{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:33:05Z","timestamp":1777480385931,"version":"3.51.4"},"reference-count":63,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.neuropharm.2011.09.028","type":"journal-article","created":{"date-parts":[[2011,10,16]],"date-time":"2011-10-16T14:50:19Z","timestamp":1318776619000},"page":"947-958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evidence that LPS-reactive arthritis in rats depends on the glial activity and the fractalkine\u2013TNF-\u03b1 signaling in the spinal cord"],"prefix":"10.1016","volume":"62","author":[{"given":"Elis\u00e2ngela","family":"Bressan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaite Cristiane","family":"Peres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Rog\u00e9rio","family":"Tonussi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2011.09.028_bib1","first-page":"725","article-title":"Post-traumatic reactive arthritis. Etiologic, clinical and diagnostic aspects. Apropos of 6 cases","volume":"56","author":"Alcalay","year":"1989","journal-title":"Rev. Rhum. Mal. Osteoartic."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(97)00093-2","article-title":"Central neuron\u2013glial and glial\u2013glial interactions following axon injury","volume":"55","author":"Aldskogius","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib3","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1097\/00001756-200107200-00011","article-title":"Modulation of CGRP and PGE2 release from isolated rat skin by alpha-adrenoceptors and kappa-opioid-receptors","volume":"12","author":"Averbeck","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib4","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1126\/science.1067859","article-title":"Control of synaptic strength by glial TNF-alpha","volume":"295","author":"Beattie","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib5","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/art.27380","article-title":"Spinal TNF-alpha neutralization reduces peripheral inflammation and hyperalgesia and suppresses autonomic responses in experimental arthritis","volume":"62","author":"Boettger","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib6","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1172\/JCI119104","article-title":"Spinal cord adenosine receptor stimulation in rats inhibits peripheral neutrophil accumulation: the role of N-methyl-d-aspartate receptors","volume":"98","author":"Bong","year":"1996","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib7","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1371\/journal.pmed.0030338","article-title":"Regulation of peripheral inflammation by spinal p38 MAP kinase in rats","volume":"3","author":"Boyle","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cyto.2006.11.007","article-title":"Contribution of TNFalpha, IL-1beta and CINC-1 for articular incapacitation, edema and cell migration in a model of LPS-induced reactive arthritis","volume":"36","author":"Bressan","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib9","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.lfs.2010.09.002","article-title":"LPS-induced knee-joint reactive arthritis and spinal cord glial activation were reduced after intrathecal thalidomide injection in rats","volume":"87","author":"Bressan","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib10","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00011-008-8029-2","article-title":"Antiinflammatory effects of etoricoxib alone and combined with NSAIDs in LPS-induced reactive arthritis","volume":"57","author":"Bressan","year":"2008","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib11","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1213\/ane.0b013e318162cebf","article-title":"Intrathecally injected morphine inhibits inflammatory paw edema: the involvement of nitric oxide and cyclic-guanosine monophosphate","volume":"106","author":"Brock","year":"2008","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib12","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1046\/j.1460-9568.2000.00979.x","article-title":"Cyclooxygenase-1 is a marker for a subpopulation of putative nociceptive neurons in rat dorsal root ganglia","volume":"12","author":"Chopra","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ejpain.2006.02.003","article-title":"Role of spinal microglia in rat models of peripheral nerve injury and inflammation","volume":"11","author":"Clark","year":"2007","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib14","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/j.lfs.2004.11.012","article-title":"Evidence for a spinal serotonergic control of the peripheral inflammation in the rat","volume":"76","author":"Daher","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0006-8993(02)04056-8","article-title":"A\u00a0spinal mechanism for the peripheral anti-inflammatory action of indomethacin","volume":"962","author":"Daher","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pain.2007.05.002","article-title":"Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain","volume":"135","author":"Echeverry","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11926-996-0015-5","article-title":"Pathways of cell activation in spondyloarthropathies","volume":"3","author":"Fearon","year":"2001","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0006-8993(99)01186-5","article-title":"Microglial reactions after subcutaneous formalin injection into the rat hind paw","volume":"825","author":"Fu","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(91)91729-K","article-title":"Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury","volume":"565","author":"Garrison","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib20","series-title":"Neuroglia","first-page":"883","author":"Gehrmann","year":"1995"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib21","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0140-6736(90)90804-E","article-title":"Salmonella lipopolysaccharide in synovial cells from patients with reactive arthritis","volume":"335","author":"Granfors","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib22","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1056\/NEJM198901263200404","article-title":"Yersinia antigens in synovial-fluid cells from patients with reactive arthritis","volume":"320","author":"Granfors","year":"1989","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0006-8993(92)90616-H","article-title":"Selective inhibition of glial cell metabolism in\u00a0vivo by fluorocitrate","volume":"576","author":"Hassel","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib24","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.pain.2004.02.018","article-title":"HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS)","volume":"110","author":"Holguin","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib25","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.brainres.2004.08.020","article-title":"Immunocytochemical localization of TNF type 1 and type 2 receptors in the rat spinal cord","volume":"1025","author":"Holmes","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib26","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1128\/iai.64.4.1484-1487.1996","article-title":"Experimental Yersinia infection of human synovial cells: persistence of live bacteria and generation of bacterial antigen deposits including \u201cghosts,\u201d nucleic acid-free bacterial rods","volume":"64","author":"Huppertz","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib27","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"IASP, International Association for the Study of Pain","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib28","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1523\/JNEUROSCI.3338-07.2008","article-title":"Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord","volume":"28","author":"Kawasaki","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0306-4530(01)00035-X","article-title":"HPA axis function and drug addictive behaviors: insights from studies with Lewis and Fischer 344 inbred rats","volume":"27","author":"Kosten","year":"2002","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib30","first-page":"434","article-title":"Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain","volume":"6","author":"Lindia","year":"2005","journal-title":"J.\u00a0Pain"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib31","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrn1700","article-title":"Role of the immune system in chronic pain","volume":"6","author":"Marchand","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-5728(97)00217-8","article-title":"Evidence for central opioid receptors in the immunomodulatory effects of morphine: review of potential mechanism(s) of action","volume":"83","author":"Mellon","year":"1998","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib33","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1111\/j.1460-9568.2005.04470.x","article-title":"An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine","volume":"22","author":"Milligan","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib34","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1523\/JNEUROSCI.23-03-01026.2003","article-title":"Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats","volume":"23","author":"Milligan","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrn2533","article-title":"Pathological and protective roles of glia in chronic pain","volume":"10","author":"Milligan","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/cne.902300112","article-title":"The cytoarchitectonic organization of the spinal cord in the rat. The lower thoracic and lumbosacral cord","volume":"230","author":"Molander","year":"1984","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jcp.20061","article-title":"The role of substance P in inflammatory disease","volume":"201","author":"O\u2019Connor","year":"2004","journal-title":"J.\u00a0Cell Physiol."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib38","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1046\/j.1460-9568.2003.02626.x","article-title":"Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat","volume":"17","author":"Parada","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0166-2236(03)00068-7","article-title":"Cation-chloride co-transporters in neuronal communication, development and trauma","volume":"26","author":"Payne","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib40","series-title":"Glial Cell Function in Progress","first-page":"23","author":"Pekny","year":"2001"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib41","series-title":"Macrophages and the Nervous System","author":"Perry","year":"1994"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib42","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.tins.2007.07.007","article-title":"Neurotransmitter receptors on microglia","volume":"30","author":"Pocock","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib43","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/(SICI)1096-9861(19970120)377:3<443::AID-CNE10>3.0.CO;2-S","article-title":"Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats","volume":"377","author":"Popovich","year":"1997","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib44","series-title":"ImageJ. U. S. National Institutes of Health","author":"Rasband","year":"1997"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib45","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1113\/jphysiol.1995.sp020676","article-title":"The role of glutamate and GABA receptors in the generation of dorsal root reflexes by acute arthritis in the anaesthetized rat","volume":"484","author":"Rees","year":"1995","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib46","first-page":"561","article-title":"Furosemide depression of the dorsal root potentials and of the presynaptic inhibition of monosynaptic reflexes in the cat spinal cord","volume":"20","author":"Ruchinskaia","year":"1988","journal-title":"Neurofiziologia"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib47","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1001\/archsurg.133.10.1107","article-title":"Neuropeptides: mediators of inflammation and tissue repair?","volume":"133","author":"Sch\u00e4ffer","year":"1998","journal-title":"Arch. Surg."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib48","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/1529-0131(200004)43:4<720::AID-ANR2>3.0.CO;2-8","article-title":"Report on the Fourth International Workshop on Reactive Arthritis","volume":"43","author":"Sieper","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib49","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0304-3959(93)90150-N","article-title":"Centrally administered non-NMDA but not NMDA receptor antagonists block peripheral knee joint inflammation","volume":"55","author":"Sluka","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib50","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1082-3174(11)80045-0","article-title":"The role of dorsal root reflexes in neurogenic inflammation","volume":"4","author":"Sluka","year":"1995","journal-title":"Pain Forum"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib51","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0014-4886(03)00102-X","article-title":"Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers","volume":"184","author":"Sorkin","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib52","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/j.1471-4159.2010.06837.x","article-title":"Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice","volume":"114","author":"Staniland","year":"2010","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib53","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/nature04671","article-title":"Synaptic scaling mediated by glial TNF-alpha","volume":"440","author":"Stellwagen","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib54","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.4049\/jimmunol.166.12.7527","article-title":"Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia","volume":"166","author":"Tikka","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib55","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0304-3959(92)90095-S","article-title":"Rat knee-joint carrageenan incapacitation test: an objective screen for central and peripheral analgesics","volume":"48","author":"Tonussi","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib63","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1460-9568.2004.03593.x","article-title":"Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions","volume":"20","author":"Verge","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib56","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nrd1251","article-title":"Glia: a novel drug discovery target for clinical pain","volume":"2","author":"Watkins","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib57","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0166-2236(00)01854-3","article-title":"Glial activation: a driving force for pathological pain","volume":"24","author":"Watkins","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib58","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s002210050637","article-title":"Dorsal root potentials and dorsal root reflexes: a double-edged sword","volume":"124","author":"Willis","year":"1999","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib59","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.1073\/pnas.95.26.15769","article-title":"Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia","volume":"95","author":"Yrjanheikki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2011.09.028_bib60","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pain.2005.08.001","article-title":"Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia","volume":"118","author":"Zhang","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib61","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.pain.2010.11.014","article-title":"TNF-alpha contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2","volume":"152","author":"Zhang","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2011.09.028_bib62","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.bbi.2006.11.003","article-title":"Role of the CX3CR1\/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine","volume":"21","author":"Zhuang","year":"2007","journal-title":"Brain Behav. Immun."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390811004527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390811004527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T06:40:55Z","timestamp":1758436855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390811004527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0028390811004527"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2011.09.028","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence that LPS-reactive arthritis in rats depends on the glial activity and the fractalkine\u2013TNF-\u03b1 signaling in the spinal cord","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2011.09.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}