{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:52:27Z","timestamp":1788871947013,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"crossref","award":["FENDV"],"award-info":[{"award-number":["FENDV"]}],"id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["FEPB"],"award-info":[{"award-number":["FEPB"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.neuropharm.2014.06.005","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T15:54:58Z","timestamp":1402934098000},"page":"375-383","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Neuropathic plasticity in the opioid and non-opioid actions of dynorphin A fragments and their interactions with bradykinin B2 receptors on neuronal activity in the rat spinal cord"],"prefix":"10.1016","volume":"85","author":[{"given":"Kirsty","family":"Bannister","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Sun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Goncalves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Porreca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony H.","family":"Dickenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.neuropharm.2014.06.005_bib1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0304-3940(90)90797-D","article-title":"Blockade of the glycine modulatory site of NMDA receptors modifies dynorphin-induced behavioral effects","volume":"110","author":"Bakshi","year":"1990","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.neuropharm.2014.06.005_bib2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.nurt.2009.07.009","article-title":"Preclinical and early clinical investigations related to monoaminergic pain modulation","volume":"6","author":"Bannister","year":"2009","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neuropharm.2014.06.005_bib3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/299079a0","article-title":"Dynorphin and dynorphin are ligands for the kappa-subtype of opiate receptor","volume":"299","author":"Corbett","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.06.005_bib4","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1074\/jbc.273.2.829","article-title":"Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity","volume":"273","author":"Day","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2014.06.005_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ana.410270111","article-title":"Opioid and nonopioid mechanisms may contribute to dynorphin's pathophysiological actions in spinal cord injury","volume":"27","author":"Faden","year":"1990","journal-title":"Ann. Neurol."},{"issue":"2\u20133","key":"10.1016\/j.neuropharm.2014.06.005_bib6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0014-2999(83)90487-9","article-title":"Dynorphin induces partially reversible paraplegia in the rat","volume":"91","author":"Faden","year":"1983","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2014.06.005_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0167-0115(85)90029-1","article-title":"Increased dynorphin immunoreactivity in spinal cord after traumatic injury","volume":"11","author":"Faden","year":"1985","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neuropharm.2014.06.005_bib8","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0196-9781(90)90187-A","article-title":"Dynorphin increases in the dorsal spinal cord in rats with a painful peripheral neuropathy","volume":"11","author":"Kajander","year":"1990","journal-title":"Peptides"},{"issue":"6","key":"10.1016\/j.neuropharm.2014.06.005_bib9","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1523\/JNEUROSCI.1517-03.2004","article-title":"Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2","volume":"24","author":"Koetzner","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.005_bib10","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/nn1804","article-title":"Dynorphin A activates bradykinin receptors to maintain neuropathic pain","volume":"9","author":"Lai","year":"2006","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.neuropharm.2014.06.005_bib11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neulet.2008.03.088","article-title":"Pronociceptive actions of dynorphin via bradykinin receptors","volume":"437","author":"Lai","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2014.06.005_bib12","first-page":"160","article-title":"Neuropathic pain: the paradox of dynorphin","volume":"1","author":"Lai","year":"2001","journal-title":"Mol. Interv."},{"issue":"18","key":"10.1016\/j.neuropharm.2014.06.005_bib13","doi-asserted-by":"crossref","first-page":"6608","DOI":"10.1021\/ja501677q","article-title":"Discovery of amphipathic dynorphin a analogues to inhibit the neuroexcitatory effects of dynorphin a through bradykinin receptors in the spinal cord","volume":"136","author":"Lee","year":"2014","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.neuropharm.2014.06.005_bib14","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.jpain.2008.06.005","article-title":"Spinal dynorphin and bradykinin receptors maintain inflammatory hyperalgesia","volume":"9","author":"Luo","year":"2008","journal-title":"J.\u00a0Pain Official J. Am. Pain Soc."},{"key":"10.1016\/j.neuropharm.2014.06.005_bib15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0304-3959(00)00243-8","article-title":"Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats","volume":"86","author":"Malan","year":"2000","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.neuropharm.2014.06.005_bib16","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.mcn.2009.10.001","article-title":"Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression","volume":"43","author":"Minokadeh","year":"2010","journal-title":"Mol. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.neuropharm.2014.06.005_bib17","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/0006-8993(92)90090-V","article-title":"Selective potentiation of NMDA-induced activity and release of excitatory amino acids by dynorphin: possible roles in paralysis and neurotoxicity","volume":"575","author":"Skilling","year":"1992","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.neuropharm.2014.06.005_bib18","first-page":"99","article-title":"Opioid receptors mediating the antinociceptive effect of dynorphin at spinal cord level","volume":"20","author":"Spampinato","year":"1984","journal-title":"Ann. Ist. Super. Sanita"},{"key":"10.1016\/j.neuropharm.2014.06.005_bib19","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/nn966","article-title":"Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways","volume":"5","author":"Suzuki","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.005_bib20","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brainres.2004.05.108","article-title":"Descending facilitatory control of mechanically evoked responses is enhanced in deep dorsal horn neurones following peripheral nerve injury","volume":"1019","author":"Suzuki","year":"2004","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.neuropharm.2014.06.005_bib21","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1152\/jn.2000.83.5.2610","article-title":"Dynorphin A elicits an increase in intracellular calcium in cultured neurons via a non-opioid, non-NMDA mechanism","volume":"83","author":"Tang","year":"2000","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuropharm.2014.06.005_bib22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S1385-299X(03)00068-0","article-title":"In\u00a0vivo single unit extracellular recordings from spinal cord neurones of rats","volume":"12","author":"Urch","year":"2003","journal-title":"Brain Res. Brain Res. Protoc."},{"key":"10.1016\/j.neuropharm.2014.06.005_bib23","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1523\/JNEUROSCI.20-18-07074.2000","article-title":"Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance","volume":"20","author":"Vanderah","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.005_bib24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0304-3959(96)03225-3","article-title":"Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats: blockade by MK-801 but not naloxone","volume":"68","author":"Vanderah","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2014.06.005_bib25","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1126\/science.6128791","article-title":"Nonopiate effects of dynorphin and des-Tyr-dynorphin","volume":"218","author":"Walker","year":"1982","journal-title":"Science (New York, N.Y.)"},{"issue":"5","key":"10.1016\/j.neuropharm.2014.06.005_bib26","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1523\/JNEUROSCI.21-05-01779.2001","article-title":"Pronociceptive actions of dynorphin maintain chronic neuropathic pain","volume":"21","author":"Wang","year":"2001","journal-title":"J.\u00a0Neurosci."},{"issue":"19","key":"10.1016\/j.neuropharm.2014.06.005_bib27","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1523\/JNEUROSCI.5552-03.2004","article-title":"Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance","volume":"24","author":"Xu","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.005_bib28","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0196-9781(87)90046-5","article-title":"The degradation of dynorphin A in brain tissue in\u00a0vivo and in\u00a0vitro","volume":"8","author":"Young","year":"1987","journal-title":"Peptides"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390814002275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390814002275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T11:28:34Z","timestamp":1565522914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390814002275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":28,"alternative-id":["S0028390814002275"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2014.06.005","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuropathic plasticity in the opioid and non-opioid actions of dynorphin A fragments and their interactions with bradykinin B2 receptors on neuronal activity in the rat spinal cord","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2014.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}