{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:36:59Z","timestamp":1778553419704,"version":"3.51.4"},"reference-count":146,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81325025"],"award-info":[{"award-number":["81325025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202983"],"award-info":[{"award-number":["81202983"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Jiangsu province","award":["BK20141035"],"award-info":[{"award-number":["BK20141035"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.neuropharm.2014.06.020","type":"journal-article","created":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T01:31:06Z","timestamp":1403919066000},"page":"94-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"PA","title":["Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way?"],"prefix":"10.1016","volume":"96","author":[{"given":"Xiao","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongzhao","family":"Ran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangji","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiping","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2014.06.020_bib1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.bbi.2009.10.010","article-title":"Systemic inflammation sensitizes the neonatal brain to excitotoxicity through a pro-\/anti-inflammatory imbalance: key role of TNFalpha pathway and protection by etanercept","volume":"24","author":"Aden","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.neuron.2012.03.023","article-title":"Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment","volume":"74","author":"Bakker","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nbd.2009.07.031","article-title":"The blood\u2013brain barrier and immune function and dysfunction","volume":"37","author":"Banks","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib4","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.neuron.2008.10.013","article-title":"The mystery and magic of glia: a perspective on their roles in health and disease","volume":"60","author":"Barres","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib5","doi-asserted-by":"crossref","first-page":"11578","DOI":"10.1523\/JNEUROSCI.2266-11.2011","article-title":"Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes","volume":"31","author":"Barrientos","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib6","doi-asserted-by":"crossref","first-page":"14641","DOI":"10.1523\/JNEUROSCI.2173-12.2012","article-title":"Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats","volume":"32","author":"Barrientos","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib7","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1073\/pnas.1211270110","article-title":"CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging","volume":"110","author":"Baruch","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A.."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tips.2010.10.002","article-title":"Genomic and proteomic strategies to identify novel targets potentially involved in learning and memory","volume":"32","author":"Benoit","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib9","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.imlet.2008.02.002","article-title":"Differences of peripheral inflammatory markers between mild cognitive impairment and Alzheimer's disease","volume":"117","author":"Bermejo","year":"2008","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature08983","article-title":"Neural mechanisms of ageing and cognitive decline","volume":"464","author":"Bishop","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuron.2009.09.034","article-title":"Harnessing immune alterations in neurodegenerative diseases","volume":"64","author":"Bjorkqvist","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib12","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1084\/jem.20080178","article-title":"A\u00a0novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease","volume":"205","author":"Bjorkqvist","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-mediated neurotoxicity: uncovering the molecular mechanisms","volume":"8","author":"Block","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrneurol.2011.1","article-title":"Monoclonal antibody therapy-associated neurological disorders","volume":"7","author":"Bosch","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib15","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.tics.2013.08.007","article-title":"Understanding cognitive deficits in Alzheimer's disease based on neuroimaging findings","volume":"17","author":"Braskie","year":"2013","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib16","doi-asserted-by":"crossref","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib17","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1096\/fj.02-0757fje","article-title":"CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury","volume":"17","author":"Campbell","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib18","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1111\/j.1471-4159.2007.04928.x","article-title":"Immunomodulatory effects of etanercept in a model of brain injury act through attenuation of the acute-phase response","volume":"103","author":"Campbell","year":"2007","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib19","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/S0002-9440(10)62365-6","article-title":"Central nervous system injury triggers hepatic CC and CXC chemokine expression that is associated with leukocyte mobilization and recruitment to both the central nervous system and the liver","volume":"166","author":"Campbell","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib20","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.cub.2011.04.028","article-title":"The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease","volume":"21","author":"Campesan","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.05.029","article-title":"Environmental and genetic activation of a brain-adipocyte BDNF\/leptin axis causes cancer remission and inhibition","volume":"142","author":"Cao","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib22","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.bbi.2009.04.006","article-title":"Detrimental consequences of brain injury on peripheral cells","volume":"23","author":"Catania","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib23","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/ana.22082","article-title":"Role of interleukin-1beta in postoperative cognitive dysfunction","volume":"68","author":"Cibelli","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib24","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/nn.2632","article-title":"Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism","volume":"13","author":"Clapper","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib25","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrmicro2876","article-title":"The interplay between the intestinal microbiota and the brain","volume":"10","author":"Collins","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib26","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2007.06.011","article-title":"Exercise builds brain health: key roles of growth factor cascades and inflammation","volume":"30","author":"Cotman","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib27","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib28","doi-asserted-by":"crossref","first-page":"9275","DOI":"10.1523\/JNEUROSCI.2614-05.2005","article-title":"Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration","volume":"25","author":"Cunningham","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib29","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1523\/JNEUROSCI.3567-08.2009","article-title":"Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation","volume":"29","author":"D'Mello","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib30","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/ncpneuro0901","article-title":"B\u00a0cells as therapeutic targets in autoimmune neurological disorders","volume":"4","author":"Dalakas","year":"2008","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib31","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1021\/pr0700753","article-title":"Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates","volume":"6","author":"Dalrymple","year":"2007","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib33","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neuroscience.2013.02.055","article-title":"Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: behavioral and electrophysiological proofs for microbiome\u2013gut\u2013brain axis","volume":"240","author":"Davari","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib34","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neuron.2011.05.019","article-title":"Epigenetic mechanisms in cognition","volume":"70","author":"Day","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","article-title":"Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits","volume":"156","author":"De Vadder","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib36","doi-asserted-by":"crossref","first-page":"10086","DOI":"10.1523\/JNEUROSCI.1227-10.2010","article-title":"Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice","volume":"30","author":"Denes","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib37","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.bbi.2009.09.010","article-title":"Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation","volume":"24","author":"Denes","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib38","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.bbi.2011.02.008","article-title":"Brain inflammation is induced by co-morbidities and risk factors for stroke","volume":"25","author":"Drake","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib39","doi-asserted-by":"crossref","first-page":"13632","DOI":"10.1073\/pnas.2234031100","article-title":"Inflammation is detrimental for neurogenesis in adult brain","volume":"100","author":"Ekdahl","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib40","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S1474-4422(08)70061-9","article-title":"Acute ischaemic stroke and infection: recent and emerging concepts","volume":"7","author":"Emsley","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib41","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1124\/jpet.108.143420","article-title":"Challenges in the search for drugs to treat central nervous system disorders","volume":"329","author":"Enna","year":"2009","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib42","doi-asserted-by":"crossref","first-page":"e53888","DOI":"10.1371\/journal.pone.0053888","article-title":"Standardized environmental enrichment supports enhanced brain plasticity in healthy rats and prevents cognitive impairment in epileptic rats","volume":"8","author":"Fares","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrn3209","article-title":"The many faces of insulin-like peptide signalling in the brain","volume":"13","author":"Fernandez","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib44","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.tips.2010.09.003","article-title":"Targeting the correct HDAC(s) to treat cognitive disorders","volume":"31","author":"Fischer","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib45","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.tins.2013.01.005","article-title":"Gut-brain axis: how the microbiome influences anxiety and depression","volume":"36","author":"Foster","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib46","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.psyneuen.2013.11.006","article-title":"Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus","volume":"40","author":"Frank","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib47","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2174\/187152711794653751","article-title":"Targeting TNF-alpha to elucidate and ameliorate neuroinflammation in neurodegenerative diseases","volume":"10","author":"Frankola","year":"2011","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib48","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s12035-010-8137-1","article-title":"Why pleiotropic interventions are needed for Alzheimer's disease","volume":"41","author":"Frautschy","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib49","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.nbd.2009.07.028","article-title":"Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases","volume":"37","author":"Gabathuler","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib50","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1172\/JCI44911","article-title":"Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice","volume":"121","author":"Gangadharan","year":"2011","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib51","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1017\/S1462399411001918","article-title":"Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases","volume":"13","author":"Grammas","year":"2011","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib52","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.3748\/wjg.v9.i12.2776","article-title":"Alterations of intestinal mucosa structure and barrier function following traumatic brain injury in rats","volume":"9","author":"Hang","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib53","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1073\/pnas.0805453106","article-title":"Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy","volume":"106","author":"Hawkes","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib54","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1073\/pnas.1010529108","article-title":"Normal gut microbiota modulates brain development and behavior","volume":"108","author":"Heijtz","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib55","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.2353\/ajpath.2010.100442","article-title":"Glatiramer acetate attenuates pro-inflammatory T cell responses but does not directly protect neurons from inflammatory cell death","volume":"177","author":"Herrmann","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib56","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S1474-4422(09)70062-6","article-title":"Neuroinflammation in Parkinson's disease: a target for neuroprotection?","volume":"8","author":"Hirsch","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib57","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/187152711794488665","article-title":"Soothing the inflamed brain: effect of non-steroidal anti-inflammatory drugs on Alzheimer's disease pathology","volume":"10","author":"Hoozemans","year":"2011","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib58","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.cell.2013.11.024","article-title":"Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders","volume":"155","author":"Hsiao","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib59","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib60","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.2174\/138161208784705441","article-title":"Diabetes, cognitive function, and the blood-brain barrier","volume":"14","author":"Huber","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib61","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.tics.2010.11.002","article-title":"Cognitive enhancement by drugs in health and disease","volume":"15","author":"Husain","year":"2011","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib62","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3233\/JAD-2009-1164","article-title":"Increased inflammatory response both in brain and in periphery in presenilin 1 and presenilin 2 conditional double knock-out mice","volume":"18","author":"Jiang","year":"2009","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib63","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.bbi.2012.05.015","article-title":"Environmental enrichment attenuates hippocampal neuroinflammation and improves cognitive function during influenza infection","volume":"26","author":"Jurgens","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib64","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1742-2094-8-100","article-title":"Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy","volume":"8","author":"Kang","year":"2011","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib65","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jpsychires.2010.05.015","article-title":"Peripheral biomarkers and illness activity in bipolar disorder","volume":"45","author":"Kapczinski","year":"2011","journal-title":"J.\u00a0Psychiatr. Res."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib66","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1474-4422(10)70277-5","article-title":"Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease","volume":"10","author":"Kapogiannis","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib67","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/qjmed\/hcq152","article-title":"TNF-alpha antagonists beyond approved indications: stories of success and prospects for the future","volume":"103","author":"Karampetsou","year":"2010","journal-title":"QJM"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib68","doi-asserted-by":"crossref","first-page":"13203","DOI":"10.1073\/pnas.0605411103","article-title":"An internally controlled peripheral biomarker for Alzheimer's disease: Erk1 and Erk2 responses to the inflammatory signal bradykinin","volume":"103","author":"Khan","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib69","doi-asserted-by":"crossref","first-page":"8180","DOI":"10.1073\/pnas.0402268101","article-title":"T\u00a0cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions","volume":"101","author":"Kipnis","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib70","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nri3280","article-title":"Pro-cognitive properties of T cells","volume":"12","author":"Kipnis","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib71","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1161\/STROKEAHA.111.000536","article-title":"Cognitive decline after stroke: relation to inflammatory biomarkers and hippocampal volume","volume":"44","author":"Kliper","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib72","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.bbi.2011.10.006","article-title":"Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice","volume":"26","author":"Kohman","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib73","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbi.2012.09.003","article-title":"Neurogenesis, inflammation and behavior","volume":"27","author":"Kohman","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib74","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1136\/gutjnl-2011-300474","article-title":"The brain\u2013gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study","volume":"61","author":"Koloski","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib75","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.tins.2010.09.003","article-title":"When neurogenesis encounters aging and disease","volume":"33","author":"Lazarov","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib76","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.tins.2013.01.008","article-title":"Neurons as targets for T cells in the nervous system","volume":"36","author":"Liblau","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib77","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nm.1927","article-title":"Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke","volume":"15","author":"Liesz","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib78","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nm.2332","article-title":"Brain PPAR-gamma promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones","volume":"17","author":"Lu","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib79","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.nbd.2008.10.002","article-title":"Antagonism of peripheral inflammation reduces the severity of status epilepticus","volume":"33","author":"Marchi","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib80","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tins.2013.11.002","article-title":"Inflammatory pathways of seizure disorders","volume":"37","author":"Marchi","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib81","doi-asserted-by":"crossref","first-page":"9451","DOI":"10.1523\/JNEUROSCI.2674-08.2008","article-title":"Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice","volume":"28","author":"McColl","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib82","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.neurobiolaging.2013.12.026","article-title":"Age-associated dysregulation of microglial activation is coupled with enhanced blood-brain barrier permeability and pathology in APP\/PS1 mice","volume":"35","author":"Minogue","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib83","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S1474-4422(12)70226-0","article-title":"Cognitive decline in older adults with a history of traumatic brain injury","volume":"11","author":"Moretti","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib84","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nrn3200","article-title":"The ageing cortical synapse: hallmarks and implications for cognitive decline","volume":"13","author":"Morrison","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib85","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2010.07.002","article-title":"The science of stroke: mechanisms in search of treatments","volume":"67","author":"Moskowitz","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib86","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrn2735","article-title":"Plasticity during stroke recovery: from synapse to behaviour","volume":"10","author":"Murphy","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib87","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1474-4422(07)70326-5","article-title":"Strategies to advance translational research into brain barriers","volume":"7","author":"Neuwelt","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib88","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrn2995","article-title":"Engaging neuroscience to advance translational research in brain barrier biology","volume":"12","author":"Neuwelt","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib89","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.nbd.2004.07.011","article-title":"Anti-inflammatory treatment with acetylsalicylate or rofecoxib is not neuroprotective in Huntington's disease transgenic mice","volume":"17","author":"Norflus","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib90","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/ana.22344","article-title":"Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease","volume":"69","author":"Ochoa-Reparaz","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib91","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2009.07.029","article-title":"The role of the blood-CNS barrier in CNS disorders and their treatment","volume":"37","author":"Palmer","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib92","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1742-2094-8-31","article-title":"Selective adenosine A2A receptor agonists and antagonists protect against spinal cord injury through peripheral and central effects","volume":"8","author":"Paterniti","year":"2011","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib93","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.bbi.2004.01.004","article-title":"The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease","volume":"18","author":"Perry","year":"2004","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib94","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nri2015","article-title":"Systemic infections and inflammation affect chronic neurodegeneration","volume":"7","author":"Perry","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib95","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneurol.2014.38","article-title":"Microglial priming in neurodegenerative disease","volume":"10","author":"Perry","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib96","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrneurol.2010.17","article-title":"Microglia in neurodegenerative disease","volume":"6","author":"Perry","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib97","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1474-4422(03)00307-7","article-title":"Gastrointestinal dysfunction in Parkinson's disease","volume":"2","author":"Pfeiffer","year":"2003","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib98","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.nbd.2012.12.017","article-title":"Late exercise reduces neuroinflammation and cognitive dysfunction after traumatic brain injury","volume":"54","author":"Piao","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib99","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.tins.2013.07.003","article-title":"Towards a \u2018systems\u2019-level understanding of the nervous system and its disorders","volume":"36","author":"Qureshi","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib100","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1038\/nm.3400","article-title":"Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering","volume":"19","author":"Rangroo Thrane","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib101","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm1653","article-title":"Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins","volume":"13","author":"Ray","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib102","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbi.2008.07.003","article-title":"Peripheral cytokines profile in Parkinson's disease","volume":"23","author":"Reale","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib103","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0197-4580(03)00087-3","article-title":"Effects of beta-hydroxybutyrate on cognition in memory-impaired adults","volume":"25","author":"Reger","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib104","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.nbd.2011.03.017","article-title":"Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay","volume":"43","author":"Reinhart","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib105","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2011.05.031","article-title":"Treating the periphery to ameliorate neurodegenerative diseases","volume":"145","author":"Reinhart","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib106","doi-asserted-by":"crossref","first-page":"8556","DOI":"10.1523\/JNEUROSCI.1623-11.2011","article-title":"Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke","volume":"31","author":"Ren","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib107","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/npp.2008.136","article-title":"Glucocorticoid receptor blockade normalizes hippocampal alterations and cognitive impairment in streptozotocin-induced type 1 diabetes mice","volume":"34","author":"Revsin","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib108","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nrgastro.2009.35","article-title":"Principles and clinical implications of the brain-gut-enteric microbiota axis","volume":"6","author":"Rhee","year":"2009","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib109","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2565","article-title":"Regulation of innate immune responses in the brain","volume":"9","author":"Rivest","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib110","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1073\/pnas.0803237105","article-title":"Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia","volume":"105","author":"Rosas-Ballina","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib111","doi-asserted-by":"crossref","first-page":"E2895","DOI":"10.1073\/pnas.1121081109","article-title":"Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model","volume":"109","author":"Sanchez","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib112","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrn3257","article-title":"Kynurenines in the mammalian brain: when physiology meets pathology","volume":"13","author":"Schwarcz","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib113","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrneurol.2010.71","article-title":"Systemic inflammatory cells fight off neurodegenerative disease","volume":"6","author":"Schwartz","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib114","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nri3391","article-title":"Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates","volume":"13","author":"Shechter","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib115","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cmet.2013.06.014","article-title":"Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons","volume":"18","author":"Shi","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib116","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tins.2013.06.001","article-title":"Mast cells on the mind: new insights and opportunities","volume":"36","author":"Silver","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib117","doi-asserted-by":"crossref","first-page":"20595","DOI":"10.1073\/pnas.1015282107","article-title":"Modulation of postoperative cognitive decline via blockade of inflammatory cytokines outside the brain","volume":"107","author":"Steinman","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib118","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tips.2012.09.006","article-title":"An expanding range of targets for kynurenine metabolites of tryptophan","volume":"34","author":"Stone","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib119","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1136\/gut.2006.091322","article-title":"The role of the sympathetic nervous system in intestinal inflammation","volume":"55","author":"Straub","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib120","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.nbd.2009.11.004","article-title":"Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention","volume":"37","author":"Tansey","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib121","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/ana.22664","article-title":"Resolving postoperative neuroinflammation and cognitive decline","volume":"70","author":"Terrando","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib122","doi-asserted-by":"crossref","first-page":"20518","DOI":"10.1073\/pnas.1014557107","article-title":"From the Cover: tumor necrosis factor-{alpha} triggers a cytokine cascade yielding postoperative cognitive decline","volume":"107","author":"Terrando","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib123","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1172\/JCI27341","article-title":"Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology","volume":"116","author":"Tesseur","year":"2006","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib124","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.nbd.2006.10.006","article-title":"Blood-brain barrier disruption results in delayed functional and structural alterations in the rat neocortex","volume":"25","author":"Tomkins","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib125","doi-asserted-by":"crossref","first-page":"17714","DOI":"10.1523\/JNEUROSCI.1253-12.2012","article-title":"Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1beta via p38 mitogen-activated protein kinase","volume":"32","author":"Tong","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib126","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nm1781","article-title":"Blocking TGF-beta-Smad2\/3 innate immune signaling mitigates Alzheimer-like pathology","volume":"14","author":"Town","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib127","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nri2566","article-title":"Reflex control of immunity","volume":"9","author":"Tracey","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2011.05.006","article-title":"Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice","volume":"44","author":"van der Burg","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib129","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0140-6736(09)61158-2","article-title":"Systemic infection and delirium: when cytokines and acetylcholine collide","volume":"375","author":"van Gool","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib130","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.tins.2008.12.007","article-title":"Exercise and the brain: something to chew on","volume":"32","author":"van Praag","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib131","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.bbi.2005.10.005","article-title":"Release of cytokines by brain endothelial cells: a polarized response to lipopolysaccharide","volume":"20","author":"Verma","year":"2006","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib132","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.cell.2012.02.046","article-title":"Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model","volume":"149","author":"Verret","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib133","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature10357","article-title":"The ageing systemic milieu negatively regulates neurogenesis and cognitive function","volume":"477","author":"Villeda","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib134","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nm.3569","article-title":"Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice","volume":"20","author":"Villeda","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib135","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.tics.2013.08.001","article-title":"Bridging animal and human models of exercise-induced brain plasticity","volume":"17","author":"Voss","year":"2013","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib136","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3748\/wjg.v17.i5.657","article-title":"Effects of intestinal mucosal blood flow and motility on intestinal mucosa","volume":"17","author":"Wang","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib137","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2220\/biomedres.32.135","article-title":"Plasma miR-124 as a biomarker for cerebral infarction","volume":"32","author":"Weng","year":"2011","journal-title":"Biomed. Res."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib138","doi-asserted-by":"crossref","first-page":"e30525","DOI":"10.1371\/journal.pone.0030525","article-title":"CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease","volume":"7","author":"Westin","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib139","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrn2355","article-title":"Learning and memory: restoring balance in diabetes","volume":"9","author":"Whalley","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib140","doi-asserted-by":"crossref","first-page":"RRN1231","DOI":"10.1371\/currents.RRN1231","article-title":"Abnormal peripheral chemokine profile in Huntington's disease","volume":"3","author":"Wild","year":"2011","journal-title":"PLoS Curr."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib141","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuron.2009.09.035","article-title":"Taking advantage of the systemic immune system to cure brain diseases","volume":"64","author":"Yong","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib142","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.cmet.2013.09.010","article-title":"Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging","volume":"18","author":"Youm","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib143","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nature12143","article-title":"Hypothalamic programming of systemic ageing involving IKK-beta, NF-kappaB and GnRH","volume":"497","author":"Zhang","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib144","first-page":"210","article-title":"Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats","volume":"256C","author":"Zheng","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2014.06.020_bib145","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nn1629","article-title":"Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood","volume":"9","author":"Ziv","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.06.020_bib146","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.cell.2011.05.020","article-title":"Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration","volume":"145","author":"Zwilling","year":"2011","journal-title":"Cell"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390814002421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390814002421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:38:13Z","timestamp":1565570293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390814002421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":146,"alternative-id":["S0028390814002421"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2014.06.020","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way?","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2014.06.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}