{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:12:28Z","timestamp":1791270748160,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004792","name":"French Ministry of Higher Education and Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004792","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.neuropharm.2013.05.014","type":"journal-article","created":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T22:14:14Z","timestamp":1369692854000},"page":"147-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"special_numbering":"C","title":["Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice"],"prefix":"10.1016","volume":"73","author":[{"given":"Jean-Philippe","family":"Guilloux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira","family":"Mendez-David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Pehrson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno P.","family":"Guiard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Rep\u00e9rant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Orvo\u00ebn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain M.","family":"Gardier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Hen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarke","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis J.","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2013.05.014_bib1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1144400","article-title":"High-speed imaging reveals neurophysiological links to behavior in an animal model of depression","volume":"317","author":"Airan","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1742-7843.2011.00810.x","article-title":"Occupancy of the serotonin transporter after administration of Lu AA21004 and its relation to plasma concentration in healthy subjects","volume":"110","author":"Areberg","year":"2012","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2174\/138945006775515446","article-title":"Pindolol augmentation of antidepressant response","volume":"7","author":"Artigas","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/026988119500900208","article-title":"The 5-HT3 antagonist ondansetron reduces gastrointestinal side effects induced by a specific serotonin re-uptake inhibitor in man","volume":"9","author":"Bailey","year":"1995","journal-title":"J.\u00a0Psychopharmacol. (Oxf.)"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib5","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/sj.npp.1300320","article-title":"Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone","volume":"29","author":"Banasr","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib6","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1021\/jm101459g","article-title":"Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder","volume":"54","author":"Bang-Andersen","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib7","series-title":"5-HT1A Agonists, 5-HT3 Antagonists and Benzodiazepines: Their Comparative Behavioural Pharmacology","first-page":"59","article-title":"Anxiolytic effects of 5-HT1A agonists, 5-HT3 antagonists and benzodiazepines: conflict and drug discrimination studies","author":"Barrett","year":"1991"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0166-4328(01)00291-1","article-title":"Measuring normal and pathological anxiety-like behaviour in mice: a review","volume":"125","author":"Belzung","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/7854_2009_3","article-title":"Antidepressant treatment in anxiety disorders","volume":"2","author":"Bespalov","year":"2010","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib10","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1124\/jpet.107.119404","article-title":"Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents","volume":"321","author":"Bonaventure","year":"2007","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/BF02244004","article-title":"Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat","volume":"100","author":"Caccia","year":"1990","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib12","doi-asserted-by":"crossref","first-page":"8165","DOI":"10.1523\/JNEUROSCI.1816-05.2005","article-title":"Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression","volume":"25","author":"Cervo","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/1568007043482624","article-title":"5-HT3 receptors. Current drug targets","volume":"3","author":"Costall","year":"2004","journal-title":"CNS Neurol. Disord."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1755-5949.2009.00125.x","article-title":"The novel antidepressant agomelatine normalizes hippocampal neuronal activity and promotes neurogenesis in chronically stressed rats","volume":"16","author":"Dagyte","year":"2010","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1124\/jpet.106.109678","volume":"321","author":"David","year":"2007","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib16","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuron.2009.04.017","article-title":"Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety\/depression","volume":"62","author":"David","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib17","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/sj.npp.1300433","article-title":"Effects of chronic fluoxetine in animal models of anxiety and depression","volume":"29","author":"Dulawa","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib18","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0006-3223(99)00177-8","article-title":"Neural plasticity to stress and antidepressant treatment","volume":"46","author":"Duman","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib19","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neulet.2006.05.023","article-title":"Effects of the 5-HT7 receptor antagonist SB-269970 on rat hormonal and temperature responses to the 5-HT1A\/7 receptor agonist 8-OH-DPAT","volume":"404","author":"Faure","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib20","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"2008"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0764-4469(01)01332-4","article-title":"[5-HT1B serotonin receptors and antidepressant effects of selective serotonin reuptake inhibitors]","volume":"324","author":"Gardier","year":"2001","journal-title":"C.\u00a0R. Acad. Sci. III"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002130000573","article-title":"Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice","volume":"155","author":"Gingrich","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib23","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1038\/sj.npp.1301019","article-title":"Blockade of 5-HT1A receptors by (+\/\u2212)-pindolol potentiates cortical 5-HT outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-HT1A receptor knockout mice","volume":"31","author":"Guilloux","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib24","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.neuropharm.2011.02.009","article-title":"Characterization of 5-HT(1A\/1B)\u2212\/\u2212 mice: an animal model sensitive to anxiolytic treatments","volume":"61","author":"Guilloux","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib25","series-title":"Non-response to Initial Antidepressant Therapy. Psychology","doi-asserted-by":"crossref","DOI":"10.5772\/37783","author":"Guilloux","year":"2012"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib26","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.neuropharm.2004.11.015","article-title":"Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression","volume":"48","author":"Guscott","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib27","doi-asserted-by":"crossref","first-page":"S625","DOI":"10.1016\/S0924-977X(06)70008-6","article-title":"Pharmacological profile of antidepressants: a likely basis for their efficacy and side effects?","volume":"16","author":"Hamon","year":"2006","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib28","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.biopsych.2005.05.012","article-title":"5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern","volume":"58","author":"Hedlund","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0014-2999(02)02874-1","article-title":"Prior exposure to the elevated plus-maze sensitizes mice to the acute behavioral effects of fluoxetine and phenelzine","volume":"459","author":"Holmes","year":"2003","journal-title":"Eur. J. Pharmacol."},{"issue":"Suppl. 1","key":"10.1016\/j.neuropharm.2013.05.014_bib30","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.jad.2011.03.048","article-title":"Strategies to achieve clinical effectiveness: refining existing therapies and pursuing emerging targets","volume":"132","author":"Kennedy","year":"2011","journal-title":"J.\u00a0Affect. Disord."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib31","doi-asserted-by":"crossref","first-page":"10409","DOI":"10.1073\/pnas.94.19.10409","article-title":"Genetic influence on neurogenesis in the dentate gyrus of adult mice","volume":"94","author":"Kempermann","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib32","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib33","article-title":"Oppositional effects of serotonin receptors 5-HT1a, 2, and 2c in the regulation of adult hippocampal neurogenesis","volume":"3","author":"Klempin","year":"2010","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib34","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.pbb.2011.06.020","article-title":"Association between tryptophan hydroxylase-2 genotype and the antidepressant effect of citalopram and paroxetine on immobility time in the forced swim test in mice","volume":"99","author":"Kulikov","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s002130100694","article-title":"Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice","volume":"155","author":"Lucki","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib36","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","article-title":"Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus","volume":"20","author":"Malberg","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/08039488.2012.674553","article-title":"A\u00a0short-term double-blind randomized controlled pilot trial with active or placebo pindolol in patients treated with venlafaxine for major depression","volume":"66","author":"Martiny","year":"2012","journal-title":"Nord. J. Psychiatry"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib38","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/npp.2011.13","article-title":"Pharmacological blockade of 5-HT7 receptors as a putative fast acting antidepressant strategy","volume":"36","author":"Mnie-Filali","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib39","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1124\/jpet.111.189068","article-title":"Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder","volume":"340","author":"Mork","year":"2012","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib40","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0893-133X(99)00041-X","article-title":"Effects of antidepressants on 5-HT7 receptor regulation in the rat hypothalamus","volume":"21","author":"Mullins","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib41","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuint.2008.12.011","article-title":"A\u00a0genetic rat model of depression, Flinders sensitive line, has a lower density of 5-HT(1A) receptors, but a higher density of 5-HT(1B) receptors, compared to control rats","volume":"54","author":"Nishi","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib42","first-page":"1305","article-title":"Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites","volume":"283","author":"Owens","year":"1997","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.neuropharm.2013.05.014_bib43","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.euroneuro.2012.04.006","article-title":"Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters-A rat microdialysis and electrophysiology study","volume":"23","author":"Pehrson","year":"2012","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib44","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","article-title":"Forced swimming test in mice: a review of antidepressant activity","volume":"177","author":"Petit-Demouliere","year":"2005","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejphar.2009.11.037","article-title":"A\u00a0longitudinal study of 5-HT outflow during chronic fluoxetine treatment using a new technique of chronic microdialysis in a highly emotional mouse strain","volume":"628","author":"Popa","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib46","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib47","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0006-8993(02)03477-7","article-title":"5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus","volume":"955","author":"Radley","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib48","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1017\/S1461145711000356","article-title":"Beneficial behavioural and neurogenic effects of agomelatine in a model of depression\/anxiety","volume":"15","author":"Rainer","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib49","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/FBP.0b013e3282f3cfd4","article-title":"Antidepressant-like effects of serotonin type-3 antagonist, ondansetron: an investigation in behaviour-based rodent models","volume":"19","author":"Ramamoorthy","year":"2008","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib50","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0014-2999(97)00115-5","article-title":"Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test","volume":"325","author":"Redrobe","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib51","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report","volume":"163","author":"Rush","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib52","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature09817","article-title":"Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation","volume":"472","author":"Sahay","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib53","series-title":"Mood and Anxiety Related Phenotypes in Mice. Characterization Using Behavioral Tests","first-page":"107","article-title":"Novelty-suppressed feeding in the mouse","author":"Samuels","year":"2012"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib54","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib55","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbr.2010.01.022","article-title":"The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior","volume":"209","author":"Sarkisyan","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib56","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.euroneuro.2009.11.007","article-title":"Region- and phase-dependent effects of 5-HT(1A) and 5-HT(2C) receptor activation on adult neurogenesis","volume":"20","author":"Soumier","year":"2010","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib57","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1038\/npp.2009.72","article-title":"Mechanisms contributing to the phase-dependent regulation of neurogenesis by the novel antidepressant, agomelatine, in the adult rat hippocampus","volume":"34","author":"Soumier","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib58","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1523\/JNEUROSCI.3632-07.2008","article-title":"Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells","volume":"28","author":"Wang","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib59","first-page":"1","article-title":"Neuropeptide S alters anxiety, but not depression-like behaviour in Flinders Sensitive Line rats: a genetic animal model of depression","author":"Wegener","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib60","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejphar.2006.09.064","article-title":"Potential anxiolytic and antidepressant effects of the selective 5-HT7 receptor antagonist SB 269970 after intrahippocampal administration to rats","volume":"553","author":"Wesolowska","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib61","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.neuropharm.2006.04.017","article-title":"Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression","volume":"51","author":"Wesolowska","year":"2006","journal-title":"Neuropharmacology"},{"issue":"Suppl. 1","key":"10.1016\/j.neuropharm.2013.05.014_bib62","first-page":"47","article-title":"In\u00a0vitro and in\u00a0vivo effects of the multimodal antidepressant vortioxetine (Lu AA21004) at human and rat targets","volume":"16","author":"Westrich","year":"2012","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib63","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1177\/0269881108097714","article-title":"Pindolol augmentation of serotonin reuptake inhibitors for the treatment of depressive disorder: a systematic review","volume":"24","author":"Whale","year":"2010","journal-title":"J.\u00a0Psychopharmacol. (Oxf.)"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib64","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neulet.2012.05.046","article-title":"Ventral hippocampal molecular pathways and impaired neurogenesis associated with 5-HT(1)A and 5-HT(1)B receptors disruption in mice","volume":"521","author":"Xia","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2013.05.014_bib65","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1097540","article-title":"Tryptophan hydroxylase-2 controls brain serotonin synthesis","volume":"305","author":"Zhang","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2013.05.014_bib66","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0091-3057(01)00566-4","article-title":"Anxiolytic-like effects of DAIZAC, a selective high-affinity 5-HT(3) receptor antagonist, in the mouse elevated plus-maze","volume":"69","author":"Zhang","year":"2001","journal-title":"Pharmacol. Biochem. Behav."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390813002244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390813002244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T12:20:15Z","timestamp":1588940415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390813002244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":66,"alternative-id":["S0028390813002244"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2013.05.014","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2013.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}