{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:45:58Z","timestamp":1774464358330,"version":"3.50.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.neuropharm.2013.11.009","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T02:46:16Z","timestamp":1385433976000},"page":"738-749","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Neuroprotective and cognitive enhancing effects of a multi-targeted food intervention in an animal model of neurodegeneration and depression"],"prefix":"10.1016","volume":"79","author":[{"given":"Yuliya E.","family":"Borre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodora","family":"Panagaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pim J.","family":"Koelink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary. E.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrikus","family":"Hendriksen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Garssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aletta D.","family":"Kraneveld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berend","family":"Olivier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald S.","family":"Oosting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2013.11.009_bib1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0031-9384(74)90216-9","article-title":"Producing and interpreting experimental olfactory deficits","volume":"12","author":"Alberts","year":"1974","journal-title":"Physiol. Behav."},{"issue":"2","key":"10.1016\/j.neuropharm.2013.11.009_bib2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000332218","article-title":"Road to Alzheimer's disease: the pathomechanism underlying","volume":"79","author":"Anand","year":"2012","journal-title":"Pathobiol.: J. Immunopathol. Mol. Cell. Biol."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib62","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0022-3565(25)20081-7","article-title":"Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism","volume":"232","author":"Atal","year":"1985","journal-title":"Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.neuropharm.2013.11.009_bib3","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/j.1471-4159.2004.02587.x","article-title":"Zinc inhibits glutamate release via activation of pre-synaptic K channels and reduces ischaemic damage in rat hippocampus","volume":"90","author":"Bancila","year":"2004","journal-title":"J.\u00a0Neurochem."},{"issue":"11","key":"10.1016\/j.neuropharm.2013.11.009_bib4","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/syn.20683","article-title":"Zinc: the brain's dark horse","volume":"63","author":"Bitanihirwe","year":"2009","journal-title":"Synapse"},{"issue":"6785","key":"10.1016\/j.neuropharm.2013.11.009_bib63","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"issue":"5\u20136","key":"10.1016\/j.neuropharm.2013.11.009_bib5","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/j.neuropharm.2011.12.034","article-title":"Memantine partly rescues behavioral and cognitive deficits in an animal model of neurodegeneration","volume":"62","author":"Borre","year":"2012","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.neuropharm.2013.11.009_bib6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bbr.2012.07.007","article-title":"Celecoxib delays cognitive decline in an animal model of neurodegeneration","volume":"234","author":"Borre","year":"2012","journal-title":"Behav. Brain Res."},{"issue":"1\u20133","key":"10.1016\/j.neuropharm.2013.11.009_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2012.09.005","article-title":"Minocycline restores spatial but not fear memory in olfactory bulbectomized rats","volume":"697","author":"Borre","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1742-4658.2009.07487.x","article-title":"Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons","volume":"277","author":"Braidy","year":"2010","journal-title":"FEBS J."},{"issue":"8","key":"10.1016\/j.neuropharm.2013.11.009_bib9","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.biopsych.2006.08.032","article-title":"Long-term behavioral changes after cessation of chronic antidepressant treatment in olfactory bulbectomized rats","volume":"61","author":"Breuer","year":"2007","journal-title":"Biol. Psychiat."},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib64","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3233\/JAD-2012-112039","article-title":"A specific multi-nutrient diet reduces Alzheimer-like pathology in young adult A\u03b2PPswe\/PS1dE9 mice","volume":"33","author":"Broersen","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000059774","article-title":"omega 3 polyunsaturated fatty acids, inflammation and immunity","volume":"88","author":"Calder","year":"2001","journal-title":"World Rev. Nutr. Diet"},{"issue":"3","key":"10.1016\/j.neuropharm.2013.11.009_bib11","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.fct.2009.12.009","article-title":"Piperine, the main alkaloid of thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of alzheimer's disease","volume":"48","author":"Chonpathompikunlert","year":"2010","journal-title":"Food and Chem. Toxicol.: an Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"issue":"4","key":"10.1016\/j.neuropharm.2013.11.009_bib12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1517\/14728222.2011.553603","article-title":"Pathobiological targets of depression","volume":"15","author":"Chopra","year":"2011","journal-title":"Expert Opinion Ther. Targets"},{"issue":"6","key":"10.1016\/j.neuropharm.2013.11.009_bib66","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1097\/TA.0b013e31829246ad","article-title":"Immediate splenectomy down-regulates the MAPK-NF-\u03baB signaling pathway in rat brain after severe traumatic brain injury","volume":"74","author":"Chu","year":"2013","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-0-387-46401-5_8","article-title":"Neuroprotective effects of curcumin","volume":"595","author":"Cole","year":"2007","journal-title":"Mol. Targets Therap. Uses Curcumin Health Dis."},{"issue":"6","key":"10.1016\/j.neuropharm.2013.11.009_bib14","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson's disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nprot.2006.2","article-title":"T-maze alternation in the rodent","volume":"1","author":"Deacon","year":"2006","journal-title":"Nat. Protocols."},{"issue":"2\u20133","key":"10.1016\/j.neuropharm.2013.11.009_bib67","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0014-2999(94)00654-P","article-title":"Antidepressants reverse the olfactory bulbectomy-induced decreases in splenic peripheral-type benzodiazepine receptors in rats","volume":"272","author":"Dennis","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0031-6997(24)01394-2","article-title":"The glutamate receptor ion channels","volume":"51","author":"Dingledine","year":"1999","journal-title":"Pharmacol. Rev."},{"issue":"5","key":"10.1016\/j.neuropharm.2013.11.009_bib17","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3945\/jn.110.132985","article-title":"Supplementation with a fish oil-enriched, high-protein medical food leads to rapid incorporation of EPA into white blood cells and modulates immune responses within one week in healthy men and women","volume":"141","author":"Faber","year":"2011","journal-title":"J.\u00a0Nutr."},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are the dorsal and ventral hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neuropharm.2011.07.018","article-title":"Environmental enrichment has antidepressant-like action without improving learning and memory deficits in olfactory bulbectomized rats","volume":"62","author":"Hendriksen","year":"2012","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbr.2008.02.042","article-title":"Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats","volume":"191","author":"Holguin","year":"2008","journal-title":"Behav. Brain Res."},{"issue":"10","key":"10.1016\/j.neuropharm.2013.11.009_bib21","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0022-2275(20)32220-3","article-title":"Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor","volume":"42","author":"Ikemoto","year":"2001","journal-title":"J.\u00a0Lipid Res."},{"issue":"9","key":"10.1016\/j.neuropharm.2013.11.009_bib22","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.euroneuro.2009.02.002","article-title":"Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT)","volume":"19","author":"Ishrat","year":"2009","journal-title":"Eur. Neuropsychopharm."},{"issue":"1 Suppl.","key":"10.1016\/j.neuropharm.2013.11.009_bib23","doi-asserted-by":"crossref","first-page":"343S","DOI":"10.1093\/ajcn\/71.1.343s","article-title":"Dietary polyunsaturated fatty acids and inflammatory mediator production","volume":"71","author":"James","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1468-1331.2009.02737.x","article-title":"Nutrition and Alzheimer's disease: pre-clinical concepts","volume":"16","author":"Kamphuis","year":"2009","journal-title":"Eur. J. Neurol."},{"issue":"3","key":"10.1016\/j.neuropharm.2013.11.009_bib68","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3233\/JAD-2010-091558","article-title":"Can nutrients prevent or delay onset of Alzheimer's disease?","volume":"20","author":"Kamphuis","year":"2010","journal-title":"J. Alzheimers Dis."},{"issue":"8","key":"10.1016\/j.neuropharm.2013.11.009_bib25","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1007\/s12603-011-0105-6","article-title":"Efficacy of a medical food on cognition in Alzheimer's disease: results from secondary analyses of a randomized, controlled trial","volume":"15","author":"Kamphuis","year":"2011","journal-title":"J\u00a0Nutr. Health Aging"},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s002130000400","article-title":"Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat","volume":"150","author":"Mar","year":"2000","journal-title":"Psychopharmacology"},{"issue":"3","key":"10.1016\/j.neuropharm.2013.11.009_bib27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/sj.mp.4000254","article-title":"Possible mechanisms for atrophy of the human hippocampus","volume":"2","author":"McEwen","year":"1997","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.neuropharm.2013.11.009_bib70","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.phanu.2012.10.004","article-title":"Role of long-chain omega-3 fatty acids in psychiatric practice","volume":"1","author":"McNamara","year":"2013","journal-title":"PharmaNutrition"},{"issue":"8","key":"10.1016\/j.neuropharm.2013.11.009_bib71","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nri1669","article-title":"Structure and function of the spleen","volume":"5","author":"Mebius","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.neuropharm.2013.11.009_bib28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.pneurobio.2005.04.005","article-title":"Brain, aging and neurodegeneration: role of zinc ion availability","volume":"75","author":"Mocchegiani","year":"2005","journal-title":"Progr. Neurobiol."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib29","first-page":"785647","article-title":"Ion channels and zinc: mechanisms of neurotoxicity and neurodegeneration","volume":"2012","author":"Morris","year":"2012","journal-title":"J.\u00a0Toxicol."},{"issue":"6","key":"10.1016\/j.neuropharm.2013.11.009_bib30","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/(SICI)1098-1063(1998)8:6<608::AID-HIPO3>3.0.CO;2-7","article-title":"Functional differentiation in the hippocampus","volume":"8","author":"Moser","year":"1998","journal-title":"Hippocampus"},{"issue":"9","key":"10.1016\/j.neuropharm.2013.11.009_bib31","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/hbm.20934","article-title":"Hippocampal atrophy patterns in mild cognitive impairment and alzheimer's disease","volume":"31","author":"Mueller","year":"2010","journal-title":"Human Brain Map."},{"issue":"4","key":"10.1016\/j.neuropharm.2013.11.009_bib72","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.nlm.2011.06.006","article-title":"Cognitive dysfunction in depression: neurocircuitry and new therapeutic strategies","volume":"96","author":"Murrough","year":"2011","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000107420","article-title":"Effect of the COX-2 inhibitor celecoxib on behavioural and immune changes in an olfactory bulbectomised rat model of depression","volume":"14","author":"Myint","year":"2007","journal-title":"Neuroimmunomodulation"},{"issue":"3","key":"10.1016\/j.neuropharm.2013.11.009_bib33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/syn.10006","article-title":"Altered dendritic spine density in animal models of depression and in response to antidepressant treatment","volume":"42","author":"Norrholm","year":"2001","journal-title":"Synapse"},{"issue":"2","key":"10.1016\/j.neuropharm.2013.11.009_bib34","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0361-9230(03)00104-7","article-title":"Antidepressant-like effects of acute and chronic treatmentwith zinc in forced swim test and olfactory bulbectomy model in rats","volume":"61","author":"Nowak","year":"2003","journal-title":"Brain Res Bull."},{"issue":"3","key":"10.1016\/j.neuropharm.2013.11.009_bib35","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0091-6773(79)90184-6","article-title":"The development of food search behavior by rats: the effects of hippocampal damage and haloperidol","volume":"24","author":"Oades","year":"1978","journal-title":"Behav. Biol."},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib36","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1600-079X.2009.00692.x","article-title":"Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease","volume":"47","author":"Olcese","year":"2009","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib37","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrneurol.2010.17","article-title":"Microglia in neurodegenerative disease","volume":"6","author":"Perry","year":"2010","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1600-079X.2010.00802.x","article-title":"Chronic treatment with melatonin stimulates dendrite maturation and complexity in adult hippocampal neurogenesis of mice","volume":"50","author":"Ramirez-Rodriguez","year":"2011","journal-title":"J.\u00a0Pineal Res."},{"issue":"2","key":"10.1016\/j.neuropharm.2013.11.009_bib75","doi-asserted-by":"crossref","first-page":"74","DOI":"10.23861\/EJBM20112768","article-title":"Brain\u2013spleen inflammatory coupling: a literature review","volume":"27","author":"Rasouli","year":"2011","journal-title":"Einstein J. Biol. Med."},{"issue":"6","key":"10.1016\/j.neuropharm.2013.11.009_bib39","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/BF02253360","article-title":"Actions of melatonin in the reduction of oxidative stress. a review","volume":"7","author":"Reiter","year":"2000","journal-title":"J.\u00a0Biomed. Sci."},{"issue":"5 Suppl.","key":"10.1016\/j.neuropharm.2013.11.009_bib73","doi-asserted-by":"crossref","first-page":"838S","DOI":"10.1093\/jn\/127.5.838S","article-title":"Components of the AIN-93 diets as improvements in the AIN-76A diet","volume":"127","author":"Reeves","year":"1997","journal-title":"J. Nutr."},{"issue":"11","key":"10.1016\/j.neuropharm.2013.11.009_bib74","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1093\/jn\/123.11.1923","article-title":"Development and testing of the AIN-93 purified diets for rodents: results on growth, kidney calcification and bone mineralization in rats and mice","volume":"123","author":"Reeves","year":"1993","journal-title":"J. Nutr."},{"issue":"4","key":"10.1016\/j.neuropharm.2013.11.009_bib76","doi-asserted-by":"crossref","first-page":"e61052","DOI":"10.1371\/journal.pone.0061052","article-title":"Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression","volume":"8","author":"Rinwa","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.neuropharm.2013.11.009_bib40","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.appet.2004.03.005","article-title":"Preference for natural: instrumental and ideational\/moral motivations, and the contrast between foods and medicines","volume":"43","author":"Rozin","year":"2004","journal-title":"Appetite"},{"key":"10.1016\/j.neuropharm.2013.11.009_bib41","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.brainres.2007.08.089","article-title":"Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus","volume":"1182","author":"Sakamoto","year":"2007","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib42","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3233\/JAD-2012-121189","article-title":"Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial","volume":"31","author":"Scheltens","year":"2013","journal-title":"J.\u00a0Alzheimers Dis."},{"issue":"8","key":"10.1016\/j.neuropharm.2013.11.009_bib43","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1001\/archneurol.2011.69","article-title":"Lack of evidence for the efficacy of memantine in mild Alzheimer disease","volume":"68","author":"Schneider","year":"2011","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0367-326X(02)00304-0","article-title":"Cytoprotective effect of piperine against benzo[a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice","volume":"74","author":"Selvendiran","year":"2003","journal-title":"Fitoterapia"},{"issue":"9","key":"10.1016\/j.neuropharm.2013.11.009_bib45","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1073\/pnas.93.9.3908","article-title":"Hippocampal atrophy in recurrent major depression","volume":"93","author":"Sheline","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib81","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2006-957450","article-title":"Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers","volume":"64","author":"Shoba","year":"1997","journal-title":"Planta Med"},{"issue":"5","key":"10.1016\/j.neuropharm.2013.11.009_bib47","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.brainresbull.2008.01.020","article-title":"Olfactory bulbectomy reduces cerebral glucose utilization: 2-[14C]deoxyglucose autoradiographic study","volume":"76","author":"Skelin","year":"2008","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib48","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0301-0082(94)90082-5","article-title":"Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc","volume":"42","author":"Smart","year":"1994","journal-title":"Prog. Neurobiol."},{"issue":"8","key":"10.1016\/j.neuropharm.2013.11.009_bib49","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/clinchem\/25.8.1487","article-title":"Direct measurement of zinc in plasma by atomic absorption spectroscopy","volume":"25","author":"Smith","year":"1979","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib82","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/026988119400800107","article-title":"The effects of chronic lithium chloride administration on some behavioural and immunological changes in the bilaterally olfactory bulbectomized rat","volume":"8","author":"Song","year":"1994","journal-title":"J Psychopharmacol"},{"issue":"4\u20135","key":"10.1016\/j.neuropharm.2013.11.009_bib50","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.neubiorev.2005.03.010","article-title":"The olfactory bulbectomised rat as a model of depression","volume":"29","author":"Song","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib51","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1523\/JNEUROSCI.3569-08.2009","article-title":"Increased phospholipase a2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression. Effects of chronic ethyl-eicosapentaenoate treatment","volume":"29","author":"Song","year":"2009","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib52","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1523\/JNEUROSCI.3569-08.2009","article-title":"Increased phospholipase a2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression. Effects of chronic ethyl-eicosapentaenoate treatment","volume":"29","author":"Song","year":"2009","journal-title":"J.\u00a0Neurosci.: Off. J. Soc. Neurosci."},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib53","doi-asserted-by":"crossref","first-page":"105","DOI":"10.33549\/physiolres.931684","article-title":"Olfactory bulbectomy induced oxidative and cell damage in rat: protective effect of melatonin","volume":"59","author":"Tasset","year":"2010","journal-title":"Physiol Res."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib54","first-page":"367","article-title":"Memantine: a review of studies into its safety and efficacy in treating Alzheimer's disease and other dementias","volume":"4","author":"Thomas","year":"2009","journal-title":"Clin. Interv. Aging"},{"issue":"6917","key":"10.1016\/j.neuropharm.2013.11.009_bib77","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The inflammatory reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2013.11.009_bib55","doi-asserted-by":"crossref","first-page":"971021","DOI":"10.4061\/2011\/971021","article-title":"The role of zinc in Alzheimer's disease","volume":"2011","author":"Watt","year":"2010","journal-title":"Int. J. Alzheimers Dis."},{"issue":"1\u20132","key":"10.1016\/j.neuropharm.2013.11.009_bib78","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S1566-0702(01)00354-X","article-title":"Zinc sulphate-induced anosmia decreases the nerve fibre density in the anterior cerebral artery of the rat","volume":"94","author":"van Denderen","year":"2001","journal-title":"Auton Neurosci."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib56","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1016\/j.fct.2008.06.014","article-title":"Piperine, the potential functional food for mood and cognitive disorders","volume":"46","author":"Wattanathorn","year":"2008","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.neuropharm.2013.11.009_bib57","first-page":"223","article-title":"Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners","volume":"15","author":"Wollen","year":"2010","journal-title":"Alt. Med. Rev.: J. Clin. Ther."},{"issue":"1\u20132","key":"10.1016\/j.neuropharm.2013.11.009_bib58","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0006-8993(00)02619-6","article-title":"An in-vivo magnetic resonance imaging study of the olfactory bulbectomized rat model of depression","volume":"879","author":"Wrynn","year":"2000","journal-title":"Brain Research"},{"issue":"Suppl.\u00a01(0)","key":"10.1016\/j.neuropharm.2013.11.009_bib59","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.ejphar.2011.07.005","article-title":"Non-nutritional uses of nutrients","volume":"668","author":"Wurtman","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainres.2006.03.019","article-title":"Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally","volume":"1088","author":"Wurtman","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2013.11.009_bib61","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1146\/annurev-nutr-080508-141059","article-title":"Use of phosphatide precursors to promote synaptogenesis","volume":"29","author":"Wurtman","year":"2009","journal-title":"Ann. Rev. Nutr."},{"issue":"1","key":"10.1016\/j.neuropharm.2013.11.009_bib79","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.pbb.2005.08.009","article-title":"Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats","volume":"82","author":"Xu","year":"2005","journal-title":"Pharmacol. Biochem. Behav."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390813005339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390813005339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T23:09:22Z","timestamp":1746054562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390813005339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":78,"alternative-id":["S0028390813005339"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2013.11.009","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective and cognitive enhancing effects of a multi-targeted food intervention in an animal model of neurodegeneration and depression","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2013.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}