{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:22:17Z","timestamp":1790677337776,"version":"4.1.0"},"reference-count":130,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.neuropharm.2014.01.043","type":"journal-article","created":{"date-parts":[[2014,2,2]],"date-time":"2014-02-02T19:17:59Z","timestamp":1391368679000},"page":"70-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"special_numbering":"C","title":["Epigenetic modifications in the nervous system and their impact upon cognitive impairments"],"prefix":"10.1016","volume":"80","author":[{"given":"Andrii","family":"Rudenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Huei","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2014.01.043_bib2","first-page":"35","article-title":"Loss of HDAC5 impairs memory function: implications for Alzheimer's disease","author":"Agis-Balboa","year":"2013","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib3","doi-asserted-by":"crossref","first-page":"8288","DOI":"10.1523\/JNEUROSCI.0097-09.2009","article-title":"Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function","volume":"29","author":"Akhtar","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib4","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.neuron.2004.05.021","article-title":"Chromatin acetylation, memory, and LTP are impaired in CBP+\/\u2212 mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration","volume":"42","author":"Alarcon","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib7","doi-asserted-by":"crossref","first-page":"5062","DOI":"10.1523\/JNEUROSCI.0079-12.2012","article-title":"HDAC1 regulates fear extinction in mice","volume":"32","author":"Bahari-Javan","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib8","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.cell.2013.01.038","article-title":"An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders","volume":"152","author":"Baker","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib9","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/npp.2011.61","article-title":"Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory","volume":"36","author":"Barrett","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1055\/s-2007-979737","article-title":"Microscopic observations of the brain in Rett syndrome","volume":"26","author":"Bauman","year":"1995","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0092-8674(94)90400-6","article-title":"Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein","volume":"79","author":"Bourtchuladze","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib12","doi-asserted-by":"crossref","first-page":"10518","DOI":"10.1073\/pnas.1834280100","article-title":"A\u00a0mouse model of Rubinstein-Taybi syndrome: defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4","volume":"100","author":"Bourtchouladze","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1101\/lm.801108","article-title":"The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear","volume":"15","author":"Bredy","year":"2008","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1101\/lm.500907","article-title":"Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear","volume":"14","author":"Bredy","year":"2007","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib16","doi-asserted-by":"crossref","first-page":"40778","DOI":"10.1074\/jbc.M103921200","article-title":"Demethylase activity is directed by histone acetylation","volume":"276","author":"Cervoni","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib17","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.1153252","article-title":"MeCP2, a key contributor to neurological disease, activates and represses transcription","volume":"320","author":"Chahrour","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib18","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology","volume":"56","author":"Chahrour","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib19","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1242\/jcs.114.13.2363","article-title":"p300\/CBP proteins: HATs for transcriptional bridges and scaffolds","volume":"114","author":"Chan","year":"2001","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2005.12.027","article-title":"The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression","volume":"49","author":"Chang","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.nbd.2009.05.001","article-title":"Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations","volume":"35","author":"Chapleau","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"Chen","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib25","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.1086446","article-title":"Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2","volume":"302","author":"Chen","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib26","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1093\/hmg\/8.12.2317","article-title":"Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene","volume":"8","author":"Chiurazzi","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib27","doi-asserted-by":"crossref","first-page":"12732","DOI":"10.1523\/JNEUROSCI.2522-07.2007","article-title":"The nuclear kinase mitogen- and stress-activated protein kinase 1 regulates hippocampal chromatin remodeling in memory formation","volume":"27","author":"Chwang","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib28","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1101\/lm.152906","article-title":"ERK\/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning","volume":"13","author":"Chwang","year":"2006","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib29","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuron.2011.08.022","article-title":"Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function","volume":"72","author":"Cohen","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib32","series-title":"p25\/Cyclin-dependent Kinase 5 Induces Production and Intraneuronal Accumulation of Amyloid Beta in\u00a0Vivo","author":"Cruz","year":"2006"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib33","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0896-6273(03)00627-5","article-title":"Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles","volume":"40","author":"Cruz","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2009.06.028","article-title":"Histone deactylase inhibition combined with behavioral therapy enhances learning and memory following traumatic brain injury","volume":"163","author":"Dash","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib35","doi-asserted-by":"crossref","first-page":"e11383","DOI":"10.1371\/journal.pone.0011383","article-title":"Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats","volume":"5","author":"Dash","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib36","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.stem.2011.07.010","article-title":"Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development","volume":"9","author":"Dawlaty","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib38","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neuron.2011.05.019","article-title":"Epigenetic mechanisms in cognition","volume":"70","author":"Day","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib39","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cell.2010.06.020","article-title":"SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10","volume":"142","author":"Donmez","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib41","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nature12348","article-title":"Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR","volume":"499","author":"Ebert","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib42","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/29680","article-title":"DNA methylation models histone acetylation","volume":"394","author":"Eden","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib43","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1523\/JNEUROSCI.21-03-00788.2001","article-title":"DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals","volume":"21","author":"Fan","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib44","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuropharm.2012.06.043","article-title":"Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity","volume":"64","author":"Fass","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib45","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature05772","article-title":"Recovery of learning and memory is associated with chromatin remodelling","volume":"447","author":"Fischer","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1097-2765(01)00429-4","article-title":"Enzymatic activity associated with class II HDACs is dependent on a multiprotein containing HDAC3 and SMRT\/N-CoR","volume":"9","author":"Fischle","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib47","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nn.2514","article-title":"Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons","volume":"13","author":"Feng","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib48","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.mcn.2008.06.009","article-title":"Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice","volume":"39","author":"Font\u00e1n-Lozano","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib49","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/nature09271","article-title":"A\u00a0novel pathway regulates memory and plasticity via SIRT1 and miR-134","volume":"466","author":"Gao","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib50","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.biopsych.2005.07.025","article-title":"Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice","volume":"59","author":"Gemelli","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib51","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/nature00928","article-title":"Protein phosphatase 1 is a molecular constraint on learning and memory","volume":"418","author":"Genoux","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib52","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/emmm.201201923","article-title":"Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease","volume":"5","author":"Govindarajan","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib53","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1523\/JNEUROSCI.5657-12.2013","article-title":"A\u00a0dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration","volume":"33","author":"Gr\u00e4ff","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib55","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature10849","article-title":"An epigenetic blockade of cognitive functions in the neurodegenerating brain","volume":"483","author":"Gr\u00e4ff","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib56","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature07925","article-title":"HDAC2 negatively regulates memory formation and synaptic plasticity","volume":"459","author":"Guan","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib57","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cell.2011.03.022","article-title":"Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain","volume":"145","author":"Guo","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib58","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.4161\/cc.10.16.17093","article-title":"Emerging roles of TET proteins and 5- hydroxymethylcytosines in active DNA demethylation and beyond","volume":"10","author":"Guo","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib60","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nlm.2011.04.009","article-title":"Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity","volume":"96","author":"Haggarty","year":"2011","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib61","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s00018-005-5555-8","article-title":"Rubinstein-Taybi syndrome: molecular findings and therapeutic approaches to improve cognitive dysfunction","volume":"63","author":"Hallam","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib62","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1523\/JNEUROSCI.3162-12.2013","article-title":"Histone deacetylase 2 cell autonomously suppresses excitatory and enhances inhibitory synaptic function in CA1 pyramidal neurons","volume":"33","author":"Hanson","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib63","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1101\/lm.2097411","article-title":"Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory","volume":"18","author":"Hawk","year":"2011","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib66","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng1491","article-title":"Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome","volume":"37","author":"Horike","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib67","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nature09303","article-title":"Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification","volume":"466","author":"Ito","year":"2010","journal-title":"Nature"},{"issue":"Suppl.\u00a033","key":"10.1016\/j.neuropharm.2014.01.043_bib68","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng1089","article-title":"Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals","author":"Jaenisch","year":"2003","journal-title":"Nat. Genet."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.neuropharm.2014.01.043_bib69","doi-asserted-by":"crossref","first-page":"S206","DOI":"10.1016\/S0387-7604(01)00351-5","article-title":"Neurobiology of Rett syndrome: a genetic disorder of synapse development","volume":"23","author":"Johnston","year":"2001","journal-title":"Brain Dev."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib70","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/561","article-title":"Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription","volume":"19","author":"Jones","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib71","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.neuron.2013.08.032","article-title":"TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation","volume":"79","author":"Kaas","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib72","doi-asserted-by":"crossref","DOI":"10.1186\/1756-6606-5-14","article-title":"The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB","volume":"5","author":"Kandel","year":"2012","journal-title":"Mol. Brain"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib73","doi-asserted-by":"crossref","first-page":"10879","DOI":"10.1523\/JNEUROSCI.2089-12.2012","article-title":"An essential role for histone deacetylase 4 in synaptic plasticity and memory formation","volume":"32","author":"Kim","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib76","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.stem.2011.01.008","article-title":"Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells","volume":"8","author":"Koh","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib77","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.neuron.2004.06.002","article-title":"CBP histone acetyltransferase activity is a critical component of memory consolidation","volume":"42","author":"Korzus","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib78","doi-asserted-by":"crossref","first-page":"13079","DOI":"10.1523\/JNEUROSCI.3610-09.2009","article-title":"Protein phosphatase 1 regulates the histone code for long-term memory","volume":"29","author":"Koshibu","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib80","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/gerona\/gls110","article-title":"Mechanisms of age-related cognitive change and targets for intervention: epigenetics","volume":"67","author":"Kosik","year":"2012","journal-title":"J.\u00a0Gerontol. A. Biol. Sci. Med. Sci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib81","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1126\/science.1169786","article-title":"The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain","volume":"324","author":"Kriaucionis","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib82","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/nn.3181","article-title":"HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity","volume":"15","author":"Kurita","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib83","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.tins.2013.05.001","article-title":"Epigenetic layers and players underlying neurodevelopment","volume":"36","author":"LaSalle","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib84","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1749-6632.2011.06037.x","article-title":"Behavioral epigenetics","volume":"1226","author":"Lester","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib85","doi-asserted-by":"crossref","first-page":"40545","DOI":"10.1074\/jbc.M402229200","article-title":"Regulation of histone acetylation during memory formation in the hippocampus","volume":"279","author":"Levenson","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib86","doi-asserted-by":"crossref","first-page":"15763","DOI":"10.1074\/jbc.M511767200","article-title":"Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus","volume":"281","author":"Levenson","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib87","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrn1604","article-title":"Epigenetic mechanisms in memory formation","volume":"6","author":"Levenson","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib88","series-title":"Purification, Sequence, and Cellular Localization of a Novel Chromosomal Protein that Binds to Methylated DNA","author":"Lewis","year":"1992"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib89","doi-asserted-by":"crossref","DOI":"10.1126\/science.1237905","article-title":"Global epigenomic reconfiguration during mammalian brain development","volume":"341","author":"Lister","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib90","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1136\/jmedgenet-2011-100354","article-title":"Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein-Taybi syndrome","volume":"49","author":"Lopez-Atalaya","year":"2012","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib92","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.neuron.2007.07.039","article-title":"The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories","volume":"55","author":"Lubin","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib93","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1166859","article-title":"Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis","volume":"323","author":"Ma","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib94","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1073\/pnas.1213364110","article-title":"HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner","volume":"110","author":"Malvaez","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib95","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1523\/JNEUROSCI.5052-10.2011","article-title":"HDAC3 is a critical negative regulator of long-term memory formation","volume":"31","author":"McQuown","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib96","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1093\/nar\/20.19.5085","article-title":"Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA","volume":"20","author":"Meehan","year":"1992","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib97","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.cell.2012.11.022","article-title":"MeCP2 binds to 5\u00a0hmC enriched within active genes and accessible chromatin in the nervous system","volume":"151","author":"Mell\u00e9n","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib98","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.nlm.2007.07.016","article-title":"DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity","volume":"89","author":"Miller","year":"2008","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib99","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/nn.2560","article-title":"Cortical DNA methylation maintains remote memory","volume":"13","author":"Miller","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib100","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.neuron.2007.02.022","article-title":"Covalent modification of DNA regulates memory formation","volume":"53","author":"Miller","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib102","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1523\/JNEUROSCI.1001-12.2013","article-title":"Loss of histone deacetylase 2 improves working memory and accelerates extinction learning","volume":"33","author":"Morris","year":"2013","journal-title":"J.\u00a0Neurosci."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.neuropharm.2014.01.043_bib103","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/S0387-7604(01)00381-3","article-title":"Neuroimaging studies in Rett syndrome","volume":"23","author":"Naidu","year":"2001","journal-title":"Brain Dev."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib104","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0092-8674(00)81887-5","article-title":"MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin","volume":"88","author":"Nan","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib106","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1128\/MCB.01593-06","article-title":"Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin","volume":"27","author":"Nikitina","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib107","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nature07238","article-title":"S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons","volume":"455","author":"Nott","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib108","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1093\/hmg\/ddi229","article-title":"Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome","volume":"14","author":"Nuber","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib110","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/hmg\/8.3.387","article-title":"Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism","volume":"8","author":"Oike","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib111","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1101\/lm.1939811","article-title":"Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments","volume":"18","author":"Oliveira","year":"2011","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib112","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1101\/lm.656907","article-title":"Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits","volume":"14","author":"Oliveira","year":"2007","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib113","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1126\/science.1186088","article-title":"Altered histone acetylation is associated with age-dependent memory impairment in mice","volume":"328","author":"Peleg","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib114","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1042\/bj1260781","article-title":"The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid","volume":"126","author":"Penn","year":"1972","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib116","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/376348a0","article-title":"Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP","volume":"376","author":"Petrij","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib117","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/nbt.1685","article-title":"Epigenetic modifications and human disease","author":"Portella","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib118","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.1208049","article-title":"Npas4 regulates a transcriptional program in CA3 required for contextual memory formation","volume":"334","author":"Ramamoorthi","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib119","first-page":"723","article-title":"On an unusual brain atrophy syndrome in hyperammonemia in childhood","volume":"116","author":"Rett","year":"1966","journal-title":"Wien. Med. Wochenschr."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib120","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/hipo.20883","article-title":"Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease","volume":"22","author":"Ricobaraza","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib122","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1086\/429130","article-title":"Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease","volume":"76","author":"Roelfsema","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib123","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.conb.2009.05.011","article-title":"Regulation of chromatin structure in memory formation","volume":"19","author":"Roth","year":"2009","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib125","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1001\/archpedi.1963.02080040590010","article-title":"Broad thumbs and toes and facial abnormalities. possible mental retardation syndrome","volume":"105","author":"Rubinstein","year":"1963","journal-title":"Am. J. Dis. Child."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib126","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.neuron.2013.08.003","article-title":"Tet1 is critical for neuronal activity-regulated gene expression and memory extinction","volume":"79","author":"Rudenko","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib127","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.neuint.2011.02.004","article-title":"HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND)","volume":"58","author":"Saiyed","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib129","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2012.09.037","article-title":"HDAC4 governs a transcriptional program essential for synaptic plasticity and memory","volume":"15","author":"Sando","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib131","first-page":"683","article-title":"Biochemical studies on histones of the central nervous system. III. Incorporation of [14C]-acetate into the histones of different rat brain regions during a learning experiment","volume":"38","author":"Schmitt","year":"1979","journal-title":"Acta Biol. Med. Ger."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib133","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0896-6273(02)00768-7","article-title":"Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3","volume":"18","author":"Shahbazian","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib134","doi-asserted-by":"crossref","first-page":"e895","DOI":"10.1371\/journal.pone.0000895","article-title":"DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons","volume":"2","author":"Siegmund","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib135","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2013.02.004","article-title":"Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives","volume":"152","author":"Spruijt","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib136","doi-asserted-by":"crossref","first-page":"9447","DOI":"10.1073\/pnas.0903964106","article-title":"Modulation of long-term memory for object recognition via HDAC inhibition","volume":"106","author":"Stefanko","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib137","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.expneurol.2012.10.005","article-title":"Mercaptoacetamide-based class II HDAC inhibitor lowers A\u03b2 levels and improves learning and memory in a mouse model of Alzheimer's disease","volume":"239","author":"Song","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib138","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1523\/JNEUROSCI.21-10-03383.2001","article-title":"Increased histone acetyltransferase and lysine acetyltransferase activity and biphasic activation of the ERK\/RSK cascade in insular cortex during novel taste learning","volume":"21","author":"Swank","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib140","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.biopsych.2008.09.002","article-title":"Experience-dependent epigenetic modifications in the central nervous system","volume":"65","author":"Sweatt","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib141","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1038\/nn.2959","article-title":"5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging","volume":"14","author":"Szulwach","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib142","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1170116","article-title":"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib143","doi-asserted-by":"crossref","first-page":"10215","DOI":"10.1073\/pnas.94.19.10215","article-title":"Abnormal skeletal patterning in embryos lacking a single CBP allele: a partial similarity with Rubinstein-Taybi syndrome","volume":"94","author":"Tanaka","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib144","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ydbio.2013.11.005","article-title":"CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development","volume":"385","author":"Tsui","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib145","doi-asserted-by":"crossref","first-page":"15536","DOI":"10.1073\/pnas.242566899","article-title":"Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain","volume":"99","author":"Tudor","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib147","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.neuron.2010.12.023","article-title":"Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events","volume":"69","author":"Uchida","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib148","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1523\/JNEUROSCI.4737-10.2011","article-title":"Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation but does not affect cell viability","volume":"31","author":"Valor","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib150","doi-asserted-by":"crossref","first-page":"6128","DOI":"10.1523\/JNEUROSCI.0296-07.2007","article-title":"Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB: CBP-dependent transcriptional activation","volume":"27","author":"Vecsey","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib151","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.nbd.2009.10.001","article-title":"Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology","volume":"1","author":"Viosca","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib153","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1086\/302690","article-title":"Rett syndrome and beyond: recurrent spontaneous and familial MECP2 mutations at CpG hotspots","volume":"65","author":"Wan","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib154","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.devcel.2009.10.023","article-title":"CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain","volume":"18","author":"Wang","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib155","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nn1276","article-title":"Epigenetic programming by maternal behavior","volume":"8","author":"Weaver","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib157","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1101\/lm.213906","article-title":"A\u00a0transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes","volume":"13","author":"Wood","year":"2006","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib158","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1101\/lm.278206","article-title":"Combinatorial chromatin modifications and memory storage: a code for memory?","volume":"13","author":"Wood","year":"2006","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib159","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1101\/lm.86605","article-title":"Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage","volume":"12","author":"Wood","year":"2005","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuropharm.2014.01.043_bib161","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0092-8674(00)81165-4","article-title":"Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300","volume":"93","author":"Yao","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.01.043_bib160","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddu496","article-title":"Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome","author":"Yasui","year":"2014","journal-title":"Hum. Mol. Gen."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390814000501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390814000501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T03:10:22Z","timestamp":1648177822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390814000501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":130,"alternative-id":["S0028390814000501"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2014.01.043","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic modifications in the nervous system and their impact upon cognitive impairments","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2014.01.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}