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Neurobiol."},{"key":"10.1016\/j.neuropharm.2012.05.045_bib79","series-title":"pH and Brain Function","first-page":"309","article-title":"Activity-evoked changes in extracellular pH","author":"Kaila","year":"1998"},{"key":"10.1016\/j.neuropharm.2012.05.045_bib80","doi-asserted-by":"crossref","first-page":"7662","DOI":"10.1523\/JNEUROSCI.17-20-07662.1997","article-title":"Long-lasting GABA-mediated depolarization evoked by high-frequency stimulation in pyramidal neurons of rat hippocampal slice is attributable to a network-driven, bicarbonate-dependent K+ transient","volume":"17","author":"Kaila","year":"1997","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.05.045_bib81","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1113\/jphysiol.1990.sp018170","article-title":"Mechanism of action of GABA on intracellular pH and on surface pH in crayfish muscle fibres","volume":"427","author":"Kaila","year":"1990","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2012.05.045_bib82","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/330163a0","article-title":"Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance","volume":"330","author":"Kaila","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2012.05.045_bib83","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1113\/jphysiol.1993.sp019634","article-title":"The role of bicarbonate in GABAA receptor-mediated IPSPs of rat neocortical neurones","volume":"464","author":"Kaila","year":"1993","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2012.05.045_bib84","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1152\/jn.2000.84.1.281","article-title":"Reversibility and cation selectivity of the K+\u2013Cl\u2212 cotransport in rat central neurons","volume":"84","author":"Kakazu","year":"2000","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuropharm.2012.05.045_bib85","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0306-4522(01)00149-X","article-title":"The differential expression patterns of messenger RNAs encoding K\u2013Cl cotransporters (KCC1,2) and Na\u2013K\u20132Cl cotransporter (NKCC1) in the rat nervous system","volume":"104","author":"Kanaka","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2012.05.045_bib86","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature10523","article-title":"Spatio-temporal transcriptome of the human brain","volume":"478","author":"Kang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2012.05.045_bib87","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0387-7604(02)00003-7","article-title":"Long-term effectiveness and side effects of acetazolamide as an adjunct to other anticonvulsants in the treatment of refractory epilepsies","volume":"24","author":"Katayama","year":"2002","journal-title":"Brain Dev."},{"key":"10.1016\/j.neuropharm.2012.05.045_bib88","doi-asserted-by":"crossref","first-page":"9770","DOI":"10.1523\/JNEUROSCI.21-24-09770.2001","article-title":"Early development of neuronal activity in the primate hippocampus in utero","volume":"21","author":"Khazipov","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.05.045_bib89","doi-asserted-by":"crossref","first-page":"12028","DOI":"10.1523\/JNEUROSCI.3154-10.2010","article-title":"A\u00a0single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus","volume":"30","author":"Khirug","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.05.045_bib90","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1523\/JNEUROSCI.0908-08.2008","article-title":"GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na\u2013K\u20132Cl cotransporter NKCC1","volume":"28","author":"Khirug","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2012.05.045_bib91","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.neuropharm.2007.06.015","article-title":"Model-specific effects of bumetanide on epileptiform activity in the in-vitro intact hippocampus of the newborn mouse","volume":"53","author":"Kilb","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2012.05.045_bib92","doi-asserted-by":"crossref","first-page":"C1113","DOI":"10.1152\/ajpcell.00412.2006","article-title":"Role of Na+\u2013K+\u2013Cl\u2212 cotransport and Na+\/Ca2+ exchange in mitochondrial dysfunction in astrocytes following in\u00a0vitro ischemia","volume":"292","author":"Kintner","year":"2007","journal-title":"Am. 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