{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:14:59Z","timestamp":1791101699588,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.neuropharm.2012.07.004","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T09:45:29Z","timestamp":1342172729000},"page":"1051-1063","source":"Crossref","is-referenced-by-count":35,"title":["Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test"],"prefix":"10.1016","volume":"63","author":[{"given":"J.A.","family":"Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gundlah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.T.","family":"Birzin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-J.","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Flick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Warrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Yudkovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Fleischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Colwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schaeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Wilkening","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mattingly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hammond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.P.","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.neuropharm.2012.07.004_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/1096-9861(20001113)427:2<185::AID-CNE2>3.0.CO;2-G","article-title":"Estrogen-regulated progestin receptors are found in the midbrain raphe but not hippocampus of estrogen receptor alpha (ER alpha) gene-disrupted mice","volume":"427","author":"Alves","year":"2000","journal-title":"J.\u00a0Comp. Neurol."},{"issue":"9","key":"10.1016\/j.neuropharm.2012.07.004_bib2","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1046\/j.0953-816x.2001.01763.x","article-title":"Serotonin mediates oestrogen stimulation of cell proliferation in the adult dentate gyrus","volume":"14","author":"Banasr","year":"2001","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.neuropharm.2012.07.004_bib3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1124\/mol.54.1.105","article-title":"Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists\/antagonists","volume":"54","author":"Barkhem","year":"1998","journal-title":"Mol. Pharmacol."},{"issue":"6","key":"10.1016\/j.neuropharm.2012.07.004_bib4","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/0960-0760(91)90077-I","article-title":"High level expression of functional full length human thyroid hormone receptor beta 1 in insect cells using a recombinant baculovirus","volume":"38","author":"Barkhem","year":"1991","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"issue":"6","key":"10.1016\/j.neuropharm.2012.07.004_bib5","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1016\/j.ejmech.2011.03.030","article-title":"Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes","volume":"46","author":"Bertini","year":"2011","journal-title":"Eur. J. Med. Chem."},{"issue":"6","key":"10.1016\/j.neuropharm.2012.07.004_bib6","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0006-3223(99)00156-0","article-title":"Steroid regulation of tryptophan hydroxylase protein in the dorsal raphe of macaques","volume":"47","author":"Bethea","year":"2000","journal-title":"Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.neuropharm.2012.07.004_bib7","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1074\/jbc.270.8.3757","article-title":"Characterization of the human tryptophan hydroxylase gene promoter. Transcriptional regulation by cAMP requires a new motif distinct from the cAMP-responsive element","volume":"270","author":"Boularand","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"issue":"2","key":"10.1016\/j.neuropharm.2012.07.004_bib8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0306-4522(93)90335-D","article-title":"Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat","volume":"56","author":"Cameron","year":"1993","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"10.1016\/j.neuropharm.2012.07.004_bib9","first-page":"27","article-title":"Association between the TPH1 A218C polymorphism and risk of mood disorders and alcohol dependence: evidence from the current studies","volume":"138","author":"Chen","year":"2011","journal-title":"J.\u00a0Affect Disord."},{"issue":"8","key":"10.1016\/j.neuropharm.2012.07.004_bib10","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.biopsych.2005.01.013","article-title":"Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus","volume":"57","author":"Clark","year":"2005","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.neuropharm.2012.07.004_bib11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1046\/j.1471-4159.2002.00890.x","article-title":"Involvement of NF-Y and Sp1 in basal and cAMP-stimulated transcriptional activation of the tryptophan hydroxylase (TPH ) gene in the pineal gland","volume":"81","author":"Cote","year":"2002","journal-title":"J.\u00a0Neurochem."},{"issue":"2","key":"10.1016\/j.neuropharm.2012.07.004_bib12","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.neuroscience.2009.06.046","article-title":"Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei","volume":"163","author":"Donner","year":"2009","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.neuropharm.2012.07.004_bib13","first-page":"139","article-title":"Effects of estrogens and antiestrogens on estrogen receptor dynamics and the induction of progesterone receptor in MCF-7 human breast cancer cells","volume":"42","author":"Eckert","year":"1982","journal-title":"Cancer Res."},{"key":"10.1016\/j.neuropharm.2012.07.004_bib14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0079-6123(08)81013-8","article-title":"ERbeta in CNS: new roles in development and function","volume":"181","author":"Fan","year":"2010","journal-title":"Prog. Brain Res."},{"issue":"2","key":"10.1016\/j.neuropharm.2012.07.004_bib15","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1210\/en.2005-0600","article-title":"Organ messenger ribonucleic acid and plasma proteome changes in the adjuvant-induced arthritis model: responses to disease induction and therapy with the estrogen receptor-beta selective agonist ERB-041","volume":"147","author":"Follettie","year":"2006","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.neuropharm.2012.07.004_bib16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.brainresrev.2007.05.008","article-title":"Gonadal hormone modulation of neurogenesis in the dentate gyrus of adult male and female rodents","volume":"57","author":"Galea","year":"2008","journal-title":"Brain Res. Rev."},{"issue":"8","key":"10.1016\/j.neuropharm.2012.07.004_bib17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0006-3223(00)01021-0","article-title":"Regulation of hippocampal neurogenesis in adulthood","volume":"48","author":"Gould","year":"2000","journal-title":"Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.neuropharm.2012.07.004_bib18","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.biopsych.2005.01.014","article-title":"Estrogen receptor-beta regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe","volume":"57","author":"Gundlah","year":"2005","journal-title":"Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.neuropharm.2012.07.004_bib19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0006-8993(99)02475-0","article-title":"Distribution of estrogen receptor beta (ERbeta) mRNA in hypothalamus, midbrain and temporal lobe of spayed macaque: continued expression with hormone replacement","volume":"76","author":"Gundlah","year":"2000","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.neuropharm.2012.07.004_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0169-328X(01)00108-5","article-title":"Estrogen receptor beta (ERbeta) mRNA and protein in serotonin neurons of macaques","volume":"91","author":"Gundlah","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"1","key":"10.1016\/j.neuropharm.2012.07.004_bib21","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1365-2826.2011.02206.x","article-title":"Roles for estrogen receptor beta in adult brain function","volume":"24","author":"Handa","year":"2011","journal-title":"J.\u00a0Neuroendocrinol."},{"issue":"13","key":"10.1016\/j.neuropharm.2012.07.004_bib22","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1038\/npp.2011.220","article-title":"Depression, antidepressants, and neurogenesis: a critical reappraisal","volume":"36","author":"Hanson","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"10.1016\/j.neuropharm.2012.07.004_bib23","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1177\/153537020523000807","article-title":"Phytoestrogens induce differential estrogen receptor alpha- or beta-mediated responses in transfected breast cancer cells","volume":"230","author":"Harris","year":"2005","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"1","key":"10.1016\/j.neuropharm.2012.07.004_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/me.2005-0459","article-title":"Estrogen receptor-beta: recent lessons from in\u00a0vivo studies","volume":"21","author":"Harris","year":"2007","journal-title":"Mol. Endocrinol."},{"issue":"4","key":"10.1016\/j.neuropharm.2012.07.004_bib25","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jchemneu.2003.10.002","article-title":"The human raphe nuclei and the serotonergic system","volume":"26","author":"Hornung","year":"2003","journal-title":"J.\u00a0Chem. Neuroanat."},{"issue":"7","key":"10.1016\/j.neuropharm.2012.07.004_bib26","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.neuropharm.2008.03.004","article-title":"WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic\/antidepressant agent","volume":"54","author":"Hughes","year":"2008","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.neuropharm.2012.07.004_bib27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.physbeh.2004.11.002","article-title":"Lack of functional estrogen receptor beta influences anxiety behavior and serotonin content in female mice","volume":"84","author":"Imwalle","year":"2005","journal-title":"Physiol. Behav."},{"issue":"4","key":"10.1016\/j.neuropharm.2012.07.004_bib28","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.nlm.2010.08.016","article-title":"Estradiol and ERbeta agonists enhance recognition memory, and DPN, an ERbeta agonist, alters brain monoamines","volume":"94","author":"Jacome","year":"2010","journal-title":"Neurobiol. Learn. Mem."},{"issue":"2","key":"10.1016\/j.neuropharm.2012.07.004_bib29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/ptr.2966","article-title":"Caffeic acid phenethyl ester, a component of beehive propolis, is a novel selective estrogen receptor modulator","volume":"24","author":"Jung","year":"2010","journal-title":"Phytother. Res."},{"issue":"26","key":"10.1016\/j.neuropharm.2012.07.004_bib30","doi-asserted-by":"crossref","first-page":"15677","DOI":"10.1073\/pnas.95.26.15677","article-title":"Generation and reproductive phenotypes of mice lacking estrogen receptor beta","volume":"95","author":"Krege","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"6","key":"10.1016\/j.neuropharm.2012.07.004_bib31","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.coph.2010.09.009","article-title":"Regulation of specific target genes and biological responses by estrogen receptor subtype agonists","volume":"10","author":"Leitman","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.neuropharm.2012.07.004_bib32","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jsbmb.2008.03.028","article-title":"Butyl 4-(butyryloxy)benzoate functions as a new selective estrogen receptor beta agonist and induces GLUT4 expression in CHO-K1 cells","volume":"110","author":"Lin","year":"2008","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"issue":"3","key":"10.1016\/j.neuropharm.2012.07.004_bib33","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/nn2057","article-title":"Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory","volume":"11","author":"Liu","year":"2008","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.neuropharm.2012.07.004_bib34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1124\/mi.10.3.3","article-title":"A\u00a0new class of estrogen receptor beta-selective activators","volume":"10","author":"Lo","year":"2010","journal-title":"Mol. Interv."},{"issue":"10","key":"10.1016\/j.neuropharm.2012.07.004_bib35","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1046\/j.1365-2826.2001.00695.x","article-title":"Serotonergic neurones in the dorsal raphe nucleus that project into the medial preoptic area contain oestrogen receptor beta","volume":"13","author":"Lu","year":"2001","journal-title":"J.\u00a0Neuroendocrinol."},{"issue":"3","key":"10.1016\/j.neuropharm.2012.07.004_bib36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1385\/ENDO:11:3:257","article-title":"Ovarian steroid action on tryptophan hydroxylase protein and serotonin compared to localization of ovarian steroid receptors in midbrain of guinea pigs","volume":"11","author":"Lu","year":"1999","journal-title":"Endocrine"},{"issue":"23","key":"10.1016\/j.neuropharm.2012.07.004_bib37","doi-asserted-by":"crossref","first-page":"11162","DOI":"10.1073\/pnas.90.23.11162","article-title":"Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene","volume":"90","author":"Lubahn","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"1","key":"10.1016\/j.neuropharm.2012.07.004_bib38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0042-6822(89)90348-6","article-title":"High level expression of nonfused foreign genes with autographa californica nuclear polyhedrosis virus expression vectors","volume":"170","author":"Luckow","year":"1989","journal-title":"Virology"},{"issue":"21","key":"10.1016\/j.neuropharm.2012.07.004_bib39","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1021\/jm049719y","article-title":"Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands","volume":"47","author":"Malamas","year":"2004","journal-title":"J.\u00a0Med. Chem."},{"issue":"24","key":"10.1016\/j.neuropharm.2012.07.004_bib40","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","article-title":"Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus","volume":"20","author":"Malberg","year":"2000","journal-title":"J.\u00a0Neurosci."},{"issue":"12","key":"10.1016\/j.neuropharm.2012.07.004_bib41","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1021\/jm058173s","article-title":"ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity","volume":"48","author":"Mewshaw","year":"2005","journal-title":"J.\u00a0Med. Chem."},{"issue":"24","key":"10.1016\/j.neuropharm.2012.07.004_bib42","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1021\/jm010254a","article-title":"Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues","volume":"44","author":"Meyers","year":"2001","journal-title":"J.\u00a0Med. Chem."},{"issue":"5","key":"10.1016\/j.neuropharm.2012.07.004_bib43","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1210\/en.2002-221069","article-title":"Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha","volume":"144","author":"Mitra","year":"2003","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.neuropharm.2012.07.004_bib44","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1517\/13543771003657164","article-title":"Estrogen receptor beta selective nonsteroidal estrogens: seeking clinical indications","volume":"20","author":"Mohler","year":"2010","journal-title":"Expert Opin. Ther. Pat"},{"key":"10.1016\/j.neuropharm.2012.07.004_bib45","article-title":"Gender differences in the tail suspension test (TST) among C57BL\/6N (B6) and 129\/SvJ inbred mice","author":"Murphy","year":"2002","journal-title":"Soc. Neurosci."},{"issue":"1","key":"10.1016\/j.neuropharm.2012.07.004_bib46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF02700623","article-title":"Developmental role of tryptophan hydroxylase in the nervous system","volume":"35","author":"Nakamura","year":"2007","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.neuropharm.2012.07.004_bib47","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2174\/1567202043362388","article-title":"Regulation of neurogenesis and angiogenesis in depression","volume":"1","author":"Newton","year":"2004","journal-title":"Curr. Neurovasc Res."},{"issue":"2","key":"10.1016\/j.neuropharm.2012.07.004_bib48","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.neuroscience.2004.09.028","article-title":"Differential distribution of estrogen receptor (ER)-alpha and ER-beta in the midbrain raphe nuclei and periaqueductal gray in male mouse: predominant role of ER-beta in midbrain serotonergic systems","volume":"130","author":"Nomura","year":"2005","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.neuropharm.2012.07.004_bib49","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1210\/endo.139.12.6357","article-title":"Roles of estrogen receptor-alpha gene expression in reproduction-related behaviors in female mice","volume":"139","author":"Ogawa","year":"1998","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.neuropharm.2012.07.004_bib50","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.1210\/endo.139.12.6358","article-title":"Modifications of testosterone-dependent behaviors by estrogen receptor-alpha gene disruption in male mice","volume":"139","author":"Ogawa","year":"1998","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.neuropharm.2012.07.004_bib51","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1177\/108705710000500609","article-title":"Development of a homogeneous time-resolved fluorescence assay for high throughput screening to identify Lck inhibitors: comparison with scintillation proximity assay and streptavidin-coated plate assay","volume":"5","author":"Ohmi","year":"2000","journal-title":"J.\u00a0Biomol. Screen."},{"issue":"2","key":"10.1016\/j.neuropharm.2012.07.004_bib52","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0306-4522(00)00474-7","article-title":"Reproductive status influences cell proliferation and cell survival in the dentate gyrus of adult female meadow voles: a possible regulatory role for estradiol","volume":"102","author":"Ormerod","year":"2001","journal-title":"Neuroscience"},{"issue":"10","key":"10.1016\/j.neuropharm.2012.07.004_bib53","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.bbagen.2009.11.001","article-title":"Underlying mechanisms mediating the antidepressant effects of estrogens","volume":"1800","author":"Osterlund","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.neuropharm.2012.07.004_bib54","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/20024091064291","volume":"32","author":"Owens","year":"2002","journal-title":"Crit. Rev. Toxicol."},{"issue":"17","key":"10.1016\/j.neuropharm.2012.07.004_bib55","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1016\/j.bmcl.2006.05.103","article-title":"Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists","volume":"16","author":"Parker","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.neuropharm.2012.07.004_bib56","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"issue":"4","key":"10.1016\/j.neuropharm.2012.07.004_bib57","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.neuropharm.2012.07.004_bib58","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00213-004-2078-1","article-title":"17 Beta-estradiol-induced antidepressant-like effect in the forced swim test is absent in estrogen receptor-beta knockout (BERKO) mice","volume":"179","author":"Rocha","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"10.1016\/j.neuropharm.2012.07.004_bib59","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/ajmg.b.30991","article-title":"The tryptophan hydroxylase 1 (TPH1) gene, schizophrenia susceptibility, and suicidal behavior: a multi-centre case-control study and meta-analysis","volume":"153B","author":"Saetre","year":"2010","journal-title":"Am. J. Med. Genet. B. Neuropsychiatr. Genet."},{"issue":"1\u20132","key":"10.1016\/j.neuropharm.2012.07.004_bib60","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.molbrainres.2004.12.011","article-title":"A\u00a0second tryptophan hydroxylase isoform, TPH-2 mRNA, is increased by ovarian steroids in the raphe region of macaques","volume":"135","author":"Sanchez","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"8","key":"10.1016\/j.neuropharm.2012.07.004_bib61","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/00008877-200312000-00001","article-title":"Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice","volume":"14","author":"Shearman","year":"2003","journal-title":"Behav. Pharmacol."},{"issue":"4","key":"10.1016\/j.neuropharm.2012.07.004_bib62","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/(SICI)1096-9861(19971201)388:4<507::AID-CNE1>3.0.CO;2-6","article-title":"Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system","volume":"388","author":"Shughrue","year":"1997","journal-title":"J.\u00a0Comp. Neurol."},{"issue":"6","key":"10.1016\/j.neuropharm.2012.07.004_bib63","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.bmcl.2005.12.057","article-title":"6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists","volume":"16","author":"Sun","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"14","key":"10.1016\/j.neuropharm.2012.07.004_bib64","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1523\/JNEUROSCI.19-14-05792.1999","article-title":"Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat","volume":"19","author":"Tanapat","year":"1999","journal-title":"J.\u00a0Neurosci."},{"issue":"1","key":"10.1016\/j.neuropharm.2012.07.004_bib65","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neulet.2009.10.069","article-title":"TPH1 218A\/C polymorphism is associated with major depressive disorder and its treatment response","volume":"468","author":"Viikki","year":"2010","journal-title":"Neurosci. Lett."},{"issue":"6","key":"10.1016\/j.neuropharm.2012.07.004_bib66","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/sj.npp.1301067","article-title":"A\u00a0review and update of mechanisms of estrogen in the hippocampus and amygdala for anxiety and depression behavior","volume":"31","author":"Walf","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.neuropharm.2012.07.004_bib67","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1177\/0269881108089598","article-title":"Adult female wildtype, but not oestrogen receptor beta knockout, mice have decreased depression-like behaviour during pro-oestrus and following administration of oestradiol or diarylpropionitrile","volume":"23","author":"Walf","year":"2009","journal-title":"J.\u00a0Psychopharmacol."},{"issue":"3","key":"10.1016\/j.neuropharm.2012.07.004_bib68","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.pbb.2004.03.023","article-title":"Antidepressant effects of ERbeta-selective estrogen receptor modulators in the forced swim test","volume":"78","author":"Walf","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"9","key":"10.1016\/j.neuropharm.2012.07.004_bib69","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0006-2952(03)00556-2","article-title":"A\u00a0unique central tryptophan hydroxylase isoform","volume":"66","author":"Walther","year":"2003","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.neuropharm.2012.07.004_bib70","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1210\/en.2008-1355","article-title":"Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress","volume":"150","author":"Weiser","year":"2009","journal-title":"Endocrinology"},{"issue":"13","key":"10.1016\/j.neuropharm.2012.07.004_bib71","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1016\/j.bmcl.2006.03.098","article-title":"The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands","volume":"16","author":"Wilkening","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"24","key":"10.1016\/j.neuropharm.2012.07.004_bib72","doi-asserted-by":"crossref","first-page":"21262","DOI":"10.1074\/jbc.M007520200","article-title":"Autoregulation of cell-specific MAP kinase control of the tryptophan hydroxylase promoter","volume":"276","author":"Wood","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"issue":"4","key":"10.1016\/j.neuropharm.2012.07.004_bib73","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/WNR.0b013e3283377445","article-title":"Estradiol or fluoxetine alters depressive behavior and tryptophan hydroxylase in rat raphe","volume":"21","author":"Yang","year":"2010","journal-title":"Neuroreport"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390812003346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390812003346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:52:53Z","timestamp":1642726373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390812003346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":73,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0028390812003346"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2012.07.004","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}