{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:28:18Z","timestamp":1792787298515,"version":"4.5.0"},"reference-count":146,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"crossref","award":["1 R21 NS074169"],"award-info":[{"award-number":["1 R21 NS074169"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"crossref","award":["1 U01 NS074509"],"award-info":[{"award-number":["1 U01 NS074509"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"crossref","award":["2 U01 NS058158 (RD)"],"award-info":[{"award-number":["2 U01 NS058158 (RD)"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000052","name":"Office of the Director, NIH","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002803","name":"Fondazione Cariplo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondazione Monzino","id":[{"id":"https:\/\/ror.org\/006pq9r08","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009882","name":"Regione Lombardia","doi-asserted-by":"crossref","award":["14501A"],"award-info":[{"award-number":["14501A"]}],"id":[{"id":"10.13039\/501100009882","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.neuropharm.2012.04.004","type":"journal-article","created":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T14:33:09Z","timestamp":1334327589000},"page":"16-24","source":"Crossref","is-referenced-by-count":471,"special_numbering":"C","title":["The role of inflammation in epileptogenesis"],"prefix":"10.1016","volume":"69","author":[{"given":"Annamaria","family":"Vezzani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Dingledine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2012.04.004_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4049\/jimmunol.158.1.438","article-title":"Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice","volume":"158","author":"Akassoglou","year":"1997","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nri1664","article-title":"Interleukin-1 and neuronal injury","volume":"5","author":"Allan","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib4","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1476-5381.2010.00715.x","article-title":"Prostaglandin signalling in cerebral ischaemia","volume":"160","author":"Andreasson","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib5","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1212\/WNL.38.9.1407","article-title":"The risk of unprovoked seizures after encephalitis and meningitis","volume":"38","author":"Annegers","year":"1988","journal-title":"Neurology"},{"issue":"Suppl. 3","key":"10.1016\/j.neuropharm.2012.04.004_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1528-1167.2011.03033.x","article-title":"Inflammation in epilepsy: clinical observations","volume":"52","author":"Aronica","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib7","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1046\/j.1460-9568.2000.00131.x","article-title":"Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy","volume":"12","author":"Aronica","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib8","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.nbd.2007.01.015","article-title":"Complement activation in experimental and human temporal lobe epilepsy","volume":"26","author":"Aronica","year":"2007","journal-title":"Neurobiol. Dis."},{"issue":"Suppl. 5","key":"10.1016\/j.neuropharm.2012.04.004_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1528-1167.2007.01286.x","article-title":"Inflammation exacerbates seizure-induced injury in the immature brain","volume":"48","author":"Auvin","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.nbd.2010.06.004","article-title":"Inflammation enhances epileptogenesis in immature rat brain","volume":"40","author":"Auvin","year":"2010","journal-title":"Neurobiol. Dis."},{"issue":"Suppl. 3","key":"10.1016\/j.neuropharm.2012.04.004_bib11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1528-1167.2010.02606.x","article-title":"Inflammation induced by LPS enhances epileptogenesis in immature rat and may be partially reversed by IL1RA","volume":"51","author":"Auvin","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib12","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0006-8993(99)01797-7","article-title":"Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus","volume":"843","author":"Baik","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0306-4522(91)90412-H","article-title":"Receptors for interleukin-1 (alpha and beta) in mouse brain: mapping and neuronal localization in hippocampus","volume":"43","author":"Ban","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib14","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/glia.10144","article-title":"Visualising microglial activation in\u00a0vivo","volume":"40","author":"Banati","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0166-4328(02)00043-8","article-title":"Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus","volume":"134","author":"Barrientos","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib16","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbi.2008.07.002","article-title":"Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection","volume":"23","author":"Barrientos","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1460-9568.2005.04539.x","article-title":"Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus","volume":"23","author":"Battista","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0006-8993(93)90959-Q","article-title":"Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus","volume":"628","author":"Bellinger","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib19","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2174\/1568007054546171","article-title":"Inflammation and neurogenesis in temporal lobe epilepsy","volume":"4","author":"Bernardino","year":"2005","journal-title":"Curr. Drug Targets CNS Neurol. Disord."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib20","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/89490","article-title":"CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity","volume":"4","author":"Bezzi","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-065X.2007.00574.x","article-title":"High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity","volume":"220","author":"Bianchi","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib22","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","article-title":"Role of transforming growth factor beta in human disease","volume":"342","author":"Blobe","year":"2000","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib23","article-title":"Imaging inflammation in a patient with epilepsy due to focal cortical dysplasia","author":"Butler","year":"2011","journal-title":"J.\u00a0Neuroimaging"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib24","doi-asserted-by":"crossref","first-page":"8927","DOI":"10.1523\/JNEUROSCI.0430-09.2009","article-title":"Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis","volume":"29","author":"Cacheaux","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib25","doi-asserted-by":"crossref","first-page":"10061","DOI":"10.1073\/pnas.90.21.10061","article-title":"Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6","volume":"90","author":"Campbell","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"Suppl","key":"10.1016\/j.neuropharm.2012.04.004_bib26","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/0022-510X(91)90002-O","article-title":"Traumatic brain injuries: structural changes","volume":"103","author":"Cervos-Navarro","year":"1991","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib27","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1523\/JNEUROSCI.4268-04.2005","article-title":"Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines","volume":"25","author":"Chakravarty","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.prostaglandins.2005.07.001","article-title":"Lipid signaling: sleep, synaptic plasticity, and neuroprotection","volume":"77","author":"Chen","year":"2005","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib29","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1152\/jn.2002.87.6.2851","article-title":"Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity","volume":"87","author":"Chen","year":"2002","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib145","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1460-9568.2011.07723.x","article-title":"Neutralization of interleukin-1\u03b2 reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice","volume":"34","author":"Clausen","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib30","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s11064-005-6878-4","article-title":"Lipid signaling in experimental epilepsy","volume":"30","author":"Cole-Edwards","year":"2005","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib31","first-page":"845","article-title":"Epilepsy and the blood brain barrier: endothelial cell responses to seizures","volume":"79","author":"Cornford","year":"1999","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib32","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1111\/j.1460-9568.2008.06251.x","article-title":"COX-2, but not COX-1, activity is necessary for the induction of perforant path long-term potentiation and spatial learning in\u00a0vivo","volume":"27","author":"Cowley","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-4757-6376-8_4","article-title":"Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword","volume":"548","author":"Croll","year":"2004","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib34","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/0028-3908(94)90045-0","article-title":"Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures","volume":"33","author":"Dawson","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib35","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1046\/j.1460-9568.2000.00140.x","article-title":"Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus","volume":"12","author":"De Simoni","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib36","doi-asserted-by":"crossref","first-page":"10674","DOI":"10.1523\/JNEUROSCI.2001-07.2007","article-title":"Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus","volume":"27","author":"Ding","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib37","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.brainres.2005.01.027","article-title":"Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production","volume":"1038","author":"Dohgu","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib38","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/ana.20358","article-title":"Interleukin-1beta contributes to the generation of experimental febrile seizures","volume":"57","author":"Dub\u00e9","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib39","doi-asserted-by":"crossref","first-page":"7484","DOI":"10.1523\/JNEUROSCI.0551-10.2010","article-title":"Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers","volume":"30","author":"Dub\u00e9","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib40","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.neuroscience.2008.06.052","article-title":"Brain inflammation and adult neurogenesis: the dual role of microglia","volume":"158","author":"Ekdahl","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib41","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/cne.903610410","article-title":"Type 1 interleukin-1 receptor in the rat brain: distribution, regulation, and relationship to sites of IL-1-induced cellular activation","volume":"361","author":"Ericsson","year":"1995","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib42","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/nm.1878","article-title":"A\u00a0role for leukocyte-endothelial adhesion mechanisms in epilepsy","volume":"14","author":"Fabene","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib43","doi-asserted-by":"crossref","first-page":"9312","DOI":"10.1523\/JNEUROSCI.2836-06.2006","article-title":"Astrocytic glutamate is not necessary for the generation of epileptiform neuronal activity in hippocampal slices","volume":"26","author":"Fellin","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib44","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1056\/NEJMp048288","article-title":"Coxibs and cardiovascular disease","volume":"351","author":"Fitzgerald","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib45","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0301-0082(97)00066-X","article-title":"Transforming growth factor-betas in neurodegenerative disease","volume":"54","author":"Flanders","year":"1998","journal-title":"Prog. Neurobiol."},{"issue":"Suppl. 3","key":"10.1016\/j.neuropharm.2012.04.004_bib46","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1528-1167.2011.03034.x","article-title":"Molecular cascades that mediate the influence of inflammation on epilepsy","volume":"52","author":"Friedman","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib47","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.eplepsyres.2009.03.005","article-title":"Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy","volume":"85","author":"Friedman","year":"2009","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib48","doi-asserted-by":"crossref","first-page":"6904","DOI":"10.1523\/JNEUROSCI.1901-08.2008","article-title":"Postnatal inflammation increases seizure susceptibility in adult rats","volume":"28","author":"Galic","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib49","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.nbd.2009.07.025","article-title":"Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats","volume":"36","author":"Galic","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib50","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/j.1476-5381.2009.00618.x","article-title":"The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain","volume":"159","author":"Goncalves","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib51","doi-asserted-by":"crossref","first-page":"11083","DOI":"10.1523\/JNEUROSCI.2766-06.2006","article-title":"Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy","volume":"26","author":"Gorter","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib52","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.psyneuen.2007.09.004","article-title":"A\u00a0dual role for interleukin-1 in hippocampal-dependent memory processes","volume":"32","author":"Goshen","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib53","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev-med-011209-153129","article-title":"Emotion recollected in tranquility: lessons learned from the COX-2 saga","volume":"61","author":"Grosser","year":"2010","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib54","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/nbm.1222","article-title":"Non-invasive detection of hippocampal sclerosis: correlation between metabolite alterations detected by (1)H-MRS and neuropathology","volume":"21","author":"Hammen","year":"2008","journal-title":"NMR Biomed."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib55","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1073\/pnas.94.5.2007","article-title":"Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage","volume":"94","author":"Hara","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib56","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1111\/j.1528-1167.2005.00294.x","article-title":"Causal links between brain cytokines and experimental febrile convulsions in the rat","volume":"46","author":"Heida","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib57","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1111\/j.0013-9580.2004.13704.x","article-title":"Lipopolysaccharide-induced febrile convulsions in the rat: short-term sequelae","volume":"45","author":"Heida","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib58","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1111\/j.1528-1167.2005.00286.x","article-title":"Febrile convulsions induced by the combination of lipopolysaccharide and low-dose kainic acid enhance seizure susceptibility, not epileptogenesis, in rats","volume":"46","author":"Heida","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib59","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12035-009-8066-z","article-title":"Neuroinflammation and memory: the role of prostaglandins","volume":"40","author":"Hein","year":"2009","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib60","unstructured":"Hirvonen, J., Kreisl, W., Fujita, M., Dustin, I., Miranda, S., Zhang, Y., Morse, C., Pike, V.R., Innis, R., Theodore, W.H., 2010. Increased in\u00a0vivo expression of an inflammatory marker in temporal lobe epilepsy. American Epilepsy Society, S. Antonio (TX), Abst 3.230."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib61","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.eplepsyres.2010.06.011","article-title":"Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy","volume":"91","author":"Holtman","year":"2010","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib62","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/brain\/awl317","article-title":"TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis","volume":"130","author":"Ivens","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib63","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1073\/pnas.0909310107","article-title":"Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor","volume":"107","author":"Jiang","year":"2010","journal-title":"Proc. Nat. Acad. Sci. U S A"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib64","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1073\/pnas.1120195109","article-title":"Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2","volume":"109","author":"Jiang","year":"2012","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib65","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.nbd.2006.02.016","article-title":"Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus","volume":"23","author":"Jung","year":"2006","journal-title":"Neurobiol. Dis"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib66","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.1523\/JNEUROSCI.0388-10.2010","article-title":"Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy","volume":"30","author":"Katsuno","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib67","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1073\/pnas.93.6.2317","article-title":"COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex","volume":"93","author":"Kaufmann","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib68","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nm1362","article-title":"Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity","volume":"12","author":"Kawano","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib69","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/j.1460-9568.2011.07609.x","article-title":"A\u00a0new chapter in the field of memory: adult hippocampal neurogenesis","volume":"33","author":"Koehl","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib70","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1358\/dot.2009.45.2.1322481","article-title":"Cyclooxygenase in epilepsy: from perception to application","volume":"45","author":"Kulkarni","year":"2009","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib71","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.pediatrneurol.2008.03.001","article-title":"Epilepsy surgery in a case of encephalitis: use of 11C-PK11195 positron emission tomography","volume":"38","author":"Kumar","year":"2008","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib72","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jneuroim.2006.03.001","article-title":"Interleukin-1 beta modulates AMPA receptor expression and phosphorylation in hippocampal neurons","volume":"175","author":"Lai","year":"2006","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib73","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0304-3940(00)00907-1","article-title":"Quantitative changes in interleukin proteins following focal stroke in the rat","volume":"282","author":"Legos","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib74","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1097\/00004647-199609000-00017","article-title":"Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat","volume":"16","author":"Loddick","year":"1996","journal-title":"J.\u00a0Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib75","doi-asserted-by":"crossref","first-page":"24794","DOI":"10.1074\/jbc.271.40.24794","article-title":"Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist","volume":"271","author":"Marcheselli","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib76","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nm.2127","article-title":"Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures","volume":"16","author":"Maroso","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib77","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s13311-011-0039-z","article-title":"Interleukin-1beta biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice","volume":"8","author":"Maroso","year":"2011","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib78","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000258723","article-title":"Chronic expression of transforming growth factor-beta enhances adult neurogenesis","volume":"17","author":"Mathieu","year":"2010","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib79","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1523\/JNEUROSCI.4485-03.2004","article-title":"Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia","volume":"24","author":"McCullough","year":"2004","journal-title":"J.\u00a0Neurosci."},{"issue":"Suppl. 9","key":"10.1016\/j.neuropharm.2012.04.004_bib80","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1528-1167.2007.01396.x","article-title":"The basic science of memory as it applies to epilepsy","volume":"48","author":"Meador","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib81","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0006-291X(05)80225-6","article-title":"Effects of kainic acid on messenger RNA levels of IL-1 beta, IL-6, TNF alpha and LIF in the rat brain","volume":"176","author":"Minami","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib82","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1034\/j.1600-0404.2000.102003175.x","article-title":"Magnetic resonance spectroscopy of tubers in patients with tuberous sclerosis","volume":"102","author":"Mizuno","year":"2000","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib83","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0028-3908(02)00375-1","article-title":"A\u00a0role for COX-2 and p38 mitogen activated protein kinase in long-term depression in the rat dentate gyrus in\u00a0vitro","volume":"44","author":"Murray","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib146","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2217\/bmm.11.65","article-title":"Hippocampal MRI and other structural biomarkers: experimental approach to epileptogenesis","volume":"5","author":"Nehlig","year":"2011","journal-title":"Biomark. Med"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib84","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1227\/01.NEU.0000097715.11966.8E","article-title":"Mechanisms of disease: the blood-brain barrier","volume":"54","author":"Neuwelt","year":"2004","journal-title":"Neurosurgery"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib85","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1046\/j.1460-9568.2000.00900.x","article-title":"Age-related impairment in LTP is accompanied by enhanced activity of stress-activated protein kinases: analysis of underlying mechanisms","volume":"12","author":"O'Donnell","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib86","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0166-2236(96)01035-1","article-title":"NF-kappa B: a crucial transcription factor for glial and neuronal cell function","volume":"20","author":"O'Neill","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib87","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1582-4934.2003.tb00211.x","article-title":"Inflammatory mechanisms associated with brain damage induced by kainic acid with special reference to the interleukin-1 system","volume":"7","author":"Oprica","year":"2003","journal-title":"J.\u00a0Cell. Mol. Med."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib88","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.4049\/jimmunol.0904133","article-title":"Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling","volume":"184","author":"Peltier","year":"2010","journal-title":"J.\u00a0Immunol."},{"issue":"Suppl. 1","key":"10.1016\/j.neuropharm.2012.04.004_bib89","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.yebeh.2008.09.023","article-title":"Molecular and cellular basis of epileptogenesis in symptomatic epilepsy","volume":"14","author":"Pitkanen","year":"2009","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0922-4106(94)90202-X","article-title":"Interleukin-1 beta inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C","volume":"266","author":"Plata-Salaman","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib91","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0169-328X(99)00306-X","article-title":"Kindling modulates the IL-1beta system, TNF-alpha, TGF-beta1, and neuropeptide mRNAs in specific brain regions","volume":"75","author":"Plata-Salaman","year":"2000","journal-title":"Brain. Res. Mol. Brain. Res."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib92","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.expneurol.2010.03.014","article-title":"The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy","volume":"224","author":"Polascheck","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib93","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuroscience.2005.07.063","article-title":"Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type I in the rat limbic system","volume":"137","author":"Ravizza","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib94","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/j.1528-1167.2006.00590.x","article-title":"Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy","volume":"47","author":"Ravizza","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib95","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.nbd.2007.08.012","article-title":"Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy","volume":"29","author":"Ravizza","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib96","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.nbd.2008.05.007","article-title":"Interleukin converting enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production","volume":"31","author":"Ravizza","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib97","series-title":"Epilepsy. Mechanisms, Models, and Translational Perpsectives","first-page":"45","article-title":"Brain inflammation and epilepsy","author":"Ravizza","year":"2010"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib98","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neulet.2011.02.040","article-title":"Inflammation and prevention of epileptogenesis","volume":"497","author":"Ravizza","year":"2011","journal-title":"Neurosci Lett."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib99","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.eplepsyres.2009.09.004","article-title":"Contributions of peripheral inflammation to seizure susceptibility: cytokines and brain excitability","volume":"89","author":"Riazi","year":"2010","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib100","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1093\/brain\/awp177","article-title":"The cortical innate immune response increases local neuronal excitability leading to seizures","volume":"132","author":"Rodgers","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib101","first-page":"13179","article-title":"Cytokines in neurodegeneration and repair","author":"Rothwell","year":"1995","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib102","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.neuroscience.2003.08.043","article-title":"The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice: involvement of proinflammatory factors: nitric oxide and prostaglandins","volume":"122","author":"Sayyah","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib103","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neulet.2008.03.052","article-title":"Effect of cytokines on neuronal excitability","volume":"437","author":"Schafers","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib104","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s00424-003-1155-3","article-title":"Effects of kinase inhibitors on TGF-beta induced upregulation of Kv1.3 K+ channels in brain macrophages","volume":"447","author":"Schilling","year":"2003","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib105","doi-asserted-by":"crossref","first-page":"7778","DOI":"10.1073\/pnas.95.13.7778","article-title":"A\u00a0neuromodulatory role of interleukin-1beta in the hippocampus","volume":"95","author":"Schneider","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib106","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.1523\/JNEUROSCI.1751-04.2004","article-title":"Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex","volume":"24","author":"Seiffert","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib107","doi-asserted-by":"crossref","first-page":"14850","DOI":"10.1523\/JNEUROSCI.3922-11.2011","article-title":"Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus","volume":"31","author":"Serrano","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib108","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"issue":"Suppl. 6","key":"10.1016\/j.neuropharm.2012.04.004_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1167.2008.01748.x","article-title":"Central nervous system infections and epilepsy","volume":"49","author":"Singh","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib110","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.neuropharm.2005.04.019","article-title":"Inhibition of cyclooxygenase-2 elicits a CB1-mediated decrease of excitatory transmission in rat CA1 hippocampus","volume":"49","author":"Slanina","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib111","doi-asserted-by":"crossref","first-page":"33157","DOI":"10.1074\/jbc.271.52.33157","article-title":"Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2","volume":"271","author":"Smith","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib112","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bbi.2009.02.015","article-title":"IL-1\/IL-1ra balance in the brain revisited \u2013 evidence from transgenic mouse models","volume":"23","author":"Spulber","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib113","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jneuroim.2009.01.010","article-title":"Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain","volume":"208","author":"Spulber","year":"2009","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib114","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0002-9440(10)65620-9","article-title":"Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor","volume":"153","author":"Stalder","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib115","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0361-9230(01)00428-2","article-title":"Cytokines and the central nervous system","volume":"54","author":"Szelenyi","year":"2001","journal-title":"Brain. Res. Bull."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib116","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1210\/endo-127-6-3070","article-title":"Interleukin-1 receptors in mouse brain: characterization and neuronal localization","volume":"127","author":"Takao","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib117","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neures.2006.06.003","article-title":"Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region","volume":"56","author":"Takemiya","year":"2006","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib118","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1172\/JCI27341","article-title":"Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology","volume":"116","author":"Tesseur","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib119","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1136\/jnnp.2007.126425","article-title":"Blood-brain barrier disruption in post-traumatic epilepsy","volume":"79","author":"Tomkins","year":"2008","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatr."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib120","doi-asserted-by":"crossref","first-page":"765923","DOI":"10.1155\/2011\/765923","article-title":"Blood-brain barrier breakdown following traumatic brain injury: a possible role in posttraumatic epilepsy","volume":"2011","author":"Tomkins","year":"2011","journal-title":"Cardiovasc. Psychiatry Neurol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib121","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.neuro.2008.08.008","article-title":"NMDA-induced seizure intensity is enhanced in COX-2 deficient mice","volume":"29","author":"Toscano","year":"2008","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib122","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/497987","article-title":"Toll-like receptors expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application","volume":"2010","author":"Trudler","year":"2010","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib123","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s003300051045","article-title":"Serial MRI and MRS studies with unusual findings in Rasmussen's encephalitis","volume":"10","author":"Turkdogan-Sozuer","year":"2000","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib124","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.nbd.2004.03.010","article-title":"Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy","volume":"16","author":"Turrin","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib125","doi-asserted-by":"crossref","first-page":"5054","DOI":"10.1523\/JNEUROSCI.19-12-05054.1999","article-title":"Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures","volume":"19","author":"Vezzani","year":"1999","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib126","doi-asserted-by":"crossref","first-page":"11534","DOI":"10.1073\/pnas.190206797","article-title":"Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice","volume":"97","author":"Vezzani","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib127","first-page":"43","article-title":"ICE\/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy","volume":"11","author":"Vezzani","year":"2010","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib128","unstructured":"Vezzani, A., Aronica, E., Mazarati, A., Pittman, Q.J. Epilepsy and brain inflammation. Exp. Neurol., 2011 Oct 1. [Epub ahead of print] PMID: 21985866"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib129","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","article-title":"The role of inflammation in epilepsy","volume":"7","author":"Vezzani","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib130","unstructured":"Vezzani, A., Iori, V., Ravizza, T., Bianchi, M. E., Maroso, M., 2011b. Activation of Toll-like receptor 4 (TLR4) and Receptor for Advanced Glycation End Products (RAGE) signaling contributes to ictogenesis and epileptogenesis. Society for Neuroscience Meeting, Washington DC Poster number 889.20."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib131","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.bbi.2011.03.018","article-title":"IL-1 receptor\/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures","volume":"25","author":"Vezzani","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib132","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1046\/j.1471-4159.2000.740457.x","article-title":"Inflammatory\" cytokines: neuromodulators in normal brain?","volume":"74","author":"Vitkovic","year":"2000","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib133","doi-asserted-by":"crossref","first-page":"8692","DOI":"10.1523\/JNEUROSCI.23-25-08692.2003","article-title":"Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases","volume":"23","author":"Viviani","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib134","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0074-7742(07)82013-7","article-title":"Cytokines and neuronal ion channels in health and disease","volume":"82","author":"Viviani","year":"2007","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib135","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/brain\/awl318","article-title":"Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy","volume":"130","author":"van Vliet","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib136","first-page":"497","article-title":"Interleukin-1beta inhibits gamma-aminobutyric acid type A (GABA(A)) receptor current in cultured hippocampal neurons","volume":"292","author":"Wang","year":"2000","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib137","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuron.2008.04.002","article-title":"Astrocytes in the epileptic brain","volume":"58","author":"Wetherington","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib138","doi-asserted-by":"crossref","first-page":"15511","DOI":"10.1523\/JNEUROSCI.3688-11.2011","article-title":"Microglia and memory: modulation by early-life infection","volume":"31","author":"Williamson","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib139","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0896-6273(93)90192-T","article-title":"Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids","volume":"11","author":"Yamagata","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2012.04.004_bib140","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbi.2010.10.015","article-title":"Immune modulation of learning, memory, neural plasticity and neurogenesis","volume":"25","author":"Yirmiya","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib141","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1523\/JNEUROSCI.6210-10.2011","article-title":"Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy","volume":"31","author":"Zattoni","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib142","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0006-8993(97)00787-7","article-title":"Interleukin-1beta does not increase synaptic inhibition in hippocampal CA3 pyramidal and dentate gyrus granule cells of the rat in\u00a0vitro","volume":"768","author":"Zeise","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib143","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.nbd.2009.12.028","article-title":"Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1beta","volume":"38","author":"Zhang","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2012.04.004_bib144","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/brain\/awr032","article-title":"Activation of TLR, RAGE and HMGB1 signaling in malformations of cortical development","volume":"134","author":"Zurolo","year":"2011","journal-title":"Brain"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390812001396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390812001396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T20:00:11Z","timestamp":1687377611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390812001396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":146,"alternative-id":["S0028390812001396"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2012.04.004","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}