{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:04:40Z","timestamp":1785769480662,"version":"3.56.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de S\u00e3o Paulo","award":["#1998\/14303-3"],"award-info":[{"award-number":["#1998\/14303-3"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"},{"name":"Funda\u00e7\u00e3o Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)"},{"name":"Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa (AFIP)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.neuropharm.2012.06.058","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T07:57:26Z","timestamp":1341561446000},"page":"365-370","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Inhibitory effects of modafinil on emotional memory in mice"],"prefix":"10.1016","volume":"64","author":[{"given":"Helaine A.","family":"Fernandes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina A.","family":"Zanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla L.","family":"Patti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Wuo-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita C.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Fernandes-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia R.A.","family":"Bittencourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Frussa-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2012.06.058_bib1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1101\/lm.61704","article-title":"A\u00a0facilitative role for corticosterone in the acquisition of a spatial task under moderate stress","volume":"11","author":"Akirav","year":"2004","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib2","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.nlm.2008.07.013","article-title":"Paradoxical sleep deprivation impairs acquisition, consolidation, and retrieval of a discriminative avoidance task in rats","volume":"90","author":"Alvarenga","year":"2008","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00213-010-1839-2","article-title":"Dopamine transporter-related effects of modafinil in rhesus monkeys","volume":"210","author":"Andersen","year":"2010","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00001756-200102120-00038","article-title":"First evidence of a delay-dependent working memory \u2013 enhancing effect of modafinil in mice","volume":"12","author":"B\u00e9racoch\u00e9a","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib5","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0091-3057(02)00877-8","article-title":"Improvement of learning processes following chronic systemic administration of modafinil in mice","volume":"73","author":"B\u00e9racoch\u00e9a","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.pbb.2003.09.007","article-title":"Enhancement of learning processes following an acute modafinil injection in mice","volume":"76","author":"B\u00e9racoch\u00e9a","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-007-0915-8","article-title":"Stress modulation of the memory retrograde-enhancing effects of the awakening drug modafinil in mice","volume":"196","author":"B\u00e9racoch\u00e9a","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib8","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.brainresbull.2010.08.010","article-title":"Effect of modafinil on learning performance and neocortical long-term potentiation in rats","volume":"83","author":"Burgos","year":"2010","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/jme.2009.030882","article-title":"Smart drugs for cognitive enhancement: ethical and pragmatic considerations in the era of cosmetic neurology","volume":"35","author":"Cakic","year":"2009","journal-title":"J.\u00a0Med. Ethics"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0031-9384(99)00099-2","article-title":"Bovine brain phosphatidylserine attenuates scopolamine-induced amnesia","volume":"67","author":"Claro","year":"1999","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00008877-200112000-00002","article-title":"Evidence that mnesic states govern normal and disordered memory","volume":"12","author":"Colpaert","year":"2001","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.yfrne.2009.03.002","article-title":"Glucocorticoids and the regulation of memory in health and disease","volume":"30","author":"de Quervain","year":"2009","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0304-3940(98)00629-6","article-title":"The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission","volume":"253","author":"Ferraro","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib14","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/BF02245237","article-title":"Raised corticosterone in the rat after exposure to the elevated plus-maze","volume":"113","author":"File","year":"1994","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib15","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1369-1600.2010.00209.x","article-title":"Nicotine acts in the anterior cingulate, but not dorsal or ventral hippocampus, to reverse ethanol-induced learning impairments in the plus-maze discriminative avoidance task","volume":"16","author":"Gulick","year":"2011","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib16","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0301-0082(03)00085-6","article-title":"Dopamine: a potential substrate for synaptic plasticity and memory mechanisms","volume":"69","author":"Jay","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib17","first-page":"763","article-title":"Modafinil in psychiatric disorders: the promising state reconsidered","volume":"52","author":"Joos","year":"2010","journal-title":"Tijdschr Psychiatr."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00213-006-0684-9","article-title":"Dissociation of the effects of ethanol on memory, anxiety, and motor behavior in mice tested in the plus-maze discriminative avoidance task","volume":"192","author":"Kameda","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3389\/fnbeh.2010.00183","article-title":"Emotional memory formation under lower versus higher stress conditions","volume":"4","author":"Kogan","year":"2010","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib20","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1212\/01.wnl.0000200985.04239.53","article-title":"Modafinil for fatigue in MS: a randomized placebo-controlled double-blind study","volume":"65","author":"Kraft","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib21","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1124\/jpet.106.106583","article-title":"Modafinil occupies dopamine and norepinephrine transporters in\u00a0vivo and modulates the transporters and trace amine activity in\u00a0vitro","volume":"319","author":"Madras","year":"2006","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib22","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/sleep\/17.5.436","article-title":"Modafinil binds to the dopamine uptake carrier site with low affinity","volume":"17","author":"Mignot","year":"1994","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib23","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/sj.npp.1301534","article-title":"Modafinil: a review of neurochemical actions and effects on cognition","volume":"33","author":"Minzemberg","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib24","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1093\/sleep\/33.7.990","article-title":"Modafinil prevents inhibitory avoidance memory deficit induced by sleep deprivation in rats","volume":"33","author":"Moreira","year":"2010","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.pbb.2007.01.015","article-title":"Modafinil improves attention, inhibitory control, and reaction time in healthy, middle-aged rats","volume":"86","author":"Morgan","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/00002826-200203000-00010","article-title":"Treatment of excessive daytime sleepiness in patients with Parkinson's disease with modafinil","volume":"25","author":"Nieves","year":"2002","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib27","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1101\/lm.321006","article-title":"Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory","volume":"13","author":"O'Carroll","year":"2006","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-005-0238-6","article-title":"Effects of morphine on the plus-maze discriminative avoidance task: role of state-dependent learning","volume":"184","author":"Patti","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib29","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1093\/sleep\/33.12.1669","article-title":"Effects of sleep deprivation on memory in mice: role of state-dependent learning","volume":"33","author":"Patti","year":"2010","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.pbb.2010.09.016","article-title":"Differential effects of total sleep deprivation on contextual and spatial memory: modulatory effects of modafinil","volume":"97","author":"Pi\u00e9rard","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.pbb.2007.07.006","article-title":"Modafinil restores memory performance and neural activity impaired by sleep deprivation in mice","volume":"88","author":"Pi\u00e9rard","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbb.2005.11.018","article-title":"Modafinil-induced modulation of working memory and plasma corticosterone in chronically-stressed mice","volume":"83","author":"Pi\u00e9rard","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pnpbp.2012.01.013","article-title":"Role of state-dependency in memory impairment induced by acute administration of midazolam in mice","volume":"37","author":"Sanday","year":"2012","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib35","doi-asserted-by":"crossref","first-page":"78970","DOI":"10.1155\/2007\/78970","article-title":"Stress and memory: behavioral effects and neurobiological mechanisms","volume":"2007","author":"Sandi","year":"2007","journal-title":"Neural Plast."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1037\/a0014366","article-title":"Modafinil and memory: effects of modafinil on Morris water maze learning and Pavlovian fear conditioning","volume":"123","author":"Shuman","year":"2009","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib37","first-page":"322","article-title":"Effects of long-term ganglioside GM1 administration on a new discriminative avoidance test in normal adult mice","volume":"129","author":"Silva","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib38","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.0901-9928.2000.870304.x","article-title":"Effects of neonatal ganglioside GM1 administration on memory in adult and old rats","volume":"87","author":"Silva","year":"2000","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.nlm.2004.04.005","article-title":"Effects of pre- or post-training paradoxical sleep deprivation on two animal models of learning and memory in mice","volume":"82","author":"Silva","year":"2004","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s002130050814","article-title":"Ganglioside GM1 attenuates scopolamine-induced amnesia in rats and mice","volume":"141","author":"Silva","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0165-0270(00)00289-2","article-title":"The plus-maze discriminative avoidance task: a new model to study memory-anxiety interactions. Effects of chlordiazepoxide and caffeine","volume":"102","author":"Silva","year":"2000","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib42","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0024-3205(02)02298-1","article-title":"Naltrexone potentiates both amnestic and anxiolytic effects of chlordiazepoxide in mice","volume":"72","author":"Silva","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00213-001-0948-3","article-title":"Effects of amphetamine on the plus-maze discriminative avoidance task in mice","volume":"160","author":"Silva","year":"2002","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib44","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/cap.2000.10.311","article-title":"Efficacy of modafinil compared to dextroamphetamine for the treatment of attention deficit hyperactivity disorder in adults","volume":"10","author":"Taylor","year":"2000","journal-title":"J.\u00a0Child Adolesc. Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuropharm.2010.03.010","article-title":"The psychostimulant modafinil facilitates water maze performance and augments synaptic potentiation in dentate gyrus","volume":"59","author":"Tsanov","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib46","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/sj.npp.1300457","article-title":"Modafinil improves cognition and attentional set shifting in patients with chronic schizophrenia","volume":"29","author":"Turner","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib47","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1001\/jama.2009.351","article-title":"Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications","volume":"301","author":"Volkow","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib48","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.pbb.2004.05.005","article-title":"Modafinil facilitates performance on a delayed nonmatching to position swim task in rats","volume":"78","author":"Ward","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib49","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1177\/0269881105048995","article-title":"Assessment of modafinil on attentional processes in a five-choice serial reaction time test in the rat","volume":"19","author":"Waters","year":"2005","journal-title":"J.\u00a0Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib50","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1369-1600.2011.00341.x","article-title":"Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study","volume":"16","author":"Wuo-Silva","year":"2011","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuropharm.2012.06.058_bib51","doi-asserted-by":"crossref","unstructured":"Zanin, K.A., Patti, C.L., Fernandes-Santos, L., Oliveira, L.C., Tufik, S., Poyares, D., Frussa-Filho, R. Effects of zolpidem on sedation, anxiety, and memory in the plus-maze discriminative avoidance task. Psychopharmacology (Berl.), in press.","DOI":"10.1007\/s00213-012-2756-3"},{"key":"10.1016\/j.neuropharm.2012.06.058_bib52","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1124\/jpet.108.146142","article-title":"Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil","volume":"329","author":"Zolkowska","year":"2009","journal-title":"J.\u00a0Pharmacol. Exp. Ther."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390812003267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390812003267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T16:24:29Z","timestamp":1561911869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390812003267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":51,"alternative-id":["S0028390812003267"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2012.06.058","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}