1315033247000},"page":"1441-1451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["SEA0400, a specific Na+\/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson\u2019s disease"],"prefix":"10.1016","volume":"61","author":[{"given":"Yukio","family":"Ago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuaki","family":"Nashida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Kitamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teisuke","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Takuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2011.08.041_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/syn.20575","article-title":"Role of prefrontal dopaminergic neurotransmission in glucocorticoid receptor-mediated modulation of methamphetamine-induced hyperactivity","volume":"63","author":"Ago","year":"2009","journal-title":"Synapse"},{"key":"10.1016\/j.neuropharm.2011.08.041_bib2","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.neuropharm.2008.08.026","article-title":"Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated with changes in prefrontal dopamine in mouse models of depression","volume":"55","author":"Ago","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2011.08.041_bib3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1124\/pr.56.4.5","article-title":"Pharmacology of brain Na+\/Ca2+ exchanger: from molecular biology to therapeutic perspectives","volume":"56","author":"Annunziato","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib4","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1007\/s11064-008-9697-6","article-title":"Role of nitric oxide synthases in Parkinson\u2019s disease: a review on the antioxidant and anti-inflammatory activity of polyphenols","volume":"33","author":"Aquilano","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib5","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1046\/j.1471-4159.1995.64062437.x","article-title":"Nitroprusside and cyclic GMP stimulate Na+\u2013Ca2+ exchange activity in neuronal preparations and cultured rat astrocytes","volume":"64","author":"Asano","year":"1995","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1046\/j.1471-4159.1997.68010095.x","article-title":"Nitric oxide disrupts Ca2+ homeostasis in hippocampal neurons","volume":"68","author":"Brorson","year":"1997","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib7","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1046\/j.1471-4159.1997.69051882.x","article-title":"Disrupted [Ca2+]i homeostasis contributes to the toxicity of nitric oxide in cultured hippocampal neurons","volume":"69","author":"Brorson","year":"1997","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib8","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1089\/ars.2009.2721","article-title":"Nitric oxide in cell survival: a janus molecule","volume":"11","author":"Calabrese","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib9","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1523\/JNEUROSCI.10-06-01847.1990","article-title":"Changes in striatal dopamine neurotransmission assessed with microdialysis following recovery from a bilateral 6-OHDA lesion: variation as a function of lesion size","volume":"10","author":"Casta\u00f1eda","year":"1990","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib10","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.neuroscience.2006.04.022","article-title":"Alterations of the expression and activity of midbrain nitric oxide synthase and soluble guanylyl cyclase in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice","volume":"141","author":"Chalimoniuk","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2011.08.041_bib11","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.freeradbiomed.2004.12.008","article-title":"Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity","volume":"38","author":"Choi","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib12","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1523\/JNEUROSCI.23-10-04081.2003","article-title":"Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson\u2019s disease","volume":"23","author":"Crocker","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib13","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1046\/j.1471-4159.2000.0742213.x","article-title":"Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in\u00a0vivo","volume":"74","author":"Dehmer","year":"2000","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib14","doi-asserted-by":"crossref","first-page":"14669","DOI":"10.1073\/pnas.251341998","article-title":"Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson\u2019s disease","volume":"98","author":"Du","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.neuropharm.2011.08.041_bib15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0169-328X(98)00259-9","article-title":"Basal ganglia neuronal nitric oxide synthase mRNA expression in Parkinson\u2019s disease","volume":"63","author":"Eve","year":"1998","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib16","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"1997"},{"key":"10.1016\/j.neuropharm.2011.08.041_bib17","doi-asserted-by":"crossref","first-page":"26677","DOI":"10.1016\/S0021-9258(18)47072-X","article-title":"Potent and selective inhibition of human nitric oxide synthases","volume":"269","author":"Furfine","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib18","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1046\/j.1471-4159.2002.00928.x","article-title":"Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson\u2019s disease","volume":"81","author":"Gao","year":"2002","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib19","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1523\/JNEUROSCI.23-04-01228.2003","article-title":"Critical role of microglia NADPH oxidase-derived free radicals in the MPTP model of Parkinson\u2019s disease","volume":"23","author":"Gao","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1517\/14728222.7.2.187","article-title":"MAPKs: new targets for neurodegeneration","volume":"7","author":"Harper","year":"2003","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.neuropharm.2011.08.041_bib21","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1523\/JNEUROSCI.4564-03.2004","article-title":"Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson\u2019s disease","volume":"24","author":"Hayley","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib22","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0306-4522(95)00578-1","article-title":"Nitric oxide synthase and neuronal vulnerability in Parkinson\u2019s disease","volume":"72","author":"Hunot","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2011.08.041_bib23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.neures.2007.08.005","article-title":"Pael receptor is involved in dopamine metabolism in the nigrostriatal system","volume":"59","author":"Imai","year":"2007","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib24","doi-asserted-by":"crossref","first-page":"7544","DOI":"10.1074\/jbc.M310491200","article-title":"Molecular determinants of Na+\/Ca2+ exchange (NCX1) inhibition by SEA0400","volume":"279","author":"Iwamoto","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib25","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.neuropharm.2008.05.032","article-title":"A\u00a0neuroprotective agent, T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate), prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice","volume":"55","author":"Kawasaki","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2011.08.041_bib26","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1124\/jpet.106.119206","article-title":"Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum","volume":"322","author":"Kawasaki","year":"2007","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib27","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejphar.2006.05.012","article-title":"Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum","volume":"542","author":"Kawasaki","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib28","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuint.2010.04.016","article-title":"The Na+\/Ca2+ exchanger-mediated Ca2+ influx triggers nitric oxide-induced cytotoxicity in cultured astrocytes","volume":"57","author":"Kitao","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib29","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1097\/00001756-200004270-00024","article-title":"Inhibition of neuronal nitric oxide synthase protects against MPTP toxicity","volume":"11","author":"Klivenyi","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2011.08.041_bib30","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1179\/016164102101200717","article-title":"Role of nitric oxide synthase against MPTP neurotoxicity in mice","volume":"24","author":"Kurosaki","year":"2002","journal-title":"Neurol. Res."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib31","first-page":"509","article-title":"Therapeutic potential of novel Na+\u2013Ca2+ exchange inhibitors in attenuating ischemia-reperfusion injury","volume":"21","author":"Lee","year":"2005","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib32","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/70978","article-title":"Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease","volume":"5","author":"Liberatore","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbadis.2003.09.007","article-title":"Endomorphins, endogenous opioid peptides, provide antioxidant defense in the brain against free radical-induced damage","volume":"1639","author":"Lin","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuropharm.2011.08.041_bib34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1750-3639.1999.tb00214.x","article-title":"Oxidative stress in brain ischemia","volume":"9","author":"Love","year":"1999","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib35","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1042\/BJ20070619","article-title":"Na+\/Ca2+ exchangers: three mammalian gene families control Ca2+ transport","volume":"406","author":"Lytton","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0022-3565(24)29375-7","article-title":"SEA0400, a novel and selective inhibitor of the Na+\u2013Ca2+ exchanger, attenuates reperfusion injury in the in\u00a0vitro and in\u00a0vivo cerebral ischemic models","volume":"298","author":"Matsuda","year":"2001","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib37","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1006\/exnr.1996.6406","article-title":"S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity","volume":"143","author":"Matthews","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib38","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2174\/092986708783769731","article-title":"MAPKs as mediators of cell fate determination: an approach to neurodegenerative diseases","volume":"15","author":"Miloso","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12035-010-8159-8","article-title":"NO orchestrates the loss of synaptic boutons from adult \u201csick\u201d motoneurons: modeling a molecular mechanism","volume":"43","author":"Moreno-L\u00f3pez","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib40","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1471-4159.2004.02511.x","article-title":"Up-regulation of Na+\u2013Ca2+ exchange activity by interferon-\u03b3 in cultured rat microglia","volume":"90","author":"Nagano","year":"2004","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib41","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/sj.bjp.0706104","article-title":"SEA0400, a specific inhibitor of the Na+\u2013Ca2+ exchanger, attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia","volume":"144","author":"Nagano","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuint.2011.03.026","article-title":"The specific Na+\/Ca2+ exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells","volume":"59","author":"Nashida","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/cne.10665","article-title":"Differential expression of the Na+\u2013Ca2+ exchanger transcripts and proteins in rat brain regions","volume":"461","author":"Papa","year":"2003","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib44","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.physiol.62.1.111","article-title":"Sodium-calcium exchange: a molecular perspective","volume":"62","author":"Philipson","year":"2000","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib45","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1073\/pnas.93.10.4565","article-title":"Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity","volume":"93","author":"Przedborski","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.neuropharm.2011.08.041_bib46","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0166-4328(01)00309-6","article-title":"Behavioral phenotyping of the MPTP mouse model of Parkinson\u2019s disease","volume":"125","author":"Sedelis","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib47","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/1098-1136(200103)33:3<256::AID-GLIA1024>3.0.CO;2-J","article-title":"Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices","volume":"33","author":"Stence","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.neuropharm.2011.08.041_bib48","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10072-010-0245-1","article-title":"Parkinson\u2019s disease: oxidative stress and therapeutic approaches","volume":"31","author":"Surendran","year":"2010","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib49","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0924-977X(03)00065-8","article-title":"Protective effects of neuronal nitric oxide synthase inhibitor in mouse brain against MPTP neurotoxicity: an immunohistological study","volume":"14","author":"Watanabe","year":"2004","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib50","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/sj.bjp.0707167","article-title":"Inflammation as a causative factor in the aetiology of Parkinson\u2019s disease","volume":"150","author":"Whitton","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib51","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1523\/JNEUROSCI.22-05-01763.2002","article-title":"Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease","volume":"22","author":"Wu","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2011.08.041_bib52","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.pharmthera.2005.05.007","article-title":"Role of nitric oxide in Parkinson\u2019s disease","volume":"109","author":"Zhang","year":"2006","journal-title":"Pharmacol. Ther."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390811003741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390811003741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:26:41Z","timestamp":1784910401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390811003741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0028390811003741"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2011.08.041","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SEA0400, a specific Na+\/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2011.08.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}